Basic aims of the Follicle Biology Laboratory, led by Prof. Ellen Anckaert are the design and validation of new culture systems for ovarian follicles and unripe egg cells to establish practical, applicable strategies for fertility clinics.
Fundamental and pre-clinical research:
1) optimization of multistep systems for in vitro follicle activation, growth and maturation: mouse in vitro models for culturing ovarian follicles ...
The academic staff of the Liver Cell Biology Lab (LIVR) is formed by Prof. Leo van Grunsven (Head of LIVR) and Prof. Hendrik Reynaert (Head of Gastroenterology Department at the UZ Brussel hospital).
In general, research projects at LIVR aim to better characterize the different liver cell types in healthy and pathological conditions, and to gain a better insight in the pathogenesis of liver fibrosis and the mechanisms of liver ...
research
1. Pluripotent Stem Cells and Reprogramming
2. Pluripotent Stem Cell Differentiation
3. Adult Stem Cells
4. Disease Modelling and Regenerative Therapies
The Center for Molecular and Vascular Biology performs research related to the following topics:- Pathogenesis of thrombosis and bleeding. - Development of assays for the diagnosis of thrombosis and bleeding. – Signalling and transcription factor regulation in megakaryocytes and platelets. - Genetics for bleeding and thrombotic disorders. –(patho)physiology of megakaryopoiesis. – Role of transcription factors in endothelial heterogeneity. – ...
The research program of the Laboratory for Molecular Cancer Biology is devoted to the analysis of pathways governing the genesis, progression and maintenance of cancer.Our current research efforts follow from our recent studies on the p53 tumor suppressor. p53 is a transcription factor that functions as a central component of most cellular stress responses. The outcome of p53-mediated surveillance is closely dependent on the type of stress ...
The Laboratory of Molecular Biology of Leukemia tries to understand the genetic complexity of leukemia, with the aim to use that information to develop novel treatment strategies.
Leukemia is a genetically complex disease that is characterized by the accumulation of abnormal blood cells. The leukemia cells often harbor chromosomal defects and additional more sublte changes (mutations) in their genome. This information is used for ...
Cancers are highly heterogeneous entities, both within a single tumor and across patients. Intratumoral heterogeneity stems from the spectrum of cancer cell clones and the dynamic cellular composition of the tumour microenvironment. Cross-patient heterogeneity is based on the multitude of cancer cells-of-origin and patient-specific combinations of germline and somatic genetic variants driving the tumorigenesis. Despite recent major ...
Research in the Laboratory of Computational Biology is focusing on gene and genome regulation, with applications in Drosophila and cancer, and on integrative genomics, developing computational methods for genomic data integration and analysis of next-generation sequence data.
The Laboratory of Synapse Biology aims to unravel the molecular mechanisms that control neuronal connectivity in developing circuits, and determine how perturbations in this process affect cognitive function.