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Project

Neurochemical characterization of behavioral disturbances in dementia.

Behavioral disturbances (Behavioral and psychological signs and symptoms of dementia, BPSD) are an indispensable part of dementia and consist of delusions, hallucinations, aggressiveness, activity disturbances, diurnal rhythm disturbances, affective disorders and anxieties/phobias. Research has repeatedly confirmed that there is a neurochemical basis underlying BPSD although the pathophysiology remains unclear. In this project ante-mortem behavioral data will be correlated with neurotransmitter concentrations from regional dissection of post-mortem brain tissue of patients with various forms of dementia. Changes in different neurotransmitter systems will be mutually compared between different diagnostic categories of dementia in order to unravel possible neurochemical changes that predispose to certain behavioral profiles.
Date:1 Oct 2009 →  30 Sep 2010
Keywords:DEMENTIA, NEUROCHEMISTRY, NEUROSCIENCE
Disciplines:Neurosciences, Biological and physiological psychology, Cognitive science and intelligent systems, Developmental psychology and ageing