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Human molecular genetics University of Antwerp

The main research interest lies in the field of sensory genetics. Although work is done for different forms of sensory diseases, the emphasis is on nonsyndromic sensorineural hearing impairment and otosclerosis. Large families are collected in Belgium and The Netherlands, as well as in countries with high consanguinity rate such as Iran. These pedigrees are analyzed by linkage analysis. Subsequently, the genes involved are identified by ...

Applied Molecular Genomics University of Antwerp

Psychiatric disorders, such as major depression or unipolar disorder (UP), manic depression or bipolar disorder (BP) and schizophrenia, are among the most frequent brain diseases worldwide. An estimated 9-10% of the world population suffers from major depression, while bipolar disorder and schizophrenia each affect ~1% of the population. Although the precise causes of psychiatric diseases are still largely unknown, family studies argue for a ...

Department of Pediatrics and medical genetics Ghent University

The molecular genetic research of hematological malignancies conducted in the Center for Medical Genetics focuses on the identification and analysis of acquired genetic defects in hematological disorders. Over the past years, the Centre for Medical Genetics has acquired an internationally recognised expertise in the genetic analysis of certain inherited diseases and a number of cancers. The various and rapidly growing research teams within the ...

Medical genetics of obesity and skeletal disorders (MGENOS) University of Antwerp

The general aim of the research is to identify genes that are relevant for two multifactorial conditions, osteoporosis and obesity, in order to understand the pathogenesis of these conditions and to reveal novel putative therapeutic targets. In order to obtain this, the specific aims of our work are: - identification of genes for monogenic conditions with an abnormal bone density - identification of genes involved in rat models with an increased ...

Laboratory for Genetics of Malignant Disorders KU Leuven

Responsible

The discovery and functional characterization of new, recurrent cytogenetic or molecular aberrations in malignant disorders are the most important research objectives of the laboratory for Genetics of Malignant Disorders. These research objectives connect almost seamlessly with the diagnostic, cytogenetic and molecular services which CME-UZ offers for nearly each malignant pathology: acute and chronic leukaemia, lymphomas, mesenchymal and ...

Medical Genetics (MEDGEN) University of Antwerp

The research group concentrates on 3 major topics: the development of hereditary bone tumors, the genetics of Adams-Oliver syndrome and the development of new molecular diagnostic tests for hereditary disorders. 1) Development of hereditary bone tumors (multiple osteochondromas). Osteochondromas are the most frequent hereditary bone tumors in children. Multiple osteochondromas (MO) is an autosomal dominant disorder charakterized by many ...

Centre for Medical Genetics Vrije Universiteit Brussel

Topic A : Identification of new mutations in hereditary diseases (W. Lissens, I. Liebaers), more in particular: - cystic fibrosis - iduronate sulphate deficiency - Beta-glucuronidase deficiency - anti thrombosis III deficiency Topic B : Preimplantation genetics/expression (Liebaers I, Lissens W.) - expression Beta-hexosaminidase in mouse and human embryo's - preimplantation diagnosis in couples at risk for cysticfibrosis (F508) or couples at ...

Cell Genetics Vrije Universiteit Brussel

Responsible

The laboratory for Cell Genetics (Cytogenetics) studies variation in genotype and phenotype, cell division pathways, cell death and genetic changes relevant for the increase of cancer in human. Genotoxicity tests assess the induction of DNA damage, gene mutations, structural and numerical chromosome aberrations. Their predictivity for cancer induction is supported by international studies relating mutations and activation of cancer related ...

Cognitive Genetics (COGNET) University of Antwerp

The mission of the research group "cognitive genetics" is to identify genetic causes of cognitive disorders and to study the defective genes in order to eventually develop rational therapy. We identify novel causes of cognitive disorders starting from affected families or from patients with specific chromosomal abnormalities, including microdeletions, translocations and fragile sites. To achieve this, we have developed novel technologies and ...

Plant Genetics Vrije Universiteit Brussel

Responsible

Research in the Laboratory of Plant Genetics concerns basic plant molecular genetics as well as applied research relevant to the plant biotechnology and agricultural sector. The research is focused on the following themes: · DNA repair and recombination mechanisms and methods to influence these processes. This may lead to development of improved plant breeding techniques, improved plant transformation technology and new techniques for ...