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Researcher
Lucia Chavez Gutierrez
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences
Affiliations
- Laboratory of Proteolytic Mechanisms in Neurodegeneration (VIB-KU Leuven) (Lab)
Responsible
From1 Dec 2017 → Today - Laboratory of Proteolytic Mechanisms in Neurodegeneration (VIB-KU Leuven) (Lab)
Member
From1 Oct 2018 → 30 Sep 2022 - Chávez Gutiérrez Lab (Research group)
Responsible
From1 Jul 2017 → Today - Research Group Molecular Neurobiology (VIB-KU Leuven) (Division)
Member
From1 Jan 2017 → 30 Sep 2018 - De Strooper Lab (Research group)
Member
From1 Jan 2017 → 30 Jun 2017 - Department of Human Genetics (Department)
Member
From1 Oct 2013 → 31 Dec 2016
Projects
1 - 10 of 16
- Structure-based design of stabilizers of γ-secretase-APP interactions for the treatment of Alzheimer's diseaseFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Proteolytic Surveillance of signalling molecules in the membrane: unraveling the mechanisms and endogenous regulation of aspartyl intramembrane proteases.From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Proteolytic Surveillance of signaling molecules in the membrane by SPPL2s: unraveling the mechanisms and their endogenous regulation.From1 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Uncovering the pathogenic role(s) of ABCA7 transporter in Alzheimer’s diseaseFrom10 Oct 2022 → TodayFunding: FWO fellowships
- When size matters: a platform to study molecular interactions and multimerisationFrom1 May 2022 → TodayFunding: FWO Medium Size Research Infrastructure
- Unveiling toxic amyloid-β (Aβ) assemblies and neutralizing them with Nanobodies.From28 Oct 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Nanobody-mediated detection and modulation of the molecular machinery generating Alzheimer’s disease-linked amyloid β peptidesFrom1 Oct 2020 → TodayFunding: FWO Strategic Basic Research Grant
- Investigation of environmental dependence of γ-secretase (dys)function in Alzheimer’s diseaseFrom17 Jun 2019 → 28 May 2020Funding: Own budget, for example: patrimony, inscription fees, gifts
- Structural bases of γ-secretase processivity in Familial Alzheimer's DiseaseFrom1 Feb 2019 → 1 Feb 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Deciphering Secretase mechanisms: providing the underpinnings for novel, rational-based therapeutic approachesFrom1 Jan 2019 → 31 Dec 2022Funding: FWO research project (including WEAVE projects)
Publications
1 - 10 of 49
- Functional and topological analysis of PSENEN, the fourth subunit of the γ-secretase complex.(2024)
Authors: An Zwijsen, Lucia Chavez Gutierrez, Bart De Strooper
Pages: 105533 - How Modulator Binding at the Amyloidβ-γ-Secretase Interface Enhances Substrate Binding and Attenuates Membrane Distortion(2023)
Authors: Lucia Chavez Gutierrez
Pages: 16772 - 16782 - APP substrate ectodomain defines amyloid-β peptide length by restraining γ-secretase processivity and facilitating product release(2023)
Authors: Lucia Chavez Gutierrez
- Functional and topological analysis of Pen-2, the fourth subunit of the γ-secretase complex (Withdrawal of Vol 286, art no 12271, 2011)(2023)
Authors: Lucia Chavez Gutierrez, An Zwijsen, Bart De Strooper
- Enzyme-substrate hybrid β-sheet controls geometry and water access to the γ-secretase active site(2023)
Authors: Lucia Chavez Gutierrez
- Characterization of spastic paraplegia in a family with a novel PSEN1 mutation(2023)
Authors: Lucia Chavez Gutierrez
- The PSEN1 E280G mutation leads to increased amyloid-β43 production in induced pluripotent stem cell neurons and deposition in brain tissue.(2023)
Authors: Lucia Chavez Gutierrez
Pages: fcac321 - Enzyme-substrate interface targeting by imidazole-based γ-secretase modulators activates γ-secretase and stabilizes its interaction with APP(2022)
Authors: Matthias Koch, Katarzyna Zoltowska, Lucia Chavez Gutierrez
- Computational Mass Spectrometry Imaging of Amyloid Plaque Populations in the Brains of Non-Demented and Alzheimer's Disease Patients(2022)
Authors: Thomas Enzlein, Lucia Chavez Gutierrez
- Aβ profiles generated by Alzheimer's disease causing PSEN1 variants determine the pathogenicity of the mutation and predict age at disease onset(2022)
Authors: Katarzyna Zoltowska, Thomas Enzlein, Rik Vandenberghe, Lucia Chavez Gutierrez
Pages: 2821 - 2832
Patents
1 - 3 of 3