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Project

Phylogeny of symbiotic taxa within the Neodalyellida (Platyhelminthes, Rhabditophora, Rhabdocoela), including aspects of co-evolution and cryptic biodiversity. Historic

Universiteit Hasselt

Within the species-rich taxon Platyhelminthes, diversity is also reflected in the many different types of life histories that are found within the taxon. Apart from the obligatory parasitic Neodermata, several taxa (Temnocephalida, Umagillidae, Graffillidae, Pterastericolidae) are symbiotic. The latter three will form the subject of my postdoc-project. Since little is known about the phylogentic position of the Rhabdocoela, to which the above mentioned symbionts belong, and their internal rel...

Project

Phylogeny of the rhabdocoel turbellaria and the origin of the freshwater representatives Historic

Universiteit Hasselt

The Rhabdocoela form a monophyletic taxon of freeliving platworms with more than 1000 species that live all over the world and in all moist habitats: in the marine context, litoral as well as deep see, in brackish water, in stillstanding and streaming freshwater habitats and even in moist terrestric contexts. A number of species have a cosmopolitic diffusion, with as most striking example gyratrix hermaphroditus, a species with of a quasi worldwide diffusion and occurring in fresh and brackis...

Project

Phylogeography of submersed waterplants : Najas , Ruppia and Zannichellia in Europe. Historic

Vrije Universiteit Brussel

Phylogeography of submersed waterplants : Najas , Ruppia and Zannichellia in Europe.

Project

Physical activity in COPD; using the patient experience to assess outcomes of interventions

KU Leuven

Today physical inactivity, consequence of Chronic Obstructive PulmonaryDisease (COPD), is judged to be a significant contributor to the non respiratory consequences and comorbidities of COPD. Recently, the interestto use physical activity (PA) as a predictor of poor outcome, or as a treatment goal for interventions has become a focus of research. The proposed research project has 3 general aims.(1) Determine optimal strategies for analysis of PA monitor data allowing efficient handling of the...

Project

Physical disturbance of intertidal areas by wave action of shipping. Historic

University of Antwerp

The Scheldt estuary is both economically and ecologically of high importance. The ecological functioning suffers from excessive hydrological dynamics. In this project one aspect of dynamics is focused upon: wave action by shipping. Factors influencing wave generation are evaluated. The effect of waves from shipping activity on the physical disturbance of intertidal mudflats is assessed.

Project

Physical education, physical activity and nutrition Recently ended

Ghent University

The research group will focus on measuring and analysing physical activity and nutrition behaviour, define the determinants of physial activity and nutrition behaviour, the promotion of physical activity and healthy nurtiotion behaviour and the quality of physical education lessons.

Project

Physical exercise in primary and secundary prevention: Search , diagnose, treatment en prevention of Burn-out and profession-related depression by employees in the services-sector and a dditional study about oxidat. stress by efforts. Historic

Vrije Universiteit Brussel

The aims of this study are: to obtain information regarding the incidence of burn-out and career related depression, to make an inventory of the cause and to study the medical, social, professional and financial consequences of this problem in employees in teaching and nursing professions.During this cross-sectional research attemps will be made to identify the characteristics of the high risk-environments of burn-out.More specifically, research will be done concerning the related stress-indu...

Project

Physical (in-)activity, physical fitness and health of Flemish youth (6-18 years) Recently ended

KU Leuven

The benefits of regular physical activity in children are extensively documented. However, epidemiological studies have reported an age-relateddecrease of physical activity in early adolescence. Due to the transition from primary to secondary school, the change of school environment may play an important role in this process. In epidemiological research, the assessment of physical activity under free-living conditionshas suffered from numerous methodological difficulties. A majority of studie...

Project

Physical parameters of the middle ear. Historic

University of Antwerp

By making use of high resolution techniques, important physical parameters of the middle ear will be defined. With confocal laser scanning microscopy and interferometry the thickness distribution of a tympanic membrane will be measured. 3D- structure and position of the middle ear ossicles will be studied with X-ray-microtomography. Integration of these new and accurate values in a finite element model will lead to a better insight in the action of the middle ear.

Project

Physical serious gaming Considering the aesthetics of digital games for fine motor skill rehabilitation Recently ended

Universiteit Hasselt

Digital games are a powerful form of new media that can transform one's experiences and worldview. They are immersive, evoke a sense of wonder and invite to explore digital spaces. In real life, however, it is often harder to 'level-up' than in games - especially in situations where the improvement of one's condition is most needed. For instance, a vast number of people experience fine motor skill difficulties as a consequence of a wide range of disorders. Many of these people are unable to ...

Project

Physical therapy in critically ill patients

KU Leuven

Advances in intensive care medicine have dramatically improved survivalof critically ill (CI) patients. This improved survival is, however, often associated with general deconditioning and muscle weakness.Early mobilization (e.g. bedside cycle ergometer) has been proven valuable in the treatment of CI patients even after hospital discharge. But no strength measures were proven to be reliable in CI patients. In the first study we found that handheld dynamometry, which is often used in decondit...

Project

Physico-chemical determinants of toxicity : a rational approach towards safer nanostructured materials. Historic

Vrije Universiteit Brussel

Nanomaterials are engineered structures with dimensions of 100 nm or less, which achieve unique mechanical, optical, electrical and magnetic properties. Although these materials are already widely used in different applications, ranging from cosmetics and tires to medical applications, concerns about their effects on human health, in occupational settings and possibly for the consumer and the general population at large, are raised. A number of research reports have pointed towards their harm...

Project

Physicochemical properties of asbestos and carbon nanotubes associated to genetic and epigenetic effects. Preventing fibrous hazard by design. Recently ended

KU Leuven

Fortunately, the production, use and reuse of asbestos have been gradually forbidden and disappearing since the ‘90’s in many Western countries. However, the use of carbon nanotubes (CNTs) and carbon nanofibers (CNFs) has become widespread and is increasing rapidly. Scientific concern is growing about the carcinogenicity of CNTs and CNFs since the inductionof mesothelioma in sensitive rodents. Asbestos is known to induce directly and indirectly malignant mesothelioma. Besides genotoxic effect...

Project

physics based 3D finite-element model of the cochlea Recently ended

University of Antwerp

Sound vibrations are detected by thousands of hair cells located along the basilar membrane in the cochlea. Some of these hair cells work as microscopic motors, resulting in an exaggerated, complex basilar membrane motion. In this research we will introduce more detail about the hair cell cytoarchitecture in existing computer models to understand how thousands of them work together, resulting in the exquisite properties of mammalian ears.

Project

Physiological and genetic response of Arabidopsis thaliana to multiple stressors Recently ended

Universiteit Hasselt

Nuclear energy production encompasses a variety of industrial activities, from mining and milling through to power generation and waste management. These nuclear facilities release radioactive substances together with non-radioactive substances (e.g. heavy metals). Uranium and thorium and their decay chain daughter radionuclides are the radionuclides of primary interest released from uranium mines and mills and tailings management facilities. Although ecosystems are exposed to multiple stress...

Project

Physiological and neurodocrinological aspets of exercise, endurance, underperformance and burnout in athletes. Historic

Vrije Universiteit Brussel

To date, relatively little attention has been placed on the role of the central nervous system in overtraining and fatigue during exercise and training. This study will focus on the possible involvement of the central nervous system in the onset f fatigue during exercise and the role of neurotransmitters and neuromodulators in possible mechanisms that underly underperformance 'burnout' and overtraining. Since the HPA-axis in under control of several 'higher' centres through different transmi...

Project

Physiological and pathological protein interactions in the pathogenesisof Parkinson's disease.

KU Leuven

Parkin mutations are among the most common causes of Parkinson’s disease (PD). Parkin is a E3 ubiquitin ligase. However, the physiological function of parkin remains poorly understood. Recently, we have found that parkin is part of a stable, high-molecular-weight protein complex in brain. PD-linked parkin mutations significantly impair formation of this complex. The prominent presence of the parkin complex in vivo and the disruptive effect of PD-linked parkin mutations strongly suggest that f...

Project

Physiological and pharmacological properties of angiotensin II receptors in transfecteerde cells. Historic

Vrije Universiteit Brussel

AngiotensinII receptors of the AT1-class are of medical importance because of their hypertensive properties. They have been especially investigated by means of contraction experiments (aorta) and by binding experiments on eg. liver membranes. Human AT1 receptors were recently expressed in CHO cells. These CHO AT1 cells (provided to us by Prof. V. Chhajlani) allow us to perform radiogland binding and functional experiments under strictly identical conditions. They represent an ideal system for...

Project

Physiological characterization of tolerance of sunflower Clearfield hybrids to herbicide imazamox Recently ended

Universiteit Hasselt

The herbicide imazamox belongs to the group of imidazolines. The herbicides from this group inhibit activity of the enzyme acetolactat synthase (ALS, EC 4.1.3.18) and thus block the synthesis of branched chained amino acids valine, leucine and isoleucine. The deficit of these amino acids disturbs protein metabolism and causes various functional disorders in treated plants. The growth of sensitive weeds stops at 10-12 hours after treatment, while tolerant plants manage to break down or inactiv...

Project

Physiologically based pharmacokinetic models for the accumulation and effects of microcontaminants in harbour seals (Phoca vitulina) and harbour porpoises (Phocoena phocoena). Recently ended

University of Antwerp

Aims: Development of a physiologically based pharmacokinetic model for long-term uptake and accumulation of microcontaminants by seals. Model evaluation by comparison of predicted values with observed results of microcontaminants in blood and biopsy (living animals) and other tissues (dead animals). Determination of the condition of seals by use of general condition-indices and more specific indications for homeostasis and stress by analysis of bloodsamples with special attention for endocrin...

Project

Physiologically based pharmacokinetic models for the accumulation of microcontaminants and immunological effects in harbour seals (Phoca vitulina) and harbour porpoises (Phocoena phocoena). Historic

University of Antwerp

Aims: Development of a physiologically based pharmacokinetic model for long-term uptake and accumulation of microcontaminants by seals. Model evaluation by comparison of predicted values with observed results of microcontaminants in blood and biopsy (living animals) and other tissues (dead animals). Determination of the condition of seals by use of general condition-indices and more specific indications for homeostasis and stress by analysis of bloodsamples with special attention for endocrin...

Project

Physiological, morphological and biomechanical requirelents of the musculo-skeletal system of the lower leg for top sprinters and endurance runners Recently ended

Ghent University

Speed and stamina put competing demands on the design of our locomotor system and several traits of the lower leg are antaginistic pairs with respect to sprinting vs endurance running. This project aims to investigate the physiological and functional anatomical characteristics of the lower leg musculo-ckeletal system that promote excellence in either sprinting or endurance running.

Project

Physiological, morphological and biomechanical requirements of the musculo-skeletal system of the lower leg for top spinters and endurance runners. Recently ended

University of Antwerp

This project aims to investigate the physiological and functional anatomical characteristics of the lower leg musculo-skeletal system that promote excellence in either sprinting or endurance running. In a first study we aim to develop a non-invasive and innovative technique to measure muscle fiber type composition (percentage slow vs. fast fibers), a well known antagonistic pair of traits for performance.

Project

Physiological role of the ATP13A2 gene product. A putative Mn2+ transporter.

KU Leuven

The ATP13A2 gene product is a P-type transport ATPase belonging to the P5 subfamily that is only foundnbsp;in eukaryotes (1). Little is known regarding the properties and function of the ATPases of this P5 subfamily. This project focusses on ATP13A2 and where needed also on other members of the family ATP13 A1, ATP13A3-5. Recent but indirect evidencenbsp;suggests that ATP13A2 functions asa Mn2+ transporter with lysosomal targeting. Mutations in the gene cause a familial form of juvenile parki...

Project

Physiological signaling pathways for adaptive beta cell proliferation and maturation Historic

Vrije Universiteit Brussel

KEY QUESTIONS AND AIMS Principle objective of the current project is the comparison of the beta cell phenotypes in the various physiological conditions of adaptive beta cell proliferation, in comparison with the phenotype of adult, differentiated beta cells. Phenotype is considered here as integration of specialized function (insulin synthesis and secretion measured in vitro) and gene/protein expression pattern (measured in flow-sorted pure cell fractions). We will focus on the major differen...

Project

Physiological signaling pathways for adaptive beta cell proliferation and maturation. Historic

Vrije Universiteit Brussel

Principle objective of the current project is the comparison of the beta cell phenotypes in the various physiological conditions of adaptive beta cell proliferation, in comparison with the phenotype of adult, differentiated beta cells. Phenotype is considered here as integration of specialized function (insulin synthesis and secretion measured in vitro) and gene/protein expression pattern (measured in flow-sorted pure cell fractions). We will focus on the major differences of proliferating ce...

Project

Physiology and mechanisms of action of neuregulin-ErbB signalling in the cardiovascular system. Historic

University of Antwerp

Aims: 1. to mimic trastuzumab-induced cardiotoxicity in rat in order to clarify underlying mechanisms. 2. to explain underlying mechanisms of NRG-1 mediated cardioprotection and "reverse remodelling", focusing on the role of NO en PDE5. 3. to investigate interaction between the NRG-ErbB system and the renin-angiotensin-aldosteron system.

Project

Physiology and regulation of the lysine/arginine biosynthesis of the hyperthermoacidophilic crenarchaeon Sulfolobus solfataricus. Historic

Vrije Universiteit Brussel

Lysine is synthesized via two well characterized pathways: (i) the diaminopimelate pathwy that is used by most bacteria and plants, (ii) the alpha-aminoadipate pathway (AAA) that is found in yeast and fungi. The thermophilic bacterium Thermus thermophilus synthesizes lysine through a modified AAA pathway in which the conversion of AAA to lysine proceeds in five steps that are equivalent to the conversion of glutamate to ornithine in the arginine pathway. Such a modified pathway might on basis...

Project

Physiology and regulation of the lysine/arginine biosynthesis of the hyperthermoacidophilic crenarchaeon Sulfolobus solfataricus. Historic

Vrije Universiteit Brussel

Lysine is synthesized via two well characterized pathways: (i) the diaminopimelate pathwy that is used by most bacteria and plants, (ii) the alpha-aminoadipate pathway (AAA) that is found in yeast and fungi. The thermophilic bacterium Thermus thermophilus synthesizes lysine through a modified AAA pathway in which the conversion of AAA to lysine proceeds in five steps that are equivalent to the conversion of glutamate to ornithine in the arginine pathway. Such a modified pathway might on basis...

Project

Physiology of endocrine cell differentiation in the pancreas Historic

Vrije Universiteit Brussel

There are strong indications that the pancreas, even in adults, contains epithelial stem cells which have the capacity to generate endocrine islet cells. The goals of this project are to identify these stem cells, to isolate and culture them, and to identify factors or conditions that regu1ate their differentiation. A possible application of this study is the expansion of the endogeneous isnulin-producing islet cells, or the islet cells intended for transplantation, in insulin-dependent diabe...

Project

Physiology of endocrine cell differentiation in the pancreas. Historic

Vrije Universiteit Brussel

There are strong indications that the pancreas, even in adults, contains epithelial stem cells which have the capacity to generate endocrine islet cells. The goals of this project are to identify these stem cells, to isolate and culture them, and to identify factors or conditions that regulate their differentiation. A possible application of this study is the expansion of the endogeneous insulin-producing islet cells, or the islet cells intended for transplantation, in insulin-dependent diabe...

Project

Physiopathological and genetic study of the intersection of two frequent monogenic disorders: the Marfan syndrome and autosomal dominant polycystic kidney disease. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand KAGB. UA provides KAGB research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Physiopathology of the lens capsule after implantation of an IOL. Historic

University of Antwerp

The aim of the project is to investigate the role of growth factors secreted by lens fiber cells (LFCs) in the proliferation and differentiation of lens epithelial cells (LECs) left in the capsular bag after extra-capsular cataract extraction (ECCE) and intra-ocular lens (IOL) implantation and the pathophysiology of posterior capsule opacification (PCO) or after cataract. Capsular bags obtained after ECCE on post mortem donor eyes will be cultured according to Wormstone et al. (1997).

Project

Phytochemical, analytical and preclinical research of plant extracts as potential antitumor therapy. Recently ended

University of Antwerp

This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Phytochemical and pharmacological investigations on medicinal plants from Pakistan. Recently ended

University of Antwerp

The aim of this project is the isolation, structure elucidation and phytochemical analysis of biologically active constituents in some selected medicinal plants from Pakistan. Focus of the research project will be on plants used for antimicrobial purposes (against infectious diseases), and on plants used by diabetic patients to relieve diabetic complications or to ameliorate the disease. This work may result in the characterisation of lead compounds for new therapeutic agents, and may provide...

Project

Phytochemical studies of two plants used in traditional medicine in Pakistan: Ziziyphus oxyphylla and Cedrela serrata. Historic

University of Antwerp

In this project the biologically active constituents from two medicinal plants from Pakistan, more in particular Ziziyphus oxyphylla (Rhamnaceae) and Cedrela serrata (Meliaceae) will be investigated. Their constituents will be chromatographically isolated, identified by spectroscopic means, and pharmacolligically evaluted in various models.

Project

Phytogenic mounds (nebkhas) in Mediterranean-arid landscapes: ecological function, and potential for combating desertification and biodiversity loss. Historic

University of Antwerp

Several native plant species of Mediterranean-arid ecosystems naturally fix winblown materials in small, stable, phytogenic mounds or `nebkhas', but none of them are currently used to combat desertification. In this project we screen a variety of such species, not only for sand stabilisation, but also to promote biodiversity by creating habitats for other species, since nebkhas locally improve soil fertility and water status. The project explores the potential of a new, natural rehabilitation...

Project

Phytoremediation of heavy metal contaminated surfaces in Cyprus. Historic

Universiteit Hasselt

The research group CMK of Hasselt University advises Ecorem in developing phytoremediating strategies for mine terrains originating from previous Cu ore-mining in Cyprus. They are terrains of which the soils are heavily contaminated by coctails of heavy metals. The advice is based (among on other things) on data supplied by third parties. If additional soil analyses are necessary, than they can be executed by Hasselt University. The possible additional analyses fall outside the terms of the a...

Project

Phytoremediation of polluted sites in combination with bio-energy production : possibilities of fast growing coppice culture in the Rupel region. Historic

University of Antwerp

The revegetation of polluted sites can be used for the renovation and restoration of contaminated soils through bioremediation. In this project we will investigate whether an intensive coppice culture of willow and poplar can be used for phytoremediation and phytoextraction of an old waste disposal in Boom (Rupel region) that is contaminated with serveral heavy metals. The following aspects will be studied: ditterences among genotypes, interactions between genotypes and soil type, production ...

Project

Phytotechnical use of bamboo for biomass production and soil sanitation. Historic

University of Antwerp

The aim of this project is to evaluate the use of bamboo plants in biomass production and soil sanitation. Plants will be grown on three different fields and will thus exposed to different levels of pollution. Assessment of biomass production and tolerance towards the pollutant includes growth analysis, carbon assimilation and chlorophyll fluorescence. Based upon these data, an existing growth model (FORUG) will be parametrised for bamboo.

Project

Pigs can become infected with Chlamydia psittaci, Chlamydia pecorum, Chlamydia abortus and Chlamydia suis Recently ended

Ghent University

Pigs can become infected with Chlamydia psittaci, Chlamydia pecorum, Chlamydia abortus and Chlamydia suis. These bacteria cause a variety of clinical diseases in pigs. For instance reproductive failure. Chlamydia infections cause important economical loss in the pig industry. The project is on the development of new diagnostics and innovative preventive measures against Chlamydia suis infection in pigs.

Project

Pigs can become infected with Chlamydia psittaci, Chlamydia pecorum, Chlamydia abortus and Chlamydia suis Recently ended

Ghent University

Pigs can become infected with Chlamydia psittaci, Chlamydia pecorum, Chlamydia abortus and Chlamydia suis. These bacteria cause a variety of clinical diseases in pigs. For instance reproductive failure. Chlamydia infections cause important economical loss in the pig industry. The project is on the development of new diagnostics and innovative preventive measures against Chlamydia suis infection in pigs.

Project

Pilot project "population-based study into colorectal cancer". Historic

University of Antwerp

The European code for Cancer Control recommands a population-based approach for colorectal cancer screening. In February 2009 a pilot study for colorectal cancer screening will start in Flanders. The pilot study can be split up into two parts. The first part of the pilot study focusses on people with an average risk for colorectal cancer. All inhabitants from Schilde, Vosselaar and Borgerhout aged 50 to 74 will receive an invitation to participate in the screening study. For the second part o...

