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Molecular biotechnology University of Antwerp

Biological role of ECM1 in the human skin. The extracellular matrix proteine 1 gene (ECM1) was isolated in our laboratory in 1994 and encodes for a secreted glycoprotein with a typical cystein CC-(X7-10)-C pattern. Four splice variants have been described so far: Ecm1a (540 aa), Ecm1b (415 aa), Ecm1c (559 aa) and a truncated protein of 57 aa. Ecm1 has been shown to play a role in endochondral bone formation, morphogenesis of the nephron and is a ...