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This laboratory studies the regulation of the immune response to Streptococcus pneumoniae, immunodeficiencies (with particular interest on innate immunity), and autoimmunity (with particular interest on serological markers).

The Unit of Parasite Diagnostics studies human and animal African trypanosomiases, visceral leishmaniasis and Chagas’ disease. All these diseases are caused by infections with single-cell (unicellular) Trypanosomatidae parasites.

We focus on parasitological, serological, biochemical and genetic markers for diagnosis-, and determination of the disease stage, including treatment failure and healthy carier status. We are ...

Since over 25 years the laboratory focusses on the generation and characterization of monoclonal antibodies (Mabs), antibody derivatives, nanobodies and diabodies and application as either therapeutics, diagnostics or research tools.

Major research lines include:

• Studies on structure-function relationship in proteins involved in cardiovascular disease (e.g. Plasminogen Activator inhibitor-1 (PAI-1) and Thrombin Activatable ...

The translational research activities of the diagnostic team concern the development and validation of new technologies for use in diagnostics. The lab has developed specific gene panels for various genetically heterogeneous disorders and offers 'mendelioom' sequencing within the clinical service.