Project

Pilot Study for the best method to determine the phosphate content in the upper soil layers in the water planning Eelder and Peizermaden. Historic

University of Antwerp

Pilot Study for the best method to determine the phosphate content in the upper soil layers in the water planning Eelder and Peizermaden.

Project

Pilot study recovery peat formation. Historic

University of Antwerp

Pilot study recovery peat formation.

Project

Pituitary deficency and regeneration: in search of underlying mechanisms and therapeutic targets with focus on Wnt/Lgr5.

KU Leuven

The pituitary is the ‘master gland’ producing hormones that control vital physiological processes like growth, metabolism, stress, sexual maturation and reproduction. Obviously, defects in pituitary function (hypopituitarism) cause severe and life-threatening health problems. Hypopituitarism is treated with lifelong hormone replacement. However, the administered hormones cause serious side effects and cannot mimic the gland’s dynamic secretion pattern. Therefore, it would be superior to resto...

Project

Placental uptake and transfer of environmental chemicals relating to allergy in childhood years (PLUTOCRACY). Historic

University of Antwerp

Placental uptake and transfer of environmental chemicals relating to allergy in childhood years (PLUTOCRACY).

Project

Plant- and bacteria stimulated remediation of contaminated soils and (ground)water Historic

Universiteit Hasselt

The IOF supports projects that aim at the valorisation of research. The projects must meet the specific requirements related to the aspiration to bring a scientific advancement / breakthrough closer to the market environment. The resources should be used to close the gap between the results of already conducted research and valorisation in the form of acquired contract research, patents, licenses or spin-off companies. IOF projects of the short type have a project duration of maximum one yea...

Project

Plant and Vegetation Ecology and Global Changes.

University of Antwerp

The overarching theme of the Centre of Excellence is the study of the effects of global changes, in the broadest meaning of the term, on plants and vegetations. This long-term goal is being realized a.o. by studying the responses of plants and vegetations to the, sometimes manipulated, abiotic environment over a continuum of hierarchical scales, ranging from the individual leaf to the continent. Original experimental research and long-term observations are strengthened by coupling: (i) to exi...

Project

Plant growing, DNA-extraction, Testing of IAA production, siderophores, organic acids ... Historic

Universiteit Hasselt

This offer represents a formal service agreement between the parties CMKMB (research institute at Hasselt University), and on the other hand, Productos Quimicos de Chihuahua. The research institute CMKMB provides Productor Quimicos de Chihuahua research results on 'Plant growing, DNA-extraction, Testing of IAA production, siderophores, organic acids ...' under the conditions as stipulated in the present contract.

Project

Plant growth and development

Ghent University

The project MARS IAP P7/29 (Study of Maize-Arabidopsis-Root-Shoot growth) aims to exploit the multidisciplinarity of the IAP network to investigate a complex but poorly studied area in plant biology, namely the interactions between the above-ground and below-ground parts of the plant. Such interactions are known to be essential for normal growth and for adequate response to changing conditions in the environment.

Project

Plant growth regulators and photomorphogenesis. Historic

University of Antwerp

The aim of this project is the analysis of primary action of light during photomorfogenesis and kinetic study of the endogenous content and metabolism of cAMP and phytohormones in higher plants (Phaseolus vulgaris) and Crown gall tissue (tobacco and Helianthus).

Project

Plant growth regulators: metabolism, function and mode of action. Historic

University of Antwerp

Plant growth regulators play a crucial role in controlling growth and development of higher plants. It is the aim of this research community to study the specific function and interactions of these hormones. In order to approach this subject from several angles a broad scoop of expertise was brought together in this research community.

Project

Plants as flexible biomonitors of pollution using a genotoxic effect-analysis. Historic

Vrije Universiteit Brussel

The comet-assay is a fast and sensible technique for analysing the DNA-damage in eucaryotic cells. Plants are site-bounded and may serve as polyvalent bio-indicators. The "Single Cell Gel Electrophoresis Assay" is being evaluated on plants by comparing the usual cytotoxicological tests. The application in agriculture, contaminated sites and indoor environment is checked with case-studies.

Project

Plant sterols: potent inducers of remyelination in Multiple Sclerosis? Recently ended

Universiteit Hasselt

The aim of my study is to elucidate how dietary intake of plant sterols modulates repair of damaged central nervous systems (CNS) and thereby the progression of multiple sclerosis (MS). MS is a chronic autoimmune disease of the CNS that affects 1 in 1000 young adults in the prime of their life. MS is featured by immune cell mediated destruction of the insulating myelin sheath around neuronal processes (demyelination). To date, no effective cure is available and current treatments only target ...

Project

Plasma Abeta as endophenotype for genetic studies of Alzheimer dementia. Historic

University of Antwerp

The aim of this project is to identify risk factors for Alzheimer dementia (AD), through studying the endophenotype Aß1-42 (in plasma). The use of Aß1-42 as outcome variable allows direct evaluation of the role of associated candidate genes in the amyloid cascade. Insight in the genetic variation of plasma Aß1-42 levels will in the long run contribute to targeted development of therapeutic and preventative strategies.

Project

Plasma membrane localised transportmechanisms for ascorbate and dehydroascorbate in Arabidopsis thaliana. Historic

University of Antwerp

Plasma membrane localised transportmechanisms for ascorbate and dehydroascorbate in Arabidopsis thaliana.

Project

Plasma procarboxypeptidase U: a novel regulator of fibrinolysis and potential risk factor for cardiovascular disease. Historic

University of Antwerp

Carboxypeptidase U (CPU, EC 3.4.17.20) belongs to the group of the basic carboxypeptidases. These enzymes cleave basic amino acid (lysine or arginine) from the C-terminus of the peptide chain. Carboxypeptidase U circulates in blood as an inactive zymogen,procarboxyppetidase U. During the process of coagulation and fibrinolysis it is converted to its active form, carboxypeptidase U. The physiological function of CPU is probably restricted to the coagulation-fibrinolysis system where it is inv...

Project

Plastic circuits: in vivo imaging of astrocyte-neuroninteractions in the mouse brain Recently ended

KU Leuven

The aims of this project are a perfect fit to Bio2, with itsemphasis on understanding cell-cell interactions. We aimto understand the role of astrocyte-neurons interactions inthe nervous system and how these interactions underlieexperience dependent plasticity in the living brain.

Project

Plasticity of the human exocrine pancreas Historic

Vrije Universiteit Brussel

1. Aim Insulin-dependent diabetes is an interesting target for regenerative medicine and cell replacement therapy since this disease is characterized by a deficiency of insulin-producing beta-cells and can be treated by beta-cell transplantation (1).

Project

Platform for European Preparedness Against (Re-)emerging Epidemics (PREPARE).

University of Antwerp

The PREPARE project will transform Europe's response to future severe epidemics or pandemics by providing infrastructure, co-ordination and integration of existing clinical research networks, both in community and hospital settings. It represents a new model of collaboration and will provide a one-stop shop for policy makers, public health agencies, regulators and funders of research into pathogens with epidemic potential.

Project

PM²TEN Historic

Universiteit Hasselt

This offer represents a formal service agreement between the parties CMBK milieubiologie (research institute at Hasselt University), and on the other hand, Vito. The research institute CMBK milieu biologie provides Vito research results on 'PM² TEN' under the conditions as stipulated in the present contract.

Project

Policy Information on psychiatric services and settings: continuous recording of clinical and social variables. Agreement on the support of registration system: "Minimum Psychiatric Data" Historic

Universiteit Hasselt

On the initiative of the Belgian federal government, every residential psychiatric institution registers a uniform set of patient data. This national database allows research to help policy making. Censtat is responsible for the support of the institutions in the collection of their data.

Project

Policy Information on psychiatric services and settings: continuous recording of clinical and social variables. Agreement on the support of registration system: "Minimum Psychiatric Data" Historic

Universiteit Hasselt

On the initiative of the Belgian federal government, every residential psychiatric institution registers a uniform set of patient data. This national database allows research to help policy making. Censtat is responsible for the support of the institutions in the collection of their data.

Project

Policy relevant research. Historic

Universiteit Hasselt

The mission of the "Steunpunt O&O- and innovation indicators" exists of developing and maintaining a performant system of O&O- and innovation indicators that needs to supply the Flemish Government with actualised and relevant statistical data concerning O&O- and innovation-performance of the Flemish region. The Steunpunt also develops a portfolio of relevant scientific research activities in support of this mission.

Project

Policy research center for Welfare, public health and family -UGent

Ghent University

the policy research center conducts research clustered in 3 research lines: monitoring of care use and care needs; evaluation of preventive and care interventions and organization of care and policy.

Project

Policy Research Centre on Sports 2012: sport and health among senior citizens in Flanders.

KU Leuven

The study focusses on three objectives regarding sport, exercise and physical activity in older adults in Flanders:a.) to determine the long term impact of different exercise interventions b)nbsp; to assess the degree of physical activity in elderly (70+) with special attention to the institutionalized elderly c)nbsp; to design new exercise interventionsnbsp;for specific target group.Specific questions:nbsp;nbsp;nbsp; The effect of two exercise interventions on older adults was determined in ...

Project

Policy Research Centre (PRC) Environment and Health (3rd Generation 2012-2015)

Vrije Universiteit Brussel

The 2012-2015 program builds further on the strengths and knowledge gained in the 2001-2006 and 2007-2011 programs. A healthy environment and life style are acting levels to achieve more healthy life years. Flanders aims towards a sustainable society which is particularly challenging since the region is characterized by an intensive traffic network, high population density, urbanization, important industries and intensive agriculture. A scientific understanding of the importance of environmen...

Project

Policy Research Centre Sport: Critical factors to prevent drop-out in sports and physical activity in Flemish youth.

KU Leuven

This research project contributes to the Policy Research Centre Sport (2012-2015).nbsp;The main purpose of this project is:1. To analyze the physical activity patterns (duration, intensity, time and context) in children and adolescents by means of an objective monitoring of their physical activity behaviour.2. To study the correlates and determinants of change (drop-out) in sports participation and physical activity by means of prospective and retrospective survey research.

Project

Pollution in early life, mitochondrial and epigenetic effects at birth

Universiteit Hasselt

Epigenetic effects of particulate air pollution and toxic metals have been studied in an experimental context but so far studies on populations are lacking or in case of early life exposures even not existing. The placenta plays a crucial role in fetal development. In this context we investigate the utility of placental gene expression, DNA methylation and mitochondrial DNA content in association with cord blood toxic metals and exposure to particulate air pollution. With the current approach...

Project

Pollution tolerance of Daphnia magna populations: evolutionary potential and interaction with natural stressors from an ecotoxicological, genomic and ecological perspective. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand KULeuven. UA provides KULeuven research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Polo-like kinase 1 as a target for cancer treatments: focus on combination therapies and the role of the hypoxic tumour micro environment. Recently ended

University of Antwerp

This project represents a research contract awarded by the University of Antwerp. The supervisor provides the Antwerp University research mentioned in the title of the project under the conditions stipulated by the university.

Project

PolycombGroup targets as DNA methylation biomarkers for improved diagnosis, prognosis and predictor as response to treatment of prostate cancer.

KU Leuven

The objective of this research project is to identify robust DNA methylation biomarkers for the staging, prognosis and treatment-response prediction of prostate cancer. Therefore, the hypermethylome of a set of genes will be profiled in a panel of prostate cancer biopsies. We will use paraffin-embedded as well as fresh snap-frozen biopsies. The selected genes are all established. PolycombGroup target and tumour suppressor genes, which are hypermethylated and repressed in prostate canceer. The...

Project

Poly drug using and mental health among drug users who have a demand for treatment (POLYMEH). Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Federal Public Service. UA provides the Federal Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Polygenic analysis of flavour ester production using pooled segregant whole-genome sequencing.

KU Leuven

During alcoholic fermentation sugars are transformed into alcohol and carbon dioxide, while a range of secondary metabolites, including flavourcompounds, are produced. Volatile esters are key contributors to the aroma in a wide range of alcoholic beverages and impart fruity flavours. Research has shown that the ester imparting banana flavour, isoamylacetate, is desirable in high amounts, while another ester, ethylacetate, withdescriptors such as #solvent# and #nail polish# negatively affect t...

Project

Polygenic analysis of natural and artificial genetic variation in yeastacetic acid tolerance

KU Leuven

The focus of my PhD will be on the complex trait of acetic acid tolerance in yeast. The molecular basis of acetic acid tolerance is important from a fundamental viewpoint to understand how weak organic acids cause cell toxicity and also from an applied viewpoint because acetic acid is an important inhibitor in industrial yeast fermentations. There is a wide natural diversity for acetic acid tolerance in different yeast strains. We will investigate those with the highest tolerance to identify ...

Project

Polygenic analysis of the complex trait of flavour compound production in yeast for improvement of aroma production in alcoholic beverages

KU Leuven

The goal of this project is to elucidate a well-defined aspect of the genetic basis of the most important trait of industrial yeast used for the production of alcoholic beverages, i.e. synthesis of a complex profileof flavour compounds. The project will be focused on one specific and important aspect: synthesis of a high level of isoamylacetate and of a low level of ethylacetate. Isoamylacetate has a banana-like flavour and isa highly preferred positive flavour compound in many alcoholic beve...

Project

Polyhydroxyalkanoates (PHA) as a tool for microbial resource management

Ghent University

This project will investigate energy recovery from domestic wastewater through polyhydroxyalkanoates (PHA). Following the principle of microbial resource management (MRM), we will research the processes and interactions within PHA-producing microbial communities and develop tools to steer community processes for a reliable PHA production. We will explore anaerobic digestion (AD) as a means of transforming PHA-rich waste into biogas as a fuel for electricity generation.

Project

Polystress Recently ended

KU Leuven

No English Abstract

Project

Polystress: rol van polyploïdisatie bij (a)biotische stressresistentie van tuinbouwgewassen Recently ended

KU Leuven

Worldwide, biotic and abiotic stress factors have a profound negative impact on crop production. In this respect it is imperative to develop insights into the mechanisms of natural plant resistance, as this knowledge can be used to tailor cultivation techniques or develop new, durable stress resistant cultivars.Polyploids are naturally ubiquitous throughout the plant kingdom. Their abundance indicates that polyploidy confers an adaptive advantage. In the case of artificially mitotically-doubl...

Project

Polystress: the role of ploidisation in (a)biotic stress resistance in horticultural crops Recently ended

Ghent University

In both agricultural and horticultural crops the use of polyploids is mainly found in increased production (agronomic crops) or modification of interesting morphological traits (ornamental crops). This project aims to invest if the natural defense mechanism of clonal propagated horticultural plants can be increased by polyploidisation. As model plants apple and rose (Rosaceae family) are used.

Project

Population-based next generation sequencing to elucidate the complex genetics of Alzheimer dementia.

University of Antwerp

Alzheimer dementia (AD) is a very common, incurable disease. Because of changing demographics, the prevalence of AD increases rapidly. Recently, nine novel genes were identified that contribute to the risk to develop AD, and due to large scale international collaborations, several more are in the pipeline. This PhD project aims to identify the genetic polymorphisms in these genes that cause the increase in AD risk. To this end, next generation sequencing will be performed on a study populatio...

Project

Population density and status of the weatherfish (M. fossilis) in the Flemish reserve "'t Goorken" in Arendonk. Historic

University of Antwerp

Distribution of the weatherfish (M. fossilis) in Flanders as part of the case-study in `t Goorken. The status of the species in this reserve is represented as population size and age-class distribution.

Project

Population dynamics -and simulation of earwings in orchards: density dependence in a population of generalist predators. Historic

University of Antwerp

Earwigs, Forficula auricularia (L.) (Dermaptera, Forficulidae), are very important predators in fruit orchards. They are capable of suppressing outbreaks of pest species like pear psyllid and different aphid species, in apple and pear orchards. Earwigs could play an important role in integrated fruit orchards en could be an essential key factor in organic fruit growing. However, earwig populations are very unstable with large interannual variations in population size. Therefore, their practic...

Project

Population dynamics -and simulation of earwings in orchards: density dependence in a population of generalist predators. Historic

University of Antwerp

Earwigs, Forficula auricularia (L.) (Dermaptera, Forficulidae), are very important predators in fruit orchards. They are capable of suppressing outbreaks of pest species like pear psyllid and different aphid species, in apple and pear orchards. Earwigs could play an important role in integrated fruit orchards en could be an essential key factor in organic fruit growing. However, earwig populations are very unstable with large interannual variations in population size. Therefore, their practic...

Project

Population dynamics of a gynodioecious species. Recently ended

KU Leuven

Plants display a remarkable diversity in breeding systems and reproductive modes,ranging from exclusive sexual reproduction to complete asexual reproduction. Themost common form of asexual reproduction in plants is clonal growth. Although ithas been estimated that about 80% of all plant species combine sexual reproductionwith some kind of asexual reproduction, the evolutionary consequences ofinterference between clonal expansion and sexual reproduction remain poorlyunderstood. The latter may ...

Project

Population genetics of European periwinkles (Mollusca, Gastropoda: Littorinidae). Historic

University of Antwerp

Population genetics of European periwinkles (Mollusca, Gastropoda: Littorinidae).

Project

Population Genetics, Paleogenetics and Genomics: Identifying Selection Responses along Environmental and Spatial Gradients in the Water Flea (Daphnia Spp.)

KU Leuven

Genetic structure in natural population, a within and among population genetic diversity and genetic differentiation, and the evolutionary processes (natural selection, mutation and genetic drift etc) which favors adaptation to local environmental conditions have been major topics in population genetics especially evolutionary genetics and ecology. The evolutionary forces that favor adaptation to a local environment lead to a change in population genetic structure. What is more, historical ev...

Project

Population genomic analyses of viral evolutionary dynamics. Recently ended

KU Leuven

Genetic analyses play a central role in infectious disease research. Populations of fast-evolving RNA viruses, such as HIV and HCV, can accumulate detectable genetic differences over relatively short time scales allowing them to quickly adapt to environmental change. This evolutionary potential remains a major challenge for efficient drug treatment and vaccine development. By providing a means for massively parallelized 'mechanical cloning' and sequencing, the recent development of high-throu...

Project

Population level modelling of Monopolisation theory

KU Leuven

I will model the Monopolisation theory at the population level. The Monopolisation theory is a theory that tries to explain the lower than would be expected genetic diversity within a population. It does so by stating a few processes that would collectively cause a permanent competitiveadvantage for the first colonists of a habitat. Although at the community level an individual-based-model of the monopolisation hypothesis has already been made, to date no computational models has been made AT...

Project

Population structure, transmission and host specificity in a nidicolous ectoparasite, the tick Ixodes arboricola. Recently ended

University of Antwerp

The aim of this project is to study host specialization and genetic structure in an ecologically specialized tick species, I. arboricola. This project will deliver novel insights into the evolution of host specialization in ticks and more generally in parasites, and the role of different mechanisms herein. In addition we will obtain detailed insights in host selection, transmission and dispersal in a group of ectoparasites with high societal relevance.

Project

Population viability in fragmented rainforest: integrating individual-based modeling with landscape dynamics and connectivity. Historic

University of Antwerp

This project aims to study factors that affect the long-term population viability of Afrotropical bird species for which forest deterioration and isolation act synergistically at different spatial scales. We will parameterize and integrate spatially-explicit metapopulation-, forest- and landscape-models that encompass both fine-grained and coarse-grained dynamic processes.

Project

Positional cloning and characterization of novel dementia genes. Historic

University of Antwerp

The most frequent causes of dementia are neurodegenerative brain diseases e.g. Alzheimer's disease and frontotemporal dementia. Genetic factors play a key role and to date, 5 dementia genes are identified. However, not all patients with familial dementia have a mutation in one of the known genes so that other, yet unknown dementia genes exist. The aim of this project is to identify novel dementia genes using positional cloning techniques. This will substantially contribute to our understandin...

Project

Positional cloning and characterization of novel dementia genes. Historic

University of Antwerp

The most frequent causes of dementia are neurodegenerative brain diseases e.g. Alzheimer's disease and frontotemporal dementia. Genetic factors play a key role and to date, 5 dementia genes are identified. However, not all patients with familial dementia have a mutation in one of the known genes so that other, yet unknown dementia genes exist. The aim of this project is to identify novel dementia genes using positional cloning techniques. This will substantially contribute to our understandin...

Project

Positional cloning of two genes responsible for an abnormal bone density. Historic

University of Antwerp

Positional cloning of two genes responsible for an abnormal bone density.

