Researcher
Mark Fiers
- Disciplines (Flanders Institute for Biotechnology):Analysis of next-generation sequence data, Cell death, Behavioural neuroscience
- Disciplines (KU Leuven):Genetics, Systems biology, Medical imaging and therapy, Molecular and cell biology, Other paramedical sciences
Affiliations
- De Strooper Lab (Research group)
Member
From1 Mar 2018 → Today - Department of Human Genetics (Department)
Member
From25 Apr 2013 → Today - Laboratory for the Research of Neurodegenerative Diseases (VIB-KU Leuven) (Lab)
Member
From1 Feb 2013 → 30 Apr 2022
Projects
1 - 5 of 5
- Spatial Proteomics to Investigate the Cellular Phase of Alzheimer’s DiseaseFrom13 Feb 2023 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Understanding the cellular phase of Alzheimer’s disease using spatial transcriptomicsFrom1 Sep 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Investigating the cellular phase of Alzheimer’s disease using spatial transcriptomics.From1 Jun 2021 → TodayFunding: Own budget, for example: patrimony, inscription fees, gifts
- Transcriptomics to study the cellular phase of Alzheimer's DiseaseFrom1 Oct 2017 → 30 Nov 2023Funding: Own budget, for example: patrimony, inscription fees, gifts
- Towards petascale biocomputational sciencesFrom1 Oct 2016 → 30 Sep 2018Funding: Fund Recuperation Fiscal Exemption
Publications
1 - 10 of 40
- Transcriptomics to study the cellular phase of Alzheimer's Disease(2023)
Authors: Nicky Thrupp, Bart De Strooper, Mark Fiers
- The y-secretase substrate proteome and its role in cell signaling regulation(2023)
Authors: Nicola Fattorelli, Dries T'Syen, Sriram Balusu, Tom Theys, Bart De Strooper, Mark Fiers
Pages: 4106 - + - MEG3 activates necroptosis in human neuron xenografts modeling Alzheimer's disease(2023)
Authors: Sriram Balusu, Nicky Thrupp, Dries T'Syen, Annerieke Sierksma, Dietmar Thal, Mark Fiers, Bart De Strooper
Pages: 1176 - + - microRNA-132 regulates gene expression programs involved in microglial homeostasis(2023)
Authors: Kristofer Davie, Nicky Thrupp, Mark Fiers, Bart De Strooper
- Early alterations in the MCH system link aberrant neuronal activity and sleep disturbances in a mouse model of Alzheimer's disease(2023)
Authors: Nicky Thrupp, Mark Fiers, Joris de Wit, Kristofer Davie, Dietmar Thal, Bart De Strooper
Pages: 1021 - + - Reduced Levels of Misfolded and Aggregated Mutant p53 by Proteostatic Activation(2023)
Authors: Filip Claes, Rob van der Kant, Mark Fiers, Stein Aerts, Frederic Rousseau, Joost Schymkowitz, Frederik De Smet
- Astrocyte calcium dysfunction causes early network hyperactivity in Alzheimer's disease(2022)
Authors: Disha Shah, Willy Gsell, Jérôme Wahis, Emma Luckett, Ben Vermaercke, Pranav Preman, Daan Moechars, Mark Fiers, Matthew Holt, Dietmar Thal, et al.
- Restoring miR-132 expression rescues adult hippocampal neurogenesis and memory deficits in Alzheimer's disease(2021)
Authors: Hannah Walgrave, Sriram Balusu, Nicky Thrupp, Rudi D'Hooge, Dietmar Thal, Mark Fiers, Bart De Strooper
Pages: 1805 - + - Identifying individuals with high risk of Alzheimer's disease using polygenic risk scores(2021)
Authors: Annerieke Sierksma, Mark Fiers, Bart De Strooper
- Single-Nucleus RNA-Seq Is Not Suitable for Detection of Microglial Activation Genes in Humans(2020)
Authors: Nicky Thrupp, Nicola Fattorelli, Tom Theys, Bart De Strooper, Mark Fiers