Researcher
Paul Coucke
- Disciplines:Genetically modified animals
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2002 → 30 Sep 2018
Projects
1 - 10 of 12
- Identification of molecular mechanisms involved in Osteogenesis ImperfectaFrom1 Oct 2024 → TodayFunding: BOF - doctoral mandates
- Identification of modifier genes responsible for the phenotypic variability in Osteogenesis Imperfecta (OI)- patients using zebrafish modelsFrom14 Feb 2024 → TodayFunding: BOF - doctoral mandates
- Nuclear Transfer for female-related infertility and mitochondrial diseasesFrom1 Oct 2023 → TodayFunding: FWO Applied Biomedical Research (TBM)
- Unravelling the mitochondrial DNA reversion phenomenonFrom1 Nov 2022 → TodayFunding: FWO fellowships
- Cofunding core facility - Core Zebrafish Facility Ghent (Core ZFG)From1 Jul 2022 → TodayFunding: BOF - research organisations
- Comparison of editing, complementing or replacement of defective RNA molecules as a novel treatment method to overcome early embryonic developmental arrestFrom1 Oct 2021 → 14 Sep 2023Funding: FWO junior postdoctoral fellowship
- An integrated translational platform to improve the management and outcome of rare heritable connective tissue diseaseFrom1 Jan 2021 → TodayFunding: BOF - projects
- Research equipment for behavior analysis in zebrafish disease models.From1 Dec 2020 → 30 Nov 2022Funding: BOF - scientific equipment program
- Identification of modifier genes underlying the phenotypic variability in the ‘Brittle Bone Disease’, using zebrafish models and patient-derived induced pluripotent stem cellsFrom1 Oct 2019 → TodayFunding: BOF - projects
- Genetic analysis in consanguineous families from Palestine : a focus on Cystic Fibrosis and Osteogenesis ImperfectaFrom1 Oct 2015 → 30 Sep 2019Funding: BOF - Doctoral projects
Publications
1 - 10 of 56
- Retained chromosomal integrity following CRISPR-Cas9-based mutational correction in human embryos(2023)
Authors: Bieke Bekaert, Annekatrien Boel, Lisa De Witte, Winter Vandenberghe, Mina Popovic, Panagiotis Stamatiadis, Gwenny Cosemans, Athina-Maria De Loore, Susana Marina Chuva de Sousa Lopes, Petra De Sutter, et al.
Pages: 2326 - 2341 - Crispant analysis in zebrafish as a tool for rapid functional screening of disease-causing genes for Osteogenesis Imperfecta(2023)Volume: 7
Authors: Sophie Debaenst, Hanna De Saffel, Jan Willem Bek, Adelbert De Clercq, Tamara Jarayseh, Lauren Sahd, Paul Coucke, Andy Willaert
Number of pages: 1 - Assisted oocyte activation does not overcome recurrent embryo developmental problems(2023)
Authors: Arantxa Cardona Barberán, Davina Bonte, Annekatrien Boel, Vanessa Thys, Ruth Paredis, Femke Machtelinckx, Petra De Sutter, Ilse De Croo, Luc Leybaert, Dominic Stoop, et al.
Pages: 872 - 885 - Identification of modifier genes underlying intra-familial phenotypic variability in zebrafish OI models using whole exome sequencing and linkage analysis(2023)Volume: 7
Authors: Tamara Jarayseh, Adelbert De Clercq, Toon Rosseel, Mauro Alessio Milazzo, Andy Willaert, Paul Coucke
Number of pages: 1 - Minocycline attenuates excessive DNA damage response and reduces ectopic calcification in pseudoxanthoma elasticum(2022)
Authors: Lukas Nollet, Matthias Van Gils, Andy Willaert, Paul Coucke, Olivier Vanakker
Pages: 1629 - 1638.e6 - Exploring the mutational landscape of isolated congenital heart defects : an exome sequencing study using cardiac DNA(2022)
Authors: Ilse Meerschaut, Wouter Steyaert, Thierry Bové, Katrien Francois, Thomas Martens, Katya De Groote, Hans De Wilde, Laura Muiño Mosquera, Joseph Panzer, Kristof Vandekerckhove, et al.
- Crispant screening in zebrafish as a promising approach for rapid functional screening of osteoporosis candidate genes and known genes for Osteogenesis Imperfecta(2022)
Authors: Sophie Debaenst, Hanna De Saffel, Jan Willem Bek, Adelbert De Clercq, Tamara Jarayseh, Lauren Sahd, Paul Coucke, Andy Willaert
Number of pages: 1 - A tapt1 knockout zebrafish line with aberrant lens development and impaired vision models human pediatric cataract(2022)
Authors: Tamara Jarayseh, Brecht Guillemyn, Hanna De Saffel, Jan Willem Bek, Sujatha Jagadeesh, Sofie Symoens, Fransiska Malfait, Delfien Syx, Filip Van Nieuwerburgh, Yannick Gansemans, et al.
Number of pages: 1 - Lrp5 mutant and crispant zebrafish faithfully model human osteoporosis, establishing the zebrafish as a platform for CRISPR‐based functional screening of osteoporosis candidate genes(2021)
Authors: Jan Willem Bek, Chen Shochat, Adelbert De Clercq, Hanna De Saffel, Annekatrien Boel, Juriaan Metz, Frans Rodenburg, David Karasik, Andy Willaert, Paul Coucke
Pages: 1749 - 1764 - Rare modifier variants alter the severity of cardiovascular disease in pseudoxanthoma elasticum : identification of novel candidate modifier genes and disease pathways through mixture of effects analysis(2021)
Authors: Eva De Vilder, Ludovic Martin, Georges Lefthériotis, Paul Coucke, Filip Van Nieuwerburgh, Olivier Vanakker