Eosinophilic Oesophagitis (EoE) in childhood: analysis of remission rates and Quality of Life in children from UZ Leuven treated according to Ped-EoE guidelines 2020.

Description
Eosinofilic oesoghagitis (EoE) is a chronic disorder of the oesophagus that probably requires life-long treatment. The number of children with EoE is constantly increasing. Treatment in first-line is frequently proton-pump inhibitors (PPI) but if failing, according to recent guidelines, local treatment with steroids or treatment with diet are equally positioned.  This diet can, if the effect is insuffiient, increase to the "classical six-food diet": cow's milk, wheat, chicken egg, soy, peanut/tree nuts and fish/shellfish and is called step-up diet. Or; if good effect, stepwisely decreased from the classical six-food diet to the eventual culprits and is then called step-down diet. Evaluation of the effect is done by labelling oesinophils on oesophagal biopsy and evaluation of the symptom score. Children with EoE initially often have a gastroscopy every 8 weeks and later on yearly. These procedures (together with the often restrictive diet) has an important effect on the Quality of Life of these children. 



Purpose(s)
With this study we want to document which choices within the cited possiblities are mostly chosen by the parents-children and doctors from UZ Leuven, what the effect of those choices is on the histological remissions and what the effect on the quality of Life is for the children. The latter by using validated ped-EoE QoL scores.