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Project

Evaluating the potential of nanomaterials for IP administration of chemotherapeutics and nucleic acids / Nanomedicine: an integrative approach (NANOMED)

Using a step by step approach, we aim to compare injection and nebulization of chemotherapeutics and nanoparticles , by using an in-house developed model to test PIPAC in rats at clinically relevant conditions. In the first 3 years of the project, we focused on developing the nanoparticle formulation of cisplatin and the effect of nebulization on the stability of nucleic-acid containing nanoparticles. In the last year of the project, we will focus on the antitumor efficacy of injected or nebulized cisplatin nanoparticles and on the effect of size and shape on the biodistribution of nanoparticles injected or nebulized in the peritoneal cavity.

Date:1 Mar 2019 →  31 Aug 2019
Keywords:topical administration, nanocarriers, drug delivery
Disciplines:Biomarker discovery, Clinical pharmacy, Other pharmaceutical sciences not elsewhere classified, Pharmaceutical technology, Pharmacology not elsewhere classified, In vitro testing, Small molecules, Clinical toxicology, Pharmacognosy