Get result as: RSS PDF XML

Sort: Title
SortDirection
previous 6501 - 7000 of 11514 next Page: 1...10 11 12 13 14 15 16 17 ...24 Size: 10 20 50 500
Project

Molecular genetics and pathology of signal transduction. Historic

Vrije Universiteit Brussel

The main objectives of our research are: - Identification and characterisation of hormone and neurotransmittor receptors . - Investigation of the mechanisms of receptor regulation by physiological and patho- physiological conditions with special emphasis to pathologies of the human CNS. - Tlle interaction between natural products from plants and animal venoms (conotoxins) with receptors and their ligands. - Investig,ltion of the physiological and clinical relevallce of membrane proteins witll...

Project

Molecular genetic service spin-off: Multiplex PCR algorithm in DNA profiling.

University of Antwerp

This project is centered round 3 defined goals: providing non-standard fee-for-service expertise (services); technology development to create new products and/or methods (technology development); and molecular genetics research related to complex diseases in general and psychiatric diseases in particular (complex genetics). Through our services we provide third parties the possibility to use our genetic analysis expertise, like sequence based SNP discovery and genotyping STR markers and SNPs ...

Project

Molecular genetics/genomics of psychiatric diseases in an isolated population. Historic

University of Antwerp

Aims of the project : A. Identification of novel genes for psychiatric disorders in an isolated population from Northern Sweden B. Identification of novel loci for psychiatric disorders C. Development of neurophenomics research D. Development of genetic and genomic Multiplex PCR applications

Project

Molecular genetics of Alzheimer's disease: an integrated genetic, genomics and neuropathological approach. Historic

University of Antwerp

The general aim of this project is to contribute to a bettter knowledge of the genetic etiology of AD. This knowledge is expected to provide a better insight in the genetic risk profile of a human being (early detection) and in the biology of the disease process in brain (neuropathology/biology). Specific aims: 1. Collection of materials for genetic studies of AD patients and families. 2. Genetic characterization of AD patients and genotype-phenotype correlations. 3. Identification of novel c...

Project

Molecular genetics of bimodal protein targeting in yeast.

KU Leuven

Many of the microbial processes important for the establishment of infections by bacteria or fungi can be considered 'developmental processes'.For example, the transition from a planktonic cell to a biofilm cell attached to the mucosal surface of a host requires an intricate network ofregulatory processes that determine the expression levels of a large number of genes. The student in the VIB department will help in the development of bimolecular fluorescence complementation (BiFC) in order to...

Project

Molecular genetics of early-onset Alzheimer's disease. Recently ended

University of Antwerp

Early-onset Alzheimer's disease (AD) is a fatal neurodegenerative dementia occurring in mid-life (onset of disease between 30 and 65 years) that is severely disruptive for patients and their relatives. An estimated 3000 to 11000 people have early-onset AD in Belgium. Early-onset AD has a strong genetic component, but the majority of the genetic etiology is still unresolved, as mutations in the known dementia genes and the genetic risk conferred by APOE ε4 do not explain more than 10-20% of th...

Project

Molecular genetics of frontal temporal dementia : identification of causal and genetic risk factors. Historic

University of Antwerp

The general aim of this project is to contribute to a better understanding of the genetic etiology of familial and sporadic FTD. Specific aims are: 1) Collection of FTD patients and families, 2) Identification of the genetic defect in FTDU-17, 3) Identification of novel FTD loci and 4) Genetic association study of MAPT in FTD patient populations.

Project

Molecular genetics of idiopathic epilepsies. Historic

University of Antwerp

Epilepsy is one of the most common neurologic disorders, with a cumulative life-time incidence of about 3%. The epilepsies can be classified according to their etiology. For the idiopathic epilepsies there is no underlying cause other than a possible hereditary predisposition. Molecular genetic research has already identified thirteen genes in which mutations cause epilepsy. The fact that mutations in these genes are only found in a limited part of the families indicates that the idiopathic e...

Project

Molecular genetics of idiopathic epilepsies. Historic

University of Antwerp

Epilepsy is one of the most common neurologic disorders, with a cumulative life-time incidence of about 3%. The epilepsies can be classified according to their etiology. For the idiopathic epilepsies there is no underlying cause other than a possible hereditary predisposition. Molecular genetic research has already identified thirteen genes in which mutations cause epilepsy. The fact that mutations in these genes are only found in a limited part of the families indicates that the idiopathic e...

Project

Molecular genetics of inherited ulcero-mutilating peripheral neuropathies Historic

University of Antwerp

In this project we will try to identify de genes and gene defects responsible for ulcero-mutilating peripheral neuropathies. Two loci for ulcero-mutilating neuropathies have been described, the HSN type I locus on chromosome 9q22.1-q22.3 and the CMT2B (HMSN type IIB) locus on 3q13-q22. However the responsible genes have not been identified yet. We study five families with hereditary ulcero-mutilating neuropathy. Three of these families are linked to the CMT2B locus. In the remaining two famil...

Project

Molecular genetics of mantle cell lymphoma. Recently ended

KU Leuven

Mantle cell lymphoma (MCL) is a well-defined B-cell neoplasm with a poor prognosis and a short survival. MCL is hallmarked by t(11;14)(q13;q32)that leads to overexpression of cyclin D1, an important regulator of the G1 phase of the cell cycle. This tumor shows the high level of genomicinstability, reflected by complex karyotypes and numerous non-recurrentsecondary aberrations likely playing an important role in disease maintenance and progression. Genomic abnormalities in MCL have not been fu...

Project

Molecular genetics of neurodegenerative brain diseases. Historic

University of Antwerp

The aim of this project is the identification of genes and risk factors for Parkinson's disease, parkinsonism and mixed parkinsonism and dementia, e.g. dementia with Lewy bodies (DLB). Families and patient populations are used for the identification of these genetic factors in respectively linkage and association studies. Family AD-V, a Flemish multiplex family with parkinsonism and dementia, was collected when the index patient of this family screened negative for mutations in the known deme...

Project

Molecular genetic studies of inherited epilepsies. Historic

University of Antwerp

General aims: (1) Recruiting en characterization of additional patients and families; (2) Locus and gene-identification studies; (3) Mutations analyses and studies on SCN1A in the context of SMEI; (4) Mutation analysis of known genes.

Project

Molecular genetic studies of the HPA axis as a neurobiological risk factor for mood disorders. Historic

University of Antwerp

Aims 1. Collecting patient samples with extensive clinical and HP A axis functional evaluations 2. The construction of SNP maps of candidate genes involved in HP A axis function 2. The construction of SNP maps of candidate genes involved in HPA axis function. 3. Statistical genetic investigation of the role of these genes in causing HP A axis dysfunction and major depression in populations of patients and controls.

Project

Molecular genetic study of distal hereditary motor neuropathies (distal HMN). Historic

University of Antwerp

Distal hereditary motor neuropathies (distal HMN) are pure motor disorders of the peripheral nervous system resulting in severe atrophy and wasting of distal limb muscles. Distal HMNs are clinically and genetically heterogeneous. So far 8 loci and 3 genes have been identified for autosomal dominant and recessive distal HMNs. Recently, we identified missense mutations in a novel gene in distal HMN-II families. Via mutation analysis of these genes in families and isolated patients with a distal...

Project

Molecular genetic study of distal hereditary motor neuropathies (distal HMN). Historic

University of Antwerp

Distal hereditary motor neuropathies (distal HMN) are pure motor disorders of the peripheral nervous system resulting in severe atrophy and wasting of distal limb muscles. Distal HMNs are clinically and genetically heterogeneous. So far 8 loci and 3 genes have been identified for autosomal dominant and recessive distal HMNs. Recently, we identified missense mutations in a novel gene in distal HMN-II families. Via mutation analysis of these genes in families and isolated patients with a distal...

Project

Molecular genomics of neurodegenerative brain diseases. Historic

University of Antwerp

This research project aims at the identification of genetic defects in novel loci that were identified in previous molecular genetic studies of patients with neurodegenerative brain diseases. Identification of novel genetic defects will result in better understanding the pathobiology of neurodegenerative brain diseases, that will dramatically increase in frequency in the near future due to the aging of western societies.

Project

Molecular genomics of TDP-43 positive frontotemporal lobar degeneration (FTLD-TDP): elucidation of disease pathways through an integrated approach. Historic

University of Antwerp

Frontotemporal lobar degeneration (FTLD) is a severe neurodegenerative brain disease with a prevalence similar to that of Alzheimer's disease (AD) in patients with an early onset of disease. However, an appropriate therapy is not yet available. Clinical FTLD characteristics are often accompanied by amyotrophic lateral sclerosis (ALS) symptoms. Pathologically, most patients show TDP-43-positive brain inclusions (FTLD-TDP). Genetic factors play an essential role in the etiology of the disease s...

Project

Molecular imaging and molecular profiling for head, neck, lung and rectal cancer MRT: application in dose-painting and response prediction. Recently ended

Ghent University

The KUL-UCL-UG consortium has been contributing since 2003 (thanks to the support of the Foundation against Cancer) to validate the use of molecular imaging in Target Volume (TV) delineation for the treatment of head and neck (H1N), and rectal cancers. In line with the previous researchprojects, the general aim of the study proposal is: 1) to validate the dose-painting approach to escalate radiation dose on TV(s) delineated onPET images using tracers of metabolism, hypoxia and proliferation. ...

Project

Molecular imaging for early response assessment of drugs targeting the PI3K/mTOR pathway in an HER-2 amplified breast cancer model.

University of Antwerp

The treatment with Trastuzumab in human epidermal growth factor receptor 2 (HER-2) overexpressing breast cancer is often transient and almost all the cancers eventually progress. One of the mechanisms of resistance has been linked to aberrant activation of PI3K/AKT/mTOR signaling pathway downstream of the receptor. By blocking downstream proteins at select sites resistant cancers may potentially regain sensitivity to HER-2 therapy. Recently, several potential agents for targeting this pathwa...

Project

Molecular imaging in the preclinical and prodromal phase of Alzheimers disease

KU Leuven

Molecular imaging in Alzheimer’s disease (AD) and related neurodegenerative diseases allows one to measure in vivo processes that were in the recent past only accessible for measurement post mortem. The Laboratory for Cognitive Neurology in collaboration with the Department of Nuclear Medicine have contributed significantly to the clinical development of amyloid imaging. The current PhD aims at further consolidating this position. The PhD will be focused on three questions: in patients in a p...

Project

'Molecular Imaging' meets 'Imaging Molecules' Recently ended

University of Antwerp

Magnetic Resonance imaging plays a crucial role in stem cell research in order to investigate whether administered stem cells are able to migrate to the target organ, locally survive, differentiate and contribute to regenerated tissue. However, knowledge regarding the interaction of MRI contrast agents with (sub)cellular structures is lacking. In this project, we will use advanced TEM techniques to investigate different MRI contrast agents and loading techniques for neural stem cells.

Project

Molecular imaging of HER2 expression of breast carcinoma with radiolabeled Nanobodies Historic

Vrije Universiteit Brussel

Aims of the research project Within the framework of this project we aim to develop a new targeting probe for molecular imaging of HER2 expression in breast cancer patients. For this purpose we will design a Nanobody with nanomolar affinity for HER2 that shows a fast blood clearance and low liver accumulation in vivo. Introduction: Malignant tumors are characterized by the presence of specific proteins on their cell membrane. These cancer antigens are expressed in relatively high amounts and ...

Project

Molecular imaging of stem cells via site-specific integrated human reporter genes to evaluate therapeutic efficacy in Duchenne muscular dystrophy models.

KU Leuven

Duchenne muscular dystrophy (DMD) is a lethal X-linked single gene recessive disorder with a relative frequent incidence of 1 per 3500-7500 affected newborn human males. The absence of functional dystrophin causes instability of the striated muscle because of impairment in the dystrophin-glycoprotein complex (DGC). This leads to muscle membrane fragility and the typical clinical manifestations including progressive muscle degeneration, loss of independent ambulation, respiratory and cardiac c...

Project

Molecular interactions between myofibroblasts and colon cancer cells during invasion Historic

Ghent University

During tumor progression, there is a contiuous cross talk between cancer cells, host cells and the extracellular matrix. In the microecosystem of colon cancer, fibroblasts and myofibroblasts are important host elements. Myofibroblasts stimulate invasion of these colon cancer cells, unless they are treated with 1ng/ml TGF-B1. Currently we investigate the factor(s) secreted by myofibroblasts and the signaltransduction pathways responsible for stimulation of invasion.

Project

Molecular interactions between the influenza A virus RNA polymerase complex and the host cell Historic

Ghent University

Specific interaction partners of the influenza A RNA polymerase complex will be identified. Recombinant influenza A viruses will be used in which the RNA polymerase subunits have been epitope-tagged. Co-immunoprecipitation and protein identification will allow to identify host cell factors that ineract with the replication machinery of influenza A virus.

Project

Molecular investigations in the patients with defects in the complexes of the oxidative phosphorylation and the pyruvate dehydrogenase complex. Historic

Vrije Universiteit Brussel

With the focus on mitochondrial diseases an excellent collaboration exists for several years between the laboratory of Medical Genetics of the Free University of Brussels and the laboratory of the Paediatric Department of the Ghent University Hospital. The mitochondrial centre that has emerged from this collaboration has become the reference centre for mitochondrial diseases in Belgium.With this project we want to develop new methods and new diagnostic possibilities for patients with mitochon...

Project

Molecular investigations in the patients with defects in the complexes of the oxidative phosphorylation and the pyruvate dehydrogenase complex. Historic

Vrije Universiteit Brussel

With the focus on mitochondrial diseases an excellent collaboration exists for several years between the laboratory of Medical Genetics of the Free University of Brussels and the laboratory of the Paediatric Department of the Ghent University Hospital. The mitochondrial centre that has emerged from this collaboration has become the reference centre for mitochondrial diseases in Belgium. With this project we want to develop new methods and new diagnostic possibilities for patients with mitocho...

Project

Molecular karyotyping Historic

Vrije Universiteit Brussel

Array comparative genomic hybridization (array CGH), also called molecular karyotyping, uses microarray technology (high density DNA probes on a solid surface) to detect in parallel whether any of several thousands of chromosomal fragments are deleted or duplicated in a genomic DNA sample. Array CGH can thus identify chromosomal abnormalities in patients with constitutional or acquired disorders and in embryos. From our own experience in developing this highly effective molecular technique a...

Project

Molecular markers and modulation of therapy in colorectal tumours. Historic

University of Antwerp

Aim of this study is to investigate differences in biological behaviour between sporadic colorectal tumours and to determine the relation of these differences with clinico-pathological parameters. This way we hope to find markers that can differentiate between patients with a low or a high risk of relapse.

Project

Molecular markers and modulation of therapy in colorectal tumours. Historic

University of Antwerp

(part UA) Aim of this study is to investigate differences in biological behaviour between sporadic colorectal tumours and to determine the relation of these differences with clinico-pathological parameters. This way we hope to find markers that can differentiate between patients with a low or a high risk of relapse.

Project

Molecular markers and therapy modulation in colorectal tumours Historic

Ghent University

To identify key genes and proteins involved in the response to (neo) adjuvant therapy in colorectal cancer. Tumour DNA, mRNA and proteins will be studied with the state of the art technology (tissue microarrays, RT-PCR, Western blots). Large groups of patients will be studied and we have preclinical models that allow us to test the hypoteses.

Project

Molecular markers for epidemiological monitoring of drug resistance in visceral leishmaniasis. Historic

University of Antwerp

Treatment of the tropical disease leishmanisis is beconing more difficult be cause of the emergence of widespread resistance against the first-line drugs. Epidemiological studies on the prevalence and spread of drug-resistance forms a basis for the correct positioning of treatment strategies. This project will run a phenotyping of Leishmania donovani field strains and will develop molecular tools for the detection of natural SBV-resistance. More in particular, the following objectives are con...

Project

Molecular markers of vascular calcification in chronic renal failure. Historic

University of Antwerp

Chronic renal failure is associated with a strong increase in cardiovascular mortality, with vascular calcification as a prominent feature. Although the pathophysiology of this calcification process is incompletely understood, in vitro studies have revealed important parallels with bone formation. In order to characterise this calcification process further, the temporal expression pattern of osteoblast, osteoclast and chondrocyte markers will be investigated immunohistochemically and by real ...

Project

Molecular mechanism and function of modulatory subunits of Kv channels. Recently ended

University of Antwerp

The overall goal of this project is to obtain novel insights in the molecular aspects of the association and interaction of KvS and KCNE subunits with the Kv2 and KCNQ1 subunits, respectively, using several complementary techniques to study protein-protein interaction, subcellular distribution and biophysical channel properties. Furthermore, we aim to determine the physiological role of Kv2/KvS heterotetrameric channels, using a transgenic model system (targeted deletion of Kv6.4).

Project

Molecular mechanism for the linkage between S4 movement and channel opening in voltage-gated potassium channels Historic

University of Antwerp

Ion channels are transmembrane proteins that allow selective ion permeation through a central pore which opens and closes depending on an external stimulus. In the case of voltage dependent ion channels it is the movement of S4 ' the voltage sensor ' that opens such gate in the channel pore. The heterogeneity in the voltage dependence of current activation reflects differences in coupling of S4 movement to channel opening. Shaker K channels and hyperpolarization activated (HCN) channels di...

Project

Molecular mechanisms in tumor cell invasion and diabetes: bridging novel proteomics with cell biology Historic

Ghent University

Using recently developed gel-free proteome technologies (COFRADIC), we aim at gaining new insights and identifying novel molecules involved in signaling mechnisms leading to tumor invasion and B-cell destruction in diabetes.

Project

Molecular mechanisms involved in organ-specific metastatic growth processes in breast cancer Historic

Ghent University

Breast cancers are prone to metastatise, particularly to the lymphatics, bone, liver, lungs and central nervous system tissues. The proposed STREP project "METABRE" will investigate the molecular mechanisms of this metastasis, including the identification and functional analysis of new genes and proteins that characterise the organ-specific metastatic phenotype, and the interaction of cancer cells with the affected organ tissues.

Project

Molecular mechanisms involved in the regulation of the paracaspase MALT1 in T cel receptor induced signal transduction Recently ended

Ghent University

MALT1 is an intracellular signalling protein that plays a crucial role in antigen induced activation of nuclear factor kB (NF-kB) dependent gene expression in T activation can result in autoimmune disease and some lymphomas. This project aims to elucidate the intracellular mechanisms that regulate MALT1 activity.

Project

Molecular mechanisms of apoptosis by xanthohumol in B-CLL Historic

Ghent University

The flavonoid xanthohumol induces cell death in B-CLL cells, through PARP cleavage and caspse-9 activation. The process is associated with mcl-1 and bcl-Xl downregulation, IkB kinase independent NF-kappaB suppression and activation of eIF2a phosphorylation and induction of CHOP, suggestive of endoplasmic reticulum stress as the major cell kill principle.

Project

Molecular mechanisms of bacterial resistance to biocides Historic

Ghent University

The goal of this project is to investigate the molecular mechanisms of biocide-resistance in various bacteria. As modelsystems we chose Pseudomonas aeruginosa, Burkholderia cepacia complex organisms, Escherichia coli, Stpahylococcus sp. And Enterococcus sp. The biocides that will be investigated are the often-used products for which data are available that resistance has developed already.

Project

Molecular mechanisms of bone formation and anabolism.(ANABONOS) Historic

University of Antwerp

Osteoporotic fractures are a major healthcare problem in Europe and this is set to increase as the proportion of the elderly individuals in the population expands. This proposal will advance understanding of the mechanisms responsible for bone formation, with the long-term aim of harnessing this knowledge to develop new anabolic agents for osteoporosis. These aims will be achieved by drawing leading European academic research groups together with SME's working in bone metabolism to define the...