Project

Positional cloning of two genes responsible for an abnormal bone density. Historic

University of Antwerp

This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Possibilities of NTMB for the extension of the ecological infrastructure in the port of Antwerp. Historic

University of Antwerp

Possibilities of NTMB for the extension of the ecological infrastructure in the port of Antwerp.

Project

Possibility of the integration of health and environmental aspects in the standardization of food products. Historic

Vrije Universiteit Brussel

The main purpose of this project is to make an inventory of existing knowledge concerning environmental and health aspects connected with the production and consumption of food. the key elements being : Rules and standardization, information for the consumer, environmental impact of food production and consumation (Inventory of existing knowledge) and life cycle analysis for food products.

Project

Possible involvement of the SK3 channels (Ga2+ activated K+ channels) in the generation of spontaneous electrical 'slow wave' activity in the smooth muscle of the outer muscle layer of the murine gastrointestinal tract. Historic

University of Antwerp

The project comprises an intracellular study on the spontaneous electrical 'slow wave' activity of the outer smooth muscle layer in different regions of the murine intestine. The involvement of SK3 channels in the generation of the slow waves will be studied in wild- type and transgenic mice.

Project

Postdoc fellowships to non-EU researchers Dhr. Sunil Adavanal Peter Recently ended

Vrije Universiteit Brussel

Postdoc fellowships to non-EU researchers In a nutshell... The stimulation of international mobility and the attraction of researchers from abroad is one of the priorities of the European Research Area. In this context and intending to stimulate the S&T cooperation, the Federal Science Policy Office (BELSPO), together with the Marie Curie Actions, does implement a fellowship scheme for highly qualified non EU researchers (i.e. postdoctoral level or equivalent experience), granting them an o...

Project

Postdoctoral research dr. Prim Singh. Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand BBSRC. UA provides BBSRC research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Post-doctoral sponsorship agreement Recently ended

Universiteit Hasselt

At the heart of dynamical models of person to person infectious disease transmission, are assumptions with regards to social mixing behavior. Mass action models assume that individuals mix completely and contact each other at age-specific average contact rates. This type of model is mostly used in the context of age-related dynamics of endemic infections. On the other hand, network-based models explicitly capture individual-specific contact heterogeneity and clustering by representing individ...

Project

Postdoctoral Sponsorship agreement - AXA. Exosomal communication: Identifying novel targets in Multiple Myeloma (postdoctoral research topic).

Vrije Universiteit Brussel

Multiple Myeloma (MM) is an incurable plasma cell malignancy with an incidence of 5 per 100,000 inhabitants, thus affecting approximately 25,000 new patients per year in the EU. The MM tumor clone develops primarily in the bone marrow (BM) as this microenvironment is the most optimal niche for tumor cell survival. Moreover, the BM provides protection against most types of drug treatments, leading to MM patient relapse. Therefore there is a need for alternative treatment strategies, targeting ...

Project

Postdoctoral Training in Belgium: an intercommunity network for scientific excellence and communication Recently ended

Universiteit Hasselt

In this project, Hasselt University and the Université Libre de Bruxelles will develop a sharedpostdoctoral curriculum to prepare young scientists focused on their careers in universities and businesses, to promotescientific excellence and to intensify communication between the Belgian language communities by scientific cooperation .

Project

Post-evaluation of river restoration projects and mitigation procedures in river management. Historic

University of Antwerp

A lot of river restoration projects are carried out, especially with the improving strategy of integrated water manangement. However a good scientific evaluation is often lacking. This project will focus on the evaluation of a number of diverse projects carried out by the province of Antwerp. The evaluation will be done based on a number of ecological parameters, such as macrophytes, macro-invertebrates and fish. The results of the evaluation will be used as educational material on restoratio...

Project

Post-genomic investigation of therapeutic targets for the treatment of neurodegenerative disorders.

University of Antwerp

Using advanced molecular biological techniques, the promotor intends to develop an in-depth appreciation of how dementias and neurodegeneration occur and in doing, reveal the best mechanisms to combat these diseases with new

Project

Post-genomic profiling and therapeutic targeting of specific and generic neurodegenerative mechanisms.

University of Antwerp

The primary aim of the proposed research program is to develop an understanding of the quantitative and qualitative post-genomic sequelae of CNS disorders, whose genomic origins have been extensively characterized at the Department of Molecular Genetics and at other Institutions in the VIB, these include: familial Alzheimer's disease (AD), Parkinson's disease (PD), Huntington's disease (HD), frontal temporal lobar degeneration (FTLD), mild cognitive impairment (MCI) and early-onset dementia (...

Project

Post-infectious immune reprogramming and its association with persistence and chronicity of respiratory allergic diseases

Ghent University

The central hypothesis of the Predicta project is that repeated, acute infection-mediated events may reprogram the innate, adaptive or regulatory immune responses to predipose towards a chronic inflammation pattern. The role of specific agents will be sought in order to develop innovative diagnostics for predicting disease chronicity, as well as interventions that may delay or prevent disease progression/persistence.

Project

Postnatal human skin progenitor cell-derived hepatocyte-like cells as potential in vitro model for hepatotoxicity screening of pharmaceuticals

Vrije Universiteit Brussel

In the current project, it will be investigated whether hSKPs (adult skin-derived progenitor cells) can be used as a human relevant screening system to detect liver toxicity induced by pharmaceuticals and to study, at a molecular level, their modes of action, including the potential involvement of progenitor cell activation.

Project

Post-translational modifications during the oxidative stress response in plants.

Ghent University

This project will monitor selected post-translational modification events that are triggered by increased photorespiratory H2O2 levels in plants by using COFRADIC technology. Identified events will be subjected to a detailed functional analysis, including the generation of gain- and loss-of-function mutants and a detailed phenotyping effort in order to elucidate the functionality of the identified proteins.

Project

Post-translational modifications of beta-cell antigens: key to the pathogenesis of type 1 diabetes?

KU Leuven

Type 1 diabetes is an autoimmune endocrine disease where the body’s ownimmune system destroys the pancreatic beta-cell. Understanding theetiology and pathogenesis of the disease will pave the way to prevention and cure, but the precise mechanism(s) by which immune tolerance is broken in type 1 diabetes is complex and still largely unknown. Findings in other auto-immune diseases, such as rheumatoid arthritis, celiac disease and multiple sclerosis, where post-translational modifications (PTMs)h...

Project

Post-translational modifications of the oxidative stress response in plants Recently ended

Ghent University

The goal of this project is to complement transcriptomic data of the oxidative stress response with proteomic data. Catalase deficient Arabidopsis are the experimental model system to study the effect of enhanced endogenous H2O2 levels. Besides defining the differences in protein abundances between WT and mutants using shotgun proteomics, both tyrosine nitration and methionine oxidation will be assessed by use of the COFRADIC technology.

Project

Potential interactions between peripheral and central mechanisms in patients with chronic whiplash: does reduction in white matter integrity play a role in this traumatic event?

Ghent University

The aim of this project is to explore the interrelationship between changes in muscle function, central pain mechanisms and white matter integrity in patients with chronic whiplash associated disorders (WAD). 35 subjects in each group (traumatic neck pain, non-traumatic neck pain and healthy controls) will undergo a series of investigations, including evaluation of muscle performance, muscle properties, white matter integrity and central pain mechanisms.

Project

Potential of advanced MRI measurements to be used as bio-marker in the future. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand UZA. UA provides UZA research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Potential role of bone-marrow derived stem cells in the regeneration of the beta cell mass in experimental diabetes Historic

Vrije Universiteit Brussel

Potential role of bone-marrow derived stem cells in the regeneration of the beta cell mass in experimental diabetes

Project

Potentials of leaf Saturation Isothennal Remanent Magnetisation and physiological leaf parameters as indicators of local air quality in tropical urban environments: a case study for Abidjan (Ivory Coast). (Postdoc. fellowship Y. BARIMA, Ivory Coast). Recently ended

University of Antwerp

It has recently been shown that in a temperate area it is possible to determine the spatial distribution of particulate matter in an urban environment by Saturation lsothennal Remanent Magnetization (SlRM) of plants leaves (Kardel et al. 201 l and 2012). But no such study has already been conducted in tropical (urban) environments. The first aim of this study is, therefore, to evaluate the potential of leaf magnetic and biochemical characteristics as bio-indicators of particulate matter of ur...

Project

Potential yield and energy value of biomass from Low Input - High Diversity (LIHiD)-systems in Flanders. Recently ended

KU Leuven

Because of climate change and the finiteness of fossil fuels, the interest in alternative energy strongly increases. Besides wind and solar energy, biomass is an important source of renewable energy. To date, the focus of biomass production for bioenergy lies primarily on woody vegetation and energy crops. However, the sustainability of these systems can often be questioned.This dissertation examines the possibilities of using biomass from Low-Input High Diversity (LIHiD) systems in Flanders ...

Project

Poxylation as next generation Pegylation. Recently ended

University of Antwerp

The following main challenges and yet unknown biological aspects of Poxylation, that need to be addressed to demonstrate the safety as well as potential of Poxylation over Pegylation, will be the main objectives to establish the poxylation technology. Besides developing the poxylation technology, this initial project aims to develop synthetic strategies for poxylated therapeutics.

Project

Preclinical design of RNA-modified dendritic cell vaccines for cancer and HIV Historic

University of Antwerp

The project focuses on the use of antigen-modified human dendritic cells (DC) as a potential cancer vaccine. Human dendritic cells (DC) from healthy individuals, treated cancer patients and HIV positive individuals will be cultured starting from peripheral blood monocytes. The major aim is to transfer defined tumor and HIV antigens to DC by means of transfection of DC with mRNA encoding defined antigens. Antigen-loaded DC will be used for induction of antigen-specific autologous cytotoxic T c...

Project

Preclinical design of RNA-modified dendritic cell vaccines for cancer and HIV Historic

University of Antwerp

The project focuses on the use of antigen-modified human dendritic cells (DC) as a potential cancer vaccine. Human dendritic cells (DC) from healthy individuals, treated cancer patients and HIV positive individuals will be cultured starting from peripheral blood monocytes. The major aim is to transfer defined tumor and HIV antigens to DC by means of transfection of DC with mRNA encoding defined antigens. Antigen-loaded DC will be used for induction of antigen-specific autologous cytotoxic T c...

Project

Preclinical development of an innovative immune therapy based on CD56 + dendritic cells and interleukin-15: recruitment of the innate immune system in the fight against cancer.

University of Antwerp

This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Preclinical development of an optimised dendritic cell-based vaccine against acute myeloid leukemia. Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand VLK. UA provides VLK research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Preclinical development of an optimized dendritic cell-based vaccine against acute myeloid leukemia Historic

University of Antwerp

This research aims to develop new strategies to enhance the immune stimulating and antitumor activity of dendritic cell therapy in acute myeloid leukemia.

Project

Preclinical development of beta cell implants for treatment of diabetes Recently ended

Vrije Universiteit Brussel

Diabetes is a frequent chronic disease that reduces quality of life and increases the risk for life threatening complications despite current treatment. The disease can appear at all ages with the type 1 form being most prevalent under the age of 40 years, and type 2 steadily increasing with age. Type1 diabetes is caused by massive loss of insulin-producing beta cells in the pancreas following local inflammatory and autoimmune reactivities. Patients require life-long insulin therapy, which ca...

Project

Pre-clinical evaluation of NKT-cells in multiple myeloma Historic

Vrije Universiteit Brussel

Multiple myeloma is still considered as the second most prevalent haematological malignancy and despite recent progresses in treatment options, MM still remains fatal for most patients. One of the new emerging strategies to target MM is using a patient's immune system to target the tumor. However, cancer cells can evade the immune system and tumor surveillance is often impaired. Therefore new drugs are being studied which can activate the immune system directly, thus overcoming this impairmen...

Project

Preclinical imaging of the brain cannabinoid receptors in Huntington's disease.

KU Leuven

Huntington’s disease (HD) is a progressive neurodegenerative disorder, without effective therapy. The endocannabinoid system (ECS) is dysregulated in HD. Ex vivo studies point towards a role of the type-1 cannabinoid receptor (CB1-R) in the pathogenesis, especially on the motor, cognitive and behavioral domains. The type-2 cannabinoid receptor (CB2-R), a marker of neuroinflammation, is part of an endogenous mechanism of defense.We recently investigated brain CB1-R availability in vivo using P...

Project

Preclinical research on the combination of MDM2 'small-molecule' inhibitors and conventional chemo- and/or radiotherapy, under normoxic versus hypoxic conditions. Historic

University of Antwerp

Targeted cancer medicine is regarded as the treatment strategy of the future. Small-molecule inhibitors have been designed to disrupt or prevent the interaction of p53 and its negative regulator MDM2. The aim of the study is to investigate the potential of these small-molecule inhibitors as a targeted anti-cancer therapy in p53 wt tumors, and their combination with conventional chemo-and/or radiotherapy, under normoxic and hypoxic conditions.

Project

Preclinical research on the role and mechanism of MDM2 "small molecule" inhibitors combined with conventional chemo- and/or radiotherapy under normoxic and hypoxic conditions.

University of Antwerp

This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Preclinical research on the role and mechanism of MDM2 "small molecule" inhibitors combined with conventional chemo- and/or radiotherapy under normoxic conditions. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand UZA. UA provides UZA research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Preclinical studies on promising combinations of radiochemotherapy and cytoprotective agents. Historic

University of Antwerp

The concurrent use of chemotherapy and radiation has been applied more frequently in the treatment of cancer. Besides the possibility to improve local control and to treat the disease both locally and systemically, some chemotherapeutic agents have the potential to increase the sensitivity for radiation, i.e. radiosensitization. Although the combined-modality therapy may lead to an improved therapeutic outcome, the combination of gemcitabine and radiotherapy also results in increased toxicit...

Project

Preclinical studies with chemoradiotherapy combinations. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand UZA. UA provides UZA research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Preclinical study into the combination of new chemotherapeutics and radiotherapy, to optimize cancer treatment methods. Historic

University of Antwerp

Nowadays, the concurrent use of chemotherapy and radiotherapy has been applied with success more frequently in the treatment of cancer. Besides the benefit of combining local and systemic treatment, some combinations show an interaction between the different therapies resulting in radiosensitisation. In this study, we focus on possible interactions between new cytostatic agents, such as ET-743, Vinflunine and Vinorelbine, and radiotherapy in tumour cell lines and normal cells. The interact...

Project

Preclinical study of the combination of EGFR inhibitors with gemcitabine and/or radiotherapie under normoxic versus hypoxic conditions Historic

University of Antwerp

In order to improve the efficacy of cancer therapy, the development of molecularly targeted agents has received a lot of attention. Their effects under hypoxia or in combination with radiotherapy are however largely unknown. Therefore, the integration of 2 types of EGFR inhibitors (cetuximab, a monoclonal antibody and erlotinib, a tyrosine kinase inhibitor) with gemcitabine and radiotherapy seems a promising strategy for improving chemoradiation.

Project

Preclinical study of the combination of new cytostatic agents and radiotherapy. Historic

University of Antwerp

Nowadays, the concurrent use of chemotherapy and radiotherapy has been applied with success more frequently in the treatment of cancer. Besides the benefit of combining local and systemic treatment, some combinations show an interaction between the different therapies resulting in radiosensitisation. In this study, we focus on possible interactions between new cytostatic agents, such as ET-743, Vinflunine and Vinorelbine, and radiotherapy in tumour cell lines and normal cells. The interact...

Project

Preclinical study on the combination of new chemotherapeutica and radiotherapy in the framework of the optimalisation of cancer treatments. Historic

University of Antwerp

Preclinical study on the combination of new chemotherapeutica and radiotherapy in the framework of the optimalisation of cancer treatments.

Project

Preconception Care in Flanders: Practice, knowledge, attitude and needs

Ghent University

This research will investigate practive, needs, knowledge and attitude towards preconception care of both primary care providers and women. It will also focus on incidence, determinants and pregnancy outcome of unplanned pregnancies in Flanders. An intervention will be systematically developd, tailored and implemented in primary care settings to improve practive, attitude and knowledge of patients and caregivers towards preconcepption care.

Project

Preconditions and good practice for (re-) organize and implement screening for breast, cervical and colon cancer. Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Predicitve validity of a short cognitive screening battery for older drivers in a primary health care setting. Historic

Vrije Universiteit Brussel

MAny authors were able to highlight the importance of cognitive factors in relation to the driving of older adults. On the other hand, the car has become an indispnsxable means of transport to guarantee that older people can maintain their autonomy and independence. It is therefore very important to refine the fitness to drive diagnoses of elderly people in such a way that as few fit to drive elderly as possible are judged unfit to drive. There is a need for a simple short screening battery w...

Project

Predicting Immune responses by Modeling immunoSequencing data (PIMS).

University of Antwerp

Vaccine trials study the changes in vaccine-induced antibodies and T-cells and their protective value against natural infection. As such it has been noted that not all vaccines are equally effective and that variability exists between individuals in the magnitude and duration of the immune response after vaccination. We hypothesize that individual-specific genetic characteristics collected in a short time-window after vaccination are sufficient to predict immune responses for a long time per...

Project

Prediction of drug response from genetic sequence data using regression techniques Recently ended

KU Leuven

Regression techniques are increasingly important as automatic methods to study complex biological systems. As these techniques are completely data-driven, alterations in the biological systems can be observed at a much faster pace. The project aims at developing a methodology to build regression models for genetic HIV-1 sequence data obtained during or after selective pressure of integrase inhibitors, which, besides being accurate, have a good interpretability. Given that the clonal correlati...

Project

Prediction of metal accumulation and sublethal effects in benthic invertebrates by means of the AVS-SEM model Historic

University of Antwerp

In this project the relationship between metal concentrations in sediment and accumulation and effects in Chironomidae and Oligochaeta will be investigated. Special attention will be paid to the influence of AVS concentrations in sediment on the accumulation and chronic effects (energy reserves, ion and osmoregulation, growth and survival) of metals under laboratory and field conditions.

Project

Prediction of type 1 diabetes by combination of biological, demographic and anthropometric data. Historic

University of Antwerp

Prediction of type 1 diabetes by combination of biological, demographic and anthropometric data.

Project

Predictive clustering for structured biomedical data.

KU Leuven

In many areas of science, data is generated at an increasing pace, calling for adequate data mining tools to extract usefulknowledge. Challenges encountered include the scale and the complexity (structure) of the data. An increasing number ofnew applications, including the analysis of complex biomedical data, motivate the adaptation of existing, and the designof new methodologies. In this project, we will develop new data mining methods to analyze high−dimensional andstructured biomedic...

Project

Predictive factors related to clinical response in patients with metastatic melanoma treated with dendritic cell based immunotherapy. Historic

Vrije Universiteit Brussel

Recently obtained results from different clinical trials indicate that new modalities of specific immunotherapy are active in the treatment of the patients with melanoma and other cancers. During the past 5 years our research group has conducted institutional pilot trials on therapeutic vaccination of melanoma patients with autologous dentritic cell vaccines. We believe that there are two major strategies that can help to improve the clinical efficacy of specific immunotherapy. Firstly, throu...

Project

Predictive markers for the use of anti-EGFR biotherapeutics in Head and Neck cancer: generation of resistant cell lines in view of microarray-based comparative genomic hybridization. Historic

University of Antwerp

In view of the potential success of anti-EGFR biotherapeutics in the treatment of Head and Neck cancer, it is essential to obtain markers that predict effective treatment. By using a anti-EGFR biotherapeutics sensitive cell line to generate a resistant daughter cell line, both can be used in microarray-based comparative genomic hybridization, to locate genes that are differentially expressed.

Project

Predictive models to dengue/severe dengue and join models to TB/HIV Historic

Universiteit Hasselt

Problem statement: Dengue is a viral disease with endemic behavior, transmitted to humans by the bite of Aedes mosquitoes. In the course of the disease a patient with dengue may suffer complications. Given the intensity of its manifestations can define two clinical forms: dengue or severe. At the beginning of the illness it is not possible to know which patients will have an unfavorable evolution and develop a severe form of dengue. However, some warning symptoms and signs may be present. Thi...

