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Project
Bio-inspired Scaffold Assembly via Intermolecular Cascade Olefin Cyclisations
Terpenoids, the most diverse specialized metabolites, all share a similar biosynthesis involving cascade reactions resulting in structurally well-defined three-dimensional scaffolds. Terpene scaffolds are usually synthesized via long sequences of fragment-coupling reactions because biomimetic approaches are challenging to achieve. In this project, a hybrid approach towards terpene synthesis will be explored wherein scaffolds can be assembled by designing intermolecular cascade reactions.
Date:1 Nov 2020 → 31 Oct 2021
Keywords:Cascade reactions, Carbocations, Terpenoid Natural Products
Disciplines:Natural products chemistry, Organic chemical synthesis