Project

Molecular mechanisms of inflammatory shock Historic

Ghent University

Using shock models in transgenic mice, the molecular pathways of various forms of inflammatory shock (sepsis, anaphylaxis, SIRS) are characterised. Both NO-dependent and NO-independent pathways are analysed.

Project

Molecular mechanisms of interleukin-1 receptor (IL-1R) and Toll-like receptor (TLR) induced signal transduction in inflammation and immunity Historic

Ghent University

TLRs and IL-1R induced intracellular signal transduction is crucial for the innate immune response against infection. Uncontroled activation of this response can result in different inflammatory diseases and sepsis. In this project, we aim to elucidate the mechanisms that control the activation of NF-kB dependent gene expression and caspase-1 activation, in vitro as well as in mice.

Project

Molecular mechanisms of intrinsically disordered proteins Recently ended

Vrije Universiteit Brussel

Proteins are small nanomachines that carry out almost all tasks within a living cell: catalyzing enzymatic reactions, acting as pumps or motors, regulating gene expression, ... Besides the classically well-folded proteins, there exists another class of proteins that are intrinsically disordered. Most often these proteins or protein domains only adopt a folded structure upon interaction with a partner. Their intrinsically disordered nature facilitates a number of functions that would be diffic...

Project

Molecular mechanisms of synaptic ageing: endocytosis, endosomal trafficand protein refolding.

KU Leuven

Most neurons do not divide and the contacts between neurons are often located far away from their cell bodies where new proteins are built. Neurons therefore harbor local mechanisms to keep proteins healthy maintaining in that way function over long periods of activity. Although these mechanisms are implicated in neuronal diseases, they are not well understood. Recently, we uncovered a protein we named Skywalker (Sky) that controls the sorting and degradation of dysfunctional proteins. This m...

Project

Molecular mechanisms of the interaction between neurotoxins and potassium and sodium channels.

University of Antwerp

This project focuses on the novel lipid exposed toxin/drug binding site in Kv channels that we recently characterized using the marine neurotoxin gambierol. This binding site is most likely the molecular equivalent of Nav channel 'site 5'. Site 5 (and site 2) toxins disrupt fast inactivation and cause a negative shift in the activation leading to persistent Na-current (i.e. potentiation). However, in Kv channels the toxin binding had an opposite effect and resulted in channel block. The overa...

Project

Molecular mechanisms of the lifespan-doubling effect of axenic culture in the nematode caenorhabditis elegans.

Ghent University

Axenically cultured C. Elegans lives twice as long compared to worms in bacterial culture. A list of genes will be tested for their role in this lifespan extension. In parallel, we will perform transcriptomics to gereate extra candidate genes. Genes that are shown to be required for axenic lifespan extension will be further characterzed by expression studies and Rnai.

Project

Molecular mechanisms of voltage-dependent gating in potassium channels. Historic

University of Antwerp

Specific aims: 1. Elucidate the dynamic behavior of channel opening with FRET during voltage clamp. 2. Do the S1 and S5 domains of Kv2.1 interact with each other? 3. Which residues in the S6 C-terminus in KCNQ1 are relevant for channel gating? 4. The KIKER sequence modulates gating through charge interactions.

Project

Molecular mechanisms of zinc tolerance in Suillus luteus. Recently ended

Universiteit Hasselt

Zinc is an essential micronutrient for all organisms but can become toxic when present in elevated concentrations. The quantity of free zinc in the cell has to be controlled precisely to assure growth and reproduction in all circumstances, in spite of the potential toxic nature of this element. Eukaryotes evolved a zinc homeostasis network restricting the zinc influx, storing it in specific organelles and/or chelating it when present in elevated concentrations [1]. However, at prolonged expos...

Project

Molecular mechanisms regulating the activity and specificity of CYLD in T cells

Ghent University

CYLD plays a key role in immunity and inflammation by negatively regulating NF-?B and JNK signaling pathways, which leads to the activation of pro-inflammatory gene expression. In this project we will study the role of posttranslational modifications of CYLD in TCR stimulated cells.

Project

Molecular mechanisms underlying Drosophila melanogaster-mediated transport of the brewer's yeast Saccharomyces cerevisiae Recently ended

KU Leuven

Yeast cells such as Saccharomyces cerevisae are free-living, unicellular organisms that measure approximately 5 µm in size. Like manyother microorganisms, yeasts are incapable of active transport and onlypassive movements, over a small distance, can be achieved through flocculation or formation of hyphae. However, in order to colonize new niches the microorganisms need to cross larger distances. The primary mechanism for these large displacements is the transport by insects and other animal v...

Project

Molecular Mechanisms Wich Lead to Stroma-Indenpendente Growth of Myleom Cells. Historic

Vrije Universiteit Brussel

Multiple Myeloma (MM) is a B-cel neoplasm, characterized by a clonal expansion of malignant plasma cells in the bone marrow (BM), which secrete a monoclonal immunoglobuline (Ig). Recently, a human MM cell line has been developed in our lab, starting from a long term BM culture from a MM patient. This MM 5.1 cell line exclusively grows in the presence of human BM stroma or in the presence of conditioned~nedium from normal BM cells. Moreover it was shown that the removal of the suoma induces ap...

Project

Molecular mode of action of 1,25-dihydroxyvitamin D3: from chromatin toprotein. Recently ended

KU Leuven

Although vitamin D can be derived from nutrition, the main supply of vitamin D3 derives from photosynthesis in the skin. Therefore, vitamin D is not considered as a true vitamin but rather as a precursor of a hormone. The biologically active form of vitamin D, 1,25-dihydroxyvitamin D3 [1,25-(OH)2D3] exerts its genomic effects through the vitamin D receptor (VDR). Upon binding of the ligand, VDR heterodimerizes with retinoid X receptor and binds to Vitamin D Response Elements in the promoter r...

Project

Molecular pathogenesis and Treatment of MNGIE. Historic

Vrije Universiteit Brussel

Following the models constructed of novel polymeric nanoparticles encapsulating human thymidine phosphorylase for which in vitro studies indicate that the TP-nanoreactors are enzymatically active and stable in blood. We will continue to perform pharmcokinetic studies to establish the tissue distribution and half-life of TPNR, followed by short-term toxicity and pharmacokinetic studies by administering TP-NR long-term to nucleoside-stressed TP/UP/mice to assess efficacy. We will use neuroimagi...

Project

Molecular pathological and therapeutic approaches for Alzheimer's disease. Historic

University of Antwerp

Specific aims: -To identify changes occurring in the vascular endothelium or other vascular cellular elements prior to AB deposition as well as to identify novel chaperones from the vascular compartment that facilitate dense core plaque formation. Such studies will greatly aid in identifying novel potential therapeutic targets-i.e., in facilitating therapeutic enhancement of AB clearance or in therapeutically stabilizing or repairing the blood-brain barrier. -To augment the ongoing attempts ...

Project

Molecular pathomechanisms of HSPB1 and HSPB8 mutations in motor neuropathies: study of protein-protein interactions and axonal transport in cellular and animal models. Recently ended

University of Antwerp

In recent years more than 30 disease-associated genes for inherited peripheral neuropathies have been identified and at least one third of these encode proteins with housekeeping functions, such as: stress response, RNA processing, translation synthesis, and apoptosis (Timmerman et al., 2006). The motor neurons seem to be particularly vulnerable to defects in these housekeeping proteins likely because their large axons have high metabolic requirements for maintenance, transport over long dist...

Project

Molecular, pharmacological and functional characterization of serotonin and dopamine receptors from Tribolium castaneum and Schistocerca gregaria Recently ended

KU Leuven

Dopamine and serotonin are two major neuro-active substances that were shown to induce gregarious behavior in solitarious locusts. They bind toreceptors, specialized proteins on the surface of the cell, to influence processes inside these cells. Each cell contains genes in its nucleus that ‘encode’ particular receptors. The genes are ‘transcribed’ to so called messenger (or transcripts) that are on their turn ‘translated’ to the receptor proteins. Insects contain different types of serotonin ...

Project

Molecular phenotyping and in vivo assessment of miRNA perturbation in neuroblastoma Recently ended

Ghent University

MicroRNAs (miRNAs) are a recently discovered class of biomolecules. Their involvement in the development of neuroblastoma, a childhood cancer of the sympathetic nervous system, is already well established. In this project we will try to elucidate the function of each individual miRNA in the genome using an innovative approach.

Project

Molecular phenotyping of genome-wide miRNA perturbation in neuroblastoma Historic

Ghent University

Neuroblastoma is the most frequent solid extracranial childhood tumour. Despite multimodel therapy, patient prognosis remains poor. Besed on an innovative strategy, the effects of a genome-wide miRNA perturbation in neuroblastoma cells will be evaluated.this project aims to unravel miRNA signaling networks in different subtypes of neuroblastoma tumours.

Project

Molecular phylogenetic biodiversity assessment of tropical African ectomycorrhizal fungi, with an emphasis on Russulaceae

Ghent University

This project aims to resolve the phylogeny of the genus LActifluus and wants to estimate divergence times for the origin and diversification of the genus and develop a model-based historical biogeographical hypothesis for the evolutionary diversification. We also want to reveal the hidden diversity of Russulaceae species and other ectomycorrhizal fungi using ectomycorrhizal root tip samples and pyrosequencing.

Project

Molecular phylogeography of Mastomys natalensis: an evolutionary framework for understanding rodent-borne diseases. Historic

University of Antwerp

The objective of this proposal is to complete the study of rodent-borne diseases by establishing an evolutionary framework of the host pathogen interactions. The phylogeography of the African multimammate mouse M. natalensis, reservoir for arenaviruses and other pathogens, will be realised using molecular markers. The results will be used to reconstruct the relationships among M. natalensis populations and investigate the co-evolution between M. natalensis and arenaviruses.

Project

Molecular, physiological and cytological study of the early response to ethylene during vegetative growth of Arabidopsis Historic

Ghent University

The goal of this project is two-fold. First, we will study the role of ethylene in regulating the velocity and extent of cell expansion. Several organs will be studied during their early response to the hormone. Furthermore, we aim at elucidation of the influence of the cytoskeleton upon expansion and differentiation upon ethylene exposure.

Project

Molecular-physiological and cytological study of the early response to ethylene in vegetative growth of Arabidopsis. Historic

University of Antwerp

Molecular-physiological and cytological study of the early response to ethylene in vegetative growth of Arabidopsis.

Project

Molecular physiology. Concerted actions Jacobs and Glansdorff Historic

Vrije Universiteit Brussel

Molecular physiology of plants and microorganisms

Project

Molecular physiology: investigations on the strategies of adaptation to high and low temperatures in carbamoyltransferases and carbamoylphosphate synthetases. Historic

Vrije Universiteit Brussel

The project aims at unraveling by convergent genetic, biochemical and structural approaches the molecular strategies which underlie the adaptation of enzymes involved in the metabolism of carbamoylphosphate to extremes of temperatures (high and low) and the protection of a thermolabile and potentially toxis metabolic intermediate (carbamoylphosphate) against thermodegradation in extreme and hyperthermophilic microorganisms.

Project

Molecular physiology: investigations on the strategies of adaptation to high and low temperatures in carbamoyltransferases and carbamoylphosphate synthetases. Historic

Vrije Universiteit Brussel

The project aims at unraveling by convergent genetic, biochemical and structural approaches the molecular strategies which underlie the adaptation of enzymes involved in the metabolism of carbamoylphosphate to extremes of temperatures (high and low) and the protection of a thermolabile and potentially toxis metabolic intermediate (carbamoylphosphate) against thermodegradation in extreme and hyperthermophilic microorganisms.

Project

Molecular plants physiology and biotechnology Historic

Vrije Universiteit Brussel

Matching FWO project: Meiotic restitution in microspores of higher plants.

Project

Molecular research to an ecological adaptation: toe pads in anurans Historic

Vrije Universiteit Brussel

The multiple independent emergence and disappearance of a complex organ such as toe pads is perhaps one of the most fascinating aspects of adaptive radiations in frogs. The objectives of this project are: 1. Isolation and identification of genes distally expressed in fingers and toes. 2. Identification and annotation of genes directly involved in the development of toe pads. 3. Research on quantitative and spatial differences in gene expression. 4. Research on the evolution of toe pad spe...

Project

Molecular separation in nanoporous solids: chain lenght exclusion and molecular pacj-king in cage and window structures. Recently ended

Vrije Universiteit Brussel

In this project, molecular storage effects in materials with an ordered pore structure of molecular dimensions are studied, regarding the development of new separation techniques and the the steering of selectivity in katelytistic processes.

Project

Molecular signaling and modulation of mitochondrial functions during cell death Historic

Ghent University

Mitochondria are crucial in apoptotic and necrotic cell death. The project aims at unraveling the molecular signaling by an in vitro reconstitution on isolated mitochondria. We will also molecularly analyze the modulatory influence of metabolic cellular conditions (hypoxia, ER stress, energy metabolism) on mitochondrial functioning in cell death. An important aspect concerns the proteome analysis of mitochondrial subfractionations in various metabolic conditions.

Project

Molecular Signaling in Cell Death and Inflamation: an integrative approach from basic mechanisms to disease models

Ghent University

The P7/32 DISCOBEL network will focus on the interrelation between cell death and inflammation in an integrated approach going from the study of fundamental mechanisms in cell death, NF-kB and inflammasome to validation of concepts in inflammatory, infectious and cancer disease models and bringing them to experimental therapeutic applications in mice. The main objectives of the DISCOBEL research program are: To identify molecular mechanisms and signal transduction pathways that control ...

Project

Molecular signaling in inflammation and immunity Historic

Ghent University

Cytokine and TLR induced signal transduction is crucial for the innate immune response. Uncontroled activation of this response can result in different inflammatory diseases and cancer. In this project, we aim to elucidate the mechanisms that control the activation of NF-kB dependent gene expression and caspase-1 activation, in vitro as well as in mice.

Project

Molecular signature of malignant cancer: focus on the oncogenic actin cyoskeleton in invasive prostate en breast cancer Historic

Ghent University

Using global expression profilling and proteome analysis a molecular signature of invasive prostate and breast cancer will be derived. This will possibly lead to the development of a set of proteins useful for prognosis of tumor progression in prostate and breast cancer. For individual actin binding proteins functional analysis in cells will allow to derive whether their altered expression in tumors has a causal role in invasiveness.

Project

Molecular signature recognition for improved diagnosis, prognosis and follow-up in neuroblastoma Historic

Ghent University

The objective of the study is to test a relatively small set of 59 carefully selected top ranking prognostic marker genes on a large panel of primary untreated neuroblastoma tumours and to look for a predictive difference in gene-expression between the neuroblastoma samples from uniformly treated patients that relapsed/died and those from the event-free survivors within the same risk groups.

Project

MOLECULAR SIGNATURES OF DISTINCT MACROPHAGE ACTIVATION STATES AS A MONITORING AND TARGET IDENTIFICATION TOOL FOR THERAPY AND IMMUNOMODULATION Historic

Ghent University

Identification of the macrophage genes that are involved in the inhibition of the dendritic cell function in mouse models of asthma and COPD

Project

Molecular structure-function analysis of a novel class of K-channel blocking scorpion toxins. Historic

University of Antwerp

The general aim of this project is the identification of the ion channels that are the targets of these novel toxins. Secondly, the specificity of the interaction will be used to perform structure-function analysis on these channels and toxins. Specific aims; 1. The biological target of k-Hefutoxin1 2A. Structure-function analysis of channels with a high binding affinity for k-Hefutoxin1 2B. Structure-function analysis of the k-Hefutoxin1 3. Biological targets and structure-function analysis ...

Project

Molecular Study of Mannose Binding Lectin(s) of Lactobacilli and their Potential as HIV Trap Recently ended

KU Leuven

We harbor millions of microorganisms in our body, which collectively are called the microbiota. They are found on the skin, in the mouth, nose,throat, gastrointestinal tract and the urogenital tract. In the recent decades, gut microbiota has gained a lot of attention. But microbiota inother niches is also important for human health. Lactic acid bacteria in the vagina play a crucial role in women's health by preventing urogenital and sexually transmitted infections. However, the molecules cont...

Project

Molecular Study of the Pathogenesis of Hepatic Fibrosis and Glomerulosclerosis: Purification of Stellate and Mesangial Cells by Flow Cytometric Cell Sorting. Historic

Vrije Universiteit Brussel

On the Medical Campus of V.U.B., extracellular matrix research is being performed in two laboratories. The group of Prof. Dr. A. Geerts at the Laboratory of Cell Biology and Histology studies the pathogenesis of hepatic fibrosis. The group of Prof. Dr. C. Van Den Branden at the Laboratory of Human Anatomy investigates the development of glomerulosclerosis. The link to clinical medicine is established via Prof. Dr. D. Verbeeien (Dept. of Internal Medicine, AZ-VUB). The two parts of this projec...

Project

Molecular systematics and phylogeny of holothurians Historic

Vrije Universiteit Brussel

Phylogenetic relationships between extant classes of echinoderms remain largely enigmatic for evolutionary biologists. The phylogeny of asteroids, crinoids, ophiuroids, and echinoids is largely resolved with morphological and molecular evidence. The phylogeny and evolution of holothurians is however mstly dependent on morphological evidence, whereby no consensus is reached. This study aims at revealing the phylogeny of the echinoderms and the holothurians through alignment of nucleotide seque...

Project

Molecular therapy of neuroblastoma: a p53-oriented appraoch Recently ended

Ghent University

The p53 tumor suppressor pathway offers attractive opportunities for targeted therapy of neuroblastoma. We will try to initiate a clinical trial with the p53-activating drug nutlin-3 in neuroblastoma, characterize noncoding RNA molecules and SNPs that affect the p53 network in neuroblastoma, investigate how the MYCN oncogene alters the p53 response to chemotherapy, and identify new targets for molecular therapy.

Project

Molecular understanding and application directed studies of polyoxometalates as a novel class of artificial proteases.

KU Leuven

The sequence selective activity in the presence of [MoO4]2-, whichwas reported to occur at Asp-X peptide bonds, holds promise for proteomics applications. The regioselectivity observed for Ce(IV)- and Zr(IV)-substituted polyoxotungstates is interesting in the light of protein structure determination, especially since these complexes are applicable under non-denaturating conditions and retain their selectivity even after prolonged incubation times. The main objective of this project is to furt...

Project

Molecules in confined spaces: adsorption, diffusion and reaction. Historic

Vrije Universiteit Brussel

Matching BNTW-WE: Separation of binary mixtures on metal-organic frameworks. Objectives of the project 1. To mine the potential of MOFS in separation of binary gas or liquid mixtures, by identifying combinations of {MOF + binary mixture} that afford high separation factors; 2. For selected cases, to follow the interaction between the MOF surface and the adsorbates (pure or as a binary mixture) by spectroscopic or diffraction methods, 3. For these cases, to identify relationships between adso...

Project

MOMEVIP - Molecular and metabolic bases of volatile isoprenoid-induced resistance to stresses. Recently ended

University of Antwerp

The MOMEVIP partners will integrate competences in ecology, physiology, biochemistry, molecular biology, functional genomics and bioinformatics to improve knowledge about the molecular and metabolic bases of VIP biosynthesis, and the functions of VIP (isoprene, monoterpenes and sesquiterpenes, collectively) in plant protection, per se and when interacting with other defensive pathways.

Project

Monitoring and Evaluation of Spatially Managed Areas Recently ended

Ghent University

The increasing pressures upon the marine realm call for a well planned approach of further spatial development of this area. An ecosystem-based approach to fisheries, the increasing demand for sustainable energy, coastal defence systems, building materials and safe transport routes and the need to protect marine habitats and species all compete for the same valuable space. At the same time climate change will alter the composition and functioning of marine ecosystems, calling for a robust app...

