Intracochlear diagnostics: Understanding and improving the bionic ear solution to deafness

Cochlear implant (CI) electrodes are considered the most successful sensory solution over time for severe to complete deafness. Despite its clinical success, little is known on how to optimally preserve the residual hearing function and to avoid scar tissue in order to allow future reimplantation. This project aims to study the cochlea, where the hair cells are located, using dielectric spectroscopy, an electrical analysis technique that reveals molecular relaxations and electrical properties. For the first time, we will modify standard CI electrodes with molecular imprinted polymers (MIPs) to perform in vivo chemical analysis in the cochlea.
The first goal is to answer fundamental questions concerning both physical properties (i.e. temperature and electrical properties) and the immunological (chemical) response of the cochlea to the CI implantation and to auditory stimulation. Our second goal is to increase the effectiveness of next-generation CI and decrease the risks involved with this surgical procedure. The exciting interplay between soft matter physics, biosensors and medical diagnostics will help us to better understand cochlear implants and improve the quality of life of individuals with severe auditory problems for whom the workings of this device is a life-changing medical marvel.