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Researcher
Kristien Ledeganck
- Research Expertise:We have a large experience in translational, pathophysiological and biomarker research with animal studies (Felasa C degree) and the set-up of large clinical (multicentric) clinical trials. We used several techniques such as molecular biology (real time RT-PCR, Western blotting, Elisa) and histology. An important topic of my resarch is magnesium with studies on the role of magnesium in the pathophysiology of insulin resistance and drug-induced hypomagnesemia. Besides, since 2015, I am supervising a project on the role of donor-derived cell free DNA as a biomarker of kidney transplant rejection. In a parallel study on the same (enlarged) patient population, I am investigating the role of microRNAs in the pathophysiology of kidney transplant rejection, with promising results from the first pilot data of this study. For the latter study, we will implement a kidney transplantation rat model at the lab.
- Keywords:CELL FREE DNA, REJECTION, RENAL SCREENING, Medicine
- Disciplines:Epigenetics, Epigenomics, Kidney diseases, Kidney transplantation, Endocrinology, Paediatrics, Pathophysiology, Biomarker evaluation
- Research techniques:- Set-up of clinical (multicentre - Elisa on blood and urine samples - Real time RT-PCR - Western blotting - Animal studies (rat models of drug-induced kidney injury and model of kidney transplantation (in training) - Body composition measurements - Blood pressure measurements - Blood sampling
- Users of research expertise:- PhD students - master thesis students - postdocs