Project

Monitoring and follow-up of suicide attempts in Flanders Historic

Ghent University

This study aims at examining the prevalence and risk factors of suicide attempts in Flanders by means of a monitoring-study in general hospitals. A second aim of the study involves the evaluation of the management of patients following a suicide attempt.

Project

Monitoring and management of patients with HIV in Africa. Recently ended

University of Antwerp

Within this project the management of patients with HIV in South Africa will be studied. Intervention studies will be performed to define the value of weight monitoring before and during antiretroviral treatment. Specifically studies will be looking at obese patients and patients who use alcohol.

Project

Monitoring and Modelling of Aeolian Sand Transport at the Belgian Coast.

KU Leuven

Aeolian sand transport is the movement of sand because of wind. Although much research has been done on the matter ofaeolian sand transport, the results are mostly only applicable for desert−like environments. The processes governingaeolian sand transport in coastal areas (beaches) are far less understood. In this project, a model is developed that relatesthe amount of sand transported to physical variables, such as wind speed, moisture content and grain size of the sand andbeach slope....

Project

Monitoring and modulation of stem cell migration towards brain and spinal cord lesions in a murine model for experimental autoimmune encephalomyelitis. Historic

University of Antwerp

This is a fundamental research project financed by the Research Foundation - Flanders (FWO). The project was subsidized after selection by the FWO-expert panel.

Project

Monitoring for an experiment with no mowing parts of the swamp in Drenthe AA. Historic

University of Antwerp

Monitoring for an experiment with no mowing parts of the swamp in Drenthe AA.

Project

Monitoring innate immunity in arthritis and mucosal inflammation Recently ended

Ghent University

MIAMI will establish relevant disease mechanisms and translate finding into novel biomarkers for individual adaptation of therapies(personalised medicine) for seronegative arthritis. Our research strategy leaves retracted ways of genetics and clasical autoimmunity; instead we will focus on innate immunity and inflammation. The goals of MIAMI are ambitious and will be reached with cutting-edge reseach performed by the most excellent researchers in the field, who have been combined to form a mu...

Project

Monitoring of adult Culicoides along the Zeeschelde at sites where works are scheduled in 2011 by W and Z, as well as of Culicoides larva samples along the entire salinity gradient of the Scheldt (CULIMON II). Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand KBIN. UA provides KBIN research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Monitoring of coral reefs in view of sustainable island development. Case study using hyperspectral remote sensing: Fordate, Tanimbar, Indonesia Historic

Ghent University

This project aims to assess coral reef species distribution and their health status using hyperspectral remote sensing methods, including the validation of this assessment by ground truth observations. This eventually leads to the creation of valuable remote sensing derived information on the configuration and composition of the coral reefs, useful for the integrated coastal zone management of coral reef ecosystems.

Project

Monitoring of corrosion and restoration processes of natural building stones by non-destructive optimised computerised X-ray micro-tomography Historic

Ghent University

Porosity as a fundamental (petrophysical) characteristic governs the processes of corrosion of natural building stones and their remediation. Together with a complete inventory of the petrophysical and technical properties of limestones and sandstones by means of destructive techniques, the study mainly comprises the determination of different corrosion processes and the characterisation of restoration processes by means of non-destructive monitoring with optimised computerised X-ray micro-to...

Project

Monitoring taxonomic evolutions of microbiota and their spoilage potential on Vietnamese Pangasius hypophthalmus from catch till consumer Recently ended

Ghent University

The proposed bilateral research project with Vietnam deals with studying the microbiological microbiota present on Pangasius hypophthalmus from catch till consumer. It aims at unravelling the contamination routes of specific spoilage organisms (SSO's) during the processing and distribution chain of Pangasius fillets (immediately after capture and during processing in Vietnam, after transport to Flanders, after further processing in Flanders till the end of the shelf life). Special inter...

Project

Monitoring the impact of HPV vaccination through surveys of HPV DNA prevalence in urine samples from adolescents.

University of Antwerp

This project represents a formal research agreement between UA and on the other hand IARC-WHO. UA provides IARC-WHO research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Monocytic cell heterogeneity: from Trypanosomes to liver pathogenicity and back Recently ended

Vrije Universiteit Brussel

Inflammatory immune responses against invading pathogens require the recruitment of immune cells to the site of infection. However, the infiltration of infected tissue by activated immune cells may result in tissue injury. Therefore, a profound understanding of the mechanisms underlying the recruitment and activation of inflammatory cells is crucial to provide the scientific basis for alleviating tissue injury caused by infection or even by other factors (drugs, alcohol,...), in particular in...

Project

Monte-Carlo simulations for nuclear medicine imaging Historic

Ghent University

Application of Monte Carlo techniques in order to obtain realistic simulations for SPECT and PET imaging. Monte Carlo simulations provide the unique opportunity to get a better understanding of the underlying physics of the imaging process. For a given imaging model, using simulations, it is quite straightforward to change different parameters, and thus study the influences on the imaging system.

Project

More and safer mobility in adolescents: testing a conceptual framework to explain active and safe commuting in adolescents Recently ended

Vrije Universiteit Brussel

The first purpose of this study is to promote safe short distance walking and cycling to different destinations in older adolescents as an alternative to the traffic risks related to motorized transport in this population. A second purpose is to learn safe cycle and motorized driving to avoid traffic accidents among adolescents. Understanding the characteristics of adolescents who walk, cycle or drive a motorcycle or car for short distance travelling, the reasons for choosing these travel mod...

Project

More rapid and accurate identification of (zoonotic) Salmonella serotypes subjected to official control in poultry and pork

Ghent University

In the scope of the combat against zoonotic Salmonella it is crucial to rapidly identify serotypes that may not contaminate the food chain. The classical method for serotyping by slide agglutination following the Kauffmann-Le Minor Scheme is time consuming and requires carefully trained personnel. It is for these reasons that this methode is fully mastered in only one laboratory in Belgium (Human NRC, IPH). Our project is composed of 5 challenges: 1) The development of an innovative molecular...

Project

Morpho-functional and neuropharmacological study of neuro-immune interactions in the gastrointestinal tract of the mouse. Historic

University of Antwerp

The aim of this study is the morphological, electrophysiological and neuropharmacological identification of the role, the mechanisms and the effects of the bi-directional interactions between the enteric nervous system and the enteric immune system on the functioning of the gastrointestinal tract under normal and inflammatory conditions.

Project

Morphological and biochemical study of the ontogeny of the intestine of caenorhabditis elegans. Historic

Vrije Universiteit Brussel

The ontogeny and post-embryonic development of the intestine of the nematode C. eiegans is poorly understood and it is our aim by using transmission electron microscopy to study this process in detail. As outlined in the introduction, the underlying mechanism of cell-cell interactions is poorly understood. Ultrastructural analysis will reveal any cytoplasmic contact that might be present between blastomeres. The micro-injection of lectins in embryos of G elegatls could allow inhibition of rec...

Project

Morphological and molecular species delimitations in selected East African murines (Mastomys, Arvicanthis en Lophuromys). Historic

University of Antwerp

Despite the fact that several African murines are known to spread diseases, and that some taxa are responsible for the destruction to the crops of African farmers, the taxonomy of these species is poorly known. The objective of this proposal is to combine craniometric and molecular methods to delimit and characterize some of these pest species. The result will be a tool ('DNA barcode) that allows the fast and accurate identification of these taxa, a precondition for their effective management.

Project

Morphological characterisation of pituitary adenomas: role of the Pit transcription factors. Historic

Vrije Universiteit Brussel

Study of the morphological characterisation of pituitary adenomas: role of the Pit transcription factors.

Project

Morphological feautures of the canine omentum: a study on the draining and immunoregulatory tissue organization.

Ghent University

The omentum is an important abdominal organ for various surgical applications in both man and animal. In the dog, no details are known on lympatic ducts, the primo-vascular system nor the milky spots. Immunohistochemistry and in vivo staining will be used to gain information on the draining and immunoregulatory features of the canine omentum.

Project

Morphological homology questions in Rubiaceae. A floraldevelopmental investigation using scanning electronmicroscopy. Recently ended

KU Leuven

The proposed project is a botanicalmorphological/developmental research project aiming tocontribute to a better understanding of the evolution andbiodiversity of Rubiaceae.

Project

Morphological study of human pancreatic B-cells in transplantation and diabetes. Historic

Vrije Universiteit Brussel

Quality control of human donor pancreatic tissue and isolated islet preparations intended for transplantation in diabetics. Study of diabetogenic mechanisms.

Project

Motion correction in chest tomosynthesis (MCCT): application to lung nodule reconstruction.

University of Antwerp

The innovation goal of this project is to develop an algorithm to compensate respiratory related motion artifacts in chest tomosynthesis for the reconstruction of lung nodules and pulmonary lesions.

Project

Motivated Empathic Inaccuracy in Distressed Couples

Ghent University

The current project focuses on the examination of a fundamental deficit in interpersonal perception, namely a lack of empathic accuracy in partners in distressed couples. Empathic accuracy is defined as ?the understanding of another person?s episodic thoughts/feelings as they spontaneously occur during interactions?. This project examines (1) the role of motivation in distressed couples? empathic inaccuracy, and (2) self-threat as primary motivator of distressed couples? empathic inaccuracy.

Project

Motor and functional recovery after stroke

KU Leuven

One of the most cumbersome deficits after stroke are motor and sensory impairments in the contralateral upper limb. Despite studies reporting on motor and functional recovery of the upper limb, literature on sensoryrecovery and its impact on motor and functional tasks is sparse. The somatosensory system consists of 2 major parts: the anterolateral and dorsal system. Each system transmits signals to the brain of specific sensory modalities such as tactile sensation, proprioception and stereogn...

Project

Motor cortex stimulation combined with immune modulation to achieve brain repair in vivo.

Universiteit Hasselt

Cortical injuries resulting from traumatic brain injury (TBI) belong to the leading causes of disability and social burden amongst the young population and can cause severe post-damage disabilities, such as persistent impairments in motor functioning. Experiments conducted in stroke patients who suffered from hemiparesis showed that electrical stimulation of the motor cortex by flat epidural electrode pads caused increased motor recovery of the paretic arm. Also in animal experiments using ro...

Project

Motor deficits in childeren wiht developmental coordination disorder and autism: is brain cinnectivity the core problem?

Ghent University

The core problem of Childeren with 'developmental coordiantion' disorder is a motor disorder. however a considerably number of childeren with autism show very similar motor problems. both disorders are thought to involve disrupted connectivity between brain regions. this study investigates the association beween motor deficits and reduced integrity of brain connectivity and associated changes in brain activitation patterns.

Project

Motor learning in Parkinson's disease: a randomised comparison of dual and single task gait practice Recently ended

KU Leuven

Aim of this study:Patients with Parkinson’s disease (PD) have problems performing dual tasks such as walking and talking. Due to a defect in the basal ganglia, PD patientsneed to pay conscious attention while performing ‘automatic tasks’ likewalking. Hence, dual tasking requires a lot of attentional resources and impedes walking. Based on our experience, we think that dualtask performance can be trained. Therefore, we want to compare the effect of integrated dual task training, in which two t...

Project

Motor versus sensory neurons: differential gene expression to identify novel genes for inherited peripheral neuropathies. Historic

University of Antwerp

We aim to find genes that are differentially expressed in motoneurons (anterior horn cells of the spinal cord) and in sensory neurons (neurons from the dorsal root ganglia, DRG). Defining the functions and characteristics of differentially expressed genes will lead to a better knowledge of the molecular and cell biological processes responsible for the differences between motor- and sensory neurons. Differentially expressed genes that localise within candidate regions for IPN are ideal candid...

Project

MoundForce Forcing of carbonate mounds and deep water coral reefs along the NW European continental margin Historic

Ghent University

RCMG's contribution to the ESF EUROMARGINS project MoundForce is focused on the factors controlling the development of mounds with an exceptional deep water coral ecosystem, such as Thérèse and Moira mounds in Porcupine Basin, while carbonate crusts are the focus of research of Leuven.

Project

Mountain Stream Dynamics in the Northern Ethiopian Highlands as Impacted by Land Cover/Use Changes and Rainfall Variability Recently ended

Ghent University

This study will link land cover/use changes and rainfall variability to stream dynamics in the Kira-kahsu catchment in Northern Ethiopia. The catchment shows a dramatic increase in vegetation cover as a result of conversation activities. Since mountain streams are strongly reactive to changes in their environment, the changes in vegetation cover of the catchment have brought about changes in stream dynamics.

Project

Mouse model of chemical-induced asthma: mechanisms. Recently ended

KU Leuven

Occupational asthma (OA) is an increasing problem in the industrial world. In adults 10-25 % of asthma cases are linked to occupational exposures, which makes it the most important cause of work related lung diseases. We developed a mouse model of chemical-induced asthma that reproduces the phenotype of occupational asthma. This model can also be used to investigate the mechanisms of chemical-induced asthma. With this project we will focus on the function of the different cells present in the...

Project

MOVE-AGE: European doctorate program on prevention of mobility loss with ageing.

KU Leuven

By 2050, the number of people in the EU aged 65 and above will have grown by 70% and the number of people aged over 80 by 170%. This raises an important challenge to promote the health and ability of the ageing population to live independently. Mobility is key in facing this challenge both as a determinant of the ability to live independently and as a factor in promoting health and quality of life. First, mobility is to a largeextent dependent on musculoskeletal and neurological health, which...

Project

Movement and fate of pesticides in wetland buffer zones: reactive transport and the influence of seasonal environmental changes.

KU Leuven

Riparian wetlands are re-installed to mitigate the input of agricultural contaminants to surface water, such as nitrate. Little is known about the mitigation of (weakly sorbing) pesticides. It is expected that biodegradation will be of major importance and that seasonal environmental changes (summer's drought or winter's cold) can lead to important dynamicsin the population size of pesticide degrading microorganisms. The latter can negatively influence the efficiency of the system in reducing...

Project

Movement behaviour of the bullhead (Cottus gobio), a benthic freshwater fish species: an ecological-genetical approach. Historic

University of Antwerp

Information on the movement behaviour of freshwater fishes with no commercial value, especially benthic species, is still very limited. The aim of this study is to eliminate this lacuna, in particular for the bullhead (Cottus gobio). Both direct (capture-mark-recapture, telemetry) and indirect (genetic markers) methods will be used to obtain this goal. Such an integrated approach is scientifically very relevant and innovative.

Project

Move to be fit! An intervention for promoting physical activity in family settings. Recently ended

KU Leuven

The present project aims to develop and evaluate a family-based physical activity program. This physical activity program specifically targets (young) children and their (grant)parents and will be offered within theframework of the existing ‘ontbijt je fit’ program of Gezinsbond vzw. Next to the development and evaluation of the physical activity program, specific training sessions for local physical activity coaches will be delivered in order to facilitate a wider implementation of the program.

Project

MRI study of pathogen and regulatory T-cells in the pathological process of EAE Historic

Universiteit Hasselt

The project is carried out in the framework of an IWT-specialization scholarship with prof. dr. Stinissen of Hasselt University. The duration of the project is from 01.01.2005 until 31.12.2008. The project involves an MRI study of pathogen and regulatory T-cells in the pathological process of EAE.

Project

mRNA based immunotherapy of melanoma

Vrije Universiteit Brussel

Introduction: Researchers have focused on using the body's own immune system to tackle cancer cells, as this approach offers the promise of an effective non-toxic therapy. One strategy to educate T cells so as they destroy cancer cells, is the use of dendritic cells (DCs), the professional antigen-presenting cells of our immune system. Therefore, DCs need to be loaded with cancer antigens and need to be productively activated. Previous research results: In the pursuit of an optimal DC vaccine...

Project

M.Sc. in Physical Land Resources Recently ended

Ghent University

Interuniversity (UGent-VUB) and interfaculty master programme in Physical Land Resources oriented towards developing countries. It is a full-time, two year programme, and all courses are lectured in English. There are two main subjects: Soil Science and Land Resources Engineering.

Project

MSC/MAPC-based modulation of immune/inflammatory mechanisms underlying bone marrow failure in MDS. Recently ended

University of Antwerp

The project will evaluate the effect of mesenchymal stem cell therapy on myelodysplasia/acute myeloid leukemia, in the call "kom op tegen kanker".

Project

MSn 'flexible' development of methods in the actual residue problematic Historic

Ghent University

The development of methods for thyreostats (Ge-sesquioxide) anabolic steroids (chlorodihydromethyltestosterone, flugestoneacetate, flavonoids) and beta-agonists (clenmeterol a.o.) growth hormones, veterinary drugs (NSAIDs, nitrofurans) and malachite green.

Project

MTA - Amplification of human embryonic cells lines carrying mutations responsible for monogenic deseases.

Vrije Universiteit Brussel

Human embryonic stem cells (hESCs), derived from human blastocysts, hold a great promise for regenerative medicine, drug development and basic research in developmental biology

Project

MTA - Material Transfer Agreement. Evaluation of soluble CD83 variants on human monocyte-derived dendritic cells and in allo-MLR. Historic

Vrije Universiteit Brussel

In this project we aim to evaluate the soluble CD83 molecules in the by us optimised assays. The goal is to investigate whether those molecules work immune-stimulatory or -suppresive.

Project

mTOR inhibition as a promising strategy to regress atherosclerotic plaques in mice.

University of Antwerp

This project aims to study the following topics: 1) Role of autophagy in plaque formation and critical regression by everolimus using autophagydeficient mice 2) Cholesterol efflux in macrophage-derived foam cells or atherosclerotic mice after everolimus administration 3) Effect of everolimus on intraplaque neovascularization and rupture in a unique mouse model showing substantial sprouting of neovessels in the plaque as well as acute plaque rupture Overall, this work could provide more insigh...

Project

Mucopolis. Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Muco Vereniging. UA provides the Muco Vereniging research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Mucosal wound healing and regeneration in chronic upper airway diseases. Recently ended

Ghent University

Wound healing and scar formation is a frequent problem encountered after functional endoscopic sinus surgery for chronic rhinosinusitis and nasal polyps. In this project we will identify negative factors that influence epithelial regeneration and based on this findings develop therapeutic strategies, using an in vitro model, tissue engineering of epithelium and cartilage and a pharmacologic trial

Project

Mulitdisciplinaire controle van binnenrot in paprika.

KU Leuven

De hoofddoelstelling van dit project is te komen tot een duurzame beheersing van binnenrot, afgestemd op de praktijk zowel voor de teller als voor de naoogstbewaring bij de veilingen en de distibutiesector.

Project

Multi-analyte approach for detection of relevant mycotoxin biomarkers of exposure. Historic

Ghent University

We will develop a multi-analyte approach (HPLC-MS/MS) to measure the exposure to the mycotoxins based on developed biomarkers of different mycotoxins from urine samples. We will develop a fast and reliable clean-up method (salt out assisted liquid-liquid extraction) to circumvent the influence of the urine matrix. After validation, we will apply it to human and pig urine.

Project

Multi- and interdisciplinary evaluation of cervical and lumbal spine problematics of nursing personnel through the development and application of a basic prevention programme Historic

Vrije Universiteit Brussel

Multi- and interdisciplinary evaluation of cervical and lumbal spine problematics of nursing personnel through the development and application of a basic prevention programme

Project

Multi- and interdisciplinary evaluation of cervical and lumbar spinal problems in hospital nurses with the development and application of a primary prevention programme. Historic

Vrije Universiteit Brussel

The purpose of this project is to enable the analysis and interpretation of the data acquisition from the project "Back Pain in Nursing Personnel: Preventive, epidemiological, anthropometric and ergonomic study" (Contract number HH/03/004) and elaboration to the cervical spine. Data from the multidisciplinary part of the study (extensive anthropometric and body composition measurements; an ergonomical and psycho-social questionnaire; lift measurements by means of a liftsimulator; spinal shrin...

