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Publication

Toll-like receptor 2-deficient mice are protected from insulin resistance and beta cell dysfunction induced by a high-fat diet

Journal Contribution - Journal Article

Inflammation contributes to both insulin resistance and pancreatic beta cell failure in human type 2 diabetes. Toll-like receptors (TLRs) are highly conserved pattern recognition receptors that coordinate the innate inflammatory response to numerous substances, including NEFAs. Here we investigated a potential contribution of TLR2 to the metabolic dysregulation induced by high-fat diet (HFD) feeding in mice.
Journal: DIABETOLOGIA
ISSN: 0012-186X
Issue: 8
Volume: 53
Pages: 1795 - 806
Publication year:2010
BOF-keylabel:yes
IOF-keylabel:yes
BOF-publication weight:6
CSS-citation score:3
Authors:International
Authors from:Higher Education