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Project

Biopolymer based stimuli responsive nanocarriers for targeted drug delivery. (R-11848)

Recently, nanomedicine has emerged as an inevitable option for advanced health care. In this regard, nanocarriers (NCs) for targeted drug delivery provide a great advantage as they offer additional in vivo stability by protecting the drug from degradation in the bloodstream, enhanced drug solubility, decreased toxic side effects, and help in improving the pharmacokinetic and -dynamic profiles of drugs. However, the adverse effects related to their uncontrolled drug release are a major concern. The aim of my research project is to formulate stimuli-responsive nanocarriers based on derivatized biopolymers sensitive to a physiological environment for the targeted release of drugs to treat diseases such as cancer. Biopolymers such as dextran and hyaluronic acid, with their inherent biocompatibility and biodegradability, hold a huge potential for drug delivery applications. The objective of this research is to functionalize different biopolymers by chemical modification through synthetic routes for realizing desired material properties. More specifically, this study focuses on the design and development of reactive oxygen species (ROS) sensitive biopolymer moieties and drug-polymer conjugates. In here, we will systematically explore the effects of chemical modification of biopolymers to serve as responsive NCs for controlled drug release. Furthermore, optimized responsive NCs will be tested for their in vitro therapeutic efficiency.
Date:16 Feb 2021 →  Today
Keywords:Nanomedicine, nanoparticles and -clusters
Disciplines:Synthesis of materials, Chemistry of clusters, colloids and nanomaterials, Nanobiotechnology, Biomaterials