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Endurance exercise intervention is beneficial to kidney function in a rat model of isolated abdominal venous congestion

Journal Contribution - Journal Article

Subtitle:a pilot study
In this study, the effects of moderate intense endurance exercise on heart and kidney function and morphology were studied in a thoracic inferior vena cava constricted (IVCc) rat model of abdominal venous congestion. After IVC surgical constriction, eight sedentary male Sprague-Dawley IVCc rats (IVCc-SED) were compared to eight IVCc rats subjected to moderate intense endurance exercise (IVCc-MOD). Heart and kidney function was examined and renal functional reserve (RFR) was investigated by administering a high protein diet (HPD). After 12 weeks of exercise training, abdominal venous pressure, indices of body fat content, plasma cystatin C levels, and post-HPD urinary KIM-1 levels were all significantly lower in IVCc-MOD versus IVCc-SED rats (P < 0.05). RFR did not differ between both groups. The implementation of moderate intense endurance exercise in the IVCc model reduces abdominal venous pressure and is beneficial to kidney function.
Journal: Journal of cardiovascular translational research
ISSN: 1937-5387
Volume: 13
Pages: 769 - 782
Publication year:2020
Keywords:A1 Journal article
BOF-keylabel:yes
Accessibility:Closed