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Project

The identification of actionable genetic events driving disease progression and heterogeneity in peripheral T cell lymphoma not otherwise specified

We propose an integrated genomic study to identify driver mutations in transcriptionally distinct diseases like peripheral T cell lymphoma. We will validate the oncogenic potential of candidate mutations in vitro. We will generate patient-derived xenografts and we will apply the results of our genetic analysis in a versitale bone marrow transplant model. We will use these models for pre-clinical treatment studies, that may foster future clinical trials.

Date:1 Jan 2019 →  31 Dec 2022
Keywords:integrated genomic study, driver mutations, peripheral T cell lymphoma, versitale bone marrow transplant model
Disciplines:Clinical genetics and molecular diagnostics