Project

Predictive value of early response imaging on integrated PET-CI and prognostic value of combined morphometric-pathologic response in mediastinal lymph nodes and primary tumor response. Recently ended

KU Leuven

Patiënten met "resectable" stadium IIIA-N2 "non-small cell" longkanker (NSCLC) kunnen behandeld worden met inductie-chemotherapie, gevolgd doorde chirurgische verwijdering van de tumor. Op dit ogenblik bestaat er geen betrouwbare methode om een onderscheid te kunnen maken tussen enerzijds patiënten die goed reageren op deze behandeling en een goede lange-termijn prognose hebben (responders), en anderzijds patiënten die onvoldoende op de behandeling reageren en dus geen kandidaten zijn voor de...

Project

Predictive value of guanidino compounds in the acute phase of an ischemic cerebrovascular accident. Historic

University of Antwerp

Predictive value of guanidino compounds in the acute phase of an ischemic cerebrovascular accident.

Project

PREDI-NU Preventing depression and improving awareness through networking in the EU. Recently ended

KU Leuven

PREDI-NU is a European action and research project that aims to test new interventions for the prevention of depression in adolescents. The project will be conducted by an established network of European experts in the prevention of depression and suicide, which has previously collaborated in the European Alliance Against Depression (EAAD) and Optimised Suicide Prevention and Implemention in Europe (OSPI) projects. The PREDI-NUproject builds upon these experiences and specifically focuses on ...

Project

Preeclampsia: physiological and clinical relevance of defining different subtypes.

Universiteit Hasselt

Preeclampsia (PE), defined as gestation-induced hypertension with urinary protein-loss, and fetal growth restriction (FGR) are amongst the most threathening diseases of pregnancy for both mother and child. Current therapies for these diseases are aspecific, symptomatic and haven't been changed for decades now. In this project, protocols for application of new technologies as "maternal venous Doppler sonography" and "impedance cardiography" - both validated within the research group - are used...

Project

Preimplantation Genetic Diagnosis of Monogenetic and Mitochandrial Diseases : Development and Application. Historic

Vrije Universiteit Brussel

The objective of this study is to develop new diagnostical tests on the level of preimplantation of embryos in order supply an extra diagnosis on genetic defaults to the parents as an alternative for the common procedure. The development of PGD for monogenic defaults is a science in wich we have much experience.

Project

Preklinisch onderzoek naar de neuroprotectieve effecten van de insuline-achtige groeifactor IGF-I in een ratmodel voor focale cerebrale ischemie. Recently ended

Vrije Universiteit Brussel

Een cerebrovasculair accident is de voornaamste oorzaak van morbiditeit in de Europese Unie en wereldwijd is het de belangrijkste oorzaak van verworven invaliditeit. Gezien de vergrijzing van de bevolking en de langere levensverwachting zal de incidentie in de komende jaren nog stijgen. Tachtig procent van de beroertes wordt veroorzaakt door obstructie van een bloedvat in de hersenen door een thrombose of een embool. Tot op heden is reperfusie geïnduceerd door de weefseltype-specifieke plasmi...

Project

Preklinisch testen van procedures voor diagnose en therapie voor hart- en vaatziekten met behulp van ultrageluid. Historic

University College Ghent

De hoofddoelstelling van het onderzoek bestaat uit het ontwikkelen van een geavanceerd fysisch vierkamermodel van het menselijke hart, waarbij vooral aandacht wordt besteed aan:- De realistische geometrie, voornamelijk van het linker en rechter ventrikel (i.e. de pompkamers)- De passieve en actieve mechanische eigenschappen van het wandmateriaal- De echogene karakteristieken van het wandmateriaalteneinde realistische vervormingen van de hartwand en fysiologische intraventrikulaire stromingspa...

Project

Prenatal Chromosomal Microarray Analysis and Identification of Genetic Variants in Congenital Diaphragmatic Hernia. Recently ended

KU Leuven

<w:latentstyles deflockedstate="false" defunhidewhenused="true" defsemihidden="true" defqformat="false" defpriority="99" This doctoral researchhas focused on the application of recently emerging genetic technologies to prenatal genetic diagnosis. Conventional cytogenetic analysisby karyotype visualizes stained chromosomes by light microscopy. Karyotyping can detect numerical (e.g. trisomy 21, Down syndrome) and structural rearrangements to a resolution of ~10Mb. Furthermore, karyotyping requi...

Project

Preparation + meeting with G. Molenberghs 01/07/2010 UHasselt Historic

Universiteit Hasselt

This offer represents a formal service agreement between the parties CENSTAT(research institute at Hasselt University), and on the other hand, CENTRAAL BUREAU VOOR DE STATISTIEK. The research institute CENSTAT provides CENTRAAL BUREAU VOOR DE STATISTIEK research results on Preparation and meeting with G. Molenberghs, 01/07/2010' ' under the conditions as stipulated in the present contract.

Project

Preparation of a Biotic Ligand Model (BLM) for the metals cupper and cadmium in marine and estuarine environments by the target species: the European sea bass (Dicentrarchus labrax). Historic

University of Antwerp

This study attempt to prepare a BLM for marine and estuarine environments. the aim of this BLM is to provide a model which includes the strong influence of site-specific environmental factors, such as hardness, chemical speciation, pH, temperature and salinity, as well as the strong influence of the physiological characteristics of the organism so that the bioavailability of the metals can be evaluated. Consequently, a possibility may arise of establishing appropriate site-specific water qual...

Project

Preparation of the Flemish scientific activities at the European synchotron radiation facility ESRF Historic

Vrije Universiteit Brussel

This research project proposal entitled "Preparation of the Flemish scientific activities at the European synchrotron radiation facility ESRF", has as its main aim the creation of an optimal scientific environment, where the different research projects of the applicants will be implemented, once ESRF is fully operational. It is the unanimous opinion of the applicants that this goal can best be achieved by an active collaboration in the construction in situ of the equipment dedicated to a coll...

Project

Preparatory work in the analysis and reporting of data on multi-resistance in antimicrobial resistance isolate based data collected from reporting countries for the year 2012 Recently ended

Universiteit Hasselt

European market GMO's are subject to legal regulations requiring a scientific assessment of potential risks for human or animal health. EFSA is responsible for providing independent, objective and transparent scientific advice with respect to the safety of GMO's. CenStat's role is to provide support with respect to the statistical analysis and interpretation of agronomic and compositional data contained in the GMO applications that have to be reviewed by the EFSA GMO panel.

Project

Preparatory work in the ananlysis and reporting of data on multi-resistance in antimicrobial resistance isolate based data collected from reporting countries for the year 2011 Recently ended

Universiteit Hasselt

The overall objective of this project is to analyse and report the isolate-based data on antimicrobial resistance in animals and food reported by the EU Member States and some other reporting countries for the reporting year 2011.

Project

Presenilin 1 induced tau pathology: biochemical and neuropathological characterisation in humans and mouse models. Historic

University of Antwerp

Presenilins (PS 1 and 2) are integral components of the gamma-secretase complex which is responsible for the cleavage of a number of transmembranous proteins including amyloid precursor protein (APP) and Notch. Mutations within PS1 are primary cause of familial Alzheimer's disease (FAD). It is assumed that PS mutations cause FAD due to the "amyloid cascade" where Aß accumulation lies upstream of tau phosphorylation and neurodegeneration. However, increasing evidence suggests that PS might dir...

Project

Presentation and conservation of art incorporating organic components. Historic

University College Ghent

Increasingly, and in ever more diverse ways, contemporary artists make use of organic materials, such as foodstuffs, vegetal or animal tissue and other natural materials. Without doubt one of the most adverse qualities of such works of art, is the inherently limited storage life and susceptibility to deterioration. To control and, if possible, curb decomposition, thorough knowledge of all affecting factors is required. Concerning foodstuffs, the knowledge of dealing with works of art entirely...

Project

Preservation & restauration of funcional Betacell mass in Type I-diabetes Historic

Vrije Universiteit Brussel

The objective is to develop and implement strategies for restoring the number of beta cells in type 1 diabetes patients and for protecting the cells against losses as result of inflammatory, immune, metabolic or toxic interactions. We explore the biologic program that preserves and maintains an adequate beta cell mass and applies this knowledge to produce functional beta cells in the laboratory and to regenerate them in vivo.

Project

Pressureless measurement of volume changes with sub-microliter accuracy. Historic

University of Antwerp

A new system is developed for measurement of extreme small gas volume changes without changing pressure. The system is based on motion of a droplet in a horizontal capillary. The position of the droplet is measured optically. In the project, the optical setup is developed, and measurement resolution and artefacts are studied.

Project

Pre-test PB Ekkelgaarden Historic

Universiteit Hasselt

This offer represents a formal service agreement between the parties CMK (research institute at Hasselt University), and on the other hand, Remo Milieubeheer. The research institute CMK provides Remo Milieubeheer research results on 'Pre-test PB Ekkelgaarden' under the conditions as stipulated in the present contract.

Project

Prevalence and incidence of pulmonary arterial hypertension (PAH) in congenital heart disease (CHD) in Belgium; developing detection methods ofpreclinical PAH; and influencing clinical outcome by early treatment ofpulmonary vascular disease.

KU Leuven

Pulmonary arterial hypertension (PAH) secondary to late detected shunt lesions in patients with congenital heart disease (CHD), implicates considerable morbidity and mortality. Through the recently completed and unique Belgian Registry on Adult CHD, we first want to identify the prevalence and incidence of PAH in CHD. Also predictors of the development of PAH and of outcome will be defined. Secondly, we would like to track these CHD patients who were dismissed from follow-up in the past, but ...

Project

Prevalence of Escherichia coli O157:H7 in slaughter animals in Poland and Belgium and the effect of presentation methods and decontamination on survival of the bacteria in meat. Historic

Vrije Universiteit Brussel

Verotoxin-producing E. coli (VTEC) infections are associated with different diseases such as water or brooding diarrhea, hemorrhagic colitis, hemolytic uremic syndrome (HUS) and thrombotic thrombocytopenic purpura (TTP). Serotype O157:H7 and its unmotile variant O157:H - are the most frequent serotypes causing HUS and TTP, two very severe clinical entities. it is clearly shown that these bacteria belong to the group of foodbome pathogens. The main reservoir of E. coli O15:H7 seems to be cattl...

Project

Prevalence of maternal antibodies against vaccine preventable infections: sero-epidemiological survey of antibody concentrations in women in third trimester of pregnancy; comparison between vaccinated mothers and mothers with natural immunity. Historic

University of Antwerp

This pilot study aims to measure the prevalence of antibodies against vaccine-preventable diseases in pregnant women as well as the feasibility of a larger study in pregnant women and their off springs. A first group consists of pregnant women who have been immunized for measles, rubella, or eventually hepatitis A and a second group of women who acquired the infection naturally. The prevalence of maternal antibodies against infections for which there are currently no universal vaccination pro...

Project

Preventative health promotion of prostitutes in Antwerp. Historic

University of Antwerp

In 1999-2000 a pilot study was conducted to evaluate the feasibility of a hepatitis B immunization project in prostitutes in the city of Antwerp. Moreover, this project involves the broader subject of information and sensibilisation of prostitutes on STI's in particular and hygiene and condom use in general. This project has been continued in 2001 and 2002 with restricted financing from Gh@pro vzw, to support that part of the personnel cost from the UA/CEV.

Project

Prevention and improved diagnosis of adolescent genital disease in schistosomiasis endemic KwaZulu-Natal, South Africa (IRSES).

University of Antwerp

Development of new diagnostic approaches and treatment modalities in the health field depends on translational research with close contact between the clinical field and the latest biotechnological development in immunology and genetics. Totally integrated translation research networks are rare, especially when it comes to solving health problems endemic in the poorer parts of the world, especially in Africa. There is a need for creation of strong networks between laboratories at the forefron...

Project

Prevention of betacelldestruction in type 1 diabetic patients and their high-risk relatives. Historic

University of Antwerp

a) Administration of monoclonal anti-CD-3 antibodies (ChAgly CD3) in newly-diagnosed type 1 diabetic patients in order to inhibit the further destruction of beta-cells and preserve the endogenous insulin production. b) Prophylactic SC insulin administration in high-risk relatives of type 1 diabetic patients in order to prevent or postpone the clinical manifestation of the disease.

Project

Prevention of HIV transmission through interference with HIV entry, reverse transcription and integration with regard to the development of new candidate microbicides. Historic

University of Antwerp

As the number of HIV-1 infections worldwide is still rising, there is an urgent need for microbicides which are vaginal formulations used by women to prevent heterosexual HIV transmission. Within this project, inhibitors of HIV-1 reverse transcription, integration and entry are evaluated as potential microbicides in vitro.

Project

Prevention of in-stent restenosis by the use of anti-proliferative drugs. Historic

University of Antwerp

In-stent restenosis remains a limitation of the percutaneous treatment modalities of coronary atherosclerosis. This project aims to develop 'single-component' and 'multi-component' directly coated drug eluting stents. Selective modulation of oxidative stress, smooth muscle cell migration and proliferation and endothelial cell regeneration are investigated, by single molecules, or combinations of locally delivered molecules. The used methodology consists of stenttechnology, farmacokinetic eva...

Project

Prevention of sanitary risks linked to rodents at the rural/peri-urban interface. (RATZOOMAN) Historic

University of Antwerp

Prevention of sanitary risks linked to rodents at the rural/peri-urban interface. (RATZOOMAN)

Project

Prevention of secondary caries adjacent to tooth restorations in composite.

KU Leuven

Decayed or traumatized teeth are most commonly restored adhesively using tooth-colored composites. However, longevity and survival studies showthat dentists need to replace composite restorations too soon and each intervention leads to further tooth weakening. Secondary caries at the restoration margins is the primary reason for this early restoration replacement. This has been ascribed in part to the inherent polymerization shrinkage and biofilm-adhesion susceptibility of composite. In the b...

Project

Preventive impact of EPO on the kidney after injury. Historic

University of Antwerp

Preventive impact of EPO on the kidney after injury.

Project

Price 'Gelijke Kansenbeleid' (equal opportunities policy) University of Antwerp. Historic

University of Antwerp

Price 'Gelijke Kansenbeleid' (equal opportunities policy) University of Antwerp.

Project

Price of the BFVUG 2008. Historic

University of Antwerp

Price of the BFVUG 2008.

Project

Price Research Council 2005. Historic

University of Antwerp

Price Research Council 2005.

Project

Price Valine de Spoelberch: Charcot-Marie-Tooth neuropathies: from genes to protein networks and disease mechanisms. Historic

University of Antwerp

This project aimed to apply novel molecular approaches to model Charcot-Marie-Tooth (CMT) mutations, validate gene function and the interaction networks.

Project

Primary care for patients with multimorbidity: developement of a guideline for nursing intervention for a more adequate selfmanagement and the maintainance of biomedical variables within the multidisciplinary team. Recently ended

Ghent University

Chronic conditions require an overwhelming therapy. Nurses are a valuable option to provide patient centered guidance. The aim is to develop nursing consulations for patients with multimorbidity. Qualitative interviews with patients and providers will be used to explore the necessary content. After implementation, mixed method research will be used to adapt and test the intervention.

Project

primary vs secondary resistance to EGFR-targeted therapy in colorectal cancer: biological and predictive significance of stromal-derived neuregulin-1 Recently ended

Ghent University

Anti-EGFR therapy (cetuximab or panitumumab) is a well known targeted therapy in metastatic colorectal cancer (mCRC). This project will search for insights in stromal-dependent delivery of signalling ligands that are associated with upfront resistance to anti-EGFR therapy or mechanisms of acquired resistance to anti-EGFR therapy; and to find biomarkers identifying patients at high risk for therapy resistance.

Project

Primate locomotion: coordination in complex environments. Historic

University of Antwerp

Biomechanics of locomotion in complex environments: brachiation in siamangs (Symphalangus syndactylus) In the literature it has been shown that gibbons are able to brachiate with very low mechanical costs on a horizontal, rigid substrate. They do this by pendular movements, where potential and kinetic energy are exchanged to create an optimum energy conservation. Moreover they must minimize their collisional energy losses by ensuring that the passage between two movements happens smoothly w...

Project

Principle component analysis (PCA) of complex data generated by chromatographic and spectroscopic analysis of biological mixtures. Historic

University of Antwerp

There is a never-ending search for novel molecules with superior pharmaceutical properties. Via an IWT-SBO project the production of novel molecules in plants, through use of combinatorial biosynthesis, was started . Because of the high amount of constructs that will be created to screen for new metabolites, a statistical approach will be necessary. To support the statistics of these analyses principle component analysis (PCA) will be necessary.

Project

Principles of regulation in P-type ion pumps. Implications for cardiac function.

KU Leuven

P-type ATPases (pumps) are membrane enzymes that play a key role in cellular ion house-keeping. Well-known representatives of this family are the Na+K+ATPase and the SERCA and SPCA Ca2+ ATPases. The transmembrane ion gradients generated by these pumps are of vital importance for amongstothers the normal heart function. Hence, both the Na+K+ATPase and the SERCA pumps are important therapeutic targets for heart failure. This research aims to further explore the general principles underlying the...

Project

Prioritization of target groups in relation to the vaccination for seasonal influenza - part 2. Historic

University of Antwerp

The two research questions are: - What is the impact of vaccinating children for seasonal influenza vaccination? - What is the cost-effectiveness of seasonal influenza vaccination, for each vaccination scenario?

Project

PRISMA - Reflecting the positive diversities of European priorities for research and Measurement in end of life care. Historic

University of Antwerp

The overall aim of this project is to inform best practice and harmonise research in end of life care for cancer patients across Europe through comparison and exchange of approaches and experiences in measurements and research priorities.

Project

Prize "Burggravin Valine de Spoelberch" Recently ended

Vrije Universiteit Brussel

Prize: Research into the mechanism of angiotensin IV and angiotensin receptor ligands in learning and memory, limbic epilepsy and Parkinson disease.

Project

Prize CBC Banque: Progranulin in neurodegenerative dementia: genetic, functional and neuropathological characterization. Historic

University of Antwerp

Frontal temporal lobar degeneration (FTD) is the second most common cause of dementia in people younger than 65 years. Molecular genetic research has successfully identified a number of causal genes. One important disease gene codes for granulin a protein with growth factor activities.The loss of 50% of granulin causes inherited autosomal dominant FTD. The biological mechanism how this happens is still largely unknown. Hereto, extensive functional research is nodded in the laboratory and in ...

Project

Prize Hilde Bruers 2004

Vrije Universiteit Brussel

prize Hilde Bruers 2004

Project

Prize ING

Vrije Universiteit Brussel

On the strength of her experience during the First World War, particularly in the four hospitals on the Belgian front, Her Majesty Queen Elisabeth created a medical foundation in 1926 with the aim of encouraging laboratory research and fostering contact between researchers and clinical practitioners. A good relationship between these two key groups was considered crucial for patient welfare.

Project

Prize "Robert Oppenheimer " 2004. Historic

University of Antwerp

This scientific prize was given for my general scientific activities.

Project

Probabilistic algorithm for finding motifs in sets of orthologous sequences Recently ended

KU Leuven

Regulation of gene expression is a key mechanism for organisms to live and grow in their natural habitat or even to adapt to new environments. Regulation at initial transcription is an important aspect herein that involves the binding of a transcription factor (TF) to specific locationswith a similar nucleotide sequence (termed as an ‘enriched’ or ‘overrepresented’ motif) in non-coding DNA. Given motifs are short and randomly distributed in possibly long promotor regions, computational algori...

Project

Probing local CaMKII activation in ventricular myocytes and the role ofCaMKII in arrhythmogenesis.

KU Leuven

Ventricular arrhythmias deteriorating into sudden cardiac death are a major cause of mortality worldwide. A large fraction of these arrhythmiasare thought to be initiated and perpetuated through a loss of a normal intracellular Ca2+ homeostasis, causing abnormal electrical activity andproarrhythmogenic events, which possibly involves calcium-calmodulin dependent kinase II (CaMKII). In physiological conditions, CaMKII regulates numerous intracellular proteins (RyR, LTCC, phospholamban) in the ...

Project

Problem Youngsters or youngsters with problems ¿ Evidence based care for violent youth in Europe. Historic

University of Antwerp

Problem Youngsters or youngsters with problems ¿ Evidence based care for violent youth in Europe.

Project

Processing of numerical data using clustering techniques. Historic

Vrije Universiteit Brussel

The objective of this application oriented project is to process large numerical datasets by means of various clusreing algorithms. The datases are being constituted and are provided by the 'Tiense Suikerraffinaderij'

Project

Processing of the data of the aneurysm follow-up using growth models Historic

Universiteit Hasselt

This offer represents a formal service agreement between the parties CENSTAT (research institute at Hasselt University), and on the other hand, Maastricht University. The research institute CENSTAT provides Maastricht University research results on 'Processing of the data of the aneurysm follow-up using growth models' under the conditions as stipulated in the present contract.

