Researcher
Claudia Spits
- Keywords:Medicine
- Disciplines:Stem cell biology, Reproductive medicine
Affiliations
- Reproduction and Genetics (Research group)
Member
From21 Jun 2010 → Today - Basic (bio-) Medical Sciences (Department)
Member
From1 Feb 2022 → Today - Basic (bio-) Medical Sciences (Department)
Member
From8 Apr 2019 → 31 Jan 2022 - Faculty of Medicine and Pharmacy (Faculty)
Member
From22 Jun 2017 → 7 Sep 2017 - Basic (bio-) Medical Sciences (Department)
Member
From1 Jan 2014 → 20 Oct 2022 - Basic (bio-) Medical Sciences (Department)
Member
From1 Jan 2014 → 31 Jan 2017 - Department of Embryology and Genetics (Department)
Member
From1 Oct 2011 → 31 Dec 2013 - Department of Embryology and Genetics (Department)
Member
From1 Jul 2002 → 31 Dec 2013
Projects
1 - 10 of 19
- Liver and brain organoids to model human pluripotent stem cell tumorigenesisFrom1 Jan 2023 → TodayFunding: FWO research project (including WEAVE projects)
- The Genetic Component to Infertility and Early Developmental FailureFrom1 Jan 2023 → TodayFunding: BOF - Methusalem
- The impact of chromosomal abnormalities in hPSC-derived retinal pigmented epithelial cellsFrom1 Jan 2022 → TodayFunding: FWO research project (including WEAVE projects)
- The impact of recurrent chromosomal abnormalities on growth advantage and differentiation capacity of human pluripotent stem cellsFrom1 Nov 2020 → TodayFunding: FWO fellowships
- Seahorse platform: the Agilent Seahorse Flux Analyser with integrated normalization systemFrom1 May 2020 → TodayFunding: Hercules - Small and Medium size research infrastructure
- The search for the origin of chromosomal abnormalities in human preimplantation embryosFrom1 Oct 2019 → 31 Oct 2023Funding: FWO fellowships
- A roadmap to the safe introduction of hESC in the clinic: the case of genetic mosaicism in hESC-derived retinal cellsFrom1 Jan 2019 → 31 Dec 2022Funding: FWO fellowships
- The origins of mitochondrial DNA mosaicism in early human developmentFrom1 Jan 2018 → 31 Dec 2018Funding: FWO research grant KAN
- The search for the origin of chromosomal abnormalities in human preimplantation embryosFrom1 Jan 2018 → 31 Dec 2021Funding: FWO research project (including WEAVE projects)
- Do children born after intracytoplasmic sperm injection have an increased risk of mutations in mitochondrial DNA?From1 Jan 2017 → 31 Dec 2017Funding: FWO research grant KAN
Publications
1 - 10 of 44
- Children born after assisted reproduction more commonly carry a mitochondrial genotype associating with low birthweight(2024)
Authors: C Spits, Joke Mertens, Florence Belva, Aafke PA van Montfoort, Marius Regin, Filippo Zambelli, Sara Seneca, Edouard Couvreu De Deckersberg, Maryse Bonduelle, H Tournaye, et al.
- Gains of 20q11.21 in human pluripotent stem cells: Insights from cancer research(2024)
Authors: Nusa Krivec, Manjusha S Ghosh, C Spits
Pages: 11-27 - SALL3 mediates the loss of neuroectodermal differentiation potential in human embryonic stem cells with chromosome 18q loss(2024)
Authors: C Spits, Yingnan Lei, Diana Al Delbany, Nusa Krivec, Marius Regin, Edouard Couvreu De Deckersberg, Charlotte Janssens, Manjusha S Ghosh, Karen Sermon
Pages: 562-578 - ISSCR standards for the use of human stem cells in basic research(2023)
Authors: Tenneille E Ludwig, Peter W Andrews, Ivana Barbaric, Nissim Benvenisty, Anita Bhattacharyya, Jeremy M Crook, Laurence M Daheron, Jonathan S Draper, Lyn E Healy, Meritxell Huch, et al.
Pages: 1744-1752 - Association between sequence variants in the FSHR gene and reproductive outcomes following IVF in predicted normoresponders(2023)
Authors: Ana Raquel Neves, Sandra Garcia, Lan Tn Vuong, C Blockeel, Gemma Arroyo, C Spits, Toan D Pham, Manh Tuong Ho, H Tournaye, Nikolaos P Polyzos
Pages: 820-828 - The consequences of recurrent genetic and epigenetic variants in human pluripotent stem cells(2022)
Authors: Peter W Andrews, Ivana Barbaric, Nissim Benvenisty, Jonathan S Draper, Tenneille Ludwig, Florian T Merkle, Yoji Sato, C Spits, Glyn N Stacey, Haoyi Wang, et al.
Pages: 1624-1636 - Mitochondrial DNA variants segregate during human preimplantation development into genetically different cell lineages that are maintained postnatally(2022)
Authors: Joke Mertens, Marius Regin, Neelke De Munck, Edouard Couvreu De Deckersberg, Florence Belva, Karen Sermon, H Tournaye, C Blockeel, Hilde Van De Velde, C Spits
Pages: 3629-3642 - Myotonic dystrophy type 1 embryonic stem cells show decreased myogenic potential, increased CpG methylation at the DMPK locus and RNA mis-splicing(2022)
Authors: Silvie Franck, Edouard Couvreu De Deckersberg, Jodi L Bubenik, Christina Markouli, Lise Barbé, Joke Allemeersch, Pierre Hilven, Geoffrey Duqué, Maurice S Swanson, Alexander Gheldof, et al.
- Measuring Early Germ-Layer Specification Bias in Human Pluripotent Stem Cells(2022)
Authors: Alexander Scott Keller, Nusa Krivec, Christina Markouli, C Spits
Pages: 57-72 - ESHRE survey results and good practice recommendations on managing chromosomal mosaicism(2022)
Authors: Martine De Rycke, Antonio Capalbo, Edith Coonen, Giovanni Coticchio, Francesco Fiorentino, Veerle Goossens, Saria Mcheik, Carmen Rubio, Karen Sermon, Ioannis Sfontouris, et al.