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Researcher
Ludo Van Den Bosch
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing
Affiliations
- Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Responsible
From1 Oct 2018 → Today - Van Den Bosch Lab (Research group)
Responsible
From1 Jan 2017 → Today - Laboratory for Neurobiology (VIB-KU Leuven) (Lab)
Member
From1 Jan 2012 → Today - Research Group Experimental Neurology (Division)
Member
From1 Oct 2002 → 31 Dec 2011
Projects
1 - 10 of 60
- Investigating the pathological mechanisms underlying KIF5A mutations in ALSFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Engineering Functional 3D Neuromuscular Junctions: Investigating Myogenic Stem Cell Differentiation and Integration with iPSC-Derived Motor NeuronsFrom1 Oct 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating fatty acid toxicity in amyotrophic lateral sclerosisFrom1 Oct 2023 → TodayFunding: FWO senior postdoctoral fellowship
- Investigating the therapeutic potential of HDAC6 inhibition in amyotrophic lateral sclerosis (ALS) using human induced pluripotent stem cells (iPSCs).From1 May 2023 → TodayFunding: Other federal public and semi-governmental institutions
- FUS-ALS hiPSC-derived astrocytes impair human motor units through both gain-of-toxicity and loss-of-support mechanismsFrom19 Apr 2023 → 31 Dec 2023Funding: Foundations, funds and other with scientific goal
- Creating iPSC-derived 3D human neuromuscular junctions to investigate amyotrophic lateral sclerosis (ALS)From15 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating mechanisms of RNA misprocessing in Amyotrophic Lateral SclerosisFrom8 Mar 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Determination and investigation of the therapeutic targets of HDAC6 inhibition in amyotrophic lateral sclerosis (ALS)From1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- Creation of a humanized mouse model for demyelinating peripheral neuropathies as a platform for therapeutic testing.From1 Jan 2023 → TodayFunding: BOF - iBOF
- Investigating the role of DNA damage and repair in the selective motor neuron death during amyotrophic lateral sclerosis (ALS)From15 Nov 2022 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
Publications
1 - 10 of 231
- FUS unveiled in mitochondrial DNA repair and targeted ligase-1 expression rescues repair-defects in FUS-linked motor neuron disease.(2024)
Authors: Ludo Van Den Bosch
Pages: 2156 - The sense of antisense therapies in ALS.(2024)
Authors: Philip Van Damme, Ludo Van Den Bosch
Pages: 252 - 262 - TUBA4A downregulation as observed in ALS post-mortem motor cortex causes ALS-related abnormalities in zebrafish(2024)
Authors: Philip Van Damme, Dietmar Thal, Valérie Bercier, Ludo Van Den Bosch
- Generation of Human Induced Pluripotent Stem Cell (hiPSC)-Derived Astrocytes for Amyotrophic Lateral Sclerosis and Other Neurodegenerative Disease Studies.(2024)
Authors: Ludo Van Den Bosch
Pages: e4936 - PP2A and GSK3 act as modifiers of FUS-ALS by modulating mitochondrial transport.(2024)
Authors: Thibaut Burg, Philip Van Damme, Ludo Van Den Bosch
Pages: 41 - Roadmap for C9ORF72 in Frontotemporal Dementia and Amyotrophic Lateral Sclerosis: Report on the C9ORF72 FTD/ALS Summit(2023)
Authors: Ludo Van Den Bosch
Pages: 1821 - 1843 - Single-cell profiling and zebrafish avatars reveal LGALS1 as immunomodulating target in glioblastoma(2023)
Authors: Lise Finotto, Basiel Cole, Maxime Vanmechelen, Bram Boeckx, Diether Lambrechts, Ludo Van Den Bosch, Steven De Vleeschouwer, Frederik De Smet
- Proteostasis plays an important role in demyelinating Charcot Marie Tooth disease.(2023)
Authors: Ludo Van Den Bosch
Pages: 115760 - lncRNA Sequencing Reveals Neurodegeneration-Associated FUS Mutations Alter Transcriptional Landscape of iPS Cells That Persists in Motor Neurons(2023)
Authors: Ludo Van Den Bosch
- TDP‑43 pathology is associated with increased tau burdens and seeding(2023)
Authors: Sandra Oliveira Tomé, Grigoria Tsaka, Klara Gawor, Philip Van Damme, Ludo Van Den Bosch, Rik Vandenberghe, Frederic Rousseau, Joost Schymkowitz, Dietmar Thal
Patents
1 - 4 of 4