Project

Process optimization for 3D plotting of scaffolds for vascular tissue engineering Historic

University College Ghent

This recently started PhD research is situated in the area of scaffolding for Tissue Engineering applications. Using a specially designed 3D plotter, porous biodegradable tubular scaffolds will be developed that are eventually destined to serve as scaffold structures for the growing of prosthetic blood vessels. Meant to replace native arteries in function, they must be designed so that they exhibit sufficient burst strength and anisotropic elastic-mechanical properties, as well as the ability...

Project

Process structure function relations of pectin in plant based food systems

KU Leuven

Research summary Recently, studies have provedthat the bio-accessibility of some nutrients, and in particular of lipophilic micronutrients, in food matrices largely depends on the microstructure of the food materials which is affected by processing (Parada & Aguilera, 2007). In fruits and vegetables, microstructural changes are remarkably related to pectin structure changes. Pectin is a family of polysaccharides and a major constituent of plant cell walls. During processing, pectin undergoes ...

Project

PRODEX-9 - NEUROPOLE in support of the AO-10-CONCORDIA-1305 and AO-10-CONCORDIA-1306. Recently ended

Vrije Universiteit Brussel

At altitudes above 2.500m, ventilation in healthy subjects commonly shows an oscillatory behavior with alternating periods of hyperventilation followed by apneas or hypopneas. This breathing pattern, called periodic breathing (PB), seems to prevail at altitudes above 5533m. Although PB has been extensively observed, there are still aspects regarding the adaptation to high altitude that remain unknown. To address the influence of altitude on the respiratory system during longer periods of time...

Project

PRODEX-9 project: Three-dimensional Ballistocardiography in microgravity (Vecto-Ballistocardiography) (B3D) in support of the ILSRA-2009-0729 project Historic

Vrije Universiteit Brussel

Abstract--Balistocardiography was recorded in 3-D on a free floating astronaut in space as well as on healthy volunteers participating to a dry immersion study in a terrestrial laboratory. We demonstrate a new technique suitable for the analysis of 3-D BCG. The spatial curve of the displacement vector is analyzed instead of the three components of acceleration. The technique presented is invariant from the axis of representation and provides important novel physiological information.

Project

Productie en kwaliteitsbeheersing van natrium gereduceerde kaas Historic

University College Ghent

Consumptiedata geven aan dat de natriuminname van heel wat consumenten hoger blijkt te liggen dan de nutritionele aanbevelingen. Een te hoge natriuminname wordt in verband gebracht met een aantal gezondheidsrisico’s zoals hypertensie en hart- en vaatziekten. Een verlaagde natriuminname kan bekomen worden door consumptie van levensmiddelen met een verlaagd zoutgehalte en bijgevolg verlaagd natriumgehalte. Dit stelt de productontwikkelaars in de levensmiddelenindustrie voor een grote uitdaging:...

Project

Production and characterization of nanobodies towards TAFI Recently ended

KU Leuven

Upon activation, thrombin-activatable fibrinolysis inhibitor (TAFI) delays lysis of blood clots. TAFI is activated by trypsin-like enzymes suchas thrombin and plasmin to active TAFI (TAFIa). TAFIa removes C-terminal lysine residues on the surface of the blood clot, thereby hampering plasmin generation and lysis of clots. Therefore, TAFI(a) is considered tobe a risk factor for cardiovascular diseases. Current thrombolytic therapy, mainly based on plasminogen activators (such as t-PA), is very ...

Project

Production kinetics of conjugated fatty acids by lactic acid bacteria during in vitro fermentations Historic

Vrije Universiteit Brussel

Recently, a lot of attention has been directed towards the health advantages of conjugated fatty acids (CFA), in particular the conjugated linoleic acids (CLA). CLA-isomers are naturally ocurring in tissues and products of ruminants, amongst others due to specific biohydrogenation and enzymatic activities of rumen bacteria (isomerases). Via directed feeding, ruminal metabolism can be directed towards higher CLA contents in the milk. Also, a number of lactic acid bacteria, bifidobacteria and p...

Project

Production of conjugated fatty acids in milk via a targeted selection of starter cultures Historic

Vrije Universiteit Brussel

Recently, a lot of attention goes to the health benefits of conjugated fatty acids (CFA), in particular the conjugated linoleic acids (CLA). CLA isomeres occur naturally in tissues and products of ruminants, which is due to the specific biohydrogenation and enzymatic activities by rumen bacteria (isomerases). Via targeted feeding, the rumenal metabolism may be steered to an increased content of CLA in milk: Also, some lactic acid bacteria, bifidobacteria, and propionic acid bacteria seem to p...

Project

Production of Documented mRNA

Vrije Universiteit Brussel

The research institute 'VUB' and the 'eTheRNA' have entered into a service-agreement concerning the project' Production of Documented mRNA'. The research results can be transferred to the company, there can be a reasonable return in case of commercialisation or there is another kind of agreement on intellectual property, as outlined in the concluded agreement.

Project

Production of Documented mRNA Historic

Vrije Universiteit Brussel

The research institute 'VUB' and the 'UZ Antwerpen' have entered into a service-agreement concerning the project' Production of Documented mRNA'. The research results can be transferred to the company, there can be a reasonable return in case of commercialisation or there is another kind of agreement on intellectual property, as outlined in the concluded agreement.

Project

Production of Documented mRNA Historic

Vrije Universiteit Brussel

The research institute 'VUB' and the 'Universitair Ziekenhuis Leuven - Labo Experimentele Gynaecologie' have entered into a service-agreement concerning the project' Production of Documented mRNA'. The research results can be transferred to the company, there can be a reasonable return in case of commercialisation or there is another kind of agreement on intellectual property, as outlined in the concluded agreement.

Project

Production of secretory VHH-IgA based antibodies in plants for passive mucosal immunization

Ghent University

Most pathogens enter through the mucosal surfaces, the entry of which can be blocked by application of antibodies at these surfaces. Our group has produced VHH-IgA based novel antibodies in seeds for application at mucosal surfaces. In this project we aim to study the parameters required for higher efficient production of these antibodies and their efficacy on application at oral and pulmonary mucosa.

Project

Production of Spirulina on nitrogen and phosphorus out of concentrated waste streams.

KU Leuven

In recent years, the cost of nutrients like N and P increased sharply. Many waste streams are relatively rich in N and P. That’s why there is an increasing interest to recycle these nutrients out of waste streams. Algae can take N and P till very low concentrations out of the aqueous waste streams and convert into biomass, which can be used as food, animal feed or energy.When using algae to remove nutrients out of waste streams, it is important that both N and P are efficiently removed. Till ...

Project

Productivity of agro-ecosystems in the Pampa Region with a particular emphasis on the yield of wheat. Historic

University of Antwerp

This project examines the impact of environmental variables (temperature, precipitation, fertilsation, soil conditions, management) on the productivity of wheat in the Pampa Region over the last three decades.

Project

Profiling (sub)clonal architecture and phylogeny in tumors by novel techniques for whole-genome sequence data mining and single-cell genome sequencing.

KU Leuven

A normal human individual has 23 pairs of chromosomes (collectively called the genome) in nearly all of its living cells. In the early 21st century, the sequence of the human genome has been determined, after a 15-year massive international effort. Cancers develop due to accumulated errors in the genome, leading to a cell whose growth can no longer be kept in check and that develops into a mass of cells that endangers the organism. The genomes of cancer cells hence differ significantly from t...

Project

Profound study of blood-brain and blood-CSF barrier disruption in systemic inflammatory disorders Recently ended

Ghent University

SIRS is a mortal disease, associated with systemic inflammation and organ dysfunction. Since the brain is the first organ affected, in this project, we will unravel the role of the CNS-barriers in the communication of the periphery with the CNS. We want to identify when, where and how barrier-leakage is induced, which is vital to identify new potential therapeutic targets.

Project

Profound study on the molecular basis of TNF-induced glucocorticoid resistance Recently ended

Ghent University

Glucocorticoids (GCs) are steroids that bind to the glucocorticoid receptor (GR) and are potent inhibitors of inflammation. Treatment with GCs is often constrained by the occurrence of GC resistance (GCR). In this project we aim to investigate the molecular basis of TNF-induced GCR. Using different technologies (MAPPIT, iMixPro and Mass spectrometry) in hepatocytes, we investigate the effects of TNF on the physiological activities of GR, focusing on its interaction profile and posttranslation...

Project

Prognostic and predictive biomarker analysis in mCRC KRAS wild type patients treated in first line with Erbitux (Cetixumab) in combination with standard chemotherapy in daily clinical practice in Belgium.

University of Antwerp

This project represents a formal research agreement between UA and on the other hand UZA. UA provides UZA research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Prognostic Parameters of the Human Endometrium in Relation to Pregnany in Controlled Ovarian Stimulation. Historic

Vrije Universiteit Brussel

Endometrial aspiration biopsies will be performed at day LH+3 in natural cycles aiming at conception and at the time of fallopain embryo transfer of 2-3 embryos in controlled ovarian stimulation. As already demonstrated in prvious work, these small biopsies , performed with an atraumatic aspiration device, 5 days before the presumed embryo implantation, are unlikely to induce a negative effect on the endometrium. Likewise, cytology of the endometrium will be performed at the day of ovum pick-...

Project

Prognostic Parameters of the Human Endometrium in Relation to Pregnany in Controlled Ovarian Stimulation. Historic

Vrije Universiteit Brussel

Endometrial aspiration biopsies will be performed at day LH+3 in natural cycles aiming at conception and at the time of fallopain embryo transfer of 2-3 embryos in controlled ovarian stimulation. As already demonstrated in prvious work, these small biopsies , performed with an atraumatic aspiration device, 5 days before the presumed embryo implantation, are unlikely to induce a negative effect on the endometrium. Likewise, cytology of the endometrium will be performed at the day of ovum pick-...

Project

Program Evaluation of universal and targeted options for use of hepatitis A vaccines in Belgium. Historic

University of Antwerp

Worldwide about 1.5 million patients still suffer from hepatitis A every year. The causative agent, the hepatitis A virus (HAV), mainly attacks the liver. Symptoms include fever, nausea, abdominal pain and discomfort, dark urine, pale stools and jaundice (yellow colorisation of the eyes and skin). Illness usually lasts one to three weeks and is almost always followed by complete recovery. Small children who become infected usually have no symptoms or the disease goes undiagnosed. Fulminant ca...

Project

Programmed death-1 as novel immunotherapeutic target in malignant pleural mesothelioma : investigation of cancer drug of the year 2013.

University of Antwerp

The prognosis of malignant pleural mesothelioma (MPM) patients remains dismal with a median overall survival of only 9-12 months. The immune system plays a critica I role in protection against MPM with preliminary clinical evidence that immunotherapy can lead to MPM contro!. Here, we will be the first to investigate the immune checkpoint programmed-death 1 (PD-1) and its ligands as novel and potentially highly effective immunotherapeutic targets in MPM.

Project

Program pre-partner (2010) for the Institutional University Cooperation between the University of Kisangani and the Flemish universities. Historic

Universiteit Hasselt

The UIS VLIR program with the university in Kisangani now includes three projects: an institutional project with Professor JM Rigo of Hasselt University, an agricultural project with Professor G. Baert of Ghent University (with research on soil fertility, improved techniques, improved planting material and disease) and a project on biodiversity in relation to food security, with Dr E. Verheyen, University of Antwerp.

Project

Progranulin and C9orf72 in Amyotrophic Lateral Sclerosis and Frontotemporal Dementia. Recently ended

KU Leuven

After Alzheimer’s disease, frontotemporal lobar degeneration (FTLD) is second most common dementia-type in individuals under 65 years. Degeneration in prefrontal and anterior temporal areas leads to variable psychiatric problems (changes in personality and social conduct), and/or disturbances in language with impaired word retrieval and/or comprehension. Behavioral symptoms disrupt normal functioning of the patient, with loss of social and professional activities. In few patients with FTLD, m...

Project

Progranulin in neurodegenerative dementia: genetic, functional and neuropathological characterization. Historic

University of Antwerp

The project aims to employ molecular genetic and pathological studies to further understand the role of progranulin (PGRN) in dementia, and to elucidate the role of modifier genes in the clinicopathological expression of PGRN mutations. These studies will allow designing an optimized protocol for molecular genetic diagnostics. Further, genes modifying disease onset and progression are likely to be effective targets for therapeutic interventions e.g. aiming at disease delay. Furthermore, this ...

Project

Pro-invasive response of tumor-associated myofibroblasts to radiation therapy

Ghent University

The stroma is important in the pathogenesis of colon cancer. Tumor-associated stromal myofibroblasts influence prognosis and predict pre-operative chemotherapy resistance. Therefore, we need to understand the responses of these myofibroblasts to current cancer management regimes. This study is designed to analyze the influence of neoadjuvant radiotherapy on myofibroblasts in cell culture models, mouse models, and in patient material.

Project

Project concerning the care of patients with type 2 diabetes mellitus, coordinated by general practitioners Historic

University of Antwerp

The aim of this project is to assess whether a model of `shared care', coordinated by general practitioners can significantly improve the outcome for patients with type 2 diabetes mellitus. The project will also examine which actions are necessary and effective and will calculate the corresponding care costs. Coordinated primary care teams will be developed, with dieticians, podologists and the diabetes educator as support for the GPs. A shared care program, based on a multidisciplinary care ...

Project

Project Diabetes Care. Historic

University of Antwerp

The aim of this study is to formulate policy recommendations for the quality and organisation of diabetes care, taking into account the severity of disease and associated co-morbidity. In the international literature and existing guidelines, quality indicators and essential preconditions for a hig-quality diagnosis, treatment and follow-up of diabetic patients will be searched for. Also organsation models of optimal diabetes care will be looked for. All relevant literature will be put into ev...

Project

Projects Propofol, Fluconazole and Saquinavir under the framework agreement between BIOMED and SEPS Pharma. Historic

Universiteit Hasselt

These projects are addendums to the framework agreement between Hasselt University and Seps Pharma, sigend in May 2008, where the general conditions are defined and under which Seps Pharma commissioned UHasselt-BIOMED to run experiments and where active compounds and derivatives prodrugs are administered to rats, followed by blood sampling at specific time points and analysis of these compounds.

Project

Project Title: " Solving the interpretation versus misspecification dilemma in psychological, social and behavioral measurements" Historic

Universiteit Hasselt

We propose to develop new methods to fit parsimonious latent-variable modelsparticularly item-response theory (IRT)-based modelsto complex item-response data arising from social surveys and educational and psychological tests. Rather than using a multi-dimensional model, we propose to use the uni-dimensional counterpart and relax the local dependency (LD) assumption to correct for potential 'fallouts' from model misspecification.

Project

Project Title: " Solving the interpretation versus misspecification dilemma in psychological, social and behavioral measurements" Historic

Universiteit Hasselt

We propose to develop new methods to fit parsimonious latent-variable modelsparticularly item-response theory (IRT)-based modelsto complex item-response data arising from social surveys and educational and psychological tests. Rather than using a multi-dimensional model, we propose to use the uni-dimensional counterpart and relax the local dependency (LD) assumption to correct for potential 'fallouts' from model misspecification.

Project

Project Vuilbeekvalley.(a experimental "nature repair" combined with a milieusensibilisation and a vegetation-research. Historic

Vrije Universiteit Brussel

A experimental "nature repair" combined with a milieusensibilisation and a vegetation- research.

Project

Prolactin : from gene to proteine - new physiological and pathological approaches Historic

Vrije Universiteit Brussel

PRL is a major pituitary hormone, which is also expressed in nonpituitary tissues. It is mainly involved in the regulation of fertility, lactation and control of growth.The proposed research has been integrated into three interrelated themes:1/from PRL secreting cell to prolactinomas (cell biology group)2/development of new tools aimed at getting a new insight in human (h)PRL gene regulation (molecular biology group)3/biological function of PRL in extrapituitary tissues (immunology group).Eac...

Project

Prolactin signaltransduction: functional analysis of'Suppressor of cytokine signaling (SOCS)-7': characterization of the biochemical and biological properties. Historic

Vrije Universiteit Brussel

The functional properties of SOCS7 are studied. SOCS7 is expressed in human leukocytes,brain cells, fibroblasts and hematopoïetic cells. SOCS7 interacts with the EGF-R, phosfolipase G gamma and the adaptor molecule NCK and Ash/Grb2. The working mechanisms of SOCS7 will be characterized in epithelial en lymphoid cells. The subcellular localisation of SOCS7 will be identified. The proteins interacting with SOCS7 will be defined and the in vitro rol of SOCS7 will be analyzed.

Project

Proline biosynthese in relation to osmotic adaptation in higher plants : a molecular and physiological approach. Historic

Vrije Universiteit Brussel

Physiological characterization of mutant tobacco plants modified in proline accumulation. Research project RC 370. Promotor: G. Angenon (PLAN; earlier M. Jacobs, PLAN). Co-promotor: L. Slooten (DNTK). Report covering the period 1st jan 1999-31st december 2001, submitted by L. Slooten. Introduction. Proline production is one of the defense mechanisms of plants against osmotic stress. There are two alternative pathways for proline biosynthesis, starting from glutamate or ornithine, respec...

Project

PROLONGATION: BruStem (2): Regenerative medicine of the liver using synergistic mixtures of immature or mature human hepatocytes with mesenchymal stem/progenitor cells or with hepatic stellate cells Recently ended

Vrije Universiteit Brussel

The aim of the project is to explore alternative cell candidates for liver regenerative medicine. Mesenchymal stem/progenitor cells from intra and extrahepatic sources are specifically studied with respect to their proliferation and hepatogenic differentiation potential. In parallel, the selected cells will be investigated regarding their possible use as an in vitro cell model for toxico-pharmacological screening tests. Liver stellate cells will also be studied and developed for screening of ...

Project

Prolylcarboxypeptidase in body weight control: a role for peripheral peptide cleavage? Recently ended

University of Antwerp

In a first part of the project we will investigate the protein expression and enzymatic activity of PRCP in the circulation. Thereafter, we will perform in vitro experiments to study the cleavage of apelin and enterostatin by PRCP and compare cleavage efficiency with other known PRCP substrates. A third objective is to investigate apelin and enterostatin cleavage by PRCP in vivo and to find out whether PRCP influences their effect on body weight and metabolism. Understanding how peptide hormo...

Project

Prolylcarboxypeptidase in body weight control: a role for peripheral peptide cleavage?

University of Antwerp

In a first part of the project we will investigate the protein expression and enzymatic activity of PRCP in the circulation. Thereafter, we will perform in vitro experiments to study the cleavage of apelin and enterostatin by PRCP and compare cleavage efficiency with other known PRCP substrates. A third objective is to investigate apelin and enterostatin cleavage by PRCP in vivo and to find out whether PRCP influences their effect on body weight and metabolism. Understanding how peptide hormo...

Project

Prolyl oligopeptidase and prolyl oligopeptidase inhibitors in models of neurodegeneration. Historic

University of Antwerp

The objective of this project is to investigate the interactions between prolyl oligopeptidase and relevant biomolecules, in vitro and in the cell. We envisage three lines of research: (1) the interaction with alpha-synuclein and the connection with Parkinson's disease, (2) the interaction with tubulin, intracellular transport and secretion, (3) co-localisation with other cytosolic peptidases and the connection with the aggresome.

Project

Prolyl oligopeptidase: partners and pathways in neuronal function and neurodegeneration.

University of Antwerp

In this project we aim (1) to characterize at the molecular level the role of PREP in hallmark processes of neurodegenerative disease: neuronal death, synapse loss and neuroinflammation; and (2) to investigate whether PREP-inhibitors can be used to modulate these processes.

Project

Promoting central nervous system regeneration. Genes that make a difference.

KU Leuven

Injured axons in the Central Nervous System have a very limited capacity for self-repair, in contrast to axons in the Peripheral Nervous System. For this reason, traumatic brain injury often results in devastating and irreversible disabilities. Identifying and understanding the factors which influence whether an axon either fails to regenerate, or regrows and reinnervates its postsynaptic targets, remains a major challenge.To address this problem, our group recently developed a physiologicall...

Project

Promoting healthy eating behavior and physical activity and reducing sedentary behavior in primary school children: effect and processevaluation of an online video intervention in parents Recently ended

Ghent University

1. Devolopment of a method for parents of primary schoolchildren to teach parents parenting skills to obtain health gain in the family through videos and online feedback. 2. Effect- and procesevaluation of this methodology. 3. Development of an implementation guide together with VIGEZ as primary partner and in association with partner organisations on the field.

