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Project

Catheter-based sensors for the detection of molecular biomarkers

Within this project, we develop catheter-based sensors that will be used for the diagnostics of intestinal disorders with a focus on the irritable-bowel syndrome IBS. This syndrome affects ca. 10% of the population in western countries. The catheters will allow to assess the concentration of several biomarkers such as histamine and serotonin directly inside the intestines. The concentrations and their evolution over time will help to identify the underlying disease mechanisms so that patients can receive a personalized therapy. To detect the biomarkers, we will develop molecularly imprinted polymers (MIPs) that combine electrical conductivity with highly selective binding properties for the targeted marker molecules. Special attention will go to the kinetics of molecular recognition and the correct functioning of the MIPs within a broad pH range. The measurement will use micro-electrodes that are coated with MIP materials, allowing to detect electrical impedance signals. These signals will serve as a measure for the molecular concentrations and results will be validated with respect to bioanalytical reference techniques. Since the volume inside the gastrointestinal tract is limited, we will employ micro-fabrication techniques for manufacturing these sensors. The catheters will be evaluated on healthy volunteers and several groups of patients. For this, we will closely collaborate with the University Hospital Gasthuisberg of KU Leuven, where a related Ph.D. project will be running with a focus on the medical aspects.

Date:10 Sep 2021 →  Today
Keywords:Catheder-based sensors, IBS, molecularly imprinted polymers
Disciplines:Biophysics not elsewhere classified, Biomedical instrumentation, Atomic and molecular physics not elsewhere classified
Project type:PhD project