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Publication

Astrocyte loss and astrogliosis in neuroinflammatory disorders

Journal Contribution - Journal Article

Neuroinflammation can lead to either damage of astrocytes or astrogliosis. Astrocyte loss may be caused by cytotoxic T cells as seen in Rasmussen encephalitis, auto-antibodies such as in neuromyelitis optica (aquaporin-4 antibodies), or cytokines such as TNF-alpha in major depressive disorder. Interleukins-1 and -6 appear to be important molecular mediators of astrogliosis. Chronic focal lesions in multiple sclerosis are characterized by a very dense astrogliosis. Other mechanisms, such as astrocytic beta(2) adrenergic receptor deficiency, upregulation of endothelin-1 and tissue transglutaminase, may contribute to astroglial scarring in multiple sclerosis.
Journal: Neurosci Lett
ISSN: 0304-3940
Volume: 565
Pages: 39-41
Publication year:2014
Keywords:neuroinflammation, astrocytes, astrogliosis, astrocyte loss, multiple sclerosis
  • VABB Id: c:vabb:388905
  • Scopus Id: 84897098224
  • ORCID: /0000-0002-3676-477X/work/61308427