Project

Multicenter Phase II study to evaluate the safety, tolerability and efficacy as assessed by frequent MRI measures of three doses ofatacicept monotherapy in subjects with relapsing MS. Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED(research institute at Hasselt University), and on the other hand, Merck Serono. BIOMED provides Merck Serono research results on 'Multicenter Phase II study to evaluate the safety, tolerability and efficacy as assessed by frequent MRI measures of three doses ofatacicept monotherapy in subjects with relapsing MS' under the conditions as stipulated in the present contract.

Project

Multicentre prevalence study to estimate the occurence of Giardia duodenalis in calves in Europe Historic

Ghent University

2108 calves were sampled in 213 farms in Germany, the UK, France and Italy to estimate the occurrence of Giardia duodenalis and to identify management factors that were associated with infection. Positive samples was withheld for genotyping to investigate the zoonotic potential of Giardia infections in calves. The results confirmed that giardiasis is a common infection in young calves and that calves are frequently infected with the zoonotic assemblage A.

Project

Multi-country Epidemiological Investigation of Bovine Neonatal Pancypotenia Historic

Ghent University

A case-control based epidemiological study is performed simultaneously in four countries (Netherlands, Germany, France and Belgium). The aim of this study is to determine the risk factors for Bovine Neonatal Pancytopenia on an individual and herd level.

Project

Multidiciplinary assessment of BELgian wild BEE decline to adapt mitigation management policy - BELBEES

Ghent University

BELBEES BELBEES: Multidisciplinary assessment of BELgian wild BEE decline to adapt mitigation management policy. Federaal Wetenschapsbeleid

Project

Multidimensional protein NMR: studies of lectin-carbohydrate interactions and of the hapten binding in one domain antibodies. Historic

Vrije Universiteit Brussel

Project aiming at addressing structure and functions of proteins in two important areas of protein chemistry: sugar binding lectins and one-domain antibodies. The structures are addressed in aqueous solutions by multidimensional gradient pulsed NMR assisted by molecular modelling. Lectins are important in the antifungal immune response of plants, while one-domain antibodies have recently been discovered for the first time in mammalians (camelidae) and have important potential s in biotechnolo...

Project

Multidimensional quantification of myocardial deformation using echocardiographic imaging: development, implementation and validation Historic

Ghent University

Aim of the project is the development of algorithms, the in vitro validation and implementation in existing software to measure the multi-dimensional deformation of the myocardium, starting from the raw radio frequency data. This will lead to a complete analysis of cardiac during deformation during one cardiac cycle with an angle independent approach leading to a reduction of the operator dependency.

Project

Multidisciplinaire samenwerking in de psychosociale encologie: bevorderende en belemmerende factoren. Historic

Ghent University

research on both inpatient- and transmural succes factors of a multidisciplinary cooperation in spychosocial oncology. A qualitatieve research methodology based on the principles of Grounded Theory is used. Data is collected by participant observation, individual and focus group intervieuws.

Project

Multidisciplinar analysis of the role of PCBER for wood formation and growth in poplar Historic

Ghent University

Wood is one of the most important natural renewable resources. Although wood demand for pulp, paper, and energy increases, almost nothing is known about the genes that regulate wood formation and wood quality. The project aims at elucidating the role of PCBER, the most abundant protein in wood by combined transcript and metabolite profiling.

Project

Multi-disciplinary 3D characterisation of complex pore-networks and minerals of geomaterials from sub-micron to centimeter scale

Ghent University

3D characterisation of minerals and pore-structures at a pore-scale level will be obtained by fusion of 2D and 3D data, derived from different traditional and high-technological imaging techniques. Chemical and structural 3D data gained from high-resolution X-ray CT and micro X-ray fluorescence will be linked to 2D information obtained by optical and scanning electron microscopy combined with energy-dispersive X-ray spectroscopy.

Project

Multidisciplinary Motor Centre Antwerp - M²OCEAN.

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Multidisciplinary research on vaccination and infectious diseases.

University of Antwerp

Integrated vaccine and microbiological research with a focus on increasing the understanding of the immune response in prophylactic and therapeutic vaccines (including tumour vaccines) and on the containment of antibiotic resistance. Several innovative research topics are ongoing or in the pipeline: potential development of theranostic devices (e.g. rapid Point of Care Diagnostics, optical biosensors, lab-on-chip, microarrays) for pathogen detection and associated resistance in collaboration ...

Project

Multi energy simulation and reconstruction (MESRECON). Recently ended

University of Antwerp

MESRECON aims to develope truly dual energy image reconstruction techniques. One key component of the solution is a detailed model of the acquisition and image processing. Developing such a model is a first aim of the project. The second aim is to develop dual energy reconstruction techniques based on this model and on advanced image restoration techniques.

Project

Multifactorial analysis of biomass in Arabidopsis thaliana exploring the underlying genetic network Historic

Ghent University

The projects? objective is to identify QTLs underlying biomass production in Arabidopsis thaliana. Therefore, we will analyse natural genetic variation for biomass in several accessions and map the phenotype on a high-density LD map. In addition, a multifactorial analysis of gene expression phenotypes will allow us to identify cis- and trans- acting elements and model the genetic network underlying the phenotype.

Project

Multifactorial evidence based appraoch using behavioural models in understanding and promoting fun, healthy food, play and policy for the prevention of obesity in early childhood Recently ended

Ghent University

The European ToyBox-project aims to prevent overweight and obesity in preschool children between 4 and 6 years old. An intervention will be executed in 6 European countries (Belgium, Bulgaria, Germany, Greece, Poland and Spain), during the school year 2012-2013. The intervention has four target behaviours: increasing physical activity, decreasing sedentary behaviour, more water and less sugar-sweetened beverages and healthy snacks.

Project

Multifunctional core equipment for the development of a state-of-the-art Recently ended

Ghent University

This application supports a new research strategy to focus isolation campaigns on rare or fastidious groups of bacteria. A recently acquired colony picker and MALDI-TOF mass spectrometer are central for, resp., the mass isolation and high-throughput characterization of bacteria. The new equipment will improve and extend this innovative pipeline with essential tools to allow more diversified and precise isolation campaigns.

Project

Multifunctionality en local identity as paradigms for sustainable and competitive agriculture Historic

Ghent University

The modernization of agriculture has gradually put pressure on its contribution to the yellow, green and blue services. The main objective of the project is therefore to investigate what local or regional identity means, how farming contributes to it and whether this concept can be a clue to promote multifunctional farming.

Project

Multifunctionality of flood areas: scientific determination of the impact of water storage on nature, forestry and agriculture. Historic

University of Antwerp

Multifunctionality of flood areas: scientific determination of the impact of water storage on nature, forestry and agriculture.

Project

Multifunctional transcriptional regulators of the carbamoylphosphate synthetase operon carAB in Escherichia coli: mode of action and origin. Historic

Vrije Universiteit Brussel

This project aims at the unraveling, in the molecular details and with a multidisciplinary approach, of the regulatory mechanisms that govern the expression of the Escherichia coli carAB operon (encoding carbamoyl phosphate synthase). This mechanism is particularly complex; it integrates regulatory signals from no less than three biosynthetic pathways (arginine, pyrimidines and purines) and requires at least five regulatory proteins, among which many are multifunctional and combine in a singl...

Project

Multi Gene expression signatures for accurate risk stratification of neuroblastoma patients Historic

Ghent University

Neuroblastoma is a solid cancer, diagnosed in children under 15 years and is responsible for 15% of cancer deaths in children. Neuroblastoma is characterized by a remarkable clinical and genetic heterogeneity. In this project, gene-expression signatures are being studied for accurate risk classification of neuroblastoma patients. This will allow clinicians to select for risk-related therapies, leading to increased effectiveness of cancer treatment and increse in survival rates.

Project

Multigenerational study towards health related parameters and physical performance capacity in vegetarians. Historic

Vrije Universiteit Brussel

Vegetarism is becoming more and more popular. Besides ethical considerations health related aspects play a role for choosing for a vegetarian life style (cfr mad cow disease, antibiotics in nutrition for animals). However, a certain secpticism remains concerning the completeness of a vegetarian diet. From previous research, concering the health impact of a vegetarian life style, it seems that the vegetarian diet is healthier compared to the omnivore diet and that a vegetarian diet can be a c...

Project

Multilevel and structural equation models in health services research: application to research on the organizational context of nursing care Recently ended

KU Leuven

The past two decades have witnessed a growing body of US research evidence supporting contentions that hospitals with better nurse staffing, higher proportions of bachelor-educated nurses and superior nurse practice environments have better outcomes of patient mortality, patient satisfaction with care, and nurse wellbeing. More recently, the Registered Nurse Forecasting (RN4CAST) research consortium confirmed the direction and consistency of these associations across European hospitals at a p...

Project

Multilevel functional characterization of the miRNome in cancer Recently ended

Ghent University

MicroRNAs (miRNAs) play a central role in the pathogenesis of cancer. Deregulation of their function, either through altered expression levels or sequence mutation, has been linked to both initiation and progression of malignancy. In my PhD research. I applied a combination of high-throughput experimental strategies and advanced data-analyses to gain insights into the basic cellular functions, the molecular pathways and the genes regulated by miRNAs in order to have a better understanding of ...

Project

Multilinguale thesaurus voor communicatiepathologen: een domeinspecifieke vaktermendatabank Historic

University College Ghent

Dit project vertrekt van het vertaalwoordenboek voor logopedisten en audiologen (Corthals, Van Borsel, Van Lierde, 2004). Alle termen die een aandoening, een onderzoeksprocedure of een interventie van een logopedist of een audioloog betreffen worden geselecteerd. Dit moet naar schatting ruim 1000 vaktermen in het Engels opleveren, die frequent als keyword voorkomen in publicaties op het internationale forum. Deze set wordt opgenomen in de structuur van een thesaurus, naar het voorbeeld van de...

Project

Multimodal investigation of a neuroinflammatory model in bipolar disorder. Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand Emmaus. UA provides Emmaus research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Multimodal investigation of a neuroinflammatory model in schizophrenia.

University of Antwerp

This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Multimove for children Recently ended

Ghent University

This project aims at the development of a movement program for children in different organisations in Flanders (child care, schools, sports clubs, local government bodies). The ?status questionis? of the general motor development of Flemish children between 3-8 years in 2012-2013 is studied.

Project

Multiple sclerose: from genetic profile to individualized patient care Recently ended

KU Leuven

Multiple sclerosis (MS) is a disease of the central nervous system characterized by inflammation, demyelination and axonal loss. Like most autoimmune diseases, MS is a complex disease with susceptibility controlled by the interplay of environmental and genetic factors. The past few years have seen important progress in the understanding of MS. Epidemiological studies have provided strong evidence for three environmental risk factors: Epstein‑Barr virus infection, sunlight exposure and s...

Project

Multiple Sclerosis, a multidisciplinary appraoch Recently ended

Universiteit Hasselt

Multiple Sclerosis (MS) is a chronic demyelinating disease of the central nervous system that mainly affects young adults worldwide. MS-symptoms are very diverse which makes a definitive diagnosis difficult. Although the disease cannot be cured, medications are available that suppress the incident and severity of relapses. Despite these medications, 10 years after diagnosis almost half of the MS-patients are unable to participate in normal daily life. Therefore, extensive research into the di...

Project

Multiple Sclerosis, a multidisciplinary approach.

University of Antwerp

This is a fundamental research project financed by the Research Foundation - Flanders (FWO). The project was subsidized after selection by the FWO-expert panel.

Project

Multiple Sclerosis, a multidisciplinary approach.

University of Antwerp

This is a fundamental research project financed by the Research Foundation - Flanders (FWO). The project was subsidized after selection by the FWO-expert panel.

Project

Multiple sclerosis: from genotype to phenotype.

KU Leuven

Multiple sclerosis (MS) is a common neurological disorder characterizedby inflammation, demyelination and axonal loss. The disease typically affects young adults and leads to significant physical and cognitive disability. Around 10,000 people are affected in belgium and 2.5 million worldwide. The etiology is unknown but the past few years have seen exciting progress in the field. Candidate-gene and genome-wide association studies, in which we have extensively been involved, have led to the id...

Project

Multiple Sip1/Zfhx1b knockout mouse models explaining clinical signs ofMowat-Wilson Syndrome. Recently ended

KU Leuven

Mutations in ZFHX1B (SIP1, ZEB2) cause Mowat-Wilson syndrome (MWS) in humans, characterized by various malformations in the central nervous system (CNS) [mental retardation, epilepsy] and developmental defects in the neural crest cell lineage [cranio-facial abnormalities, Hirschsprung disease]. This new project will investigate a large panel of different Sip1 knockout mouse models in the CNS and peripheral nervous system and should enable us to explain in detail the major clinical signs of MW...

Project

Multiplex PCR amplification and 454-based sequence analysis of candidate genes for schizophrenia and affective disorders. Historic

University of Antwerp

Psychiatric disorders are highly prevalent, often chronic illnesses that result from a complex interplay between multiple genetic and environmental factors. Through the multiplex PCR amplification and high throughput sequence analysis of 11 candidate genes for schizophrenia and affective disorders, this project will fundamentally aid in the identification of new genetic variants for these complex diseases.

Project

Multiscale characterization and modeling of crystallization processes in natural building stones

Ghent University

This project focuses on the kinetics of in-pore salt and ice crystallization in natural building stones using a combined experimental-modeling approach. In-pore crystallization is studied by time-lapse imaging using X-ray micro-tomography and cryo-scanning electron microscopy to cover the complete pore size range. A pore-scale model is developed describing the physics of crystallization at the pore-scale level.

Project

Multiscale mathematical modeling of root growth in Arabidopsis thaliana. Historic

University of Antwerp

This project will produce mathematical models of root development in Arabidopsis thaliana integrating the molecular regulation of cell division activity, cell elongation and transport of hormones with growth and architectural and mechanical characteristics of roots.

Project

Multi-scale modeling in bone tissue enginnering: from biomaterials to intracellular signaling via the cell. Recently ended

KU Leuven

Worldwide, every three seconds an osteoporotic bone fracture occurs. This sums up to 8.9 million fractures each year without including the fractures due to traffic or work accidents. Luckily our bones have the ability to heal without scar formation, however 5 to 10% of the patients are confronted with a delayed healing or a permanent failure of bone healing. In this PhD work, a novel mathematical model was developed to understand why certain bone fractures fail to heal and how the current tre...

Project

Multi scale modelling of gas exchange in photosynthetic tissue

KU Leuven

Photosynthesis is an important physiological process in plant growth and productivity. It is closely linked to global bioenergy and food supply. It involves exchange of gases O2 and CO2 betweenplants and their environment. The gas exchange phenomena could bedescribed by multiscale gas exchange models which are hierarchy of models that describe the phenomena at different spatial scales. The objectives of this doctoral research project are to develop a multiscale model of gas exchange in leaves...

Project

Multiscale modelling of postharvest spray application technology.

KU Leuven

There is an increased interest in the application of various types of plant protection products to fruit in cold storage after picking rather than in the field for its economic and environmental benefits. However, such applications are not yet well developed and raise concerns of optimal dose, uniformity and residue limits. An effort is needed to optimize the applications in postharvest and to develop strategies to increase theefficiency of the spray application in order to realize the potent...

Project

Multi-sectoral support of female survivors of sexual violence in South Kivu. Recently ended

Ghent University

The project objectives are the strengthening of UCB as a leading institution in terms of sexual violence in DRC, and improving the quality of care for women survivors of sexual violence. The main activities of the project are: capacity building in research methodologies, training in English, an in-depth analysis of UNFPA?s database on sexual violence, and the mapping of stakeholders in the territory of Walungu and the city of Bukavu.

Project

Multi-source inventory methods for quantifying carbon stocks and stock changes in European forests Historic

Ghent University

CarboInvent is a European Project for identifying, developing and testing methods for assessment of carbon © stocks and stock changes in forests at national/EU levels. CarboInvent focuses on improvement of estimation of forest biomass, soil carbon and other relevant carbon stocks, and the changes in these stocks, including changes resulting from major disturbances in the forest ecosystem and from different forest management strategies. The department of Geology and Soil Science is responsible...

Project

Multitoxin analysis on sorghum samples from four sub-Saharah African countries Recently ended

Ghent University

A one year multi-mycotoxin survey to assess types and levels of mycotoxin contaminations in sorghum in four major sorghum producing/exporting sub-Saharah African countries (Ethiopia, Sudan, Mali and Burkina Faso).

Project

Multivalent dual-responsive polymeric nanoparticles for targeted anti-cancer therapy

Ghent University

In this project we aim to develop a formulation that selectively delivers anti-cancer drugs to cancer cells while minimizing unwanted toxicity to healthy tissue. For this purpose we will encapsulate hydrophobic anti-cancer agents in polymeric nanoparticles thate are engineered with (1) targeting ligands to selectively bind to cancer cells and (2) stimuli-responsive properties to release their drug payload only after cellular uptake.

Project

Muscle fatigue resistance as a new, direct parameter to objectively assess the exhaustion component of Frailty: Relation with inflammation and target for new interventions countering Frailty at higher age. Recently ended

Vrije Universiteit Brussel

The research institute 'VUB' and the 'Koning Boudewijnstichting - Fonds Marie-Thérèse De Lava' have entered into a service-agreement concerning the project' Muscle fatigue resistance as e new, direct parameter to objectively assess the exhaustion component of Frailty: Relation with inflammation and target for new interventions countering Frailty at higher age. '. The research results can be transferred to the company, there can be a reasonable return in case of commercialisation or there is a...

Project

Muscle functional MRI as an innovative biomarker for fiber type composition. Study in healthy control subjects and chronic low back pain patients.

Ghent University

The invasive character of biopsy restricts extensive research on muscle fiber typing in trunk muscles. A noninvasive, in vivo alternative for biopsy may be found in Magnetic Resonance Imaging (MRI). The objective of this project is to validate T2 relaxation time as an innovative biomarker for fiber type distribution and to gain fundamental insight in structural subdivision in lumbar muscles.

Project

Mutation profiles and targeted treatment options for mismatch repair deficient tumors. Recently ended

KU Leuven

Defects in DNA repair mechanisms contribute to tumor development in a significant number of human cancers. Up to 20% of colorectal and endometrial tumors is characterized by deficiency of the mismatch DNA repair (MMR) pathway (MLH1, MSH2 and MSH6). Inthe current project I will apply “Whole genome sequencing” to tumors characterized by MMR deficiency and their matched normal DNA samples. Subsequently I will assess whether specific patterns of somatic alterations in particular single basepair s...

Project

MYCN deregulated transcription in neuroblastome: study of direct mRNA and miRNA regulated target genes Historic

Ghent University

Neuroblastoma is the most frequent extracranial solid tumour in children. Despite the existence of multimodal treatments, the prognosis of most patients remains unfavourable. A subgroup of aggressive neuroblastoma tumours is characterised by amplification of the MYCN transcription factor. The identification of new MYCN target genes could result in improved treatment stategies.

Project

Mycobacterium tuberculosis in a cholesterol and fatty acid rich environment: global response to dormancy and antibiotic resistance

Ghent University

Little is still known on the role of lipids in the survival of Mycobacterium tuberculosis. The general objective of this research project is to determine and analyze the global genetic expression of M. tuberculosis and to evaluate its drug susceptibility in an in vitro latency model in the presence of lipids cholesterol and fatty acids.

