Researcher
Jasper Neggers
- Disciplines:Microbiology, Systems biology, Laboratory medicine
Affiliations
- Laboratory of Virology and Chemotherapy (Rega Institute) (Division)
Member
From3 Sep 2013 → 31 May 2018
Projects
1 - 1 of 1
- IDENTIFICATION AND VALIDATION OF DRUG-TARGET INTERACTIONS USING CRISPR/CAS-MEDIATED GENOME EDITINGFrom1 Oct 2013 → 27 Apr 2018Funding: BOF - Doctoral projects
Publications
1 - 10 of 10
- Down-regulation of AR splice variants through XPO1 suppression contributes to the inhibition of prostate cancer progression.(2018)
Authors: Jasper Neggers, Dirk Daelemans
Pages: 35327 - 35342 - VALIDATIE EN IDENTIFICATIE VAN EIWIT-GENEESMIDDEL INTERACTIES MET BEHULP VAN CRISPR/CAS-GEMEDIËERDE MUTAGENESE(2018)
Authors: Jasper Neggers, Dirk Daelemans
Number of pages: 138 - Target identification of small molecules using large-scale CRISPR-Cas mutagenesis scanning of essential genes(2018)
Authors: Jasper Neggers, Bert Kwanten, Tim Dierckx, Hiroki Noguchi, Arnout Voet, Nicolas Kint, Michel Delforge, Thomas Vercruysse, Maarten Jacquemyn, Dirk Daelemans
Pages: 502 - 502 - The second-generation exportin-1 inhibitor KPT-8602 demonstrates potent activity against acute lymphoblastic leukemia(2017)
Authors: Thomas Vercruysse, Jolien De Bie, Jasper Neggers, Maarten Jacquemyn, Els Vanstreels, Jan Cools, Dirk Daelemans
Pages: 2528 - 2541 - Heterozygous mutation of cysteine528 in XPO1 is sufficient for resistance to selective inhibitors of nuclear export(2016)
Authors: Jasper Neggers, Els Vanstreels, Dirk Daelemans
Pages: 68842 - 68850 - XPO1-dependent nuclear export is a druggable vulnerability in KRAS-mutant lung cancer(2016)
Authors: Jasper Neggers, Dirk Daelemans
Pages: 114 - 117 - Selective Inhibitors of Nuclear Export (SINE) Compounds Suppress Both HIV Replication and AIDS Related Lymphoma(2015)
Authors: Dirk Daelemans, Eline Boons, Els Vanstreels, Maarten Jacquemyn, Tatiane C Nogueira, Jasper Neggers, Thomas Vercruysse, Joost van den Oord, Sharon Tamir, Michael Kauffman, et al.
- Human exportin-1 is a target for combined therapy of HIV and AIDS related lymphoma(2015)
Authors: Els Vanstreels, Maarten Jacquemyn, Jasper Neggers, Thomas Vercruysse, Joost van den Oord, Robert Snoeck, Christophe Pannecouque, Graciela Andrei, Dirk Daelemans
Pages: 1102 - 13 - Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing(2015)
Authors: Jasper Neggers, Thomas Vercruysse, Maarten Jacquemyn, Els Vanstreels, Erkan Baloglu, Sharon Shacham, Marsha Crochiere, Yosef Landesman, Dirk Daelemans
Pages: 107 - 116 - Identifying drug-target selectivity of small-molecule CRM1/XPO1 inhibitors by CRISPR/Cas9 genome editing(2015)
Authors: Jasper Neggers, Thomas Vercruysse, Maarten Jacquemyn, Els Vanstreels, Dirk Daelemans
Pages: 107 - 116
Patents
1 - 2 of 2