Project

Promotion of an active lifestyle for working young adults: developing and testing of a smartphone intervention Recently ended

Vrije Universiteit Brussel

For this research project we will develop and test a new smartphone intervention, which will promote an active lifestyle for working young adults.

Project

Proprioceptive impairment and the effect of proprioceptive training in individuals with recurrent non-specific low back pain: from muscle spindle to sensorimotor cortex.

KU Leuven

Low back pain (LBP) is a well-described health problem. It is the main cause of disability and absenteeism worldwide and leads to an estimated annual cost of euro; 1.2 billion for Belgian society. Approximately 84% of the world's population will experience LBP at least once in their life. In 90%, LBP is 'non-specific' as the underlying cause cannot be identified. Although clinical guidelines state that the prognosis of acute non-specific LBP is favorable, two-thirds of patients with non-speci...

Project

Prospective associations between sedentary behaviour, physical activity, physical fitness and metabolic risk in Flemish adult men and women. Recently ended

Ghent University

The present research project focuses on the longitudinal or prospective analysis of physical (in)activity, physical fitness and its components, and some health-related parameters in Flemish adults. Besides the investigation of the validity of a continuous metabolic risk score, relationship with lifestyle behavior and several health-related fitness components will be examined.

Project

Prospective epidemiological and kinematical research on the causal factors of shoulder lesions in throwing athletes. Historic

Vrije Universiteit Brussel

Concerning anterior glenohumeral instability and impingement lesions in the throwing athlete, clinical and biomechanical questions remain. It's still not clear to what extent dysfunctions in glenohumeral rhytm, scapulothoracal motion, muscle co-ordination and proprioception are causally related to the pathogenesis of these clinical syndromes. The studies published are all cross-sectional by nature and consequently, the observed dysfnctions cannot be stated as causal. A prospective study is th...

Project

Prospective evaluation of small molecule EGFR-1 tyrosine kinase inhibition as a first-line treatment in a phase II study in patients with advanced non-small cell lung cancer (NSCLC) harbouring a mutant EGFR-gene.

Vrije Universiteit Brussel

EGFR gene tyrosine kinase (TK) domain mutations increase sensitivity of the receptor both for the effects of ligand and small molecule tyrosine kinase inhibitors (TKI). Retrospective and limited prospective data have indicated impressive activity (response rate and response duration) in patients with advanced EGFR mutant lung cancer. The FIELT study is a single arm multicenter phase II study evaluating the safety and efficacy of first-line erlotinib in patients with advanced NSCLC with a docu...

Project

Prospective intervention study on the implementation of the GP Centre Merksem, ZNA Jan Palfijn. Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand ZNA/HAN. UA provides ZNA/HAN research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Prospective Intervention Study on the implementation of the GP sentry in Merksem, ZNA Palfijn. Historic

University of Antwerp

This research focusses on the implematation of an ouit of hours service in the fysical neighborhoud of a general hospital in Northern Antwerp. Data will be collected before its implementation to study future change of patient fluxes.

Project

Prospective study for a comparison of one and two-cell biopsy after preimplantation genetic diagnosis (PGD) and analysis of the polarisation in mouse-and human embryos and how it is influenced by biopsy. Historic

Vrije Universiteit Brussel

In this part of the project we want to compare single-cell biopsy and two cell biopsy on the level of (1) efficiency and accuracy of the tests and (2) on the level of embryonic development, implantation and pregnancy rates.

Project

Prospective study of patient reported outcomes in spine surgery. Recently ended

KU Leuven

This ongoing project aims at collecting patient reported outcome data at predefined timings before and after spine surgery using standardized questionnaires. This allows for quality auditing and benchmarking as wellas reporting outcomes of new or complex interventions.

Project

Prospective study of physical (in)activity, physical fitness and healthrelated parameters of Flemish adults (2002-2006 à 2012-2015).

KU Leuven

Following objectives and / or research questions are formulated in thisproject:The follow-up study of sedentary behavior, physical activity, sports participation, physical fitness and health in Flemish adults over the past 10 years;To investigate whether specific subgroups have higher risks for unhealthy behavior (inactivity, sedentary behavior, unhealthy diet, smoking) and to analyze the evolution in physical and mental health;To Identify what factors are related to (individual) changes in s...

Project

Prospective study of the direct and indirect costs of the care for HIV/AIDS patients after the introduction of the triple therapy. Historic

Vrije Universiteit Brussel

In a patient centred study persons with HIV/AIDS indicate, with the help of a diary, all care received and all costs made during a one-month period. Besides, a comparison between the costs of HIV/AIDS prior to the introduction of the triple therapy and after the introduction is endeavoured. Moreover, charges will be looked at. This methodology allows to reveal all forms of care, informal care included. On the basis of a questionnaire taken from the patient and the informal carer, the...

Project

Prospective validation of electroencephalography-correlated functional MRI (EEG-fMRI) in the presurgical work-up for epilepsy surgery. Recently ended

KU Leuven

Epilepsy is a frequent neurological disorder with a prevalence of around 0.5%. One third of patients have epileptic seizures that are not controlled with antiepileptic drugs. These refractory seizures have a negative physical, psychological and social impact. Patients with seizures starting from one circumscribed area in the brain (focal epilepsy) can be candidate for epilepsy surgery. The goal of the presurgical evaluation is to define the epileptogenic zone, the part of cortex that is indis...

Project

Prospective validation of electroencephalography-correlated functional MRI (EEG-MRI) in the presurgical work-up for epilepsy surgery. Recently ended

KU Leuven

The scientific objective of the project is the clinical validation of electroencephalography-correlated functional MRI (EEG-fMRI) to enable theuse of EEG-fMRI as a first-line, inexpensive, non-invasive clinical investigation tool in the presurgical evaluation of refractory partial epilepsy. Our scientific approach will be to develop a “gold-standard” imagedisplaying the ictal onset zone, which we will use to validate EEG-fMRI. We will create a database, consisting of a prospective and consecu...

Project

Prosthetic bras, adapted to anatomical changes in the breast and biomechanical abnormalities after breast surgery. Recently ended

Vrije Universiteit Brussel

Prosthetic bras, adapted to anatomical changes in the breast and biomechanical abnormalities after breast surgery.

Project

Protection of chickens against a broad range of Salmonella serotypes by the use of colonization-inhibition attenuated strains with defined living attenuated strains Recently ended

Ghent University

The aim of the project is to create live attenuated Salmonella strains, which protect broiler chickens after oral administration against colonization by Salmonella. These colonization-inhibition (CI) strains are produced by introducing mutations into the genome so these strains can no longer persist in the broiler, while maintaining protection against colonization.

Project

Protection of endothelia for prevention of diabetic cardiomyopathy. Historic

University of Antwerp

The central hypothesis of this project is that disturbances of endothelium-cardiomyocyte cross-talk contribute to the patrhogenesis of diabetes-induced cardiomyopathy. The aims are: 1. To test whether treatment with an endothelium-protective farmacon NEBIVOLOL protects against development of diabetic CMP (and against vascular endothelial dysfunction) 2. To test whether a disturbed paracrine endothelial regulation of cardiac function through neuregulin-1 contributes to diabetic CMP.

Project

Protection of endothelia for prevention of diabetic cardiomyopathy. Historic

University of Antwerp

The central hypothesis of this project is that disturbances of endothelium-cardiomyocyte cross-talk contribute to the patrhogenesis of diabetes-induced cardiomyopathy. The aims are: 1. To test whether treatment with an endothelium-protective farmacon NEBIVOLOL protects against development of diabetic CMP (and against vascular endothelial dysfunction) 2. To test whether a disturbed paracrine endothelial regulation of cardiac function through neuregulin-1 contributes to diabetic CMP.

Project

Protection of the European population from aneugenic chemicals (PEPFAC). Historic

Vrije Universiteit Brussel

The project addresses the basic science, potential medical effects and health problems of exposure to chemical aneugenics. Detailed dose response curves will be produced for a selected panel of aneugenic chemicals in model systems ranging from in vitro cultured cells, rodent bone marrow, peripheral blood cells, gut epithelium to male and female rodent germ cells. Response curves will be used to evaluate the quantitative and qualitative relationships between the levels of test systems and to d...

Project

Protection of the European population from aneugenic chemicals (PEPFAC). Historic

Vrije Universiteit Brussel

The project addresses the basic science, potential medical effects and health problems of exposure to chemical aneugenics. Detailed dose response curves will be produced for a selected panel of aneugenic chemicals in model systems ranging from in vitro cultured cells, rodent bone marrow, peripheral blood cells, gut epithelium to male and female rodent germ cells. Response curves will be used to evaluate the quantitative and qualitative relationships between the levels of test systems and to d...

Project

Protection of the female gametes during radiation therapy by antioxidants. Historic

Vrije Universiteit Brussel

Women are born with a definite, non renewable pool of oocytes within their ovaries. This implicates that important damage to the female gametes, as in the case of abdominal radiotherapy, can potentially lead to an exhaustion of the oocyte pool, followed by infertility and an early start of menopause. It is well known that antioxidants have a benificial effect in protecting cells against radiation induced damage. We will investigate whether model compounds as melatonin and alpha-tocopheryl suc...

Project

Protective effect of the extracellular matrix protein 1 (ECM1) against epidermal basement membrane damage: proof of concept. Historic

University of Antwerp

The extracellular matrix protein 1 (ECM1) was first identified in our laboratory of Molecular Biotechnology (UA) in 1994. From experimental work from our group and others it has been shown that ECM1 is involved in photoageing as well as in chronological ageing. The aims of this project is to evaluate the role of ECM1 as potential photo-protective agent (internal sunscreen) and anti-ageing agent using a skin equivalent model and a transgenic mouse model (Ecm1 +/- heterozygotes and Ecm1 overexp...

Project

Protective effect of xenon on ischemia-reperfusion injury in renal transplantation. Recently ended

KU Leuven

Despite originally being described as chemically inert, the noble gas xenon has been repeatedly demonstrated to exhibit remarkable biological properties. Xenon is described as having many of the characteristics of an ideal inhalational anaesthetic agent. Xenon affects haemodynamic, myocardial performance and the neurohumoral system less than other anaesthetic agents. Furthermore, xenon was found to induce both early and late pharmacological preconditioning in experimental models of myocardial...

Project

Protective effects of neuropoietic cytokines on pathological CNS responses in multiple sclerosis Recently ended

Universiteit Hasselt

Multiple sclerosis (MS) is a demyelinating disease of the central nervous system (CNS) with inflammatory and neurodegenerative components. It is common knowledge that the chronic production of proinflammatory cytokines and neurotoxic factors are the main cause of the typical MS brain pathology. However, there is also a production of factors that counteract inflammation and promote repair during neuroimmunological responses. We hypothise that members of the IL-6 cytokine family have such a ro...

Project

Protective effects of South African plants on mycotoxin-induced mutagenicity and toxicity.

University of Antwerp

The aim of the project is to evaluate extracts of South African plants as detoxifying agents against the mutagenic effects of mycotoxins using in vitro bioassays. Such plant extracts may be added to feeds and foods as a chemo-preventive measure against the genotoxic effects of mycotoxins, particularly aflatoxins.

Project

Protective gastro-intestinal effects of bovine milk fat globule membrane (MFGM) glycoproteins. Historic

University of Antwerp

The objective of the research is to obtain a series of well characterized fractions enriched in MFGM-glycoproteins with a high potential for anti-H.pylori action, due to their anti-adhesion and/or antimicrobial effects. In addition, these fractions will be checked for resistance towards gastro-intestinal digestion, and, in case of low digestibility, for possible effects on the composition and bioactivity of the microbiota in the large intestine.

Project

Protein adsorption on pectin-alginate hydrogels

KU Leuven

The interesting properties of hydrophobins make them of significant interest to biotechnologists, as they have potential for numerous applications. Hydrophobins are amphiphilic molecules mainly produced by Ascomycetes sp. and Basidiomycetes sp. Based on differences in hydropathy patterns and biophysical properties, hydrophobins can be divided into two categories: class I and class II. Hydrophobins can self-assemble into a monolayer on hydrophobic : hydrophilic interfaces such as a water : air...

Project

Protein biomarker discovery from formalin fixed, paraffin embedded human tumor tissues.

KU Leuven

In dit project wordt er op zoek gegaan naar een prognostische eiwit biomerker voor darmkanker. Dit gebeurt aan de hand van een differentiële analyse tussen patiënten die binnen de 5 jaar hervallen en patiënten met een langdurig herstel (10 à 15 jaar). Als startmateriaal wordt gebruik gemaakt van formalin fixed paraffin embedded (FFPE) weefsel. In een eerste fase van het project zal de extractie van proteïnen uit FFPE weefsel geoptimaliseerd worden. Daarnaast zal er ook een verdere optimalisat...

Project

Protein domains as information processing units Historic

Vrije Universiteit Brussel

The fundamental subject of molecular biology is information and more specifically the way in which information is encoded, transformed and perpetuated in living cells and organisms. DNA structure carries evolutionary selected information on how to build proteins, whereas protein conformational and assembly states hold the environmental information on which cells have to act in real-time (1). Notwithstanding its central role, we still do not study the processing of information by biological sy...

Project

Protein domains as information processing units Historic

Vrije Universiteit Brussel

The fundamental subject of molecular biology is information and more specifically the way in which information is encoded, transformed and perpetuated in living cells and organisms. DNA structure carries evolutionary selected information on how to build proteins, whereas protein conformational and assembly states hold the environmental information on which cells have to act in real-time (1). Notwithstanding its central role, we still do not study the processing of information by biological sy...

Project

Protein-protein interactions as a potential target voor antiviral therapy: development of inhibitors of the HCV NS5A-PI4KIII-#945; interaction.

KU Leuven

In this project we will attempt to develop protein-protein interaction inhibitors (PPIIs) that target the NS5A-PI4KIII-alpha interaction and inhibit HCV replication. As part of a rational design process, peptides and peptidomimetics will be developed. In addition, small molecule inhibitors will be developed by screening chemical libraries. Identified inhibitors will be further characterized in terms of antiviral effect, specificity, mechanism of action and genetic barrier to resistance. This ...

Project

Protein-protein interactions in the human fungal pathogen Candida albicans: analysis of essential interactions in vivo using complementary two-hybrid based methods

KU Leuven

Bimolecular fluorescence complementation (BiFC) analysis is a valuable method for protein-protein interaction (PPI) detection in vivo and is complementary to other techniques, such as the classical two-hybrid method. It provides information on in vivo localization of the interaction in the normal cellular environment. The BiFC technique relies on the reassembly of a fluorophore, such as GFP, YFP or CFP, when two proteins each fused to one of the two fragments of the fluorophore interact with ...

Project

Protein-protein interactions: towards a better understanding of interactomes, pathways and domains

Ghent University

Protein-protein interactions (PPI&apos;s) are at the heart of cellular function. In our Methusalem consortium, we will apply several techniques including MAPPIT and protein crystallography in order to obtain a deeper insight into the role of PPI&apos;s at several levels: from large-scale interactome mapping and signalling pathways down to the molecular details of designated protein interaction pairs. This program incorporates the interaction between small molecules and proteins as well.

Project

Protein-protein interactions: towards a better understanding of interactomes, pathways and domains Recently ended

Ghent University

Protein-protein interactions (PPI&apos;s) are at the heart of cellular function. In our Methusalem consortium, we will apply several techniques including MAPPIT and protein crystallography in order to obtain a deeper insight into the role of PPI&apos;s at several levels: from large-scale interactome mapping and signalling pathways down to the molecular details of designated protein interaction pairs. This program incorporates the interaction between small molecules and proteins as well.

Project

Protein structures for health: Structural biology of therapeutic membrane proteins as a starting point for effective rational drug design. Recently ended

Vrije Universiteit Brussel

Drugs targeting GPCRs accounted for over EURO60bn of the pharmaceutical industry's annual sales in 2009, about 25% of the worldwide pharmaceutical market in that year. Ion-channels and transporters represent the second largest class of drugable targets and it is expected that membrane proteins will continue to constitute the majority of drug targets in the future, because it is usually at the membrane level (receptors, channels, transporters) that specificity in signal transduction is achieve...

Project

Protein Tyrosine Phosphorylation in Cancer Development and Applications for Research Recently ended

KU Leuven

The cells of our human body respond on stimuli coming from the environment and from neighboring cells through activation of a cascade of signaling proteins in the cell. By placing a phosphate group on the tyrosine amino acid of the signaling proteins, protein tyrosine kinases (PTKs) will activate the signaling proteins. Furthermore, the protein tyrosine phosphatases (PTPs) are responsible for the well-timed inactivation of the proteins by removing the phosphate group again. Disruption of the ...

Project

Proteome analysis of biotenside synthesis in yeast. Historic

University of Antwerp

Using a proteomics based phenotyping strategy the metabolic profiling of a fermentation reaction will be investigated. For this purpose Candida bombicola is used as a model for the fermentation of renewable vegetable oils and the production of sophorolipids. By optimizing the culture parameters the production will be correlated with the phenotype with the aim to select a strain suitable for industrial fermentation.

Project

Proteome research on the physiology underlying cryotolerance and desiccation in banana meristems. Historic

University of Antwerp

The project's main objective is "To gain a fundamental insight in the cryo-physiology through a proteome study of banana meristems". It aims to contribute to a more fundamental knowledge of some of the physiological processes that underlie adaptation and acclimatization, as weIl as the mechanisms of stress injury. Many of these stress parameters are correlated. For example, water stress is often associated with salt stress in the root and/or heath stress in the leaves. Resistance towards fre...

Project

Proteome technical analysis of cell cycle related protein complexen and their dynamics in higher plants. Historic

University of Antwerp

A lot of physiological processes are carried out by protein complexes. Complex formation between cyclin dependent kinases with varying regulatory cyclins is considered the major driving forces of the cell cycle. The formation and activity of such complexes is strongly regulated by different parameters such as the participating components, phosphorylation/dephosphorylation events, interaction with inhibitory (eg. KIP-related protein) and activating (CDK subunit protein) proteins. Complementar...

Project

Proteome technical analysis of cell cycle related protein complexen and their dynamics in higher plants. Historic

University of Antwerp

A lot of physiological processes are carried out by protein complexes. Complex formation between cyclin dependent kinases with varying regulatory cyclins is considered the major driving forces of the cell cycle. The formation and activity of such complexes is strongly regulated by different parameters such as the participating components, phosphorylation/dephosphorylation events, interaction with inhibitory (eg. KIP-related protein) and activating (CDK subunit protein) proteins. Complementar...

Project

Proteome technical analysis of cell cycle related protein complexen and their dynamics in higher plants. Historic

University of Antwerp

A lot of physiological processes are carried out by protein complexes. Complex formation between cyclin dependent kinases with varying regulatory cyclins is considered the major driving forces of the cell cycle. The formation and activity of such complexes is strongly regulated by different parameters such as the participating components, phosphorylation/dephosphorylation events, interaction with inhibitory (eg. KIP-related protein) and activating (CDK subunit protein) proteins. Complementar...

Project

Protocol agreement on association 2007: Formation and information of workers en the hierachicalline about chemical risks (project n° 23). Historic

Vrije Universiteit Brussel

This project is linked to aim 3 of the federal EPD ESF (consolidation of employment) and concerns the development of a strategy for the formation and information of workers about chemical risks by prevention advisers of the companies with participation of the workers and the members of the hierarchical line. The developed method makes an appeal on the participation of the workers by offering them the opportunity to valorize their competence(in particular for older workers) en increase their k...

Project

Protocol agreement on association 2008: Formation and information of workers en the hierachicalline about chemical risks (project n° 23). Historic

Vrije Universiteit Brussel

This project is linked to aim 3 of the federal EPD ESF (consolidation of employment) and concerns the development of a strategy for the formation and information of workers about chemical risks by prevention advisers of the companies with participation of the workers and the members of the hierarchical line. The developed method makes an appeal on the participation of the workers by offering them the opportunity to valorize their competence(in particular for older workers) en increase their ...

Project

Prototyping and validation of a system for unrestrained awake brain PET imaging of small laboratory animals.

University of Antwerp

Molecular imaging of small laboratory animals typically involves a restraining procedure to avoid movement during the imaging scan. To reduce the impact of stress, animals are anesthetized, but the latter largely influences brain physiology. The current project aims to develop a prototype for awake unrestrained small animal brain positron emission tomography (PET) imaging to better mimic the clinicalsituation where human patients are seldom sedated.