Project

MycoHunt: a rapid biosensor for the detection of deoxynivalenol in wheat dust Recently ended

Ghent University

- The correlation between the amount of deoxynivalenol in wheat and wheat dust - The development of monoclonal antibody against deoxynivalenol by the use of the hybridoma technique - The determination of deoxynivalenol by the use of an amperometric immunosensor with ?screen-printed? electrodes

Project

Mycorrhizae impact on biodiversity and C-balance of grassland ecosystems under changing climate. (MYCARBIO) Historic

University of Antwerp

The research project MYCARBIO aims to investigate the impact of arbuscular mycorrhizal fungi (AMF) on biodiversity and on the carbon cycle in Belgian grassland ecosystems under changing climate conditions. To achieve this overall goal, five specific objectives have been identified: (1) the evaluation of AMF biodiversity in selected Belgian grasslands; (2) the determination of the role of AMF for seedling establishment, plant community structure, diversity and productivity in grasslands; (3) t...

Project

Mycorrhizal diversity and specificity in African Angraecum species. Recently ended

KU Leuven

De orchideeënfamilie is de meest soortenrijke familie in het Plantenrijk die meer dan 24.000 soorten bevat. Men heeft lang gedacht dat co-evolutie met bestuivers heeft geleid tot de hoge soortenrijkdom. Veel soortenzijn echter generalisten voor wat betreft hun pollinatoren, en het is tot op heden erg moeilijk gebleken om bewijzen te vinden om deze hypothese hard te maken. Omdat de beschikbaarheid van schimmels cruciaal is voorde vestiging van nieuwe individuen, werd recent gesuggereerd dat so...

Project

Mycothiol redox pathways in Actinobacteria, and beyond Recently ended

Vrije Universiteit Brussel

In this HOA research project focus will go to the mycothiol reduction pathways in Actinobacteria and to the evaluation of these pathways as possible targets against Mycobacterium tuberculosis. Members of Actinobacteria are Gram-positive bacteria encountered in a wide range of ecosystems and are known to cause important human diseases, such as tuberculosis, diphtheria and Johne's disease in ruminants. As a starting point, we will investigate arsenate reductases (ArsC) of Actinobacteria. ArsC ...

Project

Mycotoxins and mycotoxigenic fungi in China: analytical tools, dietary exposure and Fusarium diversity. Recently ended

Ghent University

The major aim of this proposal is uniting experts from both China and Belgium to conduct research on mycotoxins and mycotoxigenic fungi, including Fusarium and related toxins. The project has the following objectives: -Development of analytical tools to assess mycotoxin dietary exposure in China. -Study on the genetic and mycotoxigenic diversity of Fusarium on wheat, maize and banana in China.

Project

Myeloma stem cell network a translational programme identifying and targeting the early myeloma cell hierarchy. Historic

Vrije Universiteit Brussel

This project, sponsored by the EU, focusses on the identification of myeloma cancer stem cells, sensitivity to treatments and has the ultimate goal for developing new strategies. The VUB partner is leader of Workpackage 8.

Project

Myotonic dystrophy type 1 (DM1)-specific induced pluripotent stem cells (iPS): an innovative platform for myogenic and cardiomyogenic differentiation and validation of novel therapeutic approaches

Vrije Universiteit Brussel

Myotonic dystrophy type 1 (DM1) or Steinert's disease is a relatively common genetic disorder that results in a gradual degeneration of the function of the skeletal muscles and the heart. There is currently no cure or effective treatment available. The disease is caused by a genetic defect resulting in a toxic gene product. However, the exact mechanisms of this disease are not fully understood. The objectives of this project is to better understand how this toxic gene product interferes with ...

Project

NAIMIT. Novel immunotherapies for type 1 diabetes. Recently ended

KU Leuven

This proposal will pioneer the concept of tailored interventions with minimal immune system interference in new onset T1DM, leading to beta-cell protection and restoration, based on solid understanding of the disease pathogenesis. This will enable experimental findings to be adopted forfuture clinical application. Four workpackages are grouped around 'Reversal of autoimmunity', in which two key players of the immune system in beta-cell destruction will be targeted: the dendritic cell (WP1: Re...

Project

Naive human embryonic stem cells: the new contender?

Ghent University

Recent breakthroughs have described the production of human embryonic stem cells which resemble more the mouse counterparts. These stem cells possess a naive state of pluripotency, in contrast to 'primed' stem cells which show already some differentiation. Different culture protocols enable the derivation of naive human embryonic stem cells, but the question remains which protocol gives rise to the similar naive pluripotency state as in mice.

Project

Nanobodies as chaperones to study Biomedical Targets Historic

Vrije Universiteit Brussel

Matching project: Nucleoside hydrolases: from salvage enzymes to generic prodrug targets. The NH's are widely distributed in bacteria, protozoa, fungi, plants and insects but they are conspicuously absent in mammals. The lack of NH activity in man makes thes enzymes attractive targets for antiparasitic drug design. Nearly all parasitic protozoa lack a de novo purine biosynthesis pathway and the NH's catalyse the first step of their only metabolic alternative: the purine salvage pathway. In ...

Project

Nanobodies as crystallization chaperones for challenging biomedical targets Recently ended

Vrije Universiteit Brussel

In the early stages of structural genomics, challenging targets such as those that are poorly soluble, unstable, intrinsically (partially) unstructured, or are highly flexible have been put aside. In the last years, we proved the principle that Nanobodies can be used as crystallization chaperones in the crystallization and structure determination of challenging target proteins that would prove unsolvable using more conventional strategies. In the frame of the current project, we want to explo...

Project

Nanobodies in Health : Next generation Antibody fragments for Medical Applications Historic

Vrije Universiteit Brussel

Naturally occurring camelid Heavy-chain antibodies have evolved to be fully functional in the absence of a light chain. In a previous VUB-funded GOA project, a network consisting of the research groups of S. Muyldermans, J. Steyaert and P. De Baetselier has built on fundamental research into the properties of Heavy-chain antibodies to develop medical applications of Heavy chain antibody-derived single-domain antibody fragments referred to as Nanobodies. Collaborative scientific achievements o...

Project

Nanobodies or VHHs used as therapeutic medicines in the endgame of eradiction of poliovirus. Recently ended

Vrije Universiteit Brussel

New strategies and weapons must be developed to fight polio. In this project, the usability and application of a new generation of recombinated antibodies fragments, namely Nanobodies or VHHs being the new class of antiviral molecules, will be investigated. The obtained VHHs can serve as a model in the battle against other important human picornaviruses such as Hepatitis A or rhinoviruses (colds).

Project

Nanobody aided crystallograhpy: a worldwide standard in research and industry. Recently ended

Vrije Universiteit Brussel

By rigidifying flexible regions and obscuring aggregative surfaces, nanobody complexes warrant conformationally uniform samples that are key to protein structure determination by X-ray crystallography. The recent elucidation of the first active state GPCR structures using a conformationally selective Nanobody demonstrate the power of our Nanobody platform to generate diffracting quality crystals of the most challenging targets including membrane proteins, flexible proteins, aggregating protei...

Project

Nanobody aided purification and crystallization of G-protein coupled receptors. Recently ended

Vrije Universiteit Brussel

G-protein coupled receptors (GPCRs) are the largest, most versatile group of membrane proteins with proven therapeutic value. So far it has been very difficult to recombinantly express, purify, characterize and crystallize these receptors for structural analysis. Therefore little is known. about their 3D structure. Within this project I will exploit the unique properties of single domain antibodies or Nanobodies to overcome these bottlenecks in structural analysis of GPCRs. Nanobodies (Nbs) a...

Project

Nanobody-assisted manipulation of the tumor suppressor p53. Recently ended

Ghent University

The tumor suppressor and transcription factor p53 plays a key role in cell cycle regulation, apoptosis and senescence and is frequently inactivated in human tumors. Nanobodies against p53 are generated and characterized, in vitro and in vivo. These nanobodies are subsequently utilized to manipulate the activity of p53 in cells in terms of intracellular localization and activity.

Project

Nanobody assisted structural study of ELIC, a prokaryotic GABA-gated ion channel

Vrije Universiteit Brussel

The recent discovery of ELIC, a bacterial GABA-activated ion channel, opens new opportunities to pursue structural insight into ion channel function. In the current proposal we will take advantage of cutting-edge technologies, including nanobody-assisted crystallography, chemical biology and cysteine-trapping to study three essential aspects of ion channel function.

Project

Nanobody-based Proximity Ligation Assay for Human Toxocariasis

Vrije Universiteit Brussel

In Human toxocariasis, severe disease may issue from infection with one single Toxocara larva. Diagnosis is difficult because the parasite does not replicate in the host and is located in tissues. Serological tests remain the least invasive and most sensitive approach to detect parasite antigens (Ags), but have thus far lacked sensitivity and specificity. Novel approaches are urgently needed to deliver tests of clinical and epidemological relevance. Our strategy exploits the advantages of tw...

Project

Nanobody-Loaded and -Coated Microbubbles: A Tool For Drug Delivery and Molecular Imaging Historic

Vrije Universiteit Brussel

Nanobody-Loaded and -Coated Microbubbles: A Tool For Drug Delivery and Molecular Imaging

Project

Nanobody Translational Molecular Imaging Historic

Vrije Universiteit Brussel

The proposed project for the GOA funding includes fundamental, applied and translational research. The fundamental research is focused on the further improvement and characterization of the labeled Nanobodies including new radio labeling methods and the use of alternative Nanobody formats. The applied research is focused on the development of new Nanobodies for imaging specific targets and includes the whole process of pre-clinical validation and lead selection. Translational research is focu...

Project

Nanocomit

KU Leuven

No English Abstract

Project

Nanodiamond labelling of neuronal cells for molecular resolution neuronal and network-level imaging

University of Antwerp

This interdisciplinary project addresses the interactions of functionalised nanoparticles with neural tissues and their usage to probe the local environment and neural function. Fundamental progress must be made in two main research areas, the design of nanodiamond particles and the understanding of their chemical, electronic, and optical properties, as well as the biological and biophysics aspects, in particular insertion of the nanoprobes, their biocompatibility and non-contact detection. I...

Project

Nanomaterials to administer medicine. Historic

University of Antwerp

The scientific aim of the research consortium is to try to understand why some nanocarrriers loaded with biological active molecules (e.g. proteins, antisense oligonucleotides, RNAi, plasmid DNA) are successful and elicit a biological effect in certain cells but fail in other cell structures. It is of fundamental importance to gain insights in these topics. But this is only possible when the problems are tackled with a multidisciplinar team from different prospectives (e.g; biological, pharma...

Project

Nanoparticle-induced autophagy: unraveling the impact on nanoparticle toxicity and therapeutic efficacy

Ghent University

IWT/SB-lichting 2014 IWT/SB/Peynshaert Karen/131335 Nanoparticle-induced autophagy: unraveling the impact on nanoparticle toxicity and therapeutic efficacy

Project

NanoSensEu Recently ended

Universiteit Hasselt

This NanoSensEu project will develop a universal measuring surface for biosensors. Biosensors are highly sensitive analytical systems that can detect the presence of biomarkers in samplel material. Biomarkers are molecules or properties that can be objectively measured in several samples and who thus can provide more clarity about the state of the sample. For example, biomarkers that are characteristic for diseases at an early stage, so the chances of recovery are greatest when these biomarke...

Project

Nano structured hybrid solar cells Historic

Universiteit Hasselt

Investigation of preparation techniques and processes for the development of nanostructured hybrid solar cells, including the study of the electrical transport in the inorganic semiconductors and the study of the occurring photovoltaic mechanisms. The aimed hybrid solar cells are based on the Grätzel solar cells principle and consist of heterojunctions of TiO2 with conjugated polymers. The mesoporous TiO2 is applied with techniques such as screen printing. The nanostructuring of TiO2 oxide ...

Project

Nanostructured surfaces for biotechnology and photonics Historic

Ghent University

This project deals with the influence of nanostructured surfaces (fabricated with holography, FIB, deep UV silicon lithography and nano-imprint) on cellular processes (growth, adhesion, differentiation, inflammation, death) as well as photonics applications (photonic crystals combined with liquid crystals, wavelength tunable devices, optical memory). Novel biological sensors will be developed as well.

Project

Nanostructured surfaces for biotechnology and photonics Historic

Ghent University

This project deals with the influence of nanostructured surfaces (fabricated with holography, FIB deep UV silicon lithography and nano-imprint) on cellular processes (growth, adhesion, differentiation, inflammation, death) as well as photonics applications (photonic crystals combined with liquid crystals, wavelength tunable devices, optical memory). Novel biological sensors will be developed as well.

Project

Nanostructuring Strategies of Fiber Optic-SPR Surfaces for Improved Bio-Assay Sensitivity

KU Leuven

This doctoral research focuses on the application of optical biosensors for food and medical diagnostics. More specifically, we will use fiber optic surface plasmon resonance (FO-SPR) technology to design biosensors for the detection of proteins causing food allergenicity. SPR is an optical sensing technique that can be used to measure changes in the refractive index at the sensor gold surface. We will coat optical fibers with a thin gold layer and subsequently cover them with a layer of bior...

Project

Narratives in health communication – a multi-disciplinary approach to strengthen understanding of the roles and uses of narratives in conveying health information and changing health behaviors (HealthNar).

University of Antwerp

The objective of the HealthNar program is (1) to strengthen and consolidate the emerging field of narrative health communication and (2) to establish a flourishing and solid multidisciplinary research exchange network on narratives and health. The program does so by bringing together renowned international scholars from health psychology, media psychology, health communication, arts, and interactive communication.

Project

National databank mortality and morbidity: individual record linkage of causes of death. Historic

Vrije Universiteit Brussel

The Interface Demograhy has already executed an individual record linkage of all deaths of the period 1991-1996 (about 600,000) to the socio-economic characteristics of individuals collected in the census of 1991 ( all 10,000,000 residents in Belgium). This data bank permits the study of socio-economic determinants of differential mortality (other project). The missing piece in the existing data bank pertains to the causes of death. This information for the same 6 years can also be linked to ...

Project

Natriumreductie en/of -vervanging in deegsystemen Historic

University College Ghent

Dit project situeert zich binnen het Flanders' Food Project "Natriumreductie en/of -vervanging" met een focus op deegsystemen.

Project

Natural antioxidans in feed and animal products for animal and human health Historic

Ghent University

In this project it is aimed to supply animal products with a coctail of natural antioxidans by feeding animals with a variety of plants. In this way the shelf life and sensorial quality of the animal products could be increased. Besides, the animal and human health (oxidative status) could be improved by the consumption of this mix of antioxidans.

Project

Natural gene transfer of T-DNA from the agrobacterium TI-plasmid to the speetpotato genome and its role in domestication

Ghent University

The aim of this project is to scharacterize the complete T-DNAs found in the sweetpotato genome and their insertion sites in the genome of speetpotato and its wilt relatives. Furthermoreit will be analyzed id the sweetpotato T-DNA genes are associated with the characteristic phenotypic root thcikening in a segregating population of sweetpotato and in wild relatives.

Project

Natural gradients in temperature and soil age:Iceland represents a unique environment to clarify longterm global change effects on nutrient dynamics,vegetation and microbial communities.

University of Antwerp

This project aims at understanding how structure and function of Icelandic ecosystems are affected by global change. Global climate change is predicted to continue in the 21st century and will be most pronounced at higher latitudes. This will undeniably entail changes in ecosystem processes as nutrient dynamics and plant and microbial community compositions.

Project

Natural gradients in temperature, CO2 and soil age: Iceland represents a unique environment to clarify longterm global change effects on nutrient dynamics, vegetation and microbial communities. Recently ended

University of Antwerp

This project aims at understanding how structure and function of Icelandic ecosystems are affected by global change. Global climate change is predicted to continue in the 21st century and will be most pronounced at higher latitudes. This will undeniably entail changes in ecosystem processes as nutrient dynamics and plant and microbial community compositions.

Project

Natural history of human papillomavirus infections: role of humoral and cellular immune responses. Historic

University of Antwerp

In this follow up study we investigate the natural history of HPV (human papillomavirus) infections, focussing on humoral and cellular immune responses. This is important to get a better insight in the epidemiology of a virus which is strongly linked to the development of premalign cervical intraepithelial neoplasia (CIN) and cervical cancer.

Project

Natural Variation for Drought Tolerance Recently ended

Ghent University

In this project we want to unravel the plant?s growth regulatory network in mild drought. To study growth as quantitative trait we use the existing natural variation for this trait present in a collection of 100 different Arabidopsis accessions. Linking the transcriptome to the phenotypes of these accessions allows us to unravel the growth regulatory network of plants in drought.

Project

Natural variation in life-history traits and corresponding trade-offs between roof- and ground-nesting Herring gulls in colonies along the Flemish and Dutch (Zeeland) North Sea coast. Historic

Ghent University

The following questions are addressed: (i) Do life-history traits and phenotypic traits differ among L. argentatus colonies that differ in structure and breeding density, and does this affect trade-off functions and reaction norms ? (ii) Are trade-offs masked by variation in food availability? (iii) Do trade-off functions correlate with environmental parameters, genetic drift, parental investment, dispersal and maturation rates.

Project

Natural variation in lify history traits of Nothobranchius furzeri

KU Leuven

With this study on the annual killifish Nothobranchius furzeri we intend to gain insight in the patterns of natural variation in traits suitable for applications, and in the processes involved in the evolution of these traits. Moreover, we want to assess the transgenerational stability of these traits under experimental laboratory conditions. Besides relevant insights in eco-evolutionary processes, these results will contributeto the further optimization of Nothobranchius furzeri as a model i...

Project

Nature and evolution of pre- and post-zygotic reproductive isolation in pennate diatoms

Ghent University

Diatoms are the most species-rich group of eukaryotic microalgae. How their obligate sexual reproduction is linked to speciation is currently unknown. We will use two pennate species complexes (Seminavis robusta and Eunotia bilunaris) to unravel the genetic architecture of reproductive isolation mechanisms. To do this, ?genotyping by sequencing? (GBS) will be combined with QTL mapping and genome-wide association studies (GWAS).

Project

Natuur als sjabloon voor een nieuw concept van extensieve groendaken Recently ended

KU Leuven

In urbanized areas of northwestern Europe, green roofs are gaining moreinterest trough their numerous ecological and economical benefits. These benefits would be even more pronounced in the (sub)Mediterranean climate. Since commonly used green roof plants are often not adapted to this environment, the performance of green roofs in this climate is relatively low so that the greening industry in the south has not yet broken trough. In this study, we identify species that can be used on green ro...

Project

Navigation by sonar in bats and robots.

University of Antwerp

This project aims at immersing an artificial echolocator, the Chirocopter, i.e. an unmanned aerial vehicle (UAV) equipped with a sonar emission and recording apparatus, in real environments, re-enacting the behaviour recorded from freely behaving bats. As such, this project is the first to collect an ecologically valid set of sonar stimuli (echoes) as perceived by flying bats. In particular, the dataset collected using the Chirocopter allows testing the hypothesis that a statistical represent...

Project

nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; Biomechanical and neurological determinants of impaired trunk control in children with cerebral palsy. Recently ended

KU Leuven

The previous doctoral project provided an innovative contribution to the research on impaired trunk control in children with cerebral palsy (CP) through the development of new methodologies (clinical and biomechanical) for trunk control assessment and the identification of distinct trunk deficits within subgroups by use of these methodologies. The current project aims to further investigate the biomechanical and neurological determinants of impaired trunk control to advance our understanding ...

