Researcher
Stephen Weeks
- Disciplines:Analytical chemistry, Medicinal and biomolecular chemistry, Biochemistry and metabolism, Molecular and cell biology, Plant biology, Systems biology, Biophysics, Medical biochemistry and metabolism, Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Biocrystallography (Division)
Member
From6 Apr 2009 → 31 Mar 2019
Projects
1 - 5 of 5
- Structural Characterization of Aminoacyl-tRNA Synthetase Inhibitors as Antibiotics and Tools for Enzyme Mechanistic StudiesFrom1 Oct 2016 → 23 Sep 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Upgrade and capacity increase to the Macromolecular Crystallization FacilityFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
- Characterization of the molecular interactions between intermediate filaments and small heat shock proteinsFrom1 Jan 2016 → 31 Dec 2018Funding: FWO research grant KAN
- Rational design of tRNA synthetase inhibitors as new antibacterials.From1 Oct 2014 → 30 Sep 2018Funding: BOF - Concerted Research Project from 1994
- Structural studies of human small heat shock proteins and their complexes (SHSPCOMPLEX).From1 Sep 2010 → 31 Aug 2014Funding: Marie Curie - People
Publications
1 - 10 of 30
- Structural Characterization of Aminoacyl-tRNA Synthetase Inhibitors as Antibiotics and Tools for Enzyme Mechanistic Studies(2020)
Authors: Luping Pang, Arthur Van Aerschot, Sergei Strelkov, Stephen Weeks
- Structural studies of aminoacyl-tRNA synthetases: development of new antibiotics(2020)
Authors: Steff De Graef, Sergei Strelkov, Arthur Van Aerschot, Stephen Weeks
- Design and synthesis of various nucleoside analogues as aminoacyl-tRNA synthetase inhibitors(2019)
Authors: Manesh Nautiyal, Arthur Van Aerschot, Stephen Weeks, Bharat Gadakh
- Rational design of an XNA ligase through docking of unbound nucleic acids to toroidal proteins(2019)
Authors: Michiel Vanmeert, Muhammad Usman Mirza, Stephen Weeks, Jef Rozenski, Mathy Froeyen, Piet Herdewyn, Vitor Bernardes Pinheiro, Eveline Lescrinier
Pages: 1 - 12 - Acylated sulfonamide adenosines as potent inhibitors of the adenylate-forming enzyme superfamily(2019)
Authors: Dries De Ruysscher, Luping Pang, Steff De Graef, Manesh Nautiyal, Wim De Borggraeve, Jef Rozenski, Sergei Strelkov, Stephen Weeks, Arthur Van Aerschot
Pages: 252 - 264 - Comparative analysis of pyrimidine substituted aminoacyl-sulfamoyl nucleosides as potential inhibitors targeting class I aminoacyl-tRNA synthetases(2019)
Authors: Manesh Nautiyal, Steff De Graef, Luping Pang, Sergei Strelkov, Stephen Weeks, Arthur Van Aerschot
Pages: 154 - 166 - Discovery of a new Pro-Pro endopeptidase, PPEP-2, provides mechanistic insights into the differences in substrate specificity within the PPEP family(2018)
Authors: Oleg Klychnikov, Stephen Weeks, Sergei Strelkov
Pages: 11154 - 11165 - The Role of the Arginine in the Conserved N-Terminal Domain RLFDQxFG Motif of Human Small Heat Shock Proteins HspB1, HspB4, HspB5, HspB6, and HspB8(2018)
Authors: Stephen Weeks, Sergei Strelkov
- Family wide analysis of aminoacyl-sulfamoyl-3-deaza-adenosine analogues as inhibitors of aminoacyl-tRNA synthetases(2018)
Authors: Baole Zhang, Steff De Graef, Manesh Nautiyal, Luping Pang, Bharat Gadakh, Mathy Froeyen, Lieve Vanmellaert, Sergei Strelkov, Stephen Weeks, Arthur Van Aerschot
Pages: 384 - 396 - Characterization of human small heat shock protein HSPB1 alpha-crystallin domain localized mutants associated with hereditary motor neuron diseases(2018)
Authors: Stephen Weeks, Michelle Heirbaut, Sergei Strelkov