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Project

Novel approaches in the diagnosis and treatment of upper gastrointestinal motility disorders

We will study the contribution of new diagnostic and therapeutic evolutions in the management of upper gastrointestinal motility disorders. The focus will be on esophageal and gastric motlility disorders, and on eosinophilic esophagitis. The novel diagnostic approaches are: 1) the use of the endoluminal functional lumen imaging probe (Endoflip) to measure distensibility in the esophagus and the pylorus. 2) the use of confocal laser endoscopic (CLE) imaging to identify specific food allergic reactions in the upper gastrointestinal tract. 3) the use of a fiberoptic novel catheter to measure luminal diameters in the esophagus These techniques will be used together with the classical work-up, in esophageal and gastric disorders, combined with current and novel treatment approaches, to investigate whether they can predict outcomes and help select patients. The novel therapeutic interventions will be: 1) A placebo-controlled add-on therapy of prucalopride for refractory gastro-esophageal reflux disease (GERD). 2) Elimination diet for eosinophilic esophagitis based on CLE-identified gastrointestinal specific food allergy 3) Gastric peroral endoscopic myotomy (G-POEM) for gastroparesis  4) A controlled trial with velusetrag in chronic intestinal pseudo-obstruction (CIPO).

Date:1 Sep 2021 →  Today
Keywords:motility disorders, upper gastrointestinal tract, novel therapeutic interventions, novel diagnostic interventions
Disciplines:Gastro-enterology
Project type:PhD project