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Project
Research in translational immunomodulation. (R-11571)
We are interested in mechanisms of how immune system imbalance leads to human disease. Our group focuses on the role of specific immune cell subsets in this process, in particular on the interplay of anti-‐ inflammatory CD4+ regulatory T cells (Tregs) and pro-‐inflammatory CD4+ effector T cells. Here, our major interest lies in the understanding of the processes that lead to autoimmune diseases like multiple sclerosis (MS) or are related to metabolic-‐ and cardiovascular diseases and cancer. To study these processes, we use a translational approach, combining the analysis of human samples and the use of experimental model systems by various immunological and molecular biology state-‐of-‐the-‐art techniques. Currently, we center on the following topics: a) Environmental factors influencing the immune cell balance and disease (nutrition, microbiota) (for overview: Müller et al., Nature Rev Immunol. 2019; Arroyo Hornero et al., Front Immunol. 2020 and b) Plasticity and metabolic regulation of T cell subsets in health and disease (for overview: Kleinewietfeld et al., Semin Immunol. 2013 & Immunol Rev. 2014; Binger et al., Front Immunol. 2017).
Date:1 Nov 2020 → Today
Keywords:immunology
Disciplines:Autoimmunity, Immunology not elsewhere classified