Lewis acidic $FeCl_{3}$ promoted 2-aza-Cope rearrangement to afford alpha-substituted homoallylamines in dimethyl carbonate

The iron(iii)-catalyzed efficient strategy for the synthesis of alpha-substituted homoallylamines was accomplished via a cationic 2-aza-Cope rearrangement of aldimines, generated in situ by condensation of commercially available aldehydes and easily synthesizable 1,1-diphenylhomoallylamines. This reaction features a broad substrate scope with high yields and is conducted in an eco-friendly solvent, i.e. dimethyl carbonate.

Publication year:2019

Keywords:A1 Journal article

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BOF-publication weight:1

CSS-citation score:1

Authors from:Higher Education

Accessibility:Open