Validation and evaluation of novel biomarkers for early renal damage in the clinical setting

The aim of this thesis was to contribute to the next step in the implementation of these new biomarkers for AKI. In chapter 2 and chapter 3, we focused on the determination of the most ideal collection and storage conditions prior to the biomarker measurements. In chapter 4 the goal was to establish reference values for these novel biomarkers for healthy subjects with special attention for age and gender. In the following chapters we investigated the utility of these biomarkers in different clinical settings. Chapter 5 was attributed to the research we conducted on the association between KIM-1 and urinary cadmium concentrations. Finally, in chapter 6 we investigated a panel of novel biomarkers in an attempt to detect AKI after cardiac surgery requiring a cardiopulmonary bypass.

Publication year:2014

Accessibility:Open