Asymmetric Amyloid Deposition in the Brain Following Unilateral Electroconvulsive Therapy

Electroconvulsive therapy (ECT) has been associated with brain changes that also play a role in the clearance of beta amyloid (β-amyloid), the pathologic hallmark of Alzheimer’s disease (AD). Transient changes in the blood-brain barrier (BBB) (1) and a glial response (2) are induced by ECT; defects in BBB transporters and deficient phagocytosis by microglia (3) interfere with β-amyloid clearance. We report the case of a patient with late-life depression who underwent amyloid positron emission tomography imaging before and 20 months after right unilateral ECT.

Publication year:2017

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BOF-publication weight:10

CSS-citation score:1

Authors from:Higher Education

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