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Project

Natural history and determinants of the burden of medial vascular calcification, using pseudoxanthoma elasticum as a model.

In this PhD project, a heritable form of medial vascular calcification (VCm) will be studied namely pseudoxanthoma elasticum (PXE), caused by ABCC6 mutations. The natural history of VCm in PXE patients, causative molecular mechanisms and the role of dysfunctional lipid metabolism will be studied, contributing to improved clinical management and prognosis of patients with VCm phenotypes.

Date:1 Oct 2019 →  31 Oct 2020
Keywords:natural history, pseudoxanthoma elasticum, lipid metabolism, Medial vascular calcification, Inorganic pyrophosphate
Disciplines:Cardiac and vascular medicine not elsewhere classified, Genetics not elsewhere classified, Medical biochemistry and metabolism not elsewhere classified