Project

nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp;nbsp; Estimating regional cardiac function using 3D ultrasound imaging. Recently ended

KU Leuven

Echocardiography plays a leading role in routine clinical practice for the objective assessment of regional cardiac function by measuring cardiac wall motion and deformation (i.e. strain). With advances of transducer technology, three-dimensional (3D) ultrasound (US) acquisitions now offer the possibility to improve and expand on the diagnostic capabilitiesof the traditional two-dimensional (2D) US images. Nevertheless, the large amount of image data increases computational load, and their li...

Project

Needs of people with dementia, primary caregivers and home care professionals. Historic

Vrije Universiteit Brussel

Dementia is a frequent disease in the elderly. and already in a very early stage dependency of others arises and worsens. Three quarters of the people with dementia stay at home, supported by their primary caregivers. If policy makers aim at supporting home care, then the development of services should take into account the needs of the elderly people with dementia and the primary caregivers. Therefore we will try to gain insight in the early detection patterns of dementia, to assess ...

Project

Negative regulation of the innate immune response in the peripheral nerve. Historic

University of Antwerp

This is a fundamental research project financed by the Research Foundation - Flanders (FWO). The project was subsidized after selection by the FWO-expert panel.

Project

Negative regulation of the innate immune response in the peripheral nerve. Historic

University of Antwerp

This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Negative regulation of the innate immune response in the peripheral nerve. Recently ended

University of Antwerp

This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Neighborhoud Environmental and Socioeconomic Correlates of Health Enhancing Physical Activity and Overweight among Adults in Nigeria Historic

Ghent University

(1) A study on cross-cultural adaptation and validation of internationally used questionaires (the International Physical Activity Questionnaire (IPAQ-SF), the Physical Activity Neighborhood Environment Scale (PANES) and the Neighborhood Environemnt Walkability Scale (NEWS) in Nigeria; (2) A population based cross-sectional study to determine the associations between outcomes (physical activity, and overweight status), and environmental variables and socioeconomic status among adults in Niger...

Project

Nerve regeneration by human dental pulp stem cells in hydrogel based scaffolds: characterization by label-free optical imaging

Universiteit Hasselt

A variety of traumas and diseases can cause peripheral nerve injury (PNI). In the process of spontaneous healing, Schwann cells (SC) are important players as they align to guide axonal outgrowth and produce myelin sheaths to allow fast neural action potential propagation. However, large gap nerve injuries require artificial bridging strategies for repair. In neural tissue engineering, autologous SC have been successfully used in 3D scaffolds to promote neuroregeneration, but their painful and...

Project

Nested modelling of the Greenland ice sheet in support of the dating and the interpretation of the NEEM ice core record (NEEM-B) Historic

Vrije Universiteit Brussel

1. Background and importance of the project Starting with the initial projects in the 1960s (Camp Century and Byrd), deep ice cores have become a crucial pillar of knowledge about Late Quaternary palaeoclimatic changes. The current state of the art is represented in Greenland by the detailed records drilled at Summit (GRIP - Greenland Ice core Project - and GISP2 - Greenland Ice Sheet Project 2) and at NGRIP (NorthGRIP), cf. Dansgaard et al. (1993), NGRIP project members (2004). The most comp...

Project

Nestlé Nutrition Institute Fellowship Funding agreement for Cristina Julian Almarcegui Recently ended

Ghent University

The fellowship is intended to allow the Student to undertake the training of the 6 months research/pratical training at GHent University, Faculity of Medicine and Health Sciences, department of Public Health in Ghent between 01/08/2013 and 31/01/2014

Project

NET-INJURY-IN-SEPSIS: Endothelial injury during sepsis: do NET-attachedproteases participate in this process? Recently ended

KU Leuven

(MMP-9) and Neutrophil Extracellular Traps or NETs are chromatin extrusions in which proteins are extracellularly bound to DNA of dying neutrophilic granulocytes. In this project we will investigate whether NET-bound proteases, for instance, gelatinase B or matrix metalloproteinase-9 (MMP-9) and neutrophil elastase (NE), can cause damage to bystander cells, such as endothelial cells. This research has implications for severe infections, including bacterial sepsis. Practically, the following r...

Project

Network-based approaches for determining mode of action

Ghent University

Develop a network-based integration strategy that exploits public information for the interpretation of dedicated in-house experimental data. It relies on the compilation of molecular interaction network in the target organism. In addition an efficient path finding inference algorithm is needed to flexibly interrogate the network with the dedicated in-house data. The strategy will be tested on a bacterial model organism.

Project

Network-based approaches for the identification and mode of action determination of anti-bacterial agents

Ghent University

Drug repurposing and the design of polypharmacological and drug-cocktailing strategies by combining in-house phenotypic and molecular data with advanced bioinformatics approaches. This implies 1) constructing drug-target networks, 2) constructing interaction networks from publicly available data, 3) determining the mode of action of drugs by interrogating interaction networks with in-house data, 4) testing the phenotypic and molecular effect of anti-biofilm agents.

Project

Network ESPOL, Ecuador Historic

Ghent University

In this VLIR-UOS network programme, several Ecuadorean institutes of higher education (Escuela Superior Politécnica del Litoral, Universidad de Cuenca, Universidad Técnica del Norte and Escuela Politécnica Nacional) work together in order to contribute to the sustainable management of Ecuador's natural resources by strengthening advanced human talent in the areas of biodiversity (project 1) and water resource management (project 2). In the first phase of these projects, two joint master...

Project

Network in Europe on Male Osteoporosis (NEMO) Historic

Ghent University

NEMO is a Thematic Network in the frame of QLK6 programme addressing the issue of the identification of men at high risk for osteoporotic fracture using a multidisciplinary approach. The main achievement will be the creation of an algorithm to be used for risk assessment in clinical practice and as the basis for evaluation of intervention strategies in male osteoporosis.

Project

Networking complex cases. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand Provincie Antwerpen. UA provides Provincie Antwerpen research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Network Phase I 'Biodev Ecuador' programme(2013-2018) for Network University Cooperation between Ecuadorian and Flemish universities

Ghent University

ESPOL Network Network Phase I 'Biodev Ecuador' programme(2013-2018) for Network University Cooperation between Ecuadorian and Flemish universities VLIR UOS ZIUS2013-2018AP032

Project

Network rhythms and the dynamical response properties of neuronal microcircuits. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand Francqui-fonds. UA provides Francqui-fonds research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Network rhythms and the dynamical response properties of neuronal microcircuits. (Cofinancing mandate by Francqui-fund) Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand Francqui-fonds. UA provides Francqui-fonds research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Network Statistics for Sexually Transmitted Infections Epidemiology

Universiteit Hasselt

Epidemics of HIV and other Sexually Transmitted Infections (STIs) continue to cause an unacceptably high burden of morbidity and mortality worldwide, especially in sub-Saharan Africa. The spread of STIs, and consequent implications for prevention and treatment, strongly depend on the sexual networks in which these infections propagate. The Scientific Research Community (SRC), funded by the Flemish Scientific Research Fund (FWO), will formalise the joining of forces between groups that are int...

Project

Neural basis for the interactions between head, arms and legs during gait. Recently ended

KU Leuven

Because humans are bipeds, most studies on gait have focused on leg movements. However, rhythmic arm swing has recently attracted a lot of attention since there is increasing evidence that arm swing movements during gait are controlled by locomotor central pattern generators (CPGs), similar to the situation for the legs. Furthermore it is thought thatthese centers are coupled either through spinal connections or by control from supraspinal centers. This coupling is the topic of the first 2 pa...

Project

Neural correlates of learned movements: contributions from apraxia and functional imaging Recently ended

Ghent University

The aim of our study is twofold: (1) to investigate the neural correlates of pantomiming tool use and explore the factors that influence its lateralization, and (2) to determine how knowledge about tools and their use is distributed in the brain. The first aim will be achieved by tool pantomiming paradigms involving different tasks performed by different groups of normal volunteers in an fMRI study. The second aim will be tackled in a lesion-function study by presenting a test battery of tool...

Project

Neural correlates of perceptual-motor (dys-)functioning in children with obesity

Ghent University

This project will further document the nature of perceptual-motor (dys-)function in obese children by means of specific motor tasks. Advanced neuroimaging will be used to investigate characteristics of brain structural and functional networks. Using a cross-sectional and longitudinal (pre-post) design, the extent to which (a decreased) BMI, motor behavioral measures and structural / functional characteristics of the brain are correlated.

Project

Neural correlates of somatosensory deficits in the upperlimb after stroke Recently ended

KU Leuven

This project is a collaboration between the fields ofrehabilitation sciences (G Verheyden, H Feys),experimental neurology (V Thijs) and radiology (SSunaert). It is lead by the department of rehabilitationsciences and hence, we have chosen the panel of healthsciences.

Project

Neural Representations of Numbers in the Human Cortex

KU Leuven

During the last decade there has been a boost of behavioral and neuroimaging research about numerical cognition in order to reveal the underlying neural mechanisms of number processing. This PhD aims to unravel some fundamental questions in the field of numerical cognition, namely (a) distinguishing neural representations of different numbers, (b) revealing the influence of arithmetical contexts on the numerical representations, and (c) investigating how numerical representations in arithmeti...

Project

Neural stem cells: molecular and physiological control of in vivo differentiation, migration and immunogenicity. Historic

University of Antwerp

Future research will be focussed on three main topics: 1) Characterization of neural stem cells. While culture conditions have recently been established for adherently growing NSC, many questions remain regarding: (a) optimal growth conditions, (b) identity, and (c) differentiation potential in vitro and in vivo. 2) In vivo migration and survival of neural stem cells. While NSC-based therapies have demonstrated beneficial outcome in animal models of neurotrauma and/or -inflammation, currently...

Project

Neural Stem Cells: molecular and physiological control of in vivo migration and differentiation. Recently ended

University of Antwerp

This proposed multidisciplinary research consortium, consisting of 6 different laboratories from the University of Antwerp, aims to understand the cellular and/or functional interactions of NSC implants in healthy and injured neural tissue (cuprizone-mediated demyelinisation mouse model). With this research project, which focuses on the in vivo molecular and physiological control of NSC, we aim to contribute to the in vivo study and modulation of NSC migration, survival, differentiation and f...

Project

Neureguline, angiopoietine and VEGF signal transduction systems in the interaction between cardiac and endothelial myocyte in adult heart. Historic

University of Antwerp

Neureguline, angiopoietine and VEGF signal transduction systems in the interaction between cardiac and endothelial myocyte in adult heart.

Project

Neurobehavioral effects of environmental pollution in primary school children and adolescents.

Universiteit Hasselt

Although it is well known that environmental pollution may negatively affect the neurobehavioral function, there exist many unresolved issues. For many toxicants including metals, it is unclear what level of exposure can be assumed safe. Moreover, the cognitive effects of some pollutants including traffic-related air pollution have not been extensively studied to date. In this project, we investigate the neurobehavioral effects of environmental pollution in primary school children and adolesc...

Project

Neurobehavioral effects of fine particulate air pollution in primary schoolchildren Recently ended

Universiteit Hasselt

The cardiorespiratory effects of particulate air pollution have been largely investigated. In contrast, little is known about the neurological effects. Studies in animals suggest biological plausibility of detrimental neurological effects of air pollution. However, information based on studies in humans is very limited. OBJECTIVES 1. To investigate the association between residential distance to major roads and the neurobehavioral function of children. 2. To investigate the association bet...

Project

Neuroblastoma transcriptome based study of molecular pathogenesis and the development of prognostic microbead tests Historic

Ghent University

Neuroblastoma is a tumor that originates from progenitor cells of the sympathetic nervous system cells. Using differential expression profiling of these neuroblastoma progenitors versus neuroblastoma samples, we aim to identify genes that are involved in neuroblastoma pathogenesis. In a second part of the porject, we aim at developing a new test for the prognostic stratification and clinical-genetic classification of neuroblastomas using microbeads.

Project

Neurochemical and neuropharmacological investigation of the involvement of glutamate transporters in limbic epilepsy and Parkinson's disease Historic

Vrije Universiteit Brussel

Using glutamate transporter specific antibodies, specific inhibitors and glutamate transporter deficient mice, we investigate the involvement of the high-affinity Na/K-dependent glutamate transporters, the vesicular glutamate transporters and the cystine/glutamate antiporter in rodent models for Parkinson's disease and limbic epilepsy.

Project

Neurochemical and neuropharmacological investigation of the involvement of glutamate transporters in limbic epilepsy and Parkinson's disease. Historic

Vrije Universiteit Brussel

Within this project we investigate the expression levels and activity of the high-affinity Na/K-dependent glutamate transporters as well as the cystine/glutamate antiporter in Parkinson's disease and epilepsy. This will be accomplished using immunohistochemistry, Western blotting and in vivo microdialysis.

Project

Neurochemical and Neuropharmacological Studies in Animal Models for Parkinson's Disease and Focal Epilepsy. Historic

Vrije Universiteit Brussel

Animal models are used to study the pathophysiology and pharmacotherapy of disease states. Although one should always try to work with alternative experimental methods, it is impossible to eliminate animal experiments from preclinical drug research en development. In our laboratory we developed rat models for a few major neurological disorders such as Parkinson's disease and psychomotor epilepsy. These models are routinely used for the fundamental study of pathophysiological alterations in th...

Project

Neurochemical characterization of behavioral disturbances in dementia. Historic

University of Antwerp

Behavioral disturbances (Behavioral and psychological signs and symptoms of dementia, BPSD) are an indispensable part of dementia and consist of delusions, hallucinations, aggressiveness, activity disturbances, diurnal rhythm disturbances, affective disorders and anxieties/phobias. Research has repeatedly confirmed that there is a neurochemical basis underlying BPSD although the pathophysiology remains unclear. In this project ante-mortem behavioral data will be correlated with neurotransmitt...

Project

Neurochemical correlates of behavioral and psychological signs and symptoms of Dementia of the Alzheimer Typen and Frontal Lobe Dementia. Historic

University of Antwerp

The aim of the present study is to trace for neurochemical correlates of BPSD in a population of DAT and FLD patients. We will focus on paranoid and delusional ideations, hallucinations, aggressiveness, affective distrubances and anxiety. Rating scales for BPSD will be used for reasons of standardization and quantification of observations. Especially serotonergic and catecholaminergic neurotransmitter systems will be studied as a physiopathological link with psychosis, aggressive behavior...

Project

Neurodegenerative disorders, neuroprotective mechanisms and the aging brain. Recently ended

KU Leuven

The understanding of neuronal aging and survival, neuronal networks, motor function, cognition and memory, and how these basic functions go astray in neurodegenerative disease are without doubt challenging and interesting scientific questions. Because 5 Million people are affected by age associated dementia in the European Union alone, the potential social and economic relevance of such research is even more compelling. The impact of these disorders on the European healthcare systems and soci...

Project

Neuroelectronics and nanotechnology: towards a multidisciplinary approach for the science and engineering of neuronal networks (NAMASEN).

University of Antwerp

We identify Neuroelectronics as a novel mature discipline, at the boundaries between neurobiology, electrophysiology, computational neurosciences, microelectronics, material sciences, and nanotechnologies. In the Marie-Curie consortium, each of these components, as well as the specific application contexts (i.e. basic research, neuroprosthetics, and pharmaceutical applications), are represented and combined in a concerted effort, towards the training of a new generation of researchers and pro...

Project

Neuroendocrine control of reproduction in ecdysozoan model organisms: from genomics to phenomics.

KU Leuven

In recent years, the availability of genome and EST sequence data from a variety of model organisms has revolutioned research in biology and medicine. The current challenge is to decipher the regulation and functions of this plethora of genes and gene products. In this project, we will combine our expertises in functional genomics, peptidomics, molecular biology and physiology to study and compare neuroendocrine signalling pathways controlling reproduction in excysozoan research models. In pa...

Project

Neuroendocrine interactions in the gastrointestinal tract under normal and pathological conditions. Historic

University of Antwerp

1. Morphological, pharmacological and electrophysiological analysis of enteric microcircuits in mammals including man; 2. Inhibitory neurotransmission in the digestive tract; 3. Pathogenesis of intestinal suffering in schistosomiasis, chemically induced inflammation and axotomy-induced neurochemical changes; 4. Role of VPAC1, VPAC2, PAC1, glucagon and CGRP in the digestive tract; 5. Role of ghrelin/ghrelin receptors in the digestive tract and; 6. Role of ICCs in the control of gastrointestina...

Project

Neuro Image-guided decoding of mechanisms involved in healthy, accelerated and pathological aging.

University of Antwerp

The overall goal of project is to contribute new information that will greatly increase our understanding about underlying mechanisms of hypothalamus-driven normal, accelerated and pathological aging of the brain, with the focus on structural alterations and subsequent alterations of specific functional networks such as the default mode network (DMN) and its anticorrelated networks. Our results will provide fundamental knowledge for age dependent intrinsic network structural changes as a refe...

Project

Neuro-immune interaction in postoperative ileus: new targets for treatment Recently ended

KU Leuven

Postoperative ileus (POI) is the transient inhibition of bowel motility after abdominal surgery resulting in delayed transit of intestinal contents and/or intolerance of food intake and inability to defecate. The current POI therapies focus on shortening the duration of the disease by introduction of early feeding, optimal analgesia and opting for laparoscopic surgery instead of conventional open surgery. In addition, prokinetics or compounds that increase gastro-intestinal (GI) smooth muscle...

Project

Neuro-immune interactions in the upper airways. Recently ended

KU Leuven

Persistent rhinitis is variable in severity and affects upon 30% of thewestern population. Patients suffering from persistent rhinitis report difficulties of nasal breathing, a runny nose, sneezing and/or itching in the nose or eyes. In one third of this patient population, the symptoms are severe and are accompanied with sleep reduction, diminished concentration and general decreased socio-economic productivity. The three most frequent subtypes of rhinitis are allergic rhinitis (AR), infecti...

Project

Neuro-immune mechanisms of visceral and airway hypersensitivity.

KU Leuven

Both the airways and the intestine are continuously exposed to antigens of microbial, nutritional and environmental origin.Recognition of harmless versus threatening antigens by the immune system is of crucial importance to maintain immune homeostasis thereby preventing an excessive immune response with subsequent tissue damage and impaired organ function.In line, the epithelial barrier tightly regulates the exposure of foreign antigens to the immune system to guarantee proper function of the...

Project

Neurological biomarkers in predicting upper limb function and treatmenteffects in children with unilateral cerebral palsy.

KU Leuven

Children with unilateral cerebral palsy (CP) face many sensorimotor impairments and limitations in their arm and hand function. In this project, we will use state-of-the art technology including brain imaging and non-invasive brain stimulation to identify which neurological biomarkers best predict upper limb (UL) function in children with unilateral CP. This proposal is triggered by the current inability to provide well-targeted UL treatment plans for the individual child, which arises from i...

Project

Neurological effects in association with in utero and early life exposure to particulate air pollution. Recently ended

Universiteit Hasselt

Cardiorespiratory effects and mechanisms of fine particulate air pollution have been largely investigated. In contrast, little is known regarding neurological effects, with only some preliminary evidence. First, we study in a birth cohort neurocognitive measures of development (motor development, verbal and nonverbal IQ, behavioral development) till the age of three in association with particulate and traffic related air pollution during different exposure windows (in utero and during first y...

Project

Neurological factors in predicting upper limb function and treatment response in children with unilateral cp

KU Leuven

In children with unilateral cerebral palsy (CP), sensory and motor impairments are often more pronounced in the upper limb (UL) than in the lower limb, though the variability in outcome is large. This is not surprising since these children present with various brain lesions. So far, it is still unclear which neurological factors determine UL function in these children. Further research is necessary to unravel the complex neuropathophysiology underlying UL dysfunction. Magnetic resonance imagi...

