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Project

Mechanisms involved in metastasis of luminal breast cancer

This project is aimed at the validation of the results obtained from our
previous exploratory study on luminal breast cancer metastasis. Comparison
of plasma profiles between patients who did or did not develop metastasis
showed that there exist, already at diagnosis, small but significant differences
in the plasma levels of several chemokines and microRNAs between early
relapsing versus long-term non-relapsing patients. Also, the tumor
transcriptomic profile of primary metastasized tumors appeared to be
markedly different from that of comparable tumors that are not (yet)
metastasized. Confirmation of these results in new independent cohorts will
provide solid evidence that baseline plasma levels of chemokines and
microRNAs could have prognostic value in luminal breast cancer. Validation
of the differential gene expression patterns of metastasized versus nonmetastasized
tumors could improve our understanding of the mechanisms
underlying metastasis and could also have important clinical implications with
regard to standard tumor staging procedures at diagnosis

Date:1 Mar 2021 →  28 Feb 2022
Keywords:luminal breast cancer, metastasis
Disciplines:Cancer biology