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Project

Development and evaluation of new classes of CXCR2 antagonists with applications in inflammation and infection

The PhD project is part of a broader multidisciplinary research approach that ultimately aims: 1) to provide novel pharmacological tools (small molecules) that specifically target the human CXCR2 receptor by evaluating the compounds in pharmacological assays, and 2) to develop biologically relevant assays to demonstrate that the best-in-class molecules are able to modulate the important function of CXCR2 (e.g. in inflammation and infection).

The aim is to identify specific small molecule ligands that function as highly potent CXCR2 antagonists (i.e., blocking CXCR2 mediated processes).The most important part of this PhD work will be the biological profiling of novel classes of compounds.

 

Date:3 Sep 2019 →  3 Sep 2023
Keywords:receptor, chemokines, Signaling, Inflammation
Disciplines:Microbiology not elsewhere classified
Project type:PhD project