Project

Neuromechanics of locomotion in frogs: historical or ecological basis? Historic

University of Antwerp

Several major radiations of amphibians have evolved from terrestrial ancestors. Some lineages have further developed the terrestrial design while others have derived an aquatic habit. Among frogs, constraints imposed by ancestral traits have significantly affected the evolution of locomotor mode: almost every frog group has evolved very specialised morphological adaptations for a saltatory (jumping) locomotion. Despite the apparent conflicting demands of jumping and swimming in frogs, hypothe...

Project

Neuromodulation and functional imaging of morally dysfunctional behaviour. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand UZA. UA provides UZA research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Neuromodulation for refractory epilepsy Historic

Ghent University

Patients with refractory epilepsy still suffer from uncontrolled seizures, even during optimal treatment with anti-epileptica. Neuromodulation by stimulating nerve structures electrically (neurostimulation) provides a new way of treatment for these patients. The aim of the study is to investigate the mechanism of action, the feasibility, the efficacy and safety of different kinds of neuromodulation. These are vaugs nerve stimulation, which is already being used in clinical practice the experi...

Project

Neuronal networks in vitro: spontaneous activity and synaptic plasticity in health and disease. Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

NEURONET combats neurosis Recently ended

Universiteit Hasselt

NEURONET wants to study from a biomedical point of view, nerve diseases like Alzheimer dementia, Parkinson and the disease of Charcot-Marie-Tooth. The degeneration of the nerve cells with all these diseases is a complex proces where as well genetic as environmental aspects have an effect. The Methusalem-project NEURONET collects biological material of patients and family to look into the mechanisms that are the basis of neurodegeneration. Next to that, NEURONET wants to contribute the develop...

Project

NEURON II - Proteolytic remodeling of the extracellular matrix in aberrant synaptic plasticity underlying epilepsy evoked by traumatic brain injury (TBI Epilepsy).

University of Antwerp

In the present project we aim at testing a hypothesis that MMP-9 and uPA/uPAR contribute to circuitry remodeling during post-traumatic epileptogenesis. We focus on those two molecular systems, because there is a strong support for their involvement in other models of epileptogenesis, as well as the partners of this consortium have excellent tools and expertise to investigate these molecules.

Project

Neuropatholgical image analyses in Alzheimer's disease mouse models treated with anti-amyloidotic and vasogenic compounds

University of Antwerp

The varied morphological and biochemical forms in which Aβ deposits in brain of Alzheimer's disease (AD) patients are complex and the mechanisms that drive their formation are not yet properly understood. Aβ is predominantly deposited in brain as dense-core and diffuse plaques and in cerebral vascular walls. The dense-core plaques and vascular amyloid, but not diffuse plaques, are associated with tau pathological changes in the surrounding brain tissue, suggesting that such amyloid deposits a...

Project

Neuropatholgical image analysis in Alzheimer's disease (AD) patients and in AD mouse models treated with anti-amyloidotic and vasogenic compounds. Historic

University of Antwerp

Neuropatholgical image analysis in Alzheimer's disease (AD) patients and in AD mouse models treated with anti-amyloidotic and vasogenic compounds.

Project

Neuropathy and neuroplasticity of the enteric nervous system playing a part in the ethiopathogenesis of necrotizing enterocolitis in the preterm piglet and neonatal rat. Recently ended

University of Antwerp

Approximately 10% of the low birth weight infants develop necrotizing enterocolitis (NEC). Symptoms of NEC such as abnormal intestinal motility, permeability and blood flow can be linked to a neuropathy of the enteric nervous system (ENS). In the preterm piglet and neonatal rat, in vivo and in vitro experiments will be used to challenge the hypothesis that a neuropathy of the ENS plays a role in the ethiopathogenesis of NEC.

Project

Neuropeptide GPCRs as a target against plagues of the desert locust: Schistocerca gregaria

KU Leuven

For centuries, the desert locust, Schistocerca gregaria is a threat to agricultural production in Northern Africa, the Middle East and the Indian subcontinent. These locusts exhibit an extreme form of phenotypic plasticity (polyphenism). In low density conditions, they develop into relatively harmless solitarious animals. But at high densities, they developinto swarming, devastating gregarious animals. Not only do they differ in behaviour, they also differ in colour, morphology and physiology...

Project

Neuropeptiden in veroudering en neurodegenerative.

KU Leuven

Uit onderzoek blijkt dat het verouderingsproces gereguleerd wordt door verschillende cellulaire signaalwegen. Ons inzicht over hoe al deze signaalwegen aan elkaar worden gelinkt en hoe deze een complex proces als veroudering kunnen reguleren is echter beperkt. Het lijkt erop dat endocriene signalisatie hiervoor verantwoordelijk is, en dat er een belangrijkerol is weggelegd voor neuropeptiden. Een verdere identificatie van dezeneuropeptiden kan dus meer inzicht bieden over de endocriene zijde ...

Project

Neuropeptide Y: interaction with met receptors and binding proteins. Historic

Vrije Universiteit Brussel

This study aims a better knowledge about the peptide neurotransmitter Neuropeptide Y (NPY) and its receptors. These receptors comprise at least 3 subtypes (Y1, Y2, Y3) and non-peptide antagonists are of medical interest because of their potental hypotensive a appetite-reducing properties. A) Comparison of the binding of labelled NPY with the binding of recently developed non-peptide antagonists on e.g. cell lines of human origin (Y1: SK-N-MC, Y2: SK-N-BE). B) Human Y1-receptors are in their o...

Project

Neuropharmacology in experimental animal models for epilepsy Historic

Ghent University

Epileptic seizures can be ended using various antiepileptic drugs. The processes leading towards these spontaneous seizures, however, remain pharamcologically unaffected. The aim of the study is to investigate the antiepileptogenic properties of several promising antiepileptic drugs in animal model for epilepsy. The Rapid Kindling with recurrent Hippocampal Seizures (RKRHS), a status epilepticus model and a model for absence epilepsy (the Genetic Absence Epilepsy Rats from Strasbourg (GAERS) ...

Project

Neurophysiological aspects of speech disfluencies Historic

Ghent University

In a study of the spectral changer of the EEG during language perception and language production in individuals with developmental stuttering and normal controls differences in temporal brain activation will be examined. Next we will try to elicit dysfluencies in normal speaking volunteers through rTMS at the left frontal lobe.

Project

Neurophysiological relationship between sound intensity perception and hypophonic speech production in Parkinson's disease: unraveling the role of primary auditory perception, gating and attention.

Ghent University

The aim of this proposal is to assess the role of primary auditory perception in hypophonic speech production in Parkinson?s disease (PD). 50 PD patients and 50 normal control subjects will be auditorily and neurophysiologically tested. The effect of gating and attention on speech perception and production will be studied.

Project

Neuroplasticity in Parkinson's disease: consolidation of motor learningand its related brain activity changes.

KU Leuven

A smaller handwriting size, a decrease in movement speed and hesitations while writing, also known as micrographia, is often one of the first manifestations of Parkinson’s disease. In this study we will compare the effect of an intensive writing training with the effect of stretch- and relaxation training. In the course of 6 weeks, exercises will increase in difficulty every week for both training programs. We want to investigate whether these interventions can improve writing performance of ...

Project

Neuroplasticity in Parkinson's Disease: consolidation of motor learningand its related brain activity changes. Recently ended

KU Leuven

The basal ganglia play an important role during the consolidation of motor learning, begging the question whether it is possible to sustain learning increments in a neurodegenerative condition such as Parkinson’s Disease (PD). This project aims to gain knowledge on how neuroplasticity is modulated by PD and by the practice context offered (cued versus non-cued conditions). We propose to investigate a novel relearning program for writing skills. Study 1 will compare changes in writing performa...

Project

Neuropotention of Multipotent Adult Progenitor cells (MAPC) isolated from adult human and rat tissues Historic

Ghent University

Multipotent Adult Progenitor cells (MAPC's) and neural stem cellswill be evaluated for their potential to differentiate into functional neuronal cells. Phenotype and functionality of differentiated neurons will be tested in vitro using histochemical and electrophysiological techniques. In vivo functionality will be evaluated by transplantation to the brain of a status epilepticus model with neuronal damage at hippocampal sites. Functional repair will be tested using video-EEG and memory ...

Project

Neuroprotection and glaucoma: an optogenetic approach.

KU Leuven

font-family:TimesNewRoman;mso-fareast-font-family:Calibri;mso-fareast-theme-font:minor-latin;mso-bidi-font-family:TimesNewRoman;mso-ansi-language:EN-US;mso-fareast-language:EN-US" lang="EN-US">Recent neuropathological examinations in glaucoma have revealed degenerative changes in retinal target structures of the brain. Glaucoma is therefore increasingly recognized as a disease with effects beyond the eye/retina, exhibiting important similarities with other age-related neurodegenerative disord...

Project

Neuroprotection via hypoxia-dependent dendritic spine remodeling: genetic role and therapeutic potential of silencing the oxygen sensor PHD2.

KU Leuven

Neurons transmit impulses in the central nervous system. Transmission occurs at the end of its long protrusion, the axon, at the contact place (synapse) with the ‘dendrites’ of the next neuron. These dendrites carry many small appendages, dendritic ‘spines’, that increase the receptive properties of the dendrites. The spines can rapidly change their shape and activity (spine ‘plasticity’) in response to stimuli, by rearranging their intracellular protein ‘skeleton’. Neurons are highly sensiti...

Project

Neuropsychiological research in the medical settings. Historic

Vrije Universiteit Brussel

The purpose of this study is a series of investigations in the field of neuropsychology applied to specific medical settings. These will include the study of cognitive (dys)functioning in: 1 patients with respiratory problems, both children and adults. more specific, patients with sleep related OSAS have/are been studied.2 patients suffering from the chronic fatigue syndrome and fibro myositis.3 diabetes patients sustaining experimentally induced hypoglycae

Project

Neuropsychology and electrophysiology of cognitive impairment in schizophrenia. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand a privé institution. UA provides the privé institution research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Neuro-TARGET : integrated platform for target identification, validation and drug discovery with applications for neurodegenerative diseases. Historic

Vrije Universiteit Brussel

In light of the ever increasing incidence of neurodegenerative diseases, such as Alzheimer's and Parkinson's disease, in our ageing population in the western world, we propose to establish an integrated platform for target identification, validation and drug discovery to foster the development of novel therapeutics for neurodegeneration. Using cutting-edge technologies we will identify new disease-related genes from human biosamples and humanized yeast models. Generic and strategic research t...

Project

Neurotoxic effects of methyl mercury in the neocortex of the rat : Cellular physiological and mutagenicity studies Historic

Vrije Universiteit Brussel

The project aims at the comparison of the cytotxic and genotoxic effects of MMC in neocortical neurons of newborn rats of mothers, who were treated chronically by MMC before and during pregnancy together with changes of their multimodal electrophysiological parameters. This comparison will allow assess whether the neurophysiological changes are primary events or consequences of early genetic events, moreover the balance between cell survival versus cell death will be analyzed in function of...

Project

New applications of Camelid single domain antibodies (nanobodies) as research tool and potential therapeutic. Recently ended

Ghent University

Use of single domain antibodies (nanobodies) as antagonists to structural polypeptides in cells with the aim of neutralizing ar blocking their activities. This knowledge is applied to cancer cell motility.

Project

New approaches for the targeted therapy of Non-Small Cell Lung Cancer. Recently ended

KU Leuven

Lung cancer is the most common cancer fatality in Europe (335000 deaths/yr). Non-small cell lung cancer (NSCLC) consists 85% of the cases, with5 yr survival >15%. Hence, this proposal focuses on the urgent need for better NSCLC therapies. This is a European problem at societal andscientific level: better therapies are needed to keep the spiralling costs of European health systems under control, and the required expertise(basic science, clinical, biotech, experimental therapeutics) is scattere...

Project

New approach for diagnosis and treatement of leukaemia and other malignant diseases. Historic

Vrije Universiteit Brussel

Because SOCS factors possibly affect cell proliferation, much attention is devoted to their potential therapeutic properties. Therefore, the expression of these factors will be analysed (Western blotting, DNA micro-arrays, RT-PCR) in leukocytes(granulocyten, mononucleaire cellen) obtained from healthy donors and from patients with leukemia. SOCS analogues (coupled to membrane transfer sequences) are synthesized and will be evaluated for potential therapeutical properties

Project

New azaheterocyclic connections and aminoacids with potential agrochemical and pharmaceutical applications. Historic

Vrije Universiteit Brussel

A new efficient method for the production of azaheterocyclic connections by means of inducted electons cyclisation of alkenylimes (both C- and N-alk). The goal of this project is to optimise this proces for the agricultural and pharmaceutical industries .

Project

New azaheterocyclic connections and aminoacids with potential agrochemical and pharmaceutical applications. Historic

Vrije Universiteit Brussel

A new efficient method for the production of azaheterocyclic connections by means of inducted electons cyclisation of alkenylimes (both C- and N-alk). The goal of this project is to optimise this proces for the agricultural and pharmaceutical industries .

Project

Newborns and Genotoxic exposure risks: Development and application of biomarkers of dietary exposure to genotoxic and immunotoxic chemicals and of biomarkers of early effects, using mother-child birth cohorts and biobanks Historic

Vrije Universiteit Brussel

NewGeneris will test the research hypothesis that maternal exposure to dietary compounds with carcinogenic and associated immunotoxic properties results in in utero exposure and subsequent carcinogenic and immunotoxic events in the unborn child leading to increased risk of cancer and immune disorders in later childhood. Specific biomarkers will be developed and applied using high throughput techniques. The project will use existing European mother-child birth cohorts. New biobanks will be set...

Project

Newcastle disease virotherapy - a novel immunotherapeutic approach in the treatment of high-grade glioma Recently ended

KU Leuven

justify;line-height:150%">Thisresearch project investigates oncolytic virotherapy. This is a newtherapeuticapproach in which we use oncolytic viruses in the battleagainst malignantbrain tumors. Oncolytic viruses are specific viruses that only recognize andkill tumor cells, without causing damage to healthy cells and tissues. Some ofthese viruses have a natural capacity to recognize tumor cells. Others arehuman pathogens that have been genetically altered to only infect tumor cells. EN-US" lan...

Project

New diagnostic and prognostic antibody biomarkers for multiple sclerosis and chronic autoimmune arthritis.

Universiteit Hasselt

It is assumed that MS and rheumatoid arthritis (RA) are autoimmune diseases, that are the result of an exaggerated immune response against body components. MS is a chronic inflammatory disease of the central nervous system (CNS) where the myelin in the brains is damaged. RA is an autoimmune disease characterized by chronic inflammation of synovial tissue. In both disorders it has been demonstrated that the damaged tissue contains activated T-cells and B-cells. Several candidate disease marker...

Project

New diagnostic technique for measuring eardrum deformations based on endoscopic profilometry with real-time distortion correction using graphics processing units. Recently ended

University of Antwerp

In this project, we will develop a novel procedure to generate distortion corrected endoscope images and combine this technique with graphics card programming to implement a new diagnostic medical tool for measuring eardrum deformations in real-time and in vivo. As my endoscopic profilometry technique is fully non-invasive, it will be very easy to introduce the new technique in the clinical setting once its possibilities have been demonstrated.

Project

New diagnostic technique for measuring eardrum deformations based on endoscopic profilometry with realtime distortion correction using graphics processing units.

University of Antwerp

In this project, we will develop a novel procedure to generate distortion corrected endoscope images and combine this technique with graphics card programming to implement a new diagnostic medical tool for measuring eardrum deformations in real-time and in vivo. As my endoscopic profilometry technique is fully non-invasive, it will be very easy to introduce the new technique in the clinical setting once its possibilities have been demonstrated.

Project

New directions for 5-HT4 receptor agonists Historic

Ghent University

The influence of selective 5-HT4 receptor agonists on acetylcholine release from brain slices is examined for possible application in degenerative brain diseases, characterized by memory loss. Parallelly, the influence of the agonists is investigated on peripheral 5-HT4 receptors in the gastro-intestinal tract and in the heart to select the substances with as little peripheral effect as possible.

Project

New directions in the therapy of cancer. Historic

University of Antwerp

It is clear that the current options used to treat cancer will not cure many patients suffering from that disease. There is a need for the development of new treatment strategies, based on concepts different from and/or complementary to the classical treatment modalities. In this interuniversity project, experimental work will be performed in order to investigate three promising research lines leading to new options in the treatment of cancer: immunotherapy using tumor peptides and/or dendr...

Project

New entries to quinoid antibiotics an antitumor compounds Historic

Ghent University

Quinones are natural products and display a variety of biological activities, amongst which antibiotic and antitumour activity, which makes them an important class of compounds for the development of new drugs. Furthermore, the development of bacterial multiresistance in case of antibiotics represents a real problem, which necessitates continued research to new active compounds. In this respect, the current research proposal aims to develop efficient syntheses of potentially bioactive pyran...

Project

Newest generation high technology for functional genome analysis Recently ended

Ghent University

The requested infrastructure embraces the newest generation of functional genomeanalysis infrastructure, this is high technology which would allow us to unravel genetic codes ( human and other) faster (up to a factor of 1000) and more efficiently.

Project

New experimental approach in the identification and characterisation of emerging chemical risks in food security. Historic

University of Antwerp

New experimental approach in the identification and characterisation of emerging chemical risks in food security.

Project

New eyes on the world: signal processing for interpreting biogeochemical time series.

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Federal Public Service. UA provides the Federal Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

New finance model research: ZAP startcredit 2010 Historic

Vrije Universiteit Brussel

New ZAP members received a startcredit of EURO 50.000.

Project

New finance model research: ZAP startcredit 2010 Historic

Vrije Universiteit Brussel

Start credit for new ZAP members

Project

New finance model research: ZAP startcredit 2010 Historic

Vrije Universiteit Brussel

Start credit for new ZAP members

Project

New finance model research: ZAP start credit 2011

Vrije Universiteit Brussel

Start credit for new ZAP members: 2011

Project

New financing model research: ZAP start credit 2011 Historic

Vrije Universiteit Brussel

Start credit for new ZAP members 2011

Project

New functions of the BH4 domain of Bcl-2: a critical regulator of Ca2+-permeable channels.

Ghent University

We previously found that the anti-apoptotic protein Bcl-2, but not Bcl-Xl, binds to the central, modulatory domain of the inositol trisphosphate receptor through its BH4-domain, thereby inhibiting endoplasmic reticulum (ER) Ca2+ release and apoptosis. This project will explore novel functions of BH4-Bcl-2 and BH4-Bcl-Xl, focusing on the interactions with the ER ryanodine receptor and the mitochondrial voltage-dependent anion channel 1.

Project

New funding model research: ZAP-startkrediet 2012

Vrije Universiteit Brussel

Awarding of starting fund to a new member ZAP VUB

Project

New genes and signaling pathways in osteoarthritis: focus on GPR22, COG5 and SMOC2.nbsp;

KU Leuven

Osteoarthritis (OA) is one of the most common chronic musculoskeletal disorders. Its complex etiology is due to the activation of several signaling pathways in the different tissues composing the joint. Genes associated with OA include FRZB and GDF5 which were originally identified froma chondrogenic extract of articular cartilage. A 3rd protein identifiedfrom this unique extract is SMOC2 (SPARC-related modular calcium-binding protein 2), a secreted calcium-binding protein. SMOC2 can act as a...

Project

New Human Dipeptidyl Peptidases. Historic

University of Antwerp

This project concerns the molecular and biochemical study of new human dipeptidyl peptidases (DPPs). The project aims to (1) determine which dipeptidyl peptidases are present in human leucocytes besides DPPIV, (2) identify and characterize these peptidases physicochemically, (3) study which substrates are cleaved by these peptidases and (4) test known inhibitors of dipeptidyl peptidases for selectivity.

