Cytomegalovirus(CMV) infection as a predictor of influenza vaccine response in the elderly.

While it is generally accepted that ageing is associated with immune dysfunction and dysregulation, it has been suggested that this immune deterioration might be correlated with carrier status of CMV. Therefore, we elaborate to demonstrate a correlation between CMV serological status, CMV-specific T cell immunity and their association with responsiveness to influenza . This project will contribute to the identification of possible mechanisms involved in immunosenescence, which ultimately will contribute to new vaccine strategies including pre-vaccination screening, aiming an effective response in an individual whose immune system is in decline.

Keywords:T CYTOTOXIC LYMPHOCYTE, ELDERLY PEOPLE, VACCINES

Disciplines:Immunology, Microbiology