< Back to previous page

Publication

Hallmarks of environmental insults

Journal Contribution - Review Article

Environmental insults impair human health around the world. Contaminated air, water, soil, food, and occupational and household settings expose humans of all ages to a plethora of chemicals and environmental stressors. We propose eight hallmarks of environmental insults that jointly underpin the damaging impact of environmental exposures during the lifespan. Specifically, they include oxidative stress and inflammation, genomic alterations and mutations, epigenetic alterations, mitochondrial dysfunction, endocrine disruption, altered intercellular communication, altered microbiome communities, and impaired nervous system function. They provide a framework to understand why complex mixtures of environmental exposures induce severe health effects even at relatively modest concentrations.
Journal: CELL
ISSN: 0092-8674
Issue: 6
Volume: 184
Pages: 1455 - 1468
Publication year:2021
BOF-keylabel:yes
IOF-keylabel:yes
BOF-publication weight:10
Authors:International
Authors from:Higher Education
Accessibility:Open