Project

New insights in the diagnosis and treatment of chronic pulmonary aspiration in children. Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand UZA. UA provides UZA research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

NEW INSIGHTS INTO GENETICS OF PROGRESSION OF B-CELL LYMPHOMA Recently ended

KU Leuven

Lymphoma consists of a broad range of neoplasms with distinct clinical,histopathological and molecular characteristics. Recent advances in molecular analysis of lymphoma have led to a better understanding of the pathobiology of disease and to remarkable improvements in the clinical management of lymphoma. One of the challenges in lymphoma research is identification of biomarkers associated with disease progression, particularly progression and transformation of low grade (indolent) leukemias/...

Project

New insights into molecular mechanisms and improving the therapy in nephropathic cystinosis.

KU Leuven

Cystinose is een autosomaal recessieve ziekte veroorzaakt door mutatiesin het CTNS gen, dat codeert voor de lysosomale cystine transporter cystinosin. Cystinose wordt gekenmerkt door cystine stapeling in de lysosomen en presenteert zich meestal als renaal Fanconi syndroom en nierinsufficiëntie. Cysteamine is de enige medicatie die cystinestapeling in de lysosomen verlaagt en het ziekteverloop bij cystinose verbetert.Onze eigen en andere voorafgaande onderzoeksbevindingen vormen de basisvan di...

Project

New insights into the glycosylation of <em>Trichoderma reesei</em> cellulases Historic

University College Ghent

For many years, lower eukaryotes such as yeasts and fungi are being used for the expression of recombinant proteins. They combine the advantages of prokaryotes with those of higher eukaryotes; i.e. the possibilities of co- and posttranslational modifications. Several yeast and fungal strains secrete large amounts of protein and are ideal for the production of industrial enzymes at low cost. Glycoproteins secreted by these organisms carry carbohydrate chains of the high mannose type and are th...

Project

New materials for EMR-dosimetry in high energy photon beams Recently ended

Vrije Universiteit Brussel

EMR is an acronym for Electron Magnetic Resonance, other common names are EPR (Electron Paramagnetic Resonance) and ESR (Electron Spin Resonance). When a material contains "unpaired" electrons and is exposed to an external magnetic field B0, the two energy levels of the two eigenstates "spin up" and "spin down" split as a result of the quantization of the angular momentum (Zeeman splitting). By adding a precise amount of polarized microwave energy, that meets the resonance condition: ?E = g ...

Project

New mechanisms of transcription regulation in prokaryotes

Vrije Universiteit Brussel

Regulation of gene expression is essential in every organism, as it allows cells to respond to environmental triggers. Intrinsically disordered proteins are frequently involved in this regulation in eukaryotes, but seem less ubiquitous in prokaryotes. In bacterial toxin-antitoxin (TA) systems, however, intrinsic disorder and structural flexibility play a key role in the transcriptional regulation. TA systems are genetic elements generally coding for two proteins: a toxin, which is able to kil...

Project

New noninvasive markers of ventricular function and ventriculo-arterial coupling: validation and evaluation of their prognostic value in elderly patients with heart failure due to coronary artery disease Historic

Ghent University

In this project we investigate new parameters for the evaluation of ventricular function by echocardiography and tonometry. The focus is on elderly patients with heart failure and coronary artery disease. After evaluation of the reproducibility, we will investigate the relationship with conventional markers of heart failure and markers of inflammation. Also the prognostic value of these parameters will be assessed.

Project

New options to control necrotic enteritis and bacterial enteritis in poultry Recently ended

Ghent University

The efficacy of the narrow spectrum antibiotic, either or not in combination with a feed enzyme, will be determined in the in vivo model for subclinical necrotic enteritis in broilers developed at the Department of Pathology

Project

New paradigms for the Visualization of Urban Data.

KU Leuven

While the awareness of the environmental, societal and economic challenges surrounding modern cities is growing, few inhabitants understand theprinciples and structures behind these problems. Engaging stakeholders in acting towards more qualitative and sustainable cities presupposes a complex way of communication, involving both discursive and pictorial information. The aim of this research is to investigate new visualization and interface paradigms that augment the civic literacy of everyday...

Project

New Paradigms in Urban Data Visualisation

KU Leuven

The goal of this research is to formulate a guiding framework for the design and use of urban data visualization andcomputation tools to support urbanstudies.

Project

New perspectives in the treatment of hyperthyroid cats with radioactive iodine (131I) and in the early detection of kidney failure, a major complication of treatment of hyperthyroidism Historic

Ghent University

REcombinant human TSH is used in the treatment of hyperthyroid cats to stimulate thyroid uptake of 131I in order to potentialize treatment and allow a lower dosage of 131I to be used. Kideny function is evaluated through measurements of glomerular filtration ratio after treatment with 131I. Finally urinary markers are assessed as early predictors of renal damage.

Project

New perspectives in the treatment of hyperthyroid cats with radioactive iodine (I131) and in the early detection of kidney failure, a major complication of treatment of hyperthyroidism. Historic

Ghent University

Recombinant human TSH is used in the treatment of hyperthyroid cats to stimulate thyroid uptake of I131 in order to potentialize treatment and allow a lower dosage of I131 to be used. Kideny function is evaluated through measurement of glomerular filtration ratio after treatment with I131. Finally urinary markers are assessed as early predictors of renal damage.

Project

NEWRAPTOR - Exposure and effects of emerging contaminants in marine and terrestrial birds of prey.

University of Antwerp

The proposed research will be divided in two main themes: 1) studying the exposure to emerging contaminants in Norwegian birds of prey and 2) assessing the potential effects of emerging contaminants, either alone via exposure experiments using a model bird species, a well as in combination with other pollutants occurring in free-living birds of prey.

Project

New reconstruction methods for ROI micro-CT. Historic

University of Antwerp

Region of interest (ROI) cone-beam tomography has become a hot topic in the continuous quest for reducing the amount of radiation and achieving a higher resolution of the object through geometric magnification. This magnification is achieved by moving the object closer towards the object so that the ROI fully covers the field of view. A disadvantage of this method is truncation of other parts of the object, while in theory all information about the object is needed for ideal reconstruction...

Project

New reconstruction methods for ROI micro-CT. Historic

University of Antwerp

Region of interest (ROI) cone-beam tomography has become a hot topic in the continuous quest for reducing the amount of radiation and achieving a higher resolution of the object through geometric magnification. This magnification is achieved by moving the object closer towards the object so that the ROI fully covers the field of view. A disadvantage of this method is truncation of other parts of the object, while in theory all information about the object is needed for ideal reconstruction...

Project

New strategies of soluble guanylyl cyclase (sGC) activation and their potential role in the treatment of cardiovascular diseases and erectile dysfunction Recently ended

Ghent University

sGC is a cardinal enzyme in the maintenance of blood pressure and for eliciting erection. NO released from endothelial cells and NANC neurons is the main activator. Recently designed drugs that directly stimulate sGC independent of NO or that stimulate sGC through generation of CO are of potential clinical interest. The project aims ro discover the basic mechanism of action of these drugs.

Project

New tools and approaches to control Porcine Reproductive and Respiratory Syndrome (PRRS) in the EU and Asia Recently ended

Ghent University

PoRRSCon is an initiative of 14 partners originating from Europe and Asia with strong expertises in virology and immunology. They are doing frontline research on PRRSV and/or vaccine development. Two of these partners are leading European pharmaceutical companies that will guide the consortium in the direction of exploitable results. By joining their strengths they have an ideal position to be successful in one of the most difficult challenges in pig health, controlling PRRS. To reach this fi...

Project

New tools for monitoring drug resistance and treatment response in visceral leishmaniasis in the Indian subcontinent. (KALADRUG-R) Historic

University of Antwerp

This EU-FP7 multi-disciplinary project, named KALADRUG-R, aims to develop, evaluate and disseminate new tools for evaluation of drug resistance in L. donovani as well as innovative methodologies for monitoring Kala-Azar treatment effectiveness under field conditions. The UA is specifically involved in basic research related to oxidative stress sensitivity to antimony-resistant strains and in applied research related to phenotypic evaluation of drug resistance in laboratory models. This invol...

Project

New words, new questions. Construction of a conceptual model to broaden the philosophical discussion of the psychology of moral behavior Historic

Ghent University

Since the end of the twentieth century, moral psychology and moral philosophy have taken a sentimental turn: the emphasis lies on emotions as motivating factors for moral behavior. However, what role do ?rational? cognitive factors play in the production of moral behavior? This research approaches this question by using insights from evolutionary sciences and neurosciences.

Project

Next-generation biodiversity assessment and environmental monitoring of benthic communities using high-throughput DNA metabarcoding

Ghent University

Primary objective To effectively and comprehensively characterise marine benthic communities in north Norwegian waters using high-throughput DNA metabarcoding Secondary objectives 1. To develop holistic and effective methods for DNA metabarcoding of benthic communities based on PCR-free high-throughput sequencing 2. To analyse benthic diversity in unprecedented detail along a natural diversity gradient in a north Norwegian fjord 3. To analyse benthic diversity in environments influenced by tw...

Project

Next generation sequencing technology opening new frontiers in biological and medical research.

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Next generation sleep monitoring platform (NXT_SLEEP). Recently ended

University of Antwerp

Currently, these sleeping disorders are diagnosed using polysomnography (PSG), which is a sleep test that monitors different physiological signals such as heart rate, respiration, EEG, muscle tone and eye movement. This type of test needs to be performed in a sleep laboratory, under the supervision of an expert who attaches several electrodes to the patient. Although PSG is an important diagnostic tool for sleep medicine, it is an uncomfortable and costly procedure, especially when multiple n...

Project

NF1-like syndromes: identification of new genes and further characterization of Legius syndrome using the mouse model.

KU Leuven

The project is directed towards further characterization of a disorder we recently described, Legius syndrome (LS). It is a milder variant of abetter known disease neurofibromatosis type 1 (NF1). LS is caused by SPRED1 inactivation and belongs to a larger group of similar diseases (neuro#8208;facial&#8208;facial&#8208;cutaneous syndromes) connected to the same pathway.We will collect more individuals with LS to better delineate clinical characteristics, identify rare complications and studynb...

Project

NICE - Network for ice sheet and climate evolution. Historic

Vrije Universiteit Brussel

Geographics - The RTN is necessarily restricted to a few number to European Institutes. Its form is very different from an Integrated Projects (IP) in which it is possible to involve a large number of Institutes. We have focussed the NICE network on Climate - Ice sheet interactions and tried to optimise the training and synergy in our network. We are perfectly aware that they are many important laboratories not included in NICE that would be interesting partners. NICE will remain open to coll...

Project

NICHE-ETH-023 ?Capacity Building for the HEIs in Natural Resource Management, Tourism and Eco-tourism (CD-NRM-Tourism)? Recently ended

Ghent University

?Strongbow?? a project specifically designed for capacity building within HEIs in the fields of natural resource management, tourism and (eco) tourism ? constitutes a powerful programme to address an important set of interwoven, problematic issues. The project has been constructed around the principle of sustainability: staff training (including 10 PhDs); gender balancing; continuous professional development; ownership in terms of management and organisation; establishing demand?driven resear...

Project

Nieuwe functies voor het BH4 domein van Bcl-2: een kritische regulator van Ca2+-permeable kanalen.

KU Leuven

Recently, we showed a novel function for the BH4 domain of Bcl-2 as an essential and critical regulator of the IP3-dependent intracellular Ca2+-release channels by anti-apoptotic Bcl-2-family members. Binding of Bcl-2 to the IP3R suppresses intracellular Ca2+ signals and protects against Ca2+-dependent cell death (apoptosis). In this project, we will explore whether other types of intracellular Ca2+-permeable channels are regulated and controlled by anti-apoptotic Bcl-2 proteins and in partic...

Project

Nieuwe systemen voor de in vitro regeneratie van somatische stamcellen en adventiefscheuten bij planten Historic

University College Ghent

De laatste jaren kwamen een aantal veelbelovende nieuwe middelen beschikbaar om somatische stamcellen te induceren: nieuwe cytokininen, cytokinine 'enhancers', van Rhodococcus fascians afgeleide signaalmoleculen enz. Somatische stamcellen vinden niet hun oorsprong in het jonge embryo, maar ontstaan uit gedifferentieerde cellen. Ze geven aanleiding tot scheutmeristemen die uitgroeien tot adventiefscheuten. Voor elke plantensoort moeten echter de optimale combinaties en concentraties experiment...

Project

Nieuw financieringsmodel onderzoek: ZAP-startkrediet 2012

Vrije Universiteit Brussel

Function and Role of the APC/C in neural stem cells differentiation Stem cells are capable of faithfully proliferate in saecula saeculorum while preserving their infinite potential to become (differentiate into) any particular cell type of our body. For this reason, stem cells represent a virtually unlimited source of functional human cells for basic research and regenerative medicine technologies. Understanding the factors responsible of their differentiation into neurons will for example b...

Project

NIMI Non-invasive quantitative molecular imaging with applications for studying cellular process Historic

Vrije Universiteit Brussel

NIMI Non-invasive quantitative molecular imaging with applications for studying cellular process

Project

Nitrogen cycling and nitrogen sequestration in temperate forest edges

Ghent University

The overall aim of this project is to scrutinize the effect of edge proximity on N cycling and N sequestration in temperate forest ecosystems. The specific aims are to investigate (i) whether and to what extent gaseous N emissions and the N pools and sequestration in the forest floor and mineral soil are affected by edge proximity, (ii) which forest floor and soil processes and factors are principally involved in the probably altered N cycling in the forest floor and the mineral soil, and (ii...

Project

Nitrogen mineralization from (soil) organic matter: quantification of the contribution of free living nematodes and the interactions with the microbial community and the soil structure Recently ended

Ghent University

In this project we will quantify the contribution of free living nematodes to N mineralization from soil organic matter, by carrying out selective sterilization and reinoculation of soil with nematodes, and by relating this to the interaction with the soil microbial communities and the soil structure.

Project

Nitrogen processing and retention in tidal freshwater marshes: a whole ecosystem 15N labeling study. Historic

University of Antwerp

Fringing marshes are generally believed to act as a filter for the estuarine and riverine water because they can trap nutrients both in inorganic and organic form from the floodwater. This perception is based on classical exchange studies, where budgets for the flood and ebb water are compared. However, these studies are rather inaccurate and reveal only the overall changes. In a Flemish-Dutch co-operation project, we used the stable isotope 15N as a tracer in a large-scale experiment to stu...

Project

NKT cells as a target for treatment in Multiple Myeloma Recently ended

Vrije Universiteit Brussel

Multiple myeloma (MM) is an incurable blood cancer with cancer cells developing a tumor in the bone marrow (BM). The BM is a site where the MM cells can thrive as all the necessary nutrients for their exponential growth are present. MM is still fatal as patients relapse due to the cancer cells developing resistance against all the currently known therapy. A relatively new field in cancer therapy is immune therapy, where the immune cells of the patient itself are used to target the tumor. Ther...

Project

Nl Latemse Meersen - Monitoring Keuzemeersen (T=2) and Meersbeek (T=-1). Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

NMR spectroscopy for screening and diagnosis of diseases. Historic

Universiteit Hasselt

In the past decades many new drugs were developed that allow a successful treatment of different types of cancer. However, the ability to detect the presence of a tumour at an early stage is most of the time an important prerequisite but currently very difficult. Besides the mammography screenings for breast cancer, no tools are available that allow routine screening of large populations at risk for the development of a certain cancer type. This projects aims to develop a high throughput a...

Project

NMR study of the interplay between structure and dynamics in actin binding Headpiece domains and Profilin isoforms Historic

Ghent University

This research project aims at providing insight in the structural and dynamic determinants that are involved in two different classes of actin binding proteins: Headpiece domains from the C-terminal part of otherwise unrelated multidomain proteins, and the Profilin isoforms I, Iia and Iib. This is achieved b combining multidimensional and multinuclear NMR spectroscopic techniques with molecular biology and biophysical methods.

Project

Noden van alleenstaanden in de thuiszorg : de visie van alleenstaande kankerpatiënten en hun zorgverleners. VERVOLG: De psychosociale noden van alleenwonende uitbehandelde patiënten met kanker: de visie van patiënten en hun zorgverleners. Recently ended

Vrije Universiteit Brussel

Single or socially isolated patients with cancer have specific psycho-social needs. However, until now, little is known about the specific needs of these patients. Neither do we know which subgroups are especially vulnerable and therefore need extra support. The aim of this study is to 1) get a good insight in the needs of socially isolated persons with cancer and which needs they perceive as the most threatening, 2) the identification of the extra vulnerable subgroups within this populatio...

Project

No English Title

KU Leuven

During this PhD, the fish diversity of the northeastern tributaries of the Congo basin will be examined. Although the Congo basin is the secondlargest river basin of the world, the knowledge of its fish fauna is very limited. First, an inventory will be made based on the existing collections of the Royal Museum of Central Africa (Tervuren) and some smallercollections from other museums. Not yet registered collections from recent expeditions [De Vos (’90), Vreven (2009 & 2011, Ituri) andthe Co...

Project

No English Title

KU Leuven

Effect van gastransport op het centraal metabolisme van peer (Pyrus communisL.): een computational biology benadering.nbsp;

Project

No English Title

KU Leuven

Fundamenteel klinisch mandaat: Experimentele radiotherapie

Project

No information available at the moment Historic

University of Antwerp

No information available at the moment

Project

No information available at the moment Historic

University of Antwerp

No information available at the moment

Project

No information available at the moment Historic

University of Antwerp

No information available at the moment

Project

No information available at the moment Historic

University of Antwerp

No information available at the moment

Project

No information available at the moment Historic

University of Antwerp

The development of strategies for selective depletion of macrophages in atherosclerotic plaques via drug-induced cell death represents a new concept in cardiovascular research that may contribute to plaque stabilization and the prevention of coronary syndromes or sudden death

Project

No information available at the moment

University of Antwerp

This project represents a formal research agreement between UA and on the other hand UZA. UA provides UZA research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment

University of Antwerp

This project represents a formal research agreement between UA and on the other hand UZA. UA provides UZA research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand IFEB. UA provides IFEB research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the client. UA provides the client research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand Deltares. UA provides Deltares research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment

University of Antwerp

This project represents a formal research agreement between UA and on the other hand Emmaus. UA provides Emmaus research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment

University of Antwerp

This project represents a formal research agreement between UA and on the other hand VLK. UA provides VLK research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the client. UA provides the client research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment

University of Antwerp

This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the client. UA provides the client research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment

University of Antwerp

This project represents a research contract awarded by the University of Antwerp. The supervisor provides the Antwerp University research mentioned in the title of the project under the conditions stipulated by the university.

Project

No information available at the moment

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the client. UA provides the client research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

No information available at the moment Historic

University of Antwerp

No information available at the moment

Project

No information available at the moment Historic

University of Antwerp

No information available at the moment

Project

No information available at the moment Historic

University of Antwerp

No information available at the moment

Project

No information available at the moment Historic

University of Antwerp

No information available at the moment

Project

No information available at the moment Historic

University of Antwerp

No information available at the moment

Project

No information available at the moment Historic

University of Antwerp

No information available at the moment

Project

No information available at the moment Historic

University of Antwerp

Gobal change-induced losses of soil C could significantly enhance atmospheric CO2 concentrations and, thus exacerbate global warming. We propose to experimentally test the individual and interactive effects of increased temperature, altered precipitation pattern, and altered ground water level on C inputs and C losses in a wetland soil. Parameterisation of the Century model will allow predictions of C cycling in wetland soils in future climate.

previous 6501 - 7000 of 11514 next Page: 1...10 11 12 13 14 15 16 17 ...24 Size: 10 20 50 500