Researcher
Pieterjan Merckx
- Disciplines:Medicinal products, Pharmacognosy and phytochemistry, Pharmaceutics, Biomarker discovery and evaluation, Other pharmaceutical sciences, Drug discovery and development, Toxicology and toxinology, Pharmacotherapy, Pharmacology
Affiliations
- Department of Organic and Macromolecular Chemistry (Department)
Member
From17 Feb 2020 → 16 Jan 2022 - Department of Pharmaceutics (Department)
Member
From8 Sep 2015 → 20 Sep 2020
Projects
1 - 2 of 2
- BioGelator for local immunotherapyFrom15 Jul 2021 → TodayFunding: IOF - technology validation in lab
- Bio-inspired nanocomposites of pulmonary surfactant and hydrogel nanoparticles for siRNA inhalation therapyFrom1 Jan 2016 → 31 Dec 2019Funding: FWO Strategic Basic Research Grant
Publications
1 - 7 of 7
- Surfactant protein B promotes cytosolic SiRNA delivery by adopting a virus-like mechanism of action(2021)
Authors: Roberta Guagliardo, Lore Herman, Jelle Penders, Agata Zamborlin, Herlinde De Keersmaecker, Thijs Van de Vyver, Sandrine Verstraeten, Pieterjan Merckx, Marie-Paule Mingeot-Leclercq, Mercedes Echaide, et al.
Pages: 8095 - 8109 - Hydrogel-induced cell membrane disruptions enable direct cytosolic delivery of membrane-impermeable cargo(2021)
Authors: Jelter Van Hoeck, Thijs Van de Vyver, Aranit Harizaj, Glenn Goetgeluk, Pieterjan Merckx, Jing Liu, Mike Wels, Félix Sauvage, Herlinde De Keersmaecker, Christian Vanhove, et al.
- Lyophilization and nebulization of pulmonary surfactant-coated nanogels for siRNA inhalation therapy(2020)
Authors: Pieterjan Merckx, Joris Lammens, Gust Nuytten, Bram Bogaert, Roberta Guagliardo, Chris Vervaet, Thomas De Beer, Koen Raemdonck
Pages: 191 - 199 - Cationic amphiphilic drugs boost the lysosomal escape of small nucleic acid therapeutics in a nanocarrier-dependent manner(2020)
Authors: Thijs Van de Vyver, Bram Bogaert, Lynn De Backer, Freya Joris, Roberta Guagliardo, Jelter Van Hoeck, Pieterjan Merckx, Srinivas Ramishetti, Dan Peer, Katrien Remaut, et al.
Pages: 4774 - 4791 - Lung surfactant-hydrogel nanocomposites for pulmonary siRNA delivery : breaching barriers for nanomedicine-based inhalation therapy(2020)
Authors: Pieterjan Merckx
- Nanocarrier lipid composition modulates the impact of pulmonary surfactant protein B (SP-B) on cellular delivery of siRNA(2019)
Authors: Roberta Guagliardo, Pieterjan Merckx, Agata Zamborlin, Lynn De Backer, Mercedes Echaide, Jesus Pérez-Gil, Stefaan De Smedt, Koen Raemdonck
- Surfactant protein B (SP-B) enhances the cellular siRNA delivery of proteolipid coated nanogels for inhalation therapy(2018)
Authors: Pieterjan Merckx, Lynn De Backer, Lien Van Hoecke, Roberta Guagliardo, Mercedes Echaide, Pieter Baatsen, Bárbara Olmeda, Jésus Pérez-Gil, Koen Raemdonck
Pages: 236 - 246