Nanocellulose-based functional extracellular matrices

In vivo, cells are supported by a 3D extracellular matrix (ECM) with different physical and chemical properties, which controls the cellular functions and is continuously remodeled by cells. Thus, the development of nanomaterials mimicking the properties of natural ECMs is of high value for regenerative medicine and fundamental science. Cellulose-based biomaterials are among the most promising candidates for cellular scaffolds, but, up to now biomaterials are lacking the spatial and dynamic stimuli distribution of natural ECMs. Local sensors monitoring in-situ cellular responses are also lacking unfortunately. In this project, we will assemble chemically-modified cellulose nanocrystals, with or without other nanoparticles, into ECMs, and we will develop strategies for monitoring cell growth and responses. We will also explore the possibility to locally stimulate cell growth and activity, and dynamically alter the ECM characteristics during cell growth.