Organisation
Metabolomics Expertise Center (VIB-KU Leuven)
Division
Research focus : Metabolism describes the whole of enzymatic reactions occurring inside and outside the cellular environment. Understanding how this 'engine' of reactions works and more importantly, understanding the metabolic alterations occurring during specific conditions and diseases, provides a powerful tool for the development of novel drug strategies.
Current researchers
1 - 2 of 2 results
- Bart Ghesquière (Responsible)
- Rita Simões Faria (Member)
Projects
1 - 10 of 17
- Association of perfusate metabolome during normothermic liver perfusion with post-transplant outcomesFrom1 Aug 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Association of perfusate metabolomic profile during normothermic kidney perfusion with post-transplant outcomesFrom1 Aug 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- A novel hybrid metabolomics platform combining the power of gas chromatography separation with highresolution, high-accuracy mass spectrometry of full precursor masses.From1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Optimising hypothermic kidney graft perfusion preservationFrom1 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Metabolic rewiring in SORDD polyneuropathy: unraveling a polyol pathway disorderFrom1 Oct 2021 → TodayFunding: FWO fellowships
- Metabolomics as a tool for developing therapies in an endothelial cell model of congenital disorders of glycosylationFrom20 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Studying congenital disorders of glycosylation and their potential treatments using tracer metabolomicsFrom24 Sep 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Translational research-oriented technology platform for single cell analysisFrom1 May 2020 → TodayFunding: BOF - scientific equipment program
- Galactose rewires metabolism in the treatment of congenital disorders of glycosylation.From1 Jan 2020 → 31 Dec 2023Funding: FWO research project (including WEAVE projects)
- Metabolomic viability fingerprint during normothermic isolated kidney perfusion using tracer metabolomicsFrom1 Oct 2018 → 30 Sep 2022Funding: FWO fellowships
Publications
1 - 10 of 73
- HYPOXIA DRIVES A HYPERINFLAMMATORY NEUTROPHIL PHENOTYPE IN THE LUNG(2019)
Authors: ER Watts, AJM Howden, J Hukelmann, A von Kriegsheim, Bart Ghesquière, P Sadiku, F Murphy, AS Mirchandani, DC Humphries, TM Plant, et al.
Pages: A85 - A85 - The road towards reducing preservation injury & predicting donor kidney viability(2022)
Authors: Julie De Beule, Ina Jochmans, Bart Ghesquière
- International consensus guidelines for phosphoglucomutase 1 deficiency (PGM1‐CDG ): Diagnosis, follow‐up, and management(2021)
Authors: Silvia Radenkovic, Daisy Rymen, Peter Witters
Pages: 148 - 163 - ILF3 is a substrate of SPOP for regulating serine biosynthesis in colorectal cancer(2020)
Authors: Kai Li, Jian-lin Wu, Baifu Qin, Zongmin Fan, Qin Tang, Weisi Lu, Haipeng Zhang, Fan Xing, Manqi Meng, Shaomin Zou, et al.
Pages: 163 - 178 - Expanding the clinical and metabolic phenotype of DPM2 deficient congenital disorders of glycosylation(2020)
Authors: Silvia Radenkovic
Pages: 27 - 37 - Role of glutamine and interlinked asparagine metabolism in vessel formation(2017)
Authors: Hongling Huang, Saar Vandekeere, Joanna Kalucka, Laura Bierhansl, Annalisa Zecchin, Jermaine Goveia, Bart Ghesquière, Mieke Dewerchin, Guy Eelen, Peter Carmeliet
Pages: 2334 - 2352 - A Fatty Acid Oxidation-Dependent Metabolic Shift Regulates Adult Neural Stem Cell Activity(2017)
Authors: Bart Ghesquière, Peter Carmeliet
Pages: 2144 - 2155 - 13C tracer analysis reveals the landscape of metabolic checkpoints in human CD8+ T cell differentiation and exhaustion.(2023)
Authors: Bart Ghesquière
Pages: 1267816 - Histamine Receptor H1-mediated Sensitization of TRPV1 Mediates Visceral Hypersensitivity and Symptoms in Patients With Irritable Bowel Syndrome(2016)
Authors: Mira Wouters, Dafne Balemans, Sander van Wanrooy, James Dooley, Yeranddy Aguiar Alpizar, Paul P Van Veldhoven, Schalk Van der Merwe, Bart Ghesquière, Carla Cirillo, Peter Carmeliet, et al.
Pages: 875 - 887 - Current Insights into the Metabolome during hypothermic Kidney Perfusion—A Scoping Review(2023)
Authors: Laurence Verstraeten, Bart Ghesquière, Ina Jochmans