Researcher
Pieter Annaert
- Disciplines:Biomarker discovery and evaluation, Drug discovery and development, Medicinal products, Pharmaceutics, Pharmacognosy and phytochemistry, Pharmacology, Pharmacotherapy, Toxicology and toxinology, Other pharmaceutical sciences
Affiliations
- Department of Pharmaceutical and Pharmacological Sciences (Department)
Responsible
From1 Aug 2020 → Today - Drug Delivery and Disposition (Division)
Member
From1 Oct 2005 → Today
Projects
1 - 10 of 33
- Investigating current gaps in time-dependent inhibition (TDI) and induction drug-drug interactions (DDIs). A focus on CYP3A4 and non-CYPs drug metabolizing enzymes (DMEs).From24 May 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Improved clearance prediction using ex vivo and new in silico tools to bridge the in vitro to in vivo extrapolation (IVIVE) gapFrom1 Oct 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigation of bidirectional pharmacokinetic drug-drug interaction between vicagrel, a novel analogue for the antiplatelet drug clopidogrel, and atorvastatinFrom15 Sep 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Design and development of FabV inhibitors as a new class of antibacterials for pathogenic Gram-negative bacteriaFrom1 Oct 2021 → TodayFunding: Baekeland
- Predicting exposure of neonates to maternal medicines via breastfeedingFrom1 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Model-informed drug development: application to drug-induced cholestasisFrom1 Oct 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Drug exposure through lactation: providing neonatal physiology to improve pharmacokinetic predictionsFrom21 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Drug Design and Development: From Target to MarketFrom7 Jun 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Integrated PK/PM Model-based Medication Dosing Assist App(lication) in KlinischWerkStation (KWS). Validation Studies of Tacrolimus in (Solid) Organ TransplantationFrom1 Jan 2021 → 31 Dec 2023Funding: IOF - technology validation in lab
- In vitro and in silico investigation of pharmacokinetics in neonates undergoing therapeutic hypothermiaFrom26 Nov 2020 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 253
- Determining the exposure of maternal medicines through breastfeeding: the UmbrelLACT study protocol - A contribution from the ConcePTION project(2024)
Authors: Martje Van Neste, Nina Nauwelaerts, Michael Ceulemans, Kristel Van Calsteren, An Eerdekens, Pieter Annaert, Karel Allegaert, Anne Smits
- Second generation Al18F-labeled D-amino acid peptide for CXCR4 targeted molecular imaging.(2024)
Authors: Tom Van Loy, Christophe Deroose, Michel Koole, Dominique Schols, Kristof De Vos, Pieter Annaert, Frederik Cleeren
Pages: 108906 - Interdisciplinary Collaboration on Real World Data to Close the Knowledge Gap: A Reflection on "De Sutter et al. Predicting Volume of Distribution in Neonates: Performance of Physiologically Based Pharmacokinetic Modelling"(2024)
Authors: Karel Allegaert, Anne Smits, Pieter Annaert
- A Population Model of Time-Dependent Changes in Serum Creatinine in (Near)term Neonates with Hypoxic-Ischemic Encephalopathy During and After Therapeutic Hypothermia(2023)
Authors: Pieter Annaert, Djalila Mekahli, Anne Smits, Karel Allegaert
- Automated Generation of hiPSC-Derived Hepatic Progeny by Cost-Efficient Compounds(2023)
Authors: Kristof De Vos, Teresa Izuel Idoype, Pieter Annaert, Frederic Lluis Vinas, Catherine Verfaillie
Pages: 1076 - 1088 - Challenges Related to Acquisition of Physiological Data for Physiologically Based Pharmacokinetic (PBPK) Models in Postpartum, Lactating Women and Breastfed Infants—A Contribution from the ConcePTION Project(2023)
Authors: Martje Van Neste, Annick Bogaerts, Nina Nauwelaerts, Anne Smits, Pieter Annaert, Karel Allegaert
- PBPK Modelling for Drugs Cleared by Non-CYP Enzymes: State-of-the-Art and Future Perspectives.(2023)
Authors: Karen Leys, Pieter Annaert
Pages: DMD-AR-202 - Role of connexin and pannexin signaling in cholestasis(2023)
Authors: Axelle Cooreman, Pieter Annaert
- Assessment of in vitro antimicrobial activity of clindamycin metabolites against Staphylococcus species(2023)
Authors: Greet Van De Sijpe, Karel Allegaert, Jef Rozenski, Pieter Annaert, Stefanie Desmet
Pages: 1345 - 1347 - Assessment of in vitro antimicrobial activity of clindamycin metabolites against Staphylococcus species(2023)
Authors: Greet Van De Sijpe, Laura Armengol Álvarez, Agustos Cetin Ozbey, Karel Allegaert, Jef Rozenski, Pieter Annaert, Stefanie Desmet, Isabel Spriet
Pages: 1345 - 1347