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Neurometabolic Correlates of Reactive and Proactive Motor Inhibition in Young and Older Adults: Evidence from Multiple Regional 1H-MR Spectroscopy
Journal Contribution - Journal Article
Suboptimal inhibitory control is a major factor contributing to motor/cognitive deficits in older age and pathology. Here, we
provide novel insights into the neurochemical biomarkers of inhibitory control in healthy young and older adults and
highlight putative neurometabolic correlates of deficient inhibitory functions in normal aging. Age-related alterations in
levels of glutamate–glutamine complex (Glx), N-acetylaspartate (NAA), choline (Cho), and myo-inositol (mIns) were assessed
in the right inferior frontal gyrus (RIFG), pre-supplementary motor area (preSMA), bilateral sensorimotor cortex (SM1),
bilateral striatum (STR), and occipital cortex (OCC) with proton magnetic resonance spectroscopy (1H-MRS). Data were
collected from 30 young (age range 18–34 years) and 29 older (age range 60–74 years) adults. Associations between
age-related changes in the levels of these metabolites and performance measures or reactive/proactive inhibition were
examined for each age group. Glx levels in the right striatum and preSMA were associated with more efficient proactive
inhibition in young adults but were not predictive for reactive inhibition performance. Higher NAA/mIns ratios in the
preSMA and RIFG and lower mIns levels in the OCC were associated with better deployment of proactive and reactive
Journal: Cerebral Cortex Communications
ISSN: 2632-7376
Issue: 1
Volume: 1
Pages: 1 - 16
Publication year:2020
Accessibility:Open