Project

Provide an opportunity to Scale up Health and Immunization Financing in the Democratic Republic of Congo. Historic

University of Antwerp

Description of the project: Collect accurate data and information on the amounts, allocation, use and administration of debt relief resources with special focus on their financial impact on the health sector and the immunization programme.

Project

Provision of expertise in the field of ethical sports , including issues concerning integrity, sexual abuse and violence. Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Provision of scientific advice and support Historic

Vrije Universiteit Brussel

Provision of scientific advice and support from Professor Dr. Johan Vanderfaeillie to the study team personnel in Pfizer's Phase IIIb/IV unit within the development Operations group conducting the Pfizer clinical study with Genotropin known as A6281298.

Project

Pseudomonads and bacilli as important spoilage Historic

University College Ghent

Melk en afgeleide zuivelproducten vormen een basiselement in de dagelijkse voeding van de mens. In België wordt jaarlijks gemiddeld 2,9 miljard liter rauwe melk opgehaald en verwerkt. De kwaliteit en de veiligheid van de melk is dan ook essentieel. Bacteriën aanwezig in de rauwe melk worden afgedood door een hitteproces, namelijk pasteurisatie (16 s bij 72-80°C), sterilisatie (15 min bij 120°C) of Ultra High Temperature (UHT) behandeling (2 à 4 s bij 145°C). Sommige bacteriën (behorend tot de...

Project

Psychological and behavioral trait-frailties in the etiopathogenesis of severe major depressive disorder.

University of Antwerp

The research project aims at investigating underlying psychological and behavioral mechanisms of severe major depressive disorder. Therefore two lines of research were set up. In the first part, the personality structure of patients was assessed extensively by means of rating scales and questionnaires. In the second part, neuropsychological assessment techniques were applied to investigate psychomotor functioning in geriatric patients with MDD.

Project

Psychological impact of screening for insulin-dependent diabetes mellitus (IDDM). Historic

Vrije Universiteit Brussel

A large population screening program for the early detection and prevention of IDDM was initiated in Flanders (Belgium). Nondiabetic first-degree relatives at risk of developing diabetes are being identified in preclinical phase and invited to take part in future prevention trials. In parallel with this medical project, a study was set up to examine the psychological impact of screening for IDDM. The aim of this study is to identify psycho-social variables which could improve future recruitme...

Project

psychomotor symptoms in depression. Historic

University of Antwerp

The first part of this project aims to investigate the relationship between functional outcome and psychomotor retardation in a large group of depressed patients. In addition, the relationship will be explored between fine and gross motor activity, two important domains in the cluster of psychomotor symptoms. The second part of this project will concentrate on the brain activity accompanying the disturbances of action. Applying EEG and functional imaging techniques, activity in the (merely pr...

Project

Psychopathology in premature born children, protective and risc factors in the development of stresscoping. Historic

University of Antwerp

Psychopathology in premature born children, protective and risc factors in the development of stresscoping.

Project

Psychopathology in premature born children, protective and risc factors in the development of stresscoping. Historic

University of Antwerp

Psychopathology in premature born children, protective and risc factors in the development of stresscoping.

Project

Psychosocial risk factors and work accidents Historic

Ghent University

Research on the relationship between psychosocial factors at work and (major) accidents in Belgium. Prevention of security in the companies by also paying attention to the prevention of psychosocial aspects.

Project

Public health interventions. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand Erasmus Mundus. UA provides Erasmus Mundus research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Public health interventions. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand Erasmus Mundus. UA provides Erasmus Mundus research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Public Housing and Public Housing policies in Greater Cairo Historic

Vrije Universiteit Brussel

Joint PhD for Dooa Ahmed Shehata Abouelmagd

Project

Pulmonary rehabilitation and systemic inflammation. Historic

University of Antwerp

Pulmonary rehabilitation and systemic inflammation.

Project

Pulmonary toxicity of nanoparticles, influence on the epithelial barrier. Recently ended

KU Leuven

Normal 0 21 false false false NL-BE X-NONE X-NONE MicrosoftInternetExplorer4 EN-US" lang="EN-US">Nanoparticles (1-100 nm) are being used in several industries for a verydiverserange of products and due to their small size they might distribute tothe smallest biological structures, access and interact with fine cellular andmolecular structures. Inhalation is considered to be the most important routeof exposure, but the deleterious effects induced by inhalation of nanoparticlesare not limited t...

Project

Purchase of a new greenhouse because of the early defect of a greenhouse with day/nights lights. Historic

University of Antwerp

Purchase of a new greenhouse because of the early defect of a greenhouse with day/nights lights.

Project

Purinergic receptor subtypes : interplay between different activation pathways in platelets and vascular cells. Historic

University of Antwerp

Research of the UA partner is focused on the function and expression of P2 purinergic receptors in models of atherosclerosis (cholesterol-fed rabbits and Apo-E deficient mice) and of intimal thickening (placement of silastic collar around rabbit carotid artery). Isolated arteries with and without lesions are studied and different agonists and antagonists are used to characterise vasomotor function of purinergic receptors in arteries with and without endothelial cells. RNA is extracted from ad...

Project

Purinoceptors in the enteric nervous system, and their function in the pathogenesis of intestinal suffering during inflammation. Historic

University of Antwerp

Using different morphological (multiple immunofluorescence, confocal microscopy,¿) and molecular biological techniques (in situ hybridisation, Real-Time PCR,¿), the distribution of P2 purinoceptors, playing a key role in transducing mechanosensory signals, in the murine gastrointestinal tract is studied during normal physiological conditions and during gastrointestinal inflammation (i.e. intestinal schistosomiasis).

Project

Putative noxious effects of the insecticide deltamethrin on the enteric nervous system in mammals. Historic

University of Antwerp

The insecticide deltamethrin, a powerful synthetic pyrethroid, acts toward insects by ingestion or contact, altering normal neuronal function. Deltamethrin is known to modify sodium channel activities and intracellular calcium concentrations in neurons. It is of moderately high toxicity in mammals. Deltamethrin will increasingly be used in agriculture, resulting in an increased exposure of man to deltamethrin in time. This project focuses on the effects of the prolonged oral congestion of non...

Project

Puumala hantavirus variation in heterogeneous environments in western Europe : ecological drivers and epidemiological outcomes Historic

University of Antwerp

This project aims to investigate how large and small scale genetic variation of Puumala virus (PUUV), a common hantaviral zoonosis in Europe, is linked to heterogeneity in PUUV epidemiology and potential micro-evolutionary patterns in Belgium. Secondly, want to identify the ecological drivers of the observed genetic variation in PUUV, taking into account reservoir host genetics.

Project

Puumala hantavirus variation in heterogeneous environments in western Europe: ecological drivers and epidemiological outcomes. Historic

University of Antwerp

We aim to investigate space-time genetic variation of PUUV in Belgium and how it is linked to heterogeneity in PUUV transmission efficiency, persistence and potential micro-evolutionary patterns. Second, we want to identify the ecological drivers of the observed PUUV variation, taking into account reservoir host genetics.

Project

PYBLIK: set up of a contactpoint and lecture series on the design of public spaces in the Brussels Capital Region.

Vrije Universiteit Brussel

PYBLIK: set up of a contactpoint and lecture series on the design of public spaces in the Brussels Capital Region.

Project

Pyrethroid resistance in malaria vectors: KDR gene variation and detection. Historic

University of Antwerp

Pyrethroid resistance in malaria vectors: KDR gene variation and detection.

Project

Pyrethroid resistance in malaria vectors: KDR genvariation and detection. Historic

University of Antwerp

Malaria vector control is primarly based on the use of bed nets impregnated with pyrethroid insecticides. The appearance of insecticide resistance in a mosquito population can nullify the positive effect of the vector control. Appropriate monitoring of resistance to insecticides is an integral component of planning and evaluation of insecticide uses in malaria control programmes. The usual means of detecting insecticide resistance is a bioassay where a relative large number of insects has to...

Project

Qualitative evaluation of the program prevention school Historic

Vrije Universiteit Brussel

Research on how to prevent abscence in schools in Brussels

Project

Quality control and validation of in-vivo methods, including intrumentation used for the measurement of Body Composition (BC) issues in Health Sciences and Occupational Ergonomics. Historic

Vrije Universiteit Brussel

Most haelth and ergnonomic professionals are most likely using in-vivo Body Composition (BC) methods including anthropometry, skinfolds with associated formulae and indexes, bioelectrical impedance analysis, densitometry, air & water displacement techniques, ultrasound, DEXA e.g. for the determination of bone density, bone mass, adipose tissue (Fat), muscle mass and fat free mass. These measurements result into values that are indirect. In spite of this they are widely applied in Health Scien...

Project

Quality indicators for general medicine practioner's. Historic

University of Antwerp

The aim of the projcet is to introduce a framework for quality assurance in General Practice in Belgium. Indicators on organisation and clinical indicators will be used.

Project

Quality of Life

Vrije Universiteit Brussel

Presentation International Congress in USA

Project

Quality of medical drugs : development of capillary electrochromatography Historic

Vrije Universiteit Brussel

In this project capillary electrochromatography (CEC) and capillary liquid chromatography (CLC) are used as separation techniques for the chiral separation of drug molecules on the one hand, and for the development of fingerprints of plant extracts on the other. For the latter applications, the use of an ELS detector can present an additional advantage, as it allows detecting substances that do not absorb in the UV range. Regarding chiral separations, it is the intention to define generic sep...

Project

Quality of palliative care in primary care Recently ended

Vrije Universiteit Brussel

As part of my pre and postdoctoral FWO fellowship I coordinated the Belgian SENTI-MELC study and international EUROSENTI-MELC study (2005-2010) describing the circumstances of dying in Belgium, the Netherlands, Spain and Italy, using representative GP networks. In 2013-2014, the EUROSENTI-MELC study will be continued focusing on the development and testing of quality indicators to measure palliative care in primary care, nationally and internationally. Based on previous work of the End-of-Lif...

Project

Quantative measure of cancer treatment response using automated segmentation on volumetric and dynamic contrast enhanced CT-images in combination with pet. Historic

Vrije Universiteit Brussel

Previous studies have identified a large inter-observer variability in the definition of Gross Tumor Volume (GTV) in lung cancer due to for instance difficulties in discriminating between tumor and aelectasia, and influence of window settings on CT scan. Accurate GTV definition is a cornerstone in quality assurance in radiotherapy and any uncertainty will not only jeopardize the clinical outcome but also comparison between clinicians, institutes and more importantly different treatment modali...

Project

Quantification and molecular differentiation of Campylobacter in the broiler production chain to define interventions to obtain a reduction of the number of human campylobacter cases

Ghent University

Development of a quantitative RT-PCR for the enumeration of Campylobacter on poultry meat. Quantification of the Campylobacter contamination during slaughter and cutting of broiler carcasses originating from positive and negative batches and identification of risk factors influencing the contamination level. Determination of intervention strategies to control the contamination and estimation of the reduction of the Campylobacter exposure for consumers.

Project

Quantification of diversity and local adaptation in the wild genes reservoir of local tree species ensuring an optimal cultivation of provenance material. Recently ended

KU Leuven

Many species, including people, depend ontree species for their survival. This stresses the importance of safeguardingtree populations worldwide, through maintaining genetically variable treepopulations. Genetic variation not only counteracts inbreeding depression, aprocess that results in individuals with low viability and low reproductiveoutput, but also increases the number of genetic variants underlying treecharacteristics that are beneficial in future environmental conditions, such asres...

Project

Quantification of fluxes between - and residence times in different carbon pools in the soil of a Scots pine forest. Historic

University of Antwerp

Soil organic matter (SOM) constitutes an important carbon (C) pool that exchanges C with the atmosphere. The sequestration of SOM can only be assessed by means of complicated biogeochemical models that are very difficult to parameterize. The requested funding will be used to perform measurements of 13C, 14C and 18O, which can be used to estimate the turnover of different SOM pools and to separate heterotrophic from autotrophic respiration. The main objectives are: 1) to estimate how fast do d...

Project

Quantification of functional knee joint instability by sudden balance disturbance following conservative or surgical treatment of knee ligament injury. Historic

Vrije Universiteit Brussel

Governement and health providers promote the application of effective health care. Evidence Based Medecine can only be applied if effectiveness can be found. There is insuffient information about functional instabilty which refers to the patients' complaints with giving way of the knee during activities of daily living. Using a sudden balance disturbance of the knee in the standing position the presented research protocol will examine functional instability by the reaction of the body durng t...

Project

Quantification of Multicomponent Synergistic Effects in Microporous Crystalline Catalysts Historic

Vrije Universiteit Brussel

During previous work on synzymes (e.g. cytochrome P450 mimic in zeolite y), it was shown that adsorption effects were responsible for the peculiar kinetics in some catalysts. A number of systems were found where multicomponent reactions showed selectivities very different from those expected from single component reaction tests. A number of systems will be investigated by: - batch and continuous reactions - adsorption measurements - molecular modelling. A methodology will be developed to pred...

Project

Quantification of the transfer: reed residues-zooplankton' in the sea scheldt. Historic

Vrije Universiteit Brussel

This proposal relates to the general framework of the OMES project, concerning the role of the marsh vegetations in the ecosystem 'Zeeschelde'. If future developments result in a considerable increase in reed vegetation, it will be important to know what happens to the reed deritus that is yearly compounds. These processes are studied within the OMES project.Another part of the reed deritus is a potential food source for the zooplankton, and the study of the transfer reeds- zooplankton is not...

Project

Quantification of varicella-zoster virus boosting mechanisms with their public health implications for vaccination. Recently ended

University of Antwerp

The general aim is (1) to quantify exogenous boosting by means of an observational longitudinal study, (2) implement this result in newly adapted epidemiological models, (3) assess the population effects of vaccination against VZV and (4) apply this to inform a cost-utility analysis examining vaccination against VZV.

Project

Quantification of Wilms tumor gene (WT1) transcripts and of immune activation to monitor the therapeutic efficacy of denditric cell vaccination in acute myeloid leukemia.

University of Antwerp

In this project, we want to investigate the predictive value of WTt RNA levels in peripheral blood as a tumor marker for scoring effectiveness of WT1-targeted DC vaccination in AML patients and for predicting relapse. In addition to the tumor marker, we will also examine the tumor microenvironment by monitoring immune activation to judge response to the therapeutic cancer vaccine. In this way, we will be able to distinguish patients responding to the therapeutic DC vaccine from patients at hi...

Project

Quantifying aberrant mechanical loading in medical knee osteoarthritis

KU Leuven

Normal 0 21 false false false PT X-NONE X-NONE 0cm;margin-left:0cm;margin-bottom:.0001pt;text-align:justify;line-height:150%;mso-layout-grid-align:none;text-autospace:none">mso-ansi-language:EN-US;mso-bidi-font-weight:bold" lang="EN-US">Knee joint loading mso-ansi-language:EN-US" lang="EN-US">has been identified as bold">potential risk factor affecting development and progression of kneeosteoarthritis (OA). The precise relationshipsbetween OA and mechanical loading of the knee joint are as ye...

Project

Quantifying the distributiion and impact of alien fish species on ecosystem structure and functioning in surface waters

Ghent University

The distribution and impact of invasive fish species on ecosystem structure and functioning will be investigated. Detection will be done via environmental DNA monitoring. An integrated approach will be used, coupling existing data with data obtained from lab experiments and ecological models. Food web and functional response models will be developed to obtain insight into the ecology of invasive fishes.

Project

Quantifying the sensitivity of aquatic communities in lakes to anthropogenic chemicals and environmental fluctuations throughout history (2000 BC to present) Recently ended

Ghent University

During the last 4000 years, aquatic communities have been increasingly exposed to anthropogenic stress. The consequences for the dynamic behavior of these communities is unknown. This project will gather paleoecological data that will be analyses with mathematical modeling to examine if community dynamics in European lakes can be predicted from anthropogenic stress.

Project

Quantifying the transmission dynamics of two rodent-borne viral infections in a variable environment. Recently ended

University of Antwerp

For a better understanding of the transmission of infections, an integrative approach can prove very useful. With the ultimate aim of creating stochastic, individual-based mathematical models of the transmission of a rodent-borne virus (Mopeia virus in the African multimammate mouse Mastomys natalensis), we will use laboratory as well as field experiments to collect the data necessary to feed the models. These models allow us to test fundamental epidemiological theories that have so far prove...

Project

Quantifying the transmission dynamics of two rodentborne viral infections in a variable environment.

University of Antwerp

For a better understanding of the transmission of infections, an integrative approach can prove very useful. With the ultimate aim of creating stochastic, individual-based mathematical models of the transmission of a rodent-borne virus (Mopeia virus in the African multimammate mouse Mastomys natalensis), we will use laboratory as well as field experiments to collect the data necessary to feed the models. These models allow us to test fundamental epidemiological theories that have so far prove...

Project

Quantifying threshold conditions for landward erosion and seaward expansion of tidal marsh shorelines. Historic

University of Antwerp

Tidal marshes, which are vegetated wetlands within larger-scale tidal basins, play a critical role in the physical and biological functioning of that tidal basin. The processes that control the landward erosion and seaward expansion of marsh area are, however, hardly understood. Here we aim at quantifying the hydrodynamic and geomorphic threshold conditions that cause: (1) the start of marsh expansion, by vegetation establishment on an initially bare mudflat. (2) the start of marsh erosion, b...

Project

Quantifying threshold conditions for landward erosion and seaward expansion of tidal marsh shorelines. Recently ended

University of Antwerp

Tidal marshes, which are vegetated wetlands within larger-scale tidal basins, play a critical role in the physical and biological functioning of that tidal basin. The processes that control the landward erosion and seaward expansion of marsh area are, however, hardly understood. Here we aim at quantifying the hydrodynamic and geomorphic threshold conditions that cause: (1) the start of marsh expansion, by vegetation establishment on an initially bare mudflat. (2) the start of marsh erosion, b...

Project

Quantifying threshold conditions for landward erosion and seaward expansion of tidal marsh shorelines.

University of Antwerp

Tidal marshes, which are vegetated wetlands within larger-scale tidal basins, play a critical role in the physical and biological functioning of that tidal basin. The processes that control the landward erosion and seaward expansion of marsh area are, however, hardly understood. Here we aim at quantifying the hydrodynamic and geomorphic threshold conditions that cause: (1) the start of marsh expansion, by vegetation establishment on an initially bare mudflat. (2) the start of marsh erosion, b...

Project

Quantitative analysis of time-and cell type-dependent immune responses after autologous and allogeneic stem cell transplants in the brains of healthy mice. Historic

University of Antwerp

This project represents research between the UA and a private institution. UA provides the private institution the research results named in the title of the project.

Project

Quantitative assessment of exposure and health effects of traffic emissions in Flanders with special attention to ultrafine particles (UFP): pilot project in selected hot spot (s) Historic

Universiteit Hasselt

Objectives are as follows: - selection of hot spots for ultrafine particulate exposure - drawing up a plan for: - Measuring UFP from traffic; - Assessing the relative importance of UFP to other traffic indicators in relation to possible health effects; - Estimate the personal exposure based on measurements / modeling and biomarkers - Assessing the health effects based on biomarkers

Project

Quantitative assessment of the spasticity and spasticity reducing physical therapy techniques in hemiparesis after stroke. Historic

Vrije Universiteit Brussel

The research aim is the quantitative assessment of spasticity and spasticuty reducing physical therapy techniques in patients with hemiparesis after stroke. 1) Construction of an assessment system for the quantitative measurement of spasticity and biomechanical stiffness in hemiparesis. 3) Evaluation of the correlation between two clinical assessment scales and the quantitative assessment of spasticity. 4) Evaluation of the effet of reflex inhibiting patterns and reflex inhibiting inflatable ...

Project

Quantitative cultures of PSB samples from COPD patients besides and during an exacerbation Historic

Vrije Universiteit Brussel

This project aims to research a number of parameters (body posture, the amount of fluid, injection pressure and speed, waiting time, inspiration pressure, collection of sluice fluid, ...) in order to improve the BAL technique.

Project

Quantitative deep sequencing to monitor in vivo influenza A virus quasi-species evolution in the immune host Recently ended

Ghent University

The comparison of the quasi-species evolution of influenza A viruses in naive and immune hosts by the use of deep sequencing whereby the obtained escape mutations will be characterised in terms of fitness, competitive advantages and stability. This will give a detailed insight in the complex dynamic nature of the influenza A virus quasi-species diversity under different immune selection pressures.

Project

Quantitative deep sequencing to monitor in vivo influenza A virus quasi-species evolution in the immune host Recently ended

Ghent University

The comparison of the quasi-species evolution influenza A viruses in naive and immune hosts by the use of deep sequencing whereby the obtained escape mutations will be characterised in terms of fitness, competitive advantages and stability. Thiss will give a detailed insight in the complex dynamic nature of the influenza A virus quasi-species diversity under different immune selection pressures.

Project

Quantitative deep sequencing to monitor in vivo influenza A virus quasi-species evolution in the immune host Recently ended

Ghent University

Next generation sequence analysis will be applied to monitor the influenza A virus evolution in the immune host. The aim of this research is to understand how influenza viruses vary in the immune host.

Project

Quantitative extraction of normaal values from (diffusion weighted) MR images of the premature brain. Recently ended

University of Antwerp

Concretely, we will develop a DTI-atlas for the premature brain (0 to 4 year) by combining non-affine registration techniques and new denoising algorithms for DWI-data as well as accounting for different growing speeds of the premature brain. Nowadays, DWI is also seen as one of the fastest growing modalities for preterm brain analysis.

Project

Quantitative metagenomics: application of bacterial strains as internalstandards for fecal microbiome analysis.

KU Leuven

The exploitation of the predictive/diagnostic potential of metagenomic analyses of body-associated microbial ecosystems and the translation of the technique into medical practice are currently hampered by the explorative/qualitative nature of the methods applied. This project aims at the development of quantitative metagenomic techniques that will allow to overcome these hurdles and to exploit the full potential of microbiome research in reproducible and truly quantitative diagnostics.

Project

Quantitative proteomic characterization of cellular targets of withaferin A involved in cancer therapy chemosensitisation in B-cell chronic leukemia cells.

University of Antwerp

Drug resistance is well known in chronic lymphocytic leukemia therapy, where multidrug-resistant lymphoid cancers defy the most powerful chemotherapeutics available. In this respect, there is a renewed interest in multifocal anti-cancer compounds which simultaneously inhibit multiple signal transduction/survival pathways. We have identified Withaferin A (WA) as a very effective anti-cancer compound, which chemosensitizes various therapy resistant cancers, by binding molecules from different s...

Project

Quantitative real-time PCR (qPCR) based analysis of polyhydroxyalkanoate (PHA) producing microorganisms in activated sludge

University of Antwerp

Production of poly-3-hydroxyalkanoate (PHA) bioplastic by activated sludge is a promising strategy for valorization of wastewater, which could simultaneously lower the still too high production cost of PHAs. The aim of this project is to develop a fast and reliable quantitative PCR assay for routine analysis of PHA producing microorganisms in activated sludge.

Project

Quantitative study on the influence of process design on the biophysical microenvironment in 3D cell cultures.

KU Leuven

In bone tissue engineering, in vitro bioartificial tissue is grown for use in transplantation in large and non-healing bone defects. The first step is achieving cell growth in three dimensions. Due to mass transportrestrictions, the maximum size of three-dimensional cellular constructsis limited. A solution is provided by creating microtissues, in which ahigh cell viability is maintained and subsequently assembling them intolarger-scale constructs. For example, progenitor cells can be seeded ...

Project

Quantitative tomographic segmentation of magnetic resonance images

University of Antwerp

This project proposal aims at the development of novel methods for segmentation of magnetic resonance images (MRI). Whereas conventional segmentation methods solely employ the reconstructed MRI image, we will target tomographic MRI image segmentation in which the original data from the MRI scanner is exploited. It is expected that this will lead to significantly improved segmentation accuracy.

Project

Quantitavive analysis of SC lipids after tape stripping combined with non-invasive efficacy measurements. Historic

Vrije Universiteit Brussel

The barrier function of the skin is situated in the stratum corneum and consists of horny keratinocytes surrounded by lamellar lipid bilayers, and a hydrolipidic film present on the skin's surface. Some skin pathologies show an impaired barrier, but it is not sufficiently known which lipids are involved, nor at what level the changes occur. By developping a standardised non-invasive 'stripping' model, direct measurements on volunteers' skin will be possible by bioengineering techniques. The ...

Project

Rab27B-mediated pre-metastatic niche formation: possible therapeutic opportunities Recently ended

Ghent University

Key players in exocytic and endocytic vesicle transport include Rab GTPases. The Rab27B GTPase regulates invasive growth and metastasis in breast (Hendrix et al. J. Natl. Cancer Inst. 2010). We are determined to dissect the role of Rab27B-associated vesicles in induction of invasive growth and establishment of the pre-metastatic niche using cell culture and mouse models and multidisciplinary translational approaches.

Project

Radiation and radionuclides in a multi-contaminant context : effects induced in Lemna minor. Historic

University of Antwerp

This project represents a formal research agreement between UA and on the other hand SCK. UA provides SCK research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Radiation dosimetry methodologies for in vitro and in vivo studying the effects of spatio-temporally modulated irradiations in the context of advanced radiation therapy Historic

Ghent University

In-vivo exploration using a skinfold chamber system, of the cell response to spatio-temporal modulated dose distributions, starting from interesting in-vitro observations of increased metabolic activity at intermediate doses. The realization and dosimetric quality assurance of the system is the subject of a PhD project and is an essential link in the global project (FWO application) in which the research team assesses the cellular effects of advanced radiation therapy (IMRT).

Project

Radiation dosimetry methodologies for in vitro and in vivo studying the effects of spatio-temporally modulated irradiations in the context of advanced radiation therapy. Historic

Ghent University

In-vivo exploration using a skinfold chamber system, of the cell response to spatio-temporal modulated dose distributions, starting from interesting in-vitro observations of increased metabolic activity at intermediate doses. The realization and dosimetric quality assurance of the system is the subject of a PhD project and is an essential link in the global project (FWO application) in which the research team assesses the cellular effects of advanced radiation therapy (IMRT).

Project

Radionuclide therapy with nanobodies for the treatment of cancer Recently ended

Vrije Universiteit Brussel

Nuclear medicine therapy uses unsealed radioactive sources for the selective delivery of radiation to tumours or target organs.

Project

Radio sensibilsationable potential of M1-polarized macrophages in Colorectal Cancer: the role of the mediated inhibition of cellular respiration by NO. Recently ended

Vrije Universiteit Brussel

Radio sensibilsationable potential of M1-polarized macrophages in Colorectal Cancer: the role of the mediated inhibition of cellular respiration by NO.

Project

Radiosensilatization of hypoxic tumor cells by nitric oxide through induction of apoptosis Historic

Vrije Universiteit Brussel

Hypoxia- induced radioresistance is recognized as a major obstacle in tumor radiotherapy. Our laboratory explored in previous projects the mechanisms of chemo/radioresistance known to resist conventional therapie: radiosensitizing activity of sodium nitroprusside (a nitric oxide generating donor) in hypoxic cells was shown. Our new project links up with our previous experiences and will explore wether NO can induce apoptosis in hypoxic tumor cells and thereby increase radioresponse. The hypot...

Project

Radio Therapy: Risk factors for radiation wounds Historic

Universiteit Hasselt

This offer represents a formal service agreement between the parties CENSTAT(research institute at Hasselt University), and on the other hand, JESSA ZIEKNHUIS vzw. The research institute CENSTAT provides JESSA ZIEKNHUIS vzw research results on 'Radio Therapy: Risk factors for radiation wounds' under the conditions as stipulated in the present contract.

Project

RADOX.

KU Leuven

No English Abstract

Project

Raman optical activity as the driving force in the spin-off of 'The European Centre for Chirality ".

University of Antwerp

This project represents a research agreement between the UA and on the onther hand IWT. UA provides IWT research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Randomised controlled trial of the effectiveness of PDSAFE to prevent falls among people with Parkinson's Disease.

KU Leuven

This study aims to recruit 600 people with Parkinson’s disease (PD). Itconcerns a multi-centre, single-blinded, randomised, controlled trial. The study intends to compare a fall prevention program PDSAFE (a novel personalised treatment based on the latest published research evidence and our extensive experience of managing the movement and stability problems of people with PD) with routine care (provision of a Parkinson’sinformation DVD and fall education booklet combined with standard care)....

Project

Rapid climate warming effects on the relation between benthic biodiversity and biogeochemical functioning in polar marine ecosystems

Ghent University

Polar marine ecosystems are particularly experiencing strong modifications, because of their sensitivity to sea surface warming and sea ice retreat. We aim to investigate the influence of rapidly changing environmental conditions on sea floor biodiversity and biogeochemistry in polar marine ecosystems. Since the effects will be system-specific, two very contrasting ecosystems are targeted: a deep-sea Arctic and a coastal Antarctic site.

Project

RASCOMBAT.

KU Leuven

Combat Cognitive and Behavioral Deficits in RASopathies.

Project

Rational use of existing and new methodologies in separation techniques Historic

Vrije Universiteit Brussel

Separation technology contains a number of techniques, as for instance High Performance Liquid Chromatography (HPLC) and Capillary Electrophoresis (CE), which are widely used in pharmaceutical and chemical analysis. Constantly, new developments are introduced in the different techniques. For example, new types of stationary phases for HPLC are developed, new chiral selectors for chiral separations in CE are synthesized and of the frequently used stationary phases the number of different brand...

Project

Rationele en plaatsspecifieke beheersing van schurft bij appel

KU Leuven

De algemene doelstelling is te komen tot een rationele en plaatsspecifieke bestrijding van schurft op basis van doelgerichte monitoring van de initiële sporendruk in de aangetaste bladeren van vorig seizoen, het resistentieniveau van de initiële schurftpopulatie voor bepaalde fungicidenen de actuele ascosporenuitstoot op een perceel.

Project

Reactivity of biogenic Si in terrestrial ecosystems: a crucial missing concept in our knowledge of aquatic-terrestrial links in the silica cycle and the coupled C-sinks. Recently ended

University of Antwerp

This project aims to quantify the reactivity of the bio-Si buffer in diverse ecosystems and at different temporal and spatial scale levels. An innovative extraction procedure will be developed and detailed dissolution experiments will be carried out. This innovating concept will allow us to address a crucial missing link in our knowledge of aquatic-terrestrial coupling in the biogeochemical silica cycle and the coupled carbon sinks.

Project

Realization of an interactive anti-tobacco education pack for schoolchildren.

University of Antwerp

This project represents a formal research agreement between UA and on the other hand the Flemish Public Service. UA provides the Flemish Public Service research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Realization of the administrative -logistic component of an international hub function in the research field neuroinformatics. Historic

University of Antwerp

Realization of the administrative -logistic component of an international hub function in the research field neuroinformatics.

Project

Realizing a paradigm shift in gas chromatography: enhancing detection sensitivity and separation speed using ordered micro-pillar array columns

Vrije Universiteit Brussel

The separation and detection possibilities of a new packed bed column format (Pillar Array Columns, PAC) will be explored for use in gas chromatography (GC). This format appears to be very promising for liquid chromatography (LC), but might also offer significant advantages for GC in cases where mass loadability and mass flow rate are critical.

Project

Realizing the European network in Biodosimetry (RENEB)

Ghent University

the goal of RENEB is to establish a sustainable European network in biological dosimetry involving 23 organisations from 16 countries identified by the TENEB survey, that will guarantee highest efficiency in processing and scoring of biological samples for fast and reliable results implemented in the EU emergency management in case of a large-scale radiological accident. A well organised cooperated action involving EU laboratories will offer the only chance for a fast and reliable dose asses...

Project

RealThe aging proteome and peptidome of the nematode model Caenorhabditis elegans. Recently ended

Ghent University

By means of mass spectrometry, we will study the proteomic and peptidomic patterns in aging Caenorhabditis elegans nematodes. These patterns will also be focused on in worm populations showing lifespan extension (by mutation in the Ins/IGF signal transduction pathway, the mitochondria and by dietary restriction). We will search for functional overlap in the resulting patterns.

Project

Real-time localization system for population studies of small birds. Recently ended

University of Antwerp

This project will develop a new real-time localization system for large-scale monitoring of movements of small free-living birds. The ultimate aim is to develop small miniaturised tags (max 1g) that send spatial information to detection modules in the field, which in turn send this information to a central receiving system. The objective of the current proposal is to clarify the limits and possibilities of this system.

Project

Real Time PCR, 96 reactions including reagents, samples Historic

Universiteit Hasselt

This offer represents a formal service agreement between the parties CMKMB (research institute at Hasselt University), and on the other hand, Provinciale Hogeschool Limburg. The research institute CMKMB provides Provinciale Hogeschool Limburg research results on 'Real Time PCR, 96 reactions including reagents, samples' under the conditions as stipulated in the present contract.

Project

Recellularization of decellularized rad liver with human hepatic cells as a novel 3D culture model for pharmaco-toxicological research

Vrije Universiteit Brussel

The liver, and in particular the hepatocyte, plays a key role in the occurrence of drug-induced liver damage. Hence, primary hepatocyte cultures are currently the gold standard in vitro tool to investigate potential adverse effects of candidate pharmaceuticals in the early phases of drug development. However, because of the progressive loss of their specific in vivo hepatic properties during standard 2D culture, primary hepatocyte cultures can at present only be used for short-term studies. ...

Project

Reception of two Vietnamese for training on 'Environmental Impact Assessment studies'. Historic

Vrije Universiteit Brussel

From the 3th till the 14th of June two vietnamese persons, both working in the marine sector, will follow a training course in the field of Environmental Impact Assessement and Environmental Care Systems at the Human Ecology Departement. In the first week some lecturers will set out the different disciplines in an EIA-report (noise, air, monuments and landscape,...). They will also explain the application of EIA and ECS in our Belgian harbours. Practical knowledge will be given by visits to s...

Project

Receptor tyrosine kinase signaling in heart failure with preserved ejection fraction

University of Antwerp

The "phenotype" of patients with chronic heart failure is gradually changing from a dilated, poorly contracting left ventricle (LV) to a non-dilated, "thickened" ventricle (called "concentric" hypertrophy) with a normal global pump function (referred to as "heart failure with a preserved ejection fraction" or "HFPEF"). The reason for this phenotypic shift is unclear but relates to aging of the population and the increasing incidence of obesity, hypertension and type II diabetes, especially in...

Project

Reciprocal control of glycolysis by Ras: molecular mechanisms and relevance for industrial yeast fermentation and cancer metabolism

KU Leuven

Yeast is widely used as platform for the production of bio-ethanol and ethanol for alcoholic beverages. However, at the end of the fermentationprocess yeast vitality and viability drops and ethanol productivity ceases. This is a major problem in all industrial alcoholic fermentations and still leaves room for improvement. Because of the abolishment of the fermentation process, remaining sugars are not fermented and are a possible source for more ethanol production with an increase in profit f...

Project

Reciprocal cross-talk between human natural killer cells and interleukin-15-cultured dendritic cells for improved anti-leukemic cytotoxic activity. Recently ended

University of Antwerp

This project represents a formal research agreement between UA and on the other hand STK. UA provides STK research results mentioned in the title of the project under the conditions as stipulated in this contract.

Project

Reciprocal interactions between CD4+CD25+ regulatory T cells and myeloid dendritic cells and their impact on dendritic cell based anti-tumor vaccinations Historic

Vrije Universiteit Brussel

Anti-tumor vaccines can be used as additional cancer therapy in combination with conventional therapies, or for patients whose tumor cells have acquired a multi-drug resistant phenotype. Because dendritic cells (DCs) are the only antigen-presenting cells of the immune system capable of stimulating naieve T lymphocytes, which makes them ideal candidates for use in cancer immunotherapy. It has been shown that mature DCs presenting epitopes from tumor associated antigens (TAAs), can induce an an...

Project

Recombinant expression of edible vaccines in the seeds and fruits of transgenic plants. Historic

University of Antwerp

Recombinant expression of edible vaccines in the seeds and fruits of transgenic plants.

Project

Recommendation "application laboratory tests in general practice". Historic

University of Antwerp

Recommendation "application laboratory tests in general practice".

Project

Reconfigurable Embedded Systems for Use in scalable Multimedia Environments (RESUME) Historic

Vrije Universiteit Brussel

The basic challenge of the RESUME-project is to combine the know-how of the four participating partners in their respective research domains to perform generic basic research that will result in a new platform-based solution for running scalable video applications on a reconfigurable embedded system. Among other research topics we will be working on: 1) the enhancement of video applications to take scalability of quality of service (QoS) into account, 2) scalable data encoding technology...

Project

Reconfiguration, Replacement or Removal? Evaluating the Flemish Post-WarDetached Dwelling and its Part in Contemporary Spatial Planning and Architecture. Recently ended

KU Leuven

This research explores whether the intrinsic spatial surplus of the post- war, detached dwellings and low-density, dispersed residential neighbourhoods in Flanders, holds potential for transformation in line with contemporary housing standards and demands. This work adopted an architectural approach in order to investigate the feasibility of transformative strategies. Hence, it forms one of three complementary tracks of the FWO funded project Large, Underused Dwellings in Flanders, and is bas...

Project

Reconstructing soil discontinuities with multidimensional frequency-domain electromagnetic sensors

Ghent University

We aim at investigating a combination of deep theoretical insights in the physics of frequency-domain electromagnetic signals and the advanced processing of data obtained with state-of-the-art soil sensors to significantly improve the reconstruction of soil discontinuities in 3-D such as the interface between lithologically contrasting layers and the identification of World War I remains.

Project

Reconstruction of the biological response to global warmingusing resurrection ecology: an eco-evolutionary approach. Recently ended

KU Leuven

During the past decades global warming significantly impacted species diversity and the structure and functioning of ecosystems. Recent reviewsemphasize the importance of insights into eco-evolutionary dynamics to understand biological responses to anthropogenic stress such as climate change. Water fleas (Daphnia) are exceptional model organisms because oftheir ecological importance and their amenability to evolutionary ecological research. The presence of layered egg banks is an asset for th...

Project

Recordings in premotor and posterior parietal cortex in monkeys and human patients during grasping. Recently ended

KU Leuven

Humans and other primates possess an exquisite capacity to grasp and manipulate objects. The seemingly effortless interaction with objects in everyday life is subserved by a number of cortical areas of the visual and the motor system. In order to succesfully grasp an object, the complexpattern of visual information impinging on the retina has to be transformed into a motor plan that can control the muscle contractions. The neural basis of visumotor transformations necessary for directing acti...

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Tongeren'. BIOMED provides 'het Gerecht van Tongeren' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month March 2009.

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Tongeren'. BIOMED provides 'het Gerecht van Tongeren' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month April 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Tongeren'. BIOMED provides 'het Gerecht van Tongeren' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month July 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Tongeren'. BIOMED provides 'het Gerecht van Tongeren' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month September 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Tongeren'. BIOMED provides 'het Gerecht van Tongeren' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month October 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Tongeren'. BIOMED provides 'het Gerecht van Tongeren' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month November 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Tongeren'. BIOMED provides 'het Gerecht van Tongeren' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month December 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Turnhout'. BIOMED provides 'het Gerecht van Turnhout' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month March 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Turnhout'. BIOMED provides 'het Gerecht van Turnhout' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month April 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Turnhout'. BIOMED provides 'het Gerecht van Turnhout' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month May 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Turnhout'. BIOMED provides 'het Gerecht van Turnhout' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month June 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Turnhout'. BIOMED provides 'het Gerecht van Turnhout' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month July 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Turnhout'. BIOMED provides 'het Gerecht van Turnhout' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month September 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Turnhout'. BIOMED provides 'het Gerecht van Turnhout' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month October 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Turnhout'. BIOMED provides 'het Gerecht van Turnhout' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month November 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Gerecht van Turnhout'. BIOMED provides 'het Gerecht van Turnhout' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month December 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Hasselts Gerecht. BIOMED provides 'het Hasselts Gerecht ' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month March 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Hasselts Gerecht. BIOMED provides 'het Hasselts Gerecht ' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month April 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Hasselts Gerecht. BIOMED provides 'het Hasselts Gerecht ' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month May 2009

Project

Record of fees and compensations: judicial DNA-research Historic

Universiteit Hasselt

This project represents a formal service agreement between the parties BIOMED (research institute at Hasselt University), and on the other hand, 'het Hasselts Gerecht. BIOMED provides 'het Hasselts Gerecht ' research results on the judicial DNA-research under the conditions as stipulated in the present contract. The work covers all states of the month June 2009

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