Researcher
Peter Tompa
- Research Expertise
(Vrije Universiteit Brussel):
intrinsically disordered protein
structural biology
liquid-liquid phase separation
- Keywords (Vrije Universiteit Brussel):Applied biological sciences, biotechnology
- Disciplines (Flanders Institute for Biotechnology):(Bio)molecular modelling and design, Analytical biochemistry, Medical biophysics
- Disciplines (Vrije Universiteit Brussel):Intracellular compartments and transport
- Users of research expertise
(Vrije Universiteit Brussel):
intrinsically disordered protein
structural biology
liquid-liquid phase separation
- See also: Peter Tompa (Flanders Institute for Biotechnology)
Affiliations
- Department of Bio-engineering Sciences (Department)
Member
From8 Apr 2019 → Today - Tompa Lab (Research group)
Responsible
From1 Jan 2017 → Today - Department of Bio-engineering Sciences (Department)
Member
From1 Oct 2011 → 20 Oct 2022 - Structural Biology Brussels (Research group)
Member
From1 May 2011 → 31 Mar 2024 - Department of Bio-engineering Sciences (Department)
Member
From1 May 2011 → 30 Sep 2021 - Department of Bio-engineering Sciences (Department)
Member
From1 May 2011 → 30 Sep 2014
Projects
1 - 9 of 9
- Characterizing mutations in hnRNPA2 to identify pathogenic mechanisms in degenerative disordersFrom1 Nov 2022 → TodayFunding: FWO fellowships
- Uncovering the effect of long non-coding RNAs on liquid-liquid phase separation of androgen receptor in prostate cancerFrom1 Nov 2022 → TodayFunding: FWO fellowships
- Backup mandate Research Council: Exploring prion-like nucleation of liquid-liquid phase separation of hnRNPA2 in Amyotrophic Lateral SclerosisFrom1 Nov 2021 → 31 Oct 2022Funding: BOF - doctoral mandates
- Targeting the interaction of menin and androgen receptor (AR) for developing new drugs against prostate cancerFrom1 Nov 2019 → 18 Sep 2023Funding: FWO fellowships
- Unravelling the molecular mechanism of animal adhesive secretions to widen the horizons for new bio-inspired materials.From1 Nov 2019 → 31 Oct 2023Funding: FWO fellowships
- Role of ubiquitination in phase transitions in Amyotrophic Lateral Sclerosis (ALS)From1 Nov 2019 → 31 Jan 2024Funding: FWO fellowships
- SRP-Onderzoekszwaartepunt: Optical and microfluidic tools to unravel the dynamics of bio-condensatesFrom1 Mar 2019 → 29 Feb 2024Funding: BOF - projects
- Structural biology of large and flexible macromolecules in solution: Small angle X-Ray Scatter (Bio-SAXS) and Multi-angle light scatter (MALS) (UABR/11/012)From19 Nov 2012 → 24 Apr 2017Funding: Hercules - Small and Medium size research infrastructure
- In vitro cell-free protein synthesis and purification platform.From26 Apr 2012 → 25 Apr 2017Funding: Hercules - Small and Medium size research infrastructure
Publications
1 - 10 of 90
- A cyclin D1 intrinsically disordered domain accesses modified histone motifs to govern gene transcription(2024)
Authors: Xuanmao Jiao, Gabriele Di Sante, Mathew C. Casimiro, Agnes Tantos, Anthony W Ashton, Yen Quach, Dharmendra Bhargava, Agnese Di Rocco, Claudia Pupo, Marco Crosariol, et al.
Pages: 1-16 - Biophysical characterization of the Plasmodium falciparum circumsporozoite protein's N-terminal domain(2024)
Authors: Rob Geens, Jessica Stanisich, Olivier Beyens, Stijn D'Hondt, Jean-Michel Thiberge, Amber Ryckebosch, Anke De Groot, Stefan Magez, Didier Vertommen, Rogerio Amino, et al.
- Minimum information guidelines for experiments structurally characterizing intrinsically disordered protein regions(2023)
Authors: Bálint Mészáros, András Hatos, Nicolas Palopoli, Federica Quaglia, Edoardo Salladini, Kim Van Roey, Haribabu Arthanari, Zsuzsanna Dosztányi, Isabella C Felli, Patrick D Fischer, et al.
Pages: 1291-1303 - Phase-separating fusion proteins drive cancer by dysregulating transcription through ectopic condensates(2023)
Authors: Nazanin Farahi, Tamas Lazar, Peter Tompa, Bálint Mészáros, Rita Anna Pancsa
- C9orf72-linked arginine-rich dipeptide repeats aggravate pathological phase separation of G3BP1(2023)
Authors: Margot Van Nerom, Junaid Ahmed, Tamas Lazar, Joris Van Lindt, Rita Pancsa, D. Maes, Peter Tompa
- Unraveling the role of liquid-liquid phase separation in prostate cancer and amyotrophic lateral sclerosis(2023)
Authors: Junaid Ahmed, Peter Tompa
Number of pages: 230 - Biological colloids: Unique properties of membraneless organelles in the cell(2022)
Authors: Anna Bratek-Skicki, Margot Van Nerom, D. Maes, Peter Tompa
- A Novel Tandem-tag Purification Strategy for Challenging Disordered Proteins(2022)
Authors: Attila Meszaros, Kevin Muwonge, Steven Janvier, Junaid Ahmed, Peter Tompa
Pages: 1-19 - The evolution and polymorphism of mono-amino acid repeats in androgen receptor and their regulatory role in health and disease(2022)
Authors: Attila Meszaros, Junaid Ahmed, Giorgio Russo, Peter Tompa, Tamas Lazar
- F/YGG-motif is an intrinsically disordered nucleic-acid binding motif(2022)
Authors: Donya Pakravan, Manon Demulder, Attila Meszaros, Ludo Van Den Bosch, Peter Tompa
Pages: 622-635