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Project
Precision medicine in inherited blindness using integrated omics in human and animal models
This multidisciplinary project aims (1) to decipher cis-regulation in human retina by chromatin conformation profiling, and by the study of regulatory elements in a human and animal model;; (2) to design an integrative framework for omics data analysis to explain missing heritability in inherited
blindness;; (3) to design and test antisense oligonucleotide-based treatments of novel targets, ultimately resulting in precision medicine for inherited blindness.
Date:1 Jan 2020 → Today
Keywords:photoreceptor precursor cell, proteomics, genomics, CRISPR/Cas9 editing, Xenopus tropicalis, transcriptomics, iPSC, cis-regulation, splicing, interaction profiling, Inherited retinal disease, antisense oligonucleotide treatment
Disciplines:Genetic predisposition