Research agreement to finance the PhD thesis work of Denise Van der Graaff.

Research questions: 1) What are the underlying mechanisms of the dynamic vascular alterations, leading to increased IHVR in NAFLD? a. Is there a role for α1-adrenergic mechanisms? b. Is there a role for COX-mediated mechanisms? c. Is there a role for ET-1 mediated mechanisms? d. Is there a role for angiotensin-mediated mechanisms? e. Are there any interactions, additive or synergistic effects of these vasoconstrictive mechanisms? 2) Is the development of NAFLD associated with the development of CVD? 3) Do the alterations in liver haemodynamics contribute to the progression of NAFLD? 4) Do the alterations in liver haemodynamics contribute to the development of the associated CVD? 5) What are the effects of modulating the intrahepatic vascular tone on NAFLD and associated CVD?

Keywords:LIVER STEATOSIS

Disciplines:Hepatology