Researcher
Ilie Cosmin STANCU
- Keywords:Biomedical sciences (incl. biochemistry)
- Disciplines:Inflammation, Neurological and neuromuscular diseases, Pathophysiology, Neurosurgery, Non-clinical studies
Affiliations
- Neurosciences (Department)
Member
From1 Jan 2020 → Today - Neurosciences (Research group)
Member
From1 Jan 2020 → Today - Biomedical Research Institute (Research institute)
Member
From1 Feb 2017 → Today - Faculty of Medicine and Life Sciences (Faculty)
Member
From1 Feb 2017 → Today - Physiology (Research group)
Member
From1 Jan 2018 → 31 Dec 2019 - Physiology - Biochemistry - Immunology (Department)
Member
From1 Feb 2017 → 31 Dec 2019 - Immunology - Biochemistry (Research group)
Member
From1 Feb 2017 → 31 Dec 2017
Projects
1 - 4 of 4
- Halting amyloid induced tau pathology, by modifying ApoE-dependent lipid homeostasis: checking the FACTS on FATS as a modifiable target for preventing AD.From1 Jan 2023 → TodayFunding: Foundations, funds and other with scientific goal
- The role of APOE in Tau-pathology and neurodegeneration downstream of Aβ pathology: Exploiting a human protective APOE3 (R136S) mutation to develop novel therapeutic strategies for Alzheimer's diseaseFrom1 Jan 2021 → 31 Dec 2023Funding: Foundations, funds and other with scientific goal
- The role of ApoE-mediated neuroinflammation in the progression along the pathogenetic axis in AD.From1 Oct 2020 → 30 Sep 2023Funding: FWO senior postdoctoral fellowship
- Targeting ABeta-induced tau pathology and its secondary effects, as key pathogenetic process in ADFrom1 Jan 2019 → 31 Dec 2021Funding: Foundations, funds and other with scientific goal
Publications
1 - 8 of 8
- Blood-based A beta 42 increases in the earliest pre-pathological stage before decreasing with progressive amyloid pathology in preclinical models and human subjects: opening new avenues for prevention(2022)
Authors: Pablo BOTELLA LUCENA, Sarah VANHERLE, Chritica LODDER, Manu GUTIERREZ DE RAVE, Ilie Cosmin STANCU, Ivo LAMBRICHTS, Riet Vangheluwe, Rose BRUFFAERTS, Ilse DEWACHTER
Pages: 489 - 508 - CSF1R inhibition rescues tau pathology and neurodegeneration in an A/T/N model with combined AD pathologies, while preserving plaque associated microglia(2021)
Authors: Chritica LODDER, I Scheyltjens, Ilie Cosmin STANCU, Pablo BOTELLA LUCENA, Manu GUTIERREZ DE RAVE, Sarah VANHERLE, Tim VANMIERLO, Niels CREMERS, Hannah VANRUSSELT, Bert BRONE, et al.
- Sex-regulated gene dosage effect of PPARα on synaptic plasticity(2019)
Authors: Nathalie Pierrot, Laurence Ris, Ilie Cosmin STANCU, Anna Doshina, Floriane Ribeiro, Donatienne Tyteca, Eric Baugé, Fanny Lalloyer, Liza Malong, Olivier Schakman, et al.
- Aggregated Tau activates NLRP3-ASC inflammasome exacerbating exogenously seeded and non-exogenously seeded Tau pathology in vivo(2019)
Authors: Ilie Cosmin STANCU, Niels CREMERS, Hannah VANRUSSELT, J. Couturier, Alexandre Vanoosthuyse, Sofie KESSELS, Chritica LODDER, Bert BRONE, F. Huaux, J. N. Octave, et al.
Pages: 599 - 617 - Synaptogyrin-3 Mediates Presynaptic Dysfunction Induced by Tau(2018)
Authors: Joseph McInnes, Keimpe Wierda, An Snellinx, Laura Bounti, Yu-Chun Wang, Ilie Cosmin STANCU, Nuno Apostolo, Kris Gevaert, Ilse DEWACHTER, Tara L. Spires-Jones, et al.
Pages: 823 - 835 - Preclinical models of Alzheimer’s disease for identification and preclinical validation of therapeutic targets: from fine-tuning strategies for validated targets to new venues for therapy(2017)
Authors: Bruno Vasconcelos, Matthew Bird, Ilie Cosmin STANCU, Dick TERWEL, Ilse DEWACHTER
Pages: 115 - 156 - [P4-037]: IDENTIFICATION OF NOVEL TARGETS FOR INHIBITING PRION-LIKE SEEDING AND PROPAGATION OF TAU PATHOLOGY IN VITRO AND IN VIVO(2017)
Authors: Ilse DEWACHTER, Ilie Cosmin STANCU, Alexandre VANOOSTHUYSE, Arjan Buist, Bruno Vasconcelos, Peng Wang, Pascal Kienlen-Campard, Jean-Noël Octave, Diederik Moechars
Pages: P1270 - P1270 - Tau interactome mapping based identification of Otub1 as Tau deubiquitinase involved in accumulation of pathological Tau forms in vitro and in vivo(2017)
Authors: Peng Wang, Gerard Joberty, Arjan Buist, Alexandre VANOOSTHUYSE, Ilie Cosmin STANCU, Bruno Vasconcelos, Nathalie Pierrot, Maria Faelth-Savitski, Pascal Kienlen-Campard, Jean-Noël Octave, et al.
Pages: 731 - 749