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Project

Gene identification and zebrafish disease modeling of inherited bone disorders

The requested funding will be used to actively sustain the fruitful ongoing collaborations between the five research groups mentioned below. Each of the five groups have their own complementary expertise in the field of bone development, bone metabolism and modeling and molecular analysis of heritable bone disorders. The general research focus of the different groups is to identify the causal gene mutations and to elucidate the pathophysiological mechanisms involved in monogenic bone disorders, including fragile bone disorders such as Osteogenesis Imperfecta (OI) and sclerosing bone disorders such as osteopetrosis. This approach is of importance to also reveal the contribution of specific pathogenic mechanisms underlying complex bone disorders such as osteoporosis. The final goal is to open new therapeutic avenues for the treatment of heritable fragile bone disorders.
Date:1 Jan 2017 →  31 Dec 2021
Keywords:GENE DETECTION
Disciplines:Genetics, Systems biology, Molecular and cell biology
Project type:Collaboration project