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Immunity and Inflammation Research Group KU Leuven

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The main research topics include evaluation of leukocyte migration in inflammation and tumor biology with a main focus on chemokines. This includes biological and biochemical characterization of chemoattractants, their gene regulation and posttranslational processing, G protein-coupled receptor-mediated signal transduction, interactions with glycosaminoglycans and synergistic and antagonistic activities. The role of chemoattractants in (1) ...

VIB CMN - Microglia and Inflammation in Neurological Disorders (MIND) lab University of Antwerp

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Microglia and neuroinflammation play a central role in the pathogenesis of Alzheimer's disease and other neurodegenerative disorders. Our primary focus is to examine the underlying molecular mechanisms that drive Alzheimer's disease (AD) and Frontotemporal dementia (FTD), with special focus on inflammatory networks and particularly the contribution of microglia. We use mouse models, iPSC and cutting-edge humanised mouse systems to determine the ...