Researcher

Lorenzo Cianni

Research Expertise:I have acquired strong technical abilities in the design and synthesis of organic compounds using conventional and modern organic synthesis over the last ten years of research in several institutions. Also, I have a good knowledge/experience of biological and pharmaceutical principles and a working knowledge of the use of structure-based and other computer-aided drug design tools. My research experiences resulted in a consistent track record of academic accomplishments.

Research techniques:Organic Chemistry Cutting-edge methodologies in organic synthesis Solid-phase and liquid-phase synthesis of peptides and peptidomimetic molecules Diastereoselective synthesis of peptide-like compounds State-of-the-art in the characterization of the nature and purity of synthesized products (1D-NMR, 2D-NMR, MS, IR, MPt, LC, GC, LC-MS, UPLC-MS, GC-MS, ESI-MS, FT-IR, CD) Bioorganic Chemistry Enzyme kinetics characterization by spectrophotometric and fluorometric assays Target-ligand interaction studies by ESI-MS, FRET and CD Cheminformatics and Medicinal Chemistry Structure-based and knowledge-based drug design Molecular docking with Glide (Schrödinger)® and MOE (Chemical Computing Group)® Structure activity relationships with Python®, GraphPad®, and KNIME Analytics Platform®

Users of research expertise:Pharmaceutical Company Research Institute University