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Project
Understanding the immunological basis of persistent airway obstruction in asthma
In severe asthma, there is persistent obstruction of the airways with mucus plugs containing mucins, fibrin, and Charcot-Leyden crystals. We hypothesize that plugged airways constitute a unique niche where type 2 immune cells thrive and communicate with structural cells to perpetuate disease. We will
study if eliminating plugs or key niche communication signals can treat persistent disease in mouse and man.
Date:1 Jan 2021 → Today
Keywords:T cells, protein crystals, neutrophils, epithelial cells, mucus, dendritic cells, Asthma, lung function, eosinophils
Disciplines:Respiratory medicine, Allergology, Animal immunology, Inflammation