Researcher
Kaat Durinck
- Keywords:precision oncology, pediatrics
- Disciplines:Cell division, Cell growth and development, Cell death, Cancer biology, Cancer therapy, Compound screening, In vitro testing, Non-clinical studies, Cell signalling
Affiliations
- Department of Biomolecular Medicine (Department)
Member
From1 Oct 2018 → Today - Dean's Office of the Faculty of Medicine and Health Sciences (Administrative office)
Member
From1 Jan 2016 → 30 Sep 2016 - Department of Pediatrics and medical genetics (Department)
Member
From1 Oct 2010 → 30 Sep 2018
Projects
1 - 10 of 11
- Synergistic drug interactions with CDK12-controlled DNA damage response signaling as potential therapy for high-risk neuroblastomaFrom1 Jan 2024 → TodayFunding: FWO research project (including WEAVE projects)
- Functional assessment of TAS1553 as entry point for synergistic drug interactions with the CDC7-ATR-CHK1 axis in vitro and in vivoFrom14 Nov 2023 → TodayFunding: Foreign public sponsor
- Beurs Emmanuel van der Schueren (EvdS) Carolien Van Damme: "Scrutinizing the role of GJC1 as replicative stress resistor in MYCN driven neuroblastoma"From1 Nov 2023 → TodayFunding: Nonprofit institution or equivalents
- Preclinical evaluation of synergistic drug interactions with CDK12-controlled DNA damage response signaling as potential therapy for high-risk neuroblastomaFrom1 Oct 2023 → TodayFunding: Nonprofit institution or equivalents
- Development of patient avatars in zebrafish for personalized selection of tyrosine kinase inhibitor-based combination therapy to combat relapsed pediatric sarcomaFrom25 Sep 2023 → TodayFunding: Nonprofit institution or equivalents
- Building a next-generation precision oncology platform for childhood cancerFrom1 Jan 2022 → TodayFunding: BOF - projects
- Tenure track professorship in pediatric precision oncologyFrom1 Sep 2021 → TodayFunding: BOF - tenure track
- The dual role PSIP1 in T-cell acute lymphoblastic leukemia (T-ALL)From1 Nov 2020 → TodayFunding: FWO fellowships
- The PHF6 - TLX1 cooperativity and the IL7R-JAK3 signaling axis as drug target in PHF6 deficient TALL.From1 Oct 2019 → TodayFunding: BOF - projects
- Identification of novel therapeutic targets through multi-level (epi) genomic landscaping of replicative stress resistant neuroblastoma From1 Oct 2016 → 30 Sep 2019Funding: BOF - Other initiatives
Publications
1 - 10 of 19
- HTSplotter : an end-to-end data processing, analysis and visualisation tool for chemical and genetic in vitro perturbation screening(2024)
Authors: Carolina de Carvalho Nunes, Jasper Anckaert, Fanny De Vloed, Jolien De Wyn, Kaat Durinck, Jo Vandesompele, Franki Speleman, Vanessa Vermeirssen
- Exploration of neuroblastoma xenograft models for tumor extracellular RNA profiling in murine blood plasma(2023)
Authors: Jill Deleu, Hanne Van Droogenbroeck, Jasper Anckaert, Anneleen Decock, Jilke De Wilde, Kaat Durinck, Liselot Mus, Justine Nuytens, Muhammad Rishfi, Kathleen Schoofs, et al.
- Mitotic dysregulation at tumor initiation creates a therapeutic vulnerability to combination anti-mitotic and pro-apoptotic agents for MYCN-driven neuroblastoma(2023)
Authors: Lei Zhai, Anushree Balachandran, Rebecca Larkin, Janith A. Seneviratne, Sylvia A. Chung, Amit Lalwani, Shoma Tsubota, Dominik Beck, Kenji Kadomatsu, Anneleen Beckers, et al.
- Whole transcriptome profiling of liquid biopsies from tumour xenografted mouse models enables specific monitoring of tumour-derived extracellular RNA(2022)
Authors: Vanessa Vermeirssen, Jill Deleu, Annelien Morlion, Celine Everaert, Jilke De Wilde, Jasper Anckaert, Kaat Durinck, Justine Nuytens, Muhammad Rishfi, Franki Speleman, et al.
- RRM2 enhances MYCN-driven neuroblastoma formation and acts as a synergistic target with CHK1 inhibition(2022)
Authors: Carolina de Carvalho Nunes, Lisa Depestel, Liselot Mus, Kaylee M. Keller, Louis Delhaye, Amber Louwagie, Muhammad Rishfi, Alex Whale, Neesha Kara, Simon R. Andrews, et al.
- MYCN-induced nucleolar stress drives an early senescence-like transcriptional program in hTERT-immortalized RPE cells(2021)
Authors: Sofia Zanotti, Suzanne Vanhauwaert, Christophe Van Neste, Volodimir Olexiouk, Jolien Van Laere, Marlies Verschuuren, Joni Van der Meulen, Liselot Mus, Kaat Durinck, Laurentijn Tilleman, et al.
- Recurrent chromosomal imbalances provide selective advantage to human embryonic stem cells under enhanced replicative stress conditions(2021)
Authors: Liselot Mus, Stéphane Van Haver, Mina Popovic, Wim Trypsteen, Steve Lefever, Nadja Zeltner, Yudelca Ogando, Eva Jacobs, Geertrui Denecker, Ellen Sanders, et al.
Pages: 272 - 281 - MEIS2 is an adrenergic core regulatory transcription factor involved in early initiation of TH-MYCN-driven neuroblastoma formation(2021)
Authors: Jolien De Wyn, Mark W. Zimmerman, Nina Weichert-Leahey, Carolina de Carvalho Nunes, Belamy B. Cheung, Brian J. Abraham, Anneleen Beckers, Pieter-Jan Volders, Bieke Decaesteker, Daniel R. Carter, et al.
- The ETS transcription factor ETV5 is a target of activated ALK in neuroblastoma contributing to increased tumour aggressiveness(2020)
Authors: Liselot Mus, Irina Lambertz, Shana Claeys, Candy Kumps, Wouter Van Loocke, Christophe Van Neste, Ganesh Umapathy, Marica Vaapil, Christoph Bartenhagen, Genevieve Laureys, et al.
- Distinct Notch1 and BCL11B requirements mediate human γδ/αβ T cell development(2020)
Authors: Anne-Catherine Dolens, Kaat Durinck, Marieke Lavaert, Joni Van der Meulen, Imke Velghe, Jelle De Medts, Karin Weening, Juliette Roels, Katrien De Mulder, Pieter-Jan Volders, et al.