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Project

Skeletal cell metabolism and bone regeneration

Bone tissue engineering consisting of stem or progenitor cells and growth factors, seeded onto a biocompatible scaffold, is a promising strategy for the healing of large bone defects. However, one of the key challenges in regenerative medicine is the poor survival of the grafted cells, which impedes translation of this strategy to clinical practice. A likely explanation is the lack of vascularization at the transplantation site, resulting in oxygen and nutrient deficiency. Interestingly, the chondrocyte, a skeletal progenitor-derived cell type, is well adapted to these avascular conditions. Preliminary data suggest that adaptations in cell metabolism mediate these effects, but the underlying mechanism remains unclear. I hypothesize that the unique metabolic properties of chondrocytes allow them to function in nutrient-deprived conditions. Therefore, I will characterize the specific metabolic needs for chondrocyte survival and functional performance during bone regeneration. In addition, I will monitor the ex vivo diffusion profile of nutrients and combine these insights to tailor novel carrier systems based on the metabolic needs of the implanted cells. Taken together, the knowledge gathered from PhD project will not only improve our insight in the metabolic regulation of chondrocyte behavior, but also provides proof-of-concept for innovative strategies for bone regeneration that actively engage skeletal cell metabolism.

Date:1 Oct 2016 →  21 Feb 2023
Keywords:Bone regeneration, Cell metabolism, Tissue engineering
Disciplines:Endocrinology and metabolic diseases
Project type:PhD project