Non-alcoholic fatty liver disease (NAFLD): Using single-cell RNA sequencing to profile adipose tissue macrophages.

ATMs have been suggested to be critically linked to metabolic regulation during NAFLD progression, exposing them as potential targets in the design of new therapies. We hypothesize that adipose tissue contains multiple distinct populations of macrophages with unique tissue distributions, transcriptomes, metabolomics and functions. Here we aim to unravel the cellular and functional heterogeneity within adipose macrophages particularly in human NAFLD samples at a single cell level. This work should provide new opportunities to develop new immune-directed therapies for the treatment of obesity and related